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GENE：ACVR1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ACVR1
FullNmae activin A receptor type 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:171
EnsembleID ENSG00000115170
Uniprot Q04771

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ACVR1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ACVR1 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ACVR1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ACVR1 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ACVR1 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ACVR1 GO:0001569,GO:0001701,GO:0001702,GO:0001707,GO:0001755,GO:0002526,GO:0003143,GO:0003181,GO:0003183,GO:0003272,GO:0003274,GO:0003289,GO:0003289,GO:0004672,GO:0004674,GO:0004675,GO:0005025,GO:0005515,GO:0005524,GO:0005886,GO:0005886,GO:0006468,GO:0006468,GO:0007179,GO:0007179,GO:0007281,GO:0007368,GO:0007507,GO:0009953,GO:0009968,GO:0016361,GO:0017046,GO:0018107,GO:0030278,GO:0030335,GO:0030501,GO:0030509,GO:0030509,GO:0030509,GO:0032924,GO:0032924,GO:0032926,GO:0042803,GO:0045177,GO:0045296,GO:0045669,GO:0045893,GO:0045944,GO:0045944,GO:0045944,GO:0046332,GO:0046332,GO:0046872,GO:0048179,GO:0048185,GO:0050431,GO:0050731,GO:0051145,GO:0060037,GO:0060391,GO:0060412,GO:0060923,GO:0061445,GO:0062043,GO:0070724,GO:0071363,GO:0071773,GO:1990782,GO:2000017,GO:2000134,GO:2001237

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ACVR1 hsa:90 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
ACVR1 hsa:90 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
ACVR1 hsa:90 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
ACVR1 hsa:90 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
SQSTM1 ACVR1 15761153 23180781 physical association luminescence based mammalian interactome mapping InnateDB
ACVR1 SMAD1 10085121 10583507 10652350 18988627 23331499 9136927 9748228 stimulation N/A SignaLink,SignaLink
ACVR1 SMAD5 10504300 23331499 stimulation N/A SignaLink,SignaLink
SMAD6 ACVR1 10564272 23331499 stimulation N/A SignaLink,SignaLink
SMAD7 ACVR1 10564272 23331499 stimulation N/A SignaLink,SignaLink
ACVR2B ACVR1 16446785 23331499 stimulation N/A SignaLink,SignaLink
BMPR2 ACVR1 16446785 21071413 23331499 7791754 stimulation N/A SignaLink,SignaLink
BMP8B ACVR1 10504300 23331499 stimulation N/A SignaLink
AMHR2 ACVR1 16446785 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
SOCS6 ACVR1 20005715 interaction type N/A PSP
SOCS6 ACVR1 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR ACVR1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 ACVR1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ACVR1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 ACVR1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ACVR1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 ACVR1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 ACVR1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ACVR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ACVR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ACVR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ACVR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ACVR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ACVR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ACVR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 ACVR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ACVR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 ACVR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ACVR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ACVR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003BBF48 ACVR1 22408438 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00000F4AC3 ACVR1 \N rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00000F4AC3 ACVR1 16822819 18927107 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr miR2Disease,TarBase
URS00003BBF48 ACVR1 22408438 25271001 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000315338 ACVR1 21572407 23418453 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,clip TarBase
URS0000237AF9 ACVR1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00002C0FCB ACVR1 20371350 21572407 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS000021D7C8 ACVR1 20371350 21572407 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS0000521626 ACVR1 23227223 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000031B6ED ACVR1 23227223 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000324096 ACVR1 22995917 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000023F8DA ACVR1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000015F70F ACVR1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002CF3F0 ACVR1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A ACVR1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B ACVR1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC ACVR1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000005CE28 ACVR1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000254A6 ACVR1 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ACVR2A ACVR1 25361965 interaction type N/A PTMCode2
ACVR1 ACVR2A 25361965 interaction type N/A PTMCode2
ACVR1 INHBB 25361965 interaction type N/A PTMCode2
INHBB ACVR1 25361965 interaction type N/A PTMCode2
ACVR1 INHBC 25361965 interaction type N/A PTMCode2
INHBC ACVR1 25361965 interaction type N/A PTMCode2
ACVR1 SMAD4 25361965 interaction type N/A PTMCode2
SMAD4 ACVR1 25361965 interaction type N/A PTMCode2
ACVR1 IGSF1 25361965 interaction type N/A PTMCode2
IGSF1 ACVR1 25361965 interaction type N/A PTMCode2
ACVR1 GDF5 25361965 interaction type N/A PTMCode2
GDF5 ACVR1 25361965 interaction type N/A PTMCode2
ACVR1 BMPR2 25361965 interaction type N/A PTMCode2
BMPR2 ACVR1 25361965 interaction type N/A PTMCode2
ACVR1 BMP2 25361965 interaction type N/A PTMCode2
BMP2 ACVR1 25361965 interaction type N/A PTMCode2
ACVR1 SMAD9 25361965 interaction type N/A PTMCode2
SMAD9 ACVR1 25361965 interaction type N/A PTMCode2
ACVR1 BMP7 25361965 interaction type N/A PTMCode2
BMP7 ACVR1 25361965 interaction type N/A PTMCode2
FKBP1A ACVR1 25361965 interaction type N/A PTMCode2
ACVR1 FKBP1A 25361965 interaction type N/A PTMCode2
ACVR1 FKBP1B 25361965 interaction type N/A PTMCode2
FKBP1B ACVR1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
BMP7 ACVR1 14525934 25348397 8006002 N/A experimental interaction detection,physical interaction ComPPI,HPRD
UBE2E3 ACVR1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PAK1 ACVR1 25348397 N/A in vivo ComPPI
SMAD1 ACVR1 10085121 10583507 10652350 14525934 25348397 9136927 9748228 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
TGFBR2 ACVR1 25348397 N/A physical interaction ComPPI
SMAD7 ACVR1 25348397 N/A physical interaction ComPPI
CREBBP ACVR1 14525934 25348397 9267036 N/A experimental interaction detection,in vitro ComPPI,HPRD
VDR ACVR1 14525934 25348397 9267036 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
SMAD5 ACVR1 10583507 10652350 14525934 25348397 9748228 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
THRB ACVR1 14525934 25348397 9267036 N/A two hybrid,two hybrid ComPPI,HPRD
RRAS2 ACVR1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
RASD2 ACVR1 25348397 N/A in vivo ComPPI
UBB ACVR1 25348397 N/A in vivo ComPPI
UBC ACVR1 25348397 N/A in vivo ComPPI
RPS27A ACVR1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
UBA52 ACVR1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMAD9 ACVR1 25348397 N/A in vivo ComPPI
RAB3B ACVR1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
IKBKB ACVR1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
BMPR2 ACVR1 25348397 N/A physical interaction ComPPI
RAP2A ACVR1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
AP2B1 ACVR1 25348397 N/A in vivo ComPPI
STX8 ACVR1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
FKBP4 ACVR1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1B ACVR1 25348397 N/A physical interaction ComPPI
PLEKHB1 ACVR1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVRL1 ACVR1 25348397 N/A physical interaction ComPPI
TGFBRAP1 ACVR1 25348397 N/A physical interaction ComPPI
RHOD ACVR1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
IGSF1 ACVR1 11266516 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
RHOJ ACVR1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SMURF1 ACVR1 25348397 N/A physical interaction ComPPI
BMP2 ACVR1 14525934 25348397 8006002 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 ENG 14525934 25348397 9872992 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ACVR1 FNTA 14525934 25348397 8599089 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ACVR1 INHBA 11266516 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ACVR1 INHBB 11266516 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 GDF5 25348397 N/A physical interaction,in vivo ComPPI
ACVR1 INHBC 12651901 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 CHN1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 DUSP13 25348397 N/A in vivo ComPPI
ACVR1 FANCL 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 FBXO30 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 FCHO1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 FGD6 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 DCAF6 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 NKIRAS1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 NRAS 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 NUAK2 25348397 N/A in vivo ComPPI
ACVR1 CDK14 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 PLEK 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 PLEKHJ1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 RAB17 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 RAB25 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 RAB33B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 RAB6B 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 RASL12 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 RHEBL1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 SOCS6 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 TTC17 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 USP39 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 VEPH1 25348397 N/A in vivo ComPPI
ACVR1 WDR61 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 KLHL35 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 UBXN1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 TTC27 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 TSC22D1 25348397 N/A physical interaction ComPPI
ACVR1 BAMBI 25348397 N/A physical interaction ComPPI
ACVR1 SMAD6 25348397 N/A physical interaction ComPPI
ACVR1 PEG10 25348397 N/A physical interaction ComPPI
ACVR1 ACVR2A 25348397 N/A coimmunoprecipitation,physical interaction,physical interaction ComPPI
ACVR1 BMPR1A 18436533 25348397 26186194 27898060 N/A physical interaction ComPPI,OmniPath
ACVR1 USP15 25348397 N/A physical interaction ComPPI
ACVR1 GRAMD1A 25348397 N/A physical interaction ComPPI
ACVR1 MED16 25348397 N/A physical interaction ComPPI
ACVR1 RNF149 25348397 N/A physical interaction ComPPI
ACVR1 ARV1 25348397 N/A physical interaction ComPPI
ACVR1 OTUB1 25348397 N/A physical interaction ComPPI
ACVR1 LRRIQ1 25348397 N/A physical interaction ComPPI
ACVR1 TNFRSF10A 25348397 N/A physical interaction ComPPI
ACVR1 MRAP2 25348397 N/A physical interaction ComPPI
ACVR1 CD320 25348397 N/A physical interaction ComPPI
ACVR1 RGMB 25348397 N/A physical interaction ComPPI
ACVR1 TGFBR1 14525934 15761153 24234451 24658140 25348397 physical association experimental interaction detection,ubiquitin reconstruction ComPPI,HPRD,IntAct
NEK8 ACVR1 14525934 15761153 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1 RXRA 14525934 9267036 N/A experimental interaction detection,two hybrid HPRD
ACVR1 DUSP13 14525934 15761153 N/A experimental interaction detection HPRD
ACVR1 SMAD1 10085121 10583507 10652350 19651622 27898060 9136927 9748228 stimulant N/A OmniPath
ACVR1 SMAD5 10583507 10652350 27898060 9748228 stimulant N/A OmniPath
SMAD7 ACVR1 10564272 27898060 stimulant N/A OmniPath
SMAD6 ACVR1 10564272 20663871 23455153 27898060 stimulant N/A OmniPath
BMPR2 ACVR1 27898060 7791754 7890683 stimulant N/A OmniPath
ACVR2B ACVR1 16446785 27898060 stimulant N/A OmniPath
ACVR2A ACVR1 27898060 8612709 9748228 stimulant N/A OmniPath
AMH ACVR1 14656470 27898060 N/A N/A OmniPath
GDF2 ACVR1 19996292 27898060 N/A N/A OmniPath
AMHR2 ACVR1 14746809 27898060 stimulant N/A OmniPath

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