GENE：TUSC2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TUSC2 |
| FullNmae | tumor suppressor 2, mitochondrial calcium regulator |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:17034 |
| EnsembleID | ENSG00000114383 |
| Uniprot | O75896 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TUSC2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TUSC2 | GO:0001779,GO:0005515,GO:0005739,GO:0006909,GO:0006954,GO:0007049,GO:0032700,GO:0032733,GO:0048469,GO:0051881,GO:0070945,GO:2000377 |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | TUSC2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| HIF1A | TUSC2 | 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | TUSC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | TUSC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | TUSC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | TUSC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | TUSC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | TUSC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | TUSC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYC | TUSC2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000F4AC3 | TUSC2 | 19671678 | rna interference,inhibition | western blot,miRNA interference luciferase reporter assay | miRSponge |
| URS0000508C13 | TUSC2 | 15685193 | rna interference,inhibition | array technology | miRSponge |
| URS00000451A1 | TUSC2 | 18077375 | rna interference,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | miRSponge |
| URS00000DDD35 | TUSC2 | 19671678 | rna interference,inhibition | western blot,miRNA interference luciferase reporter assay | miRSponge |
| URS0000122ED0 | TUSC2 | 19671678 | rna interference,inhibition | western blot,miRNA interference luciferase reporter assay | miRSponge |
| URS0000508C13 | TUSC2 | 15685193 25416803 | mrna cleavage,inhibition | array technology,array technology,experimental interaction detection | TarBase |
| URS00000451A1 | TUSC2 | 18077375 25416803 | mrna cleavage,inhibition | experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00000DDD35 | TUSC2 | 19671678 20371350 25416803 | mrna cleavage,inhibition | nucleotide sequence identification,western blot,miRNA interference luciferase reporter assay | TarBase |
| URS0000122ED0 | TUSC2 | 17942906 19671678 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| URS00000F4AC3 | TUSC2 | 19671678 25416803 27866223 | mrna cleavage,inhibition | nucleotide sequence identification,western blot,miRNA interference luciferase reporter assay | TarBase |
| URS0000028BB8 | TUSC2 | 17612493 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00003D5391 | TUSC2 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000006FDD4 | TUSC2 | 25416803 26367773 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RBPMS | TUSC2 | 24234451 25348397 25416956 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| MAPK9 | TUSC2 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| TUSC2 | MDFI | 24234451 25348397 25416956 | physical association | two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid | ComPPI,IntAct |
| TUSC2 | FHL5 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |