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GENE：ACVR1B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ACVR1B
FullNmae activin A receptor type 1B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:172
EnsembleID ENSG00000135503
Uniprot P36896

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ACVR1B mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ACVR1B ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ACVR1B autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ACVR1B apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ACVR1B apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ACVR1B GO:0000082,GO:0001701,GO:0001942,GO:0004674,GO:0004674,GO:0004674,GO:0004675,GO:0005515,GO:0005524,GO:0005829,GO:0005886,GO:0005886,GO:0005886,GO:0006355,GO:0006468,GO:0006468,GO:0007165,GO:0007178,GO:0007399,GO:0009986,GO:0010628,GO:0010629,GO:0016361,GO:0016361,GO:0016361,GO:0017002,GO:0018107,GO:0019838,GO:0030308,GO:0031625,GO:0032924,GO:0032924,GO:0032924,GO:0032927,GO:0034711,GO:0038092,GO:0043235,GO:0045648,GO:0046332,GO:0046777,GO:0046872,GO:0048179,GO:0048179,GO:0048185,GO:0070411,GO:0071363,GO:0097191,GO:1901165

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ACVR1B hsa:91 path:hsa04060 Cytokine-cytokine receptor interaction - Homo sapiens (human)
ACVR1B hsa:91 path:hsa04350 TGF-beta signaling pathway - Homo sapiens (human)
ACVR1B hsa:91 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ACVR1B XIAP 11356828 23180781 physical association anti tag coimmunoprecipitation InnateDB
ACVR1B ACVR2A 23180781 9032295 physical association anti tag coimmunoprecipitation InnateDB
ACVR1B FKBP1A 16720724 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD7 ACVR1B 16720724 23180781 physical association pull down InnateDB
SMURF1 ACVR1B 16720724 23180781 physical association anti tag coimmunoprecipitation InnateDB
ACVR2B ACVR1B 12364468 16446785 18988627 23180781 23331499 8622651 stimulation,physical association anti tag coimmunoprecipitation InnateDB,SignaLink,SignaLink
ZFYVE16 ACVR1B 17272273 23180781 physical association anti tag coimmunoprecipitation InnateDB
ACVR1B SMAD2 11389842 18988627 23331499 9892009 stimulation N/A SignaLink,SignaLink
ACVR1B SMAD3 23331499 9605406 stimulation N/A SignaLink
ACTR2 ACVR1B 16446785 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
TGFBRAP1 ACVR1B 20005715 interaction type N/A PSP
TGFBRAP1 ACVR1B 11278302 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
ETS1 ACVR1B 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 ACVR1B 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ACVR1B 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 ACVR1B 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 ACVR1B 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ACVR1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ACVR1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ACVR1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ACVR1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ACVR1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ACVR1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ACVR1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ACVR1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ACVR1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ACVR1B 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMAD7 ACVR1B N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000055128B ACVR1B 19826008 25416803 mrna cleavage,inhibition rna immunoprecipitation,quantitative reverse transcription pcr TarBase
URS00001CC379 ACVR1B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F4AC3 ACVR1B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000003ABC4 ACVR1B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000171CD1 ACVR1B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000031E12 ACVR1B 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000052EA98 ACVR1B 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA ACVR1B 20371350 21572407 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000042E1F ACVR1B 20371350 21572407 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000DDD35 ACVR1B 20371350 21572407 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000039E1E1 ACVR1B 20371350 21572407 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000600E6 ACVR1B 20371350 21572407 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002B3783 ACVR1B 20371350 21572407 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000298BA3 ACVR1B 20371350 21572407 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000006F90B ACVR1B 20371350 21572407 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000023133F ACVR1B 20371350 21572407 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000025EABA ACVR1B 20371350 21572407 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000001C659 ACVR1B 24802670 25416803 mrna cleavage,inhibition western blot,chromatin immunoprecipitation assay,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000076E54 ACVR1B 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS0000192A75 ACVR1B 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000235862 ACVR1B 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002578DA ACVR1B 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003676C9 ACVR1B 20371350 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000136174 ACVR1B 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00003CCBB9 ACVR1B 20371350 21572407 23446348 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005D986D ACVR1B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 ACVR1B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDAA ACVR1B 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000148B91 ACVR1B 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 ACVR1B 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ACVR1B TDP2 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
TSNAX ACVR1B 25348397 N/A physical interaction ComPPI
FKBP1A ACVR1B 16720724 24234451 25348397 physical association two hybrid,pull down,physical interaction ComPPI,IntAct
XIAP ACVR1B 24234451 25241761 25348397 physical association physical interaction,proximity ligation assay ComPPI,IntAct
SMAD4 ACVR1B 14525934 25348397 9892009 N/A experimental interaction detection,in vivo ComPPI,HPRD
HSP90AB1 ACVR1B 22939624 24234451 25348397 physical association anti tag coimmunoprecipitation,luminescence based mammalian interactome mapping ComPPI,IntAct
PRKACB ACVR1B 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TGFBR2 ACVR1B 25348397 N/A physical interaction ComPPI
SMAD7 ACVR1B 12023024 14525934 16720724 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
SMAD2 ACVR1B 14525934 25348397 9892009 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SMAD3 ACVR1B 25348397 N/A physical interaction ComPPI
HSP90AA1 ACVR1B 25348397 N/A physical interaction ComPPI
NTRK1 ACVR1B 25348397 N/A physical interaction ComPPI
SNX1 ACVR1B 11279102 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SNX2 ACVR1B 11279102 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BAG6 ACVR1B 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
BMPR2 ACVR1B 25348397 N/A physical interaction ComPPI
NEDD4L ACVR1B 25348397 N/A physical interaction ComPPI
ACVR1B TDGF1 11909953 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ACVR1B IGSF1 11266516 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ACVR1B INHBC 12651901 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1B ACVR2B 14525934 25348397 8622651 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ACVR1B TGFBRAP1 11278302 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ACVR1B INHBA 14525934 25348397 8397373 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ACVR1B INHBB 11266516 12032389 14525934 15196700 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ACVR1B ACVR2A 25348397 N/A coimmunoprecipitation,physical interaction,physical interaction ComPPI
ACVR1B ACVR1 25348397 N/A physical interaction ComPPI
ACVR1B TDGF1P3 25348397 N/A physical interaction ComPPI
ACVR1B SMURF1 25348397 N/A physical interaction ComPPI
ACVR1B TSC22D1 25348397 N/A physical interaction ComPPI
ACVR1B ELAVL1 25348397 N/A physical interaction ComPPI
ACVR1B BAMBI 25348397 N/A physical interaction ComPPI
ACVR1B SMAD6 25348397 N/A physical interaction ComPPI
ACVR1B HSP90AA2P 25348397 N/A physical interaction ComPPI
ACVR1B PEG10 25348397 N/A physical interaction ComPPI
ACVR1B OS9 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ACVR1B RXRA 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ACVR1B SPINT2 25348397 N/A physical interaction ComPPI
ACVR1B TSPAN3 25348397 N/A physical interaction ComPPI
ACVR1B TMEM30A 25348397 N/A physical interaction ComPPI
ACVR1B TSPAN17 25348397 N/A physical interaction ComPPI
ACVR1B HEPACAM2 25348397 N/A physical interaction ComPPI
ACVR1B OTUB1 25348397 N/A physical interaction ComPPI
ACVR1B VPS16 25348397 N/A physical interaction ComPPI
ACVR1B ZNF644 25348397 N/A physical interaction ComPPI
ACVR1B ADGRG5 25348397 N/A physical interaction ComPPI
ACVR1B TMEM30B 25348397 N/A physical interaction ComPPI
ACVR1B MRAP2 25348397 N/A physical interaction ComPPI
ACVR1B ACVR1B 14525934 15196700 N/A experimental interaction detection HPRD
ACVR1B SMAD2 11389842 27898060 9892009 stimulant N/A OmniPath
ACVR1B SMAD3 27898060 9605406 stimulant N/A OmniPath
ACVR2B ACVR1B 12364468 16446785 27898060 8612709 862265 8622651 stimulant N/A OmniPath
TDGF1 ACVR1B 11909953 19874624 27898060 stimulant N/A OmniPath
ACVR1B TDP2 18039968 27898060 N/A N/A OmniPath
ACTR2 ACVR1B 16446785 27898060 stimulant N/A OmniPath
ACVR2A ACVR1B 11927552 12682303 27898060 8612709 9032295 9892009 stimulant N/A OmniPath
INHBA ACVR1B 27898060 7890768 8167568 8397373 9605406 stimulant N/A OmniPath
NODAL ACVR1B 19874624 27898060 stimulant N/A OmniPath

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