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GENE：ERO1A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ERO1A
FullNmae endoplasmic reticulum oxidoreductase 1 alpha
LocusType gene with protein product
Status Approved
HGNC_id HGNC:13280
EnsembleID ENSG00000197930
Uniprot Q96HE7

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ERO1A immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ERO1A autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ERO1A apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ERO1A apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ERO1A GO:0005515,GO:0005615,GO:0005783,GO:0005788,GO:0005789,GO:0005796,GO:0006457,GO:0006979,GO:0009266,GO:0015035,GO:0016020,GO:0016491,GO:0016972,GO:0022417,GO:0030198,GO:0030425,GO:0030968,GO:0034975,GO:0034976,GO:0036211,GO:0043231,GO:0045454,GO:0050873,GO:0051085,GO:0051209,GO:0070059,GO:0071456,GO:0071949

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ERO1A hsa:30001 path:hsa04141 Protein processing in endoplasmic reticulum - Homo sapiens (human)
ERO1A hsa:30001 path:hsa05110 Vibrio cholerae infection - Homo sapiens (human)
ERO1A hsa:30001 path:hsa05417 Lipid and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ATF6 ERO1A 17991856 18360008 23850759 26192618 26587781 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
ETS1 ERO1A 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ERO1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ERO1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ERO1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ERO1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ERO1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ERO1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ERO1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ERO1A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PPARG ERO1A 18177270 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122ED0 ERO1A 19088304 25416803 26701625 mrna cleavage,inhibition array technology,clip TarBase
URS0000324096 ERO1A 18668040 25416803 26701625 mrna cleavage,inhibition experimental interaction detection,clip TarBase
URS00001C3AC1 ERO1A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000600E6 ERO1A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001CC379 ERO1A 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004DA9DB ERO1A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002E628F ERO1A 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000033B91D ERO1A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005A8A8D ERO1A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001FC26E ERO1A 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000366551 ERO1A 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000535FDD ERO1A 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000259AE4 ERO1A 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000170CF4 ERO1A 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000024DFCE ERO1A 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000008DA94 ERO1A 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000003E1A9 ERO1A 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 ERO1A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000A07C1 ERO1A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000000B1C9 ERO1A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000029979D ERO1A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000237CBD ERO1A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000254A6 ERO1A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000032EF64 ERO1A 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B0E50 ERO1A 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CBSL ERO1A 25348397 N/A physical interaction ComPPI
GPX7 ERO1A 25348397 N/A physical interaction ComPPI
HSPBP1 ERO1A 25348397 N/A physical interaction ComPPI
APPBP2 ERO1A 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
ERO1A P4HB 10970843 11707400 14525934 20802462 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
ERO1A ERP44 11847130 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ERO1A PDIA3 14525934 17170699 20802462 24234451 25348397 disulfide bond,physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
ERO1A H2AX 20000738 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ERO1A FBXO6 25348397 N/A physical interaction ComPPI
ERO1A PDIA2 10970843 20802462 25258311 25348397 27898060 N/A physical interaction ComPPI,OmniPath
ERO1A PDIA4 20802462 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ERO1A LYN 25348397 N/A physical interaction ComPPI
ERO1A PELI2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ERO1A DDX5 25348397 N/A physical interaction ComPPI
ERO1A CBS 25348397 N/A physical interaction ComPPI
ERO1A DBNL 25348397 N/A physical interaction ComPPI
ERO1A P3H1 25348397 N/A physical interaction ComPPI
ERO1A LRSAM1 25348397 N/A physical interaction ComPPI
ERO1A PPME1 25348397 N/A physical interaction ComPPI
ERO1A WDR4 25348397 N/A physical interaction ComPPI
ERO1A ERO1B 25348397 N/A physical interaction ComPPI
ERO1A NTRK1 25348397 N/A physical interaction ComPPI
ERO1A TCTN3 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ERO1A TCTN1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ERO1A RHOU 25348397 N/A physical interaction ComPPI
ERO1A GPX8 25348397 N/A physical interaction ComPPI
ERO1A EBF1 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
ERO1A LHX4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RNH1 ERO1A 25348397 N/A physical interaction ComPPI
ATF2 ERO1A 22304920 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ERO1A ERO1A 11847130 14525934 N/A experimental interaction detection HPRD
PDILT ERO1A 14525934 15475357 N/A experimental interaction detection HPRD
TANK ERO1A 24234451 30561431 association virotrap IntAct
ERO1A TNIK 24234451 30021884 physical association cross-linking study IntAct

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