GENE：SLC7A11
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | SLC7A11 |
| FullNmae | solute carrier family 7 member 11 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:11059 |
| EnsembleID | ENSG00000151012 |
| Uniprot | Q9UPY5 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| SLC7A11 | ferroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SLC7A11 | ferroptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| SLC7A11 | disulfidptosis | 37574347 | However, recent studies have uncovered an unexpected role of SLC7A11 in promoting disulfidptosis, a novel form of regulated cell death induced by disulfide stress. | retulator signature |
| SLC7A11 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| SLC7A11 | cuproptosis | 37864891 | Notably, when Elesclomol and copper were conjoined, copper accumulated within the mitochondria due to the depletion of ATP7A . This sequestration, in turn, facilitated the build-up of reactive oxygen species (ROS), thereby instigating the degradation of SLC7A11 | Driver |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| SLC7A11 | GO:0003333,GO:0005515,GO:0005886,GO:0005886,GO:0005886,GO:0006749,GO:0008542,GO:0009636,GO:0009986,GO:0014070,GO:0015179,GO:0015327,GO:0015327,GO:0015811,GO:0015813,GO:0016020,GO:0021591,GO:0021756,GO:0030534,GO:0031526,GO:0031528,GO:0033029,GO:0034599,GO:0034775,GO:0035094,GO:0042127,GO:0045177,GO:0048021,GO:0048286,GO:0050804,GO:0050807,GO:0051223,GO:0051775,GO:0060173,GO:0070306,GO:0070527,GO:0090461,GO:0097449,GO:0098712,GO:0110076,GO:0140206,GO:0140924,GO:0140926,GO:1900407,GO:1901494,GO:1903786,GO:1904717,GO:2000211 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| SLC7A11 | hsa:23657 | path:hsa04216 | Ferroptosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | SLC7A11 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA1 | SLC7A11 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | SLC7A11 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| FOXP3 | SLC7A11 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | SLC7A11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | SLC7A11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | SLC7A11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | SLC7A11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | SLC7A11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | SLC7A11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | SLC7A11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | SLC7A11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RUNX1 | SLC7A11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | SLC7A11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | SLC7A11 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00003380CC | SLC7A11 | 19296470 | rna interference,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS00003380CC | SLC7A11 | 19296470 25416803 | mrna cleavage,inhibition | quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS0000065D58 | SLC7A11 | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection,experimental interaction detection,experimental interaction detection | TarBase |
| URS0000521626 | SLC7A11 | 17612493 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000007FBA | SLC7A11 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS0000338542 | SLC7A11 | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS00000F31F4 | SLC7A11 | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00000B59A2 | SLC7A11 | 19074876 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00002FC5B0 | SLC7A11 | 20371350 22012620 22473208 25416803 | mrna cleavage,inhibition | nucleotide sequence identification,clip | TarBase |
| URS000003ABC4 | SLC7A11 | 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification | TarBase |
| URS00001B341F | SLC7A11 | 24516043 25416803 | mrna cleavage,inhibition | quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS000006FDD4 | SLC7A11 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000427B68 | SLC7A11 | 20371350 21572407 22012620 23313552 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000021D7C8 | SLC7A11 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000D2680 | SLC7A11 | 20371350 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001E0AEA | SLC7A11 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000039A052 | SLC7A11 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000045147B | SLC7A11 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000009C45F | SLC7A11 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000C85B2 | SLC7A11 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B989F | SLC7A11 | 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001A7F58 | SLC7A11 | 22012620 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004719AB | SLC7A11 | 20371350 21572407 22012620 23313552 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS00000B7E30 | SLC7A11 | 20371350 21572407 22012620 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002233F4 | SLC7A11 | 20371350 21572407 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000012930C | SLC7A11 | 20371350 21572407 22012620 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000017EA6A | SLC7A11 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00001CF056 | SLC7A11 | 20371350 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003A5E54 | SLC7A11 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000085F64 | SLC7A11 | 21572407 23313552 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS000076B539 | SLC7A11 | 21572407 23313552 23824327 25416803 27418678 | mrna cleavage,inhibition | clip | TarBase |
| URS0000224AEA | SLC7A11 | 23824327 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS00004CCA62 | SLC7A11 | 23824327 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000032835F | SLC7A11 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000023F8DA | SLC7A11 | 23824327 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000075AB14 | SLC7A11 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000016FD1A | SLC7A11 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000021D08 | SLC7A11 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000508C13 | SLC7A11 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000041E949 | SLC7A11 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000027080C | SLC7A11 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000346991 | SLC7A11 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000070CD2 | SLC7A11 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000DDD35 | SLC7A11 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000298BA3 | SLC7A11 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002B3783 | SLC7A11 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000042E1F | SLC7A11 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002075FA | SLC7A11 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000600E6 | SLC7A11 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000039E1E1 | SLC7A11 | 23313552 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| MAD2L2 | SLC7A11 | 24234451 25348397 29656893 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
| CD44 | SLC7A11 | 21397861 24234451 25348397 27898060 | colocalization,association,physical association | anti bait coimmunoprecipitation,fluorescence microscopy | ComPPI,IntAct,OmniPath |
| TERT | SLC7A11 | 25348397 | N/A | physical interaction | ComPPI |
| BAAT | SLC7A11 | 12763038 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| SLC7A11 | SLC3A2 | 11406111 12235164 25348397 27898060 | N/A | in vivo | ComPPI,OmniPath |
| FADD | SLC7A11 | 24234451 30561431 | association | virotrap | IntAct |
| TRAF2 | SLC7A11 | 24234451 30561431 | association | virotrap | IntAct |