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GENE：POLD4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol POLD4
FullNmae DNA polymerase delta 4, accessory subunit
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14106
EnsembleID ENSG00000175482
Uniprot Q9HCU8

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
POLD4 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
POLD4 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
POLD4 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
POLD4 GO:0000731,GO:0001938,GO:0003887,GO:0005515,GO:0005654,GO:0006261,GO:0006261,GO:0043625,GO:0043625

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
POLD4 hsa:57804 path:hsa03030 DNA replication - Homo sapiens (human)
POLD4 hsa:57804 path:hsa03410 Base excision repair - Homo sapiens (human)
POLD4 hsa:57804 path:hsa03420 Nucleotide excision repair - Homo sapiens (human)
POLD4 hsa:57804 path:hsa03430 Mismatch repair - Homo sapiens (human)
POLD4 hsa:57804 path:hsa03440 Homologous recombination - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
PCNA POLD4 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 26192618 interaction type N/A ACSN
POLD4 POLD1 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 26192618 27760120 27760777 interaction type N/A ACSN
POLD4 POLD3 11756412 14624239 14726013 15703371 16697054 1974050 19847258 22021614 23414611 26192618 27760120 27760777 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
ETS1 POLD4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 POLD4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 POLD4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 POLD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF POLD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 POLD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS POLD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A POLD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 POLD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR POLD4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC POLD4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 POLD4 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 POLD4 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00003380CC POLD4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000008A99 POLD4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000221168 POLD4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00005CC20C POLD4 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075C4B1 POLD4 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
POLD4 PCNA 25361965 interaction type N/A PTMCode2
PCNA POLD4 25361965 interaction type N/A PTMCode2
POLD4 POLD2 25361965 interaction type N/A PTMCode2
POLD2 POLD4 25361965 interaction type N/A PTMCode2
POLD1 POLD4 25361965 interaction type N/A PTMCode2
POLD4 POLD1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PCNA POLD4 14525934 16510448 24234451 25348397 physical association experimental interaction detection,far western blotting,physical interaction,enzyme linked immunosorbent assay,two hybrid ComPPI,HPRD,IntAct
POLE POLD4 25348397 N/A physical interaction ComPPI
POLD3 POLD4 25348397 N/A physical interaction ComPPI
POLD2 POLD4 16510448 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
RNF8 POLD4 25348397 N/A physical interaction ComPPI
WRNIP1 POLD4 14525934 15670210 24234451 25348397 association,physical association anti tag coimmunoprecipitation,experimental interaction detection ComPPI,HPRD,IntAct
POLD1 POLD4 12403614 16510448 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,cosedimentation through density gradient,molecular sieving,chromatography technology,pull down,physical interaction,ion exchange chromatography ComPPI,IntAct
POLE2 POLD4 25348397 N/A physical interaction ComPPI
DTL POLD4 25348397 N/A physical interaction ComPPI
SPRTN POLD4 25348397 N/A physical interaction ComPPI
POLD4 SEC23IP 14525934 16510448 N/A experimental interaction detection,two hybrid HPRD
PCNA POLD4 16510448 27898060 9038370 stimulant N/A OmniPath
WRN POLD4 10781066 27898060 stimulant N/A OmniPath

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