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GENE：ARHGEF2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ARHGEF2
FullNmae Rho/Rac guanine nucleotide exchange factor 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:682
EnsembleID ENSG00000116584
Uniprot Q92974

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ARHGEF2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ARHGEF2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ARHGEF2 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ARHGEF2 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
ARHGEF2 GO:0000902,GO:0000902,GO:0005085,GO:0005085,GO:0005515,GO:0005515,GO:0005737,GO:0005794,GO:0005819,GO:0005829,GO:0005856,GO:0005856,GO:0005874,GO:0005923,GO:0005925,GO:0006886,GO:0007015,GO:0007015,GO:0007026,GO:0007049,GO:0008017,GO:0008017,GO:0008270,GO:0031267,GO:0031410,GO:0031982,GO:0032587,GO:0032587,GO:0032755,GO:0032760,GO:0032991,GO:0035023,GO:0035023,GO:0042127,GO:0045087,GO:0045666,GO:0045666,GO:0045944,GO:0050731,GO:0051056,GO:0051092,GO:0055059,GO:0060546,GO:0071225,GO:0071356,GO:0071474,GO:1902042,GO:1902219,GO:2001224

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ARHGEF2 hsa:9181 path:hsa04530 Tight junction - Homo sapiens (human)
ARHGEF2 hsa:9181 path:hsa05130 Pathogenic Escherichia coli infection - Homo sapiens (human)
ARHGEF2 hsa:9181 path:hsa05131 Shigellosis - Homo sapiens (human)
ARHGEF2 hsa:9181 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ARHGEF2 RHOB 16917499 18287519 26192618 interaction type N/A ACSN
ARHGEF2 TBK1 23180781 24270516 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR ARHGEF2 18971253 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 ARHGEF2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 ARHGEF2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 ARHGEF2 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 ARHGEF2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ARHGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ARHGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ARHGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ARHGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ARHGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ARHGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ARHGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ARHGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 ARHGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ARHGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR ARHGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 ARHGEF2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 ARHGEF2 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000016FF9C ARHGEF2 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS0000070B1D ARHGEF2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000EC1BE ARHGEF2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000BE495 ARHGEF2 23592263 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00003CF1AD ARHGEF2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00005FDE70 ARHGEF2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002971AB ARHGEF2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002394F5 ARHGEF2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000047E28E ARHGEF2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000017CCCB ARHGEF2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 ARHGEF2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000585553 ARHGEF2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000383DF4 ARHGEF2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005194EC ARHGEF2 23592263 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CHEK1 ARHGEF2 22135298 phosphorylation N/A PhosphoSite
MAPK3 ARHGEF2 22135298 phosphorylation N/A PhosphoSite
MARK2 ARHGEF2 22135298 phosphorylation N/A PhosphoSite
MAPK1 ARHGEF2 22135298 phosphorylation N/A PhosphoSite
PAK1 ARHGEF2 22135298 phosphorylation N/A PhosphoSite
ARHGEF2 RAC1 25361965 interaction type N/A PTMCode2
RAC1 ARHGEF2 25361965 interaction type N/A PTMCode2
CGN ARHGEF2 25361965 interaction type N/A PTMCode2
ARHGEF2 CGN 25361965 interaction type N/A PTMCode2
YWHAH ARHGEF2 25361965 interaction type N/A PTMCode2
ARHGEF2 YWHAH 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SNW1 ARHGEF2 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L ARHGEF2 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPA8 ARHGEF2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RPP25L ARHGEF2 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
PPP2R1A ARHGEF2 25348397 N/A physical interaction ComPPI
VCP ARHGEF2 25348397 N/A physical interaction ComPPI
YWHAG ARHGEF2 14525934 15324660 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
WDR83 ARHGEF2 25348397 N/A physical interaction ComPPI
RAC1 ARHGEF2 11595749 14525934 25348397 9857026 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PAK5 ARHGEF2 25348397 N/A physical interaction ComPPI
PAK1 ARHGEF2 25348397 N/A physical interaction,in vitro ComPPI
MAPK1 ARHGEF2 25348397 N/A physical interaction ComPPI
NOTCH1 ARHGEF2 23022380 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
RHOA ARHGEF2 14525934 24234451 25348397 9857026 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach ComPPI,HPRD,IntAct
ARHGEF2 RRAS2 12384139 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ARHGEF2 YWHAZ 14525934 14970201 15161933 24234451 25348397 association,physical association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
ARHGEF2 YWHAE 14525934 14970201 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ARHGEF2 CGN 14525934 15866167 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
ARHGEF2 MYC 17314511 17353931 24234451 25348397 association,physical association anti bait coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
ARHGEF2 PLCG1 25348397 N/A physical interaction ComPPI
ARHGEF2 MARK2 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARHGEF2 TAF10 25348397 N/A physical interaction ComPPI
ARHGEF2 MARK4 14676191 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARHGEF2 YWHAH 14676191 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARHGEF2 ELAVL1 25348397 N/A physical interaction ComPPI
ARHGEF2 USP21 25348397 N/A physical interaction ComPPI
ARHGEF2 PEX14 21525035 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
ARHGEF2 MMS19 25348397 N/A physical interaction ComPPI
ARHGEF2 FBXO6 25348397 N/A physical interaction ComPPI
ARHGEF2 ANKRD28 24234451 24255178 25348397 colocalization,association anti tag coimmunoprecipitation,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ARHGEF2 PPP6C 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARHGEF2 PPP6R1 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARHGEF2 YWHAB 24234451 24255178 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARHGEF2 RPA3 25348397 N/A physical interaction ComPPI
ARHGEF2 RPA2 25348397 N/A physical interaction ComPPI
ARHGEF2 CEP250 25348397 N/A physical interaction ComPPI
ARHGEF2 MOV10 25348397 N/A physical interaction ComPPI
ARHGEF2 NXF1 25348397 N/A physical interaction ComPPI
ARHGEF2 CCDC8 25348397 N/A physical interaction ComPPI
ARHGEF2 EGFR 25348397 N/A physical interaction ComPPI
ARHGEF2 FGL1 25348397 N/A physical interaction ComPPI
ARHGEF2 NTRK1 25348397 N/A physical interaction ComPPI
ARHGEF2 COPS7A 25348397 N/A physical interaction ComPPI
ARHGEF2 KLC2 25348397 N/A physical interaction ComPPI
ARHGEF2 PRDX1 25348397 N/A physical interaction ComPPI
ARHGEF2 PSME3 25348397 N/A physical interaction ComPPI
ARHGEF2 CEP170 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ARHGEF2 CNTRL 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ARHGEF2 SCLT1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ARHGEF2 DCTN1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ARHGEF2 FOXO3 24234451 25348397 25609649 association,physical association pull down,physical interaction,tandem affinity purification ComPPI,IntAct
ARHGEF2 PPP2CA 25348397 N/A physical interaction ComPPI
ARHGEF2 PPP2CB 24234451 24525234 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARHGEF2 UBE2A 25348397 N/A physical interaction ComPPI
ARHGEF2 NFKBIE 14743216 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
ARHGEF2 FYB1 19798671 24234451 25348397 association tandem affinity purification ComPPI,IntAct
ARHGEF2 PTBP3 22575643 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ARHGEF2 PAK4 22653441 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
ARHGEF2 PPP2R5B 24234451 24525234 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ARHGEF2 PPP2R5A 24234451 24525234 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ARHGEF2 PPP2R5E 24234451 24525234 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ARHGEF2 PPP2R2A 24234451 24525234 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ARHGEF2 KSR1 24234451 24525234 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
ARHGEF2 USE1 19369418 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
ARHGEF2 NFKBID 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ARHGEF2 BET1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RPA1 ARHGEF2 25348397 N/A physical interaction ComPPI
YWHAQ ARHGEF2 25348397 N/A physical interaction ComPPI
AURKAIP1 ARHGEF2 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
WDR5 ARHGEF2 24234451 25348397 27705803 association tandem affinity purification ComPPI,IntAct
AURKA ARHGEF2 14970201 17488622 18669648 19690332 27898060 N/A N/A OmniPath
ARHGEF2 RAC1 11595749 27898060 9857026 stimulant N/A OmniPath
MAPK3 ARHGEF2 18211802 27898060 stimulant N/A OmniPath
MAPK1 ARHGEF2 18211802 19261619 27898060 stimulant N/A OmniPath
PAK1 ARHGEF2 14970201 15827085 17488622 18669648 19667072 19690332 27898060 inhibition N/A OmniPath
MARK2 ARHGEF2 19615732 20406887 21513698 22072711 24043311 24352660 27898060 inhibition N/A OmniPath
ARHGEF2 TBK1 24270516 27898060 N/A N/A OmniPath
PKN1 ARHGEF2 14970201 27898060 inhibition N/A OmniPath
ARHGEF2 ARHGAP1 27898060 9857026 stimulant N/A OmniPath
PAK4 ARHGEF2 15827085 22653441 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008B6799 ARHGEF2 27087310 direct interaction,inhibition N/A NPInter

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