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GENE：ADAM12

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ADAM12
FullNmae ADAM metallopeptidase domain 12
LocusType gene with protein product
Status Approved
HGNC_id HGNC:190
EnsembleID ENSG00000148848
Uniprot O43184

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ADAM12 pyroptosis 39316370 Pyroptosis-induced IL-18 secretion from epithelial cells activates a disintegrin and metalloprotease 12 (ADAM12) to process the epiregulin precursor into mature epiregulin. retulator signature
ADAM12 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ADAM12 GO:0004222,GO:0005515,GO:0005576,GO:0005654,GO:0005886,GO:0005886,GO:0006508,GO:0007155,GO:0007520,GO:0008237,GO:0017124,GO:0045766,GO:0046872

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR ADAM12 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 ADAM12 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 ADAM12 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 ADAM12 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 ADAM12 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ADAM12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ADAM12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ADAM12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ADAM12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ADAM12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ADAM12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ADAM12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ADAM12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ADAM12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ADAM12 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SKIL ADAM12 20457602 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000001C659 ADAM12 25416803 26437223 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS0000076995 ADAM12 25416803 25886595 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000272A3D ADAM12 25416803 25886595 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002152A8 ADAM12 25416803 25886595 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000005CF5F ADAM12 25416803 25886595 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000012A1DD ADAM12 25416803 25886595 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000171525 ADAM12 25416803 25886595 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000435A77 ADAM12 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000753AD ADAM12 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000CBE63 ADAM12 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001270D3 ADAM12 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000A9FB9 ADAM12 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000D0BB4 ADAM12 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000458AD2 ADAM12 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000011A030 ADAM12 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
YES1 ADAM12 11127814 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PACSIN3 ADAM12 12952982 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
ADAM12 PIK3R1 11313349 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
ADAM12 ACTN2 10788519 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
ADAM12 SRC 11127814 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ADAM12 GRB2 11127814 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ADAM12 EGF 11786904 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ADAM12 FSTL3 14525934 15574124 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
ADAM12 IGFBP3 10849447 11095942 14525934 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,OmniPath
ADAM12 IGFBP5 11095942 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ADAM12 FST 25348397 N/A far western blotting ComPPI
KRT8 ADAM12 24234451 30021884 physical association cross-linking study IntAct
ADAM12 SDC4 12509413 27898060 stimulant N/A OmniPath

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