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GENE：ZEB2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ZEB2
FullNmae zinc finger E-box binding homeobox 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:14881
EnsembleID ENSG00000169554
Uniprot O60315

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ZEB2 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ZEB2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ZEB2 GO:0000122,GO:0000122,GO:0000785,GO:0000785,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001227,GO:0001935,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005730,GO:0005829,GO:0006357,GO:0007399,GO:0010764,GO:0019208,GO:0030511,GO:0036446,GO:0043149,GO:0043542,GO:0045636,GO:0045944,GO:0046872,GO:0048023,GO:0048066,GO:0048143,GO:0048856,GO:0070269,GO:0072537,GO:0090263,GO:0090649,GO:0097324,GO:1903056,GO:1904330,GO:1904520,GO:1905603

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ZEB2 hsa:9839 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR ZEB2 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 ZEB2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ZEB2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 ZEB2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 ZEB2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ZEB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ZEB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ZEB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ZEB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ZEB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ZEB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ZEB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ZEB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ZEB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ZEB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR ZEB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 ZEB2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PCGF2 ZEB2 23474752 trascriptional regulation,stimulation inferred by curator TFlink
SMAD1 ZEB2 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003E1A9 ZEB2 18411277 19830559 19854497 \N rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000B59A2 ZEB2 17360662 rna interference,inhibition experimental interaction detection miRSponge
URS000008DA94 ZEB2 18376396 18381893 18411277 18829540 19703993 19854497 19931509 21049046 21529905 \N rna interference,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000012A1DD ZEB2 18376396 18411277 18829540 19839049 19854497 21049046 22311119 \N rna interference,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000171525 ZEB2 18381893 18411277 19839049 19854497 20620960 21049046 21294122 22569286 \N rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000016914 ZEB2 18376396 rna interference,inhibition array technology,western blot,miRNA interference luciferase reporter assay miRSponge
URS0000170CF4 ZEB2 20516212 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr miRSponge
URS000055BBE5 ZEB2 18411277 18829540 19854497 \N rna interference,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000019D79B ZEB2 21852381 22743998 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRDeathDB,TarBase
URS000003E1A9 ZEB2 18411277 18925646 18927107 19830559 19854497 24245745 24510096 25416803 25502084 25975736 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS000008DA94 ZEB2 18376396 18381893 18411277 18829540 18927107 19703993 19854497 19910931 19931509 21049046 21125666 21389093 21529905 22012804 23381389 23386720 24127332 24280074 24518294 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS000012A1DD ZEB2 18376396 18411277 18829540 18927107 19839049 19854497 19910931 21049046 21125666 21389093 22012804 22294131 22311119 23408168 24769353 25270520 25411357 25416803 26648487 27373709 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS0000171525 ZEB2 18381893 18411277 18925646 18927107 19839049 19854497 20620960 21049046 21125666 21294122 21389093 21874049 22569286 23807165 24127332 24510096 25416803 25502084 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS000055BBE5 ZEB2 18411277 18829540 18927107 19854497 19910931 25416803 26472725 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS0000016914 ZEB2 18376396 19244118 23474752 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004DA9DB ZEB2 21159887 25416803 mrna cleavage,inhibition experimental interaction detection,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000170CF4 ZEB2 20516212 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase
URS00003CF1AD ZEB2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F31F4 ZEB2 22033272 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr TarBase
URS0000237AF9 ZEB2 24829139 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000272039 ZEB2 25416803 26556542 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000254A6 ZEB2 25416803 25945841 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00000EED18 ZEB2 24510096 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00001DE669 ZEB2 24510096 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000153377 ZEB2 24510096 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00001F0C23 ZEB2 24510096 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00000A07C1 ZEB2 24510096 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS00002E92A8 ZEB2 25416803 27785072 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000008931A ZEB2 25416803 26503460 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000040780F ZEB2 25416803 26646296 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
UBE2I ZEB2 25348397 N/A physical interaction ComPPI
EHMT2 ZEB2 24234451 25348397 26028330 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,chromatin immunoprecipitation assay ComPPI,IntAct
SMAD1 ZEB2 10400677 12714599 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD2 ZEB2 10400677 12714599 14525934 15231748 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
EP300 ZEB2 25348397 N/A physical interaction ComPPI
SMAD3 ZEB2 10400677 12714599 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
SMAD5 ZEB2 10400677 12714599 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
CTBP1 ZEB2 12714599 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
CTBP2 ZEB2 12714599 14525934 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
HDAC4 ZEB2 25348397 N/A physical interaction ComPPI
SMAD9 ZEB2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ZFP36 ZEB2 25348397 N/A physical interaction ComPPI
RBBP4 ZEB2 24234451 25348397 26028330 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CBX4 ZEB2 25348397 N/A physical interaction ComPPI
SOX2 ZEB2 25348397 N/A physical interaction ComPPI
HDAC2 ZEB2 24234451 25348397 26028330 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MTA1 ZEB2 24234451 25348397 26028330 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction,chromatin immunoprecipitation assay ComPPI,IntAct
COPS6 ZEB2 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
ELAVL1 ZEB2 25348397 N/A physical interaction ComPPI
MBD3 ZEB2 24234451 25348397 26028330 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
ZEB2 CEBPA 25348397 N/A physical interaction ComPPI
ZEB2 MTA2 24234451 25348397 26028330 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
ZEB2 HDAC1 24234451 25348397 26028330 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,chromatin immunoprecipitation assay ComPPI,IntAct
ZEB2 RBBP7 25348397 N/A physical interaction ComPPI
ZEB2 APP 25348397 N/A physical interaction ComPPI
ZEB2 TEAD2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
ZEB2 SCHIP1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
ZEB2 MBD6 24234451 25348397 26028330 association anti tag coimmunoprecipitation ComPPI,IntAct
ZEB2 MTBP 24234451 25348397 26028330 association anti tag coimmunoprecipitation ComPPI,IntAct
ZEB2 CHD3 24234451 25348397 26028330 association anti tag coimmunoprecipitation ComPPI,IntAct
ZEB2 GATA3 24234451 25348397 26028330 association anti tag coimmunoprecipitation ComPPI,IntAct
MTA3 ZEB2 24234451 26028330 association chromatin immunoprecipitation assay IntAct
CTBP1 ZEB2 12714599 16061479 24722188 26186194 27898060 stimulant N/A OmniPath
CBX4 ZEB2 16061479 27898060 inhibition N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS000002CF11 ZEB2 18347095 23829529 27087310 direct interaction,inhibition N/A NPInter
URS00008B20C1 ZEB2 27087310 direct interaction,inhibition N/A NPInter

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