Gene Information gene info

GENE:CDC7

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CDC7
FullNmae cell division cycle 7
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1745
EnsembleID ENSG00000097046
Uniprot O00311

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CDC7 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CDC7 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CDC7 GO:0000082,GO:0000727,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005737,GO:0007165,GO:0008284,GO:0010571,GO:0010971,GO:0016301,GO:0016310,GO:0018105,GO:0044770,GO:0045171,GO:0046872,GO:0051301,GO:0072686,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CDC7 hsa:8317 path:hsa04110 Cell cycle - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
DBF4 CDC7 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 association N/A ACSN
CDC7 ORC1 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 ORC2 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 ORC3 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 ORC4 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 ORC5 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 ORC6 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 MCM2 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 MCM3 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 MCM4 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 MCM5 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 MCM6 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 MCM7 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 CDT1 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 CDC6 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 CDC45 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 RPA1 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 RPA2 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
CDC7 RPA3 15279786 17018296 17102137 17116885 17296725 17303408 17582221 17660363 18590585 19793801 26192618 7575488 interaction type N/A ACSN
HUS1 CDC7 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
RAD1 CDC7 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN
RAD17 CDC7 10884395 12086603 14726013 14988723 15136767 15175241 15459660 15703371 15798197 16697054 16713580 16805667 16885023 17102137 17116885 17296725 17303408 17384638 17493829 17582221 18469862 18995830 19282663 19342888 19622404 19793801 19847258 20051983 20478261 26192618 8943031 9524127 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
AR CDC7 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 CDC7 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 CDC7 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 CDC7 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 CDC7 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 CDC7 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 CDC7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CDC7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CDC7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CDC7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CDC7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CDC7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CDC7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CDC7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CDC7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 CDC7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYB CDC7 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000B59A2 CDC7 19074876 rna interference,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000B59A2 CDC7 19074876 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,experimental interaction detection,western blot,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000F31F4 CDC7 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00003D5391 CDC7 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000065D58 CDC7 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F CDC7 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 CDC7 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 CDC7 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000076995 CDC7 23877787 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 CDC7 22135298 phosphorylation N/A PhosphoSite
CDC7 NCL 22135298 phosphorylation N/A PhosphoSite
CDC7 MFAP1 22135298 phosphorylation N/A PhosphoSite
CDC7 MCM2 22135298 phosphorylation N/A PhosphoSite
CDC7 CDC7 22135298 phosphorylation N/A PhosphoSite
CDC7 CLSPN 22135298 phosphorylation N/A PhosphoSite
CDC7 TOP2A 22135298 phosphorylation N/A PhosphoSite
CDC7 DBF4 22135298 phosphorylation N/A PhosphoSite
CDC7 NPM1 22135298 phosphorylation N/A PhosphoSite
CDC7 PSIP1 22135298 phosphorylation N/A PhosphoSite
CDC7 RAD18 22135298 phosphorylation N/A PhosphoSite
CDK2 CDC7 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
GOLGA2 CDC7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ORC1 CDC7 12614612 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CDKN1A CDC7 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
MCM5 CDC7 12614612 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
MCM6 CDC7 25348397 N/A physical interaction ComPPI
MCM2 CDC7 10523313 11568184 12614612 14525934 16899510 24234451 25348397 N/A two hybrid,experimental interaction detection,physical interaction,protein kinase assay,in vitro,two hybrid ComPPI,HPRD,IntAct
ORC6 CDC7 12614612 14525934 15232106 24234451 25348397 N/A two hybrid,experimental interaction detection,protein array,physical interaction,in vitro,two hybrid ComPPI,HPRD,IntAct
ZBTB26 CDC7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
TOB1 CDC7 25348397 N/A physical interaction ComPPI
MCM10 CDC7 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
CDKN2A CDC7 15232106 24234451 25348397 N/A protein array,physical interaction,in vitro ComPPI,IntAct
DIAPH1 CDC7 12065429 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
CHAF1A CDC7 16826239 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
STAM2 CDC7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAPK6 CDC7 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
CILK1 CDC7 25348397 N/A physical interaction ComPPI
RAD18 CDC7 25348397 N/A physical interaction ComPPI
XPO1 CDC7 25348397 N/A physical interaction ComPPI
CDK2 CDC7 10846177 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SERTAD2 CDC7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IKZF3 CDC7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CENPJ CDC7 25348397 N/A physical interaction ComPPI
CDK9 CDC7 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
TMBIM6 CDC7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDC7 MCM3 15232106 24234451 25348397 N/A protein array,physical interaction,in vitro ComPPI,IntAct
CDC7 ORC5 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
CDC7 MCM4 12614612 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CDC7 DBF4 10373557 10523313 12614612 14525934 16899510 24234451 25348397 physical association two hybrid,experimental interaction detection,molecular sieving,pull down,x-ray crystallography,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
CDC7 DBF4B 25348397 N/A physical interaction,in vitro,in vivo ComPPI
CDC7 CDK4 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
CDC7 MCM7 12614612 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CDC7 CLSPN 25348397 N/A physical interaction ComPPI
CDC7 APP 25348397 N/A physical interaction ComPPI
CDC7 CDKN2A 25348397 N/A physical interaction ComPPI
CDC7 GRHPR 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDC7 GPT 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDC7 PAF1 25348397 N/A physical interaction ComPPI
CDC7 KMT2E 25348397 N/A physical interaction ComPPI
CDC7 IFT122 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
CDC7 MCMBP 22540012 24234451 24299456 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
CDC7 RIPK4 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
CDC7 HMBOX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDC7 TSNAXIP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDC7 TSPY10 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDC7 GOLGA6A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDC7 TRIM27 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDC7 IKZF4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDC7 GMEB2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDC7 LZTS1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDC7 ZBTB8B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDC7 TRIM37 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDC7 CALCOCO2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ICE1 CDC7 24234451 30021884 physical association cross-linking study IntAct
CDC7 CHEK2 18372119 20733106 23564203 27898060 N/A N/A OmniPath
CHEK1 CDC7 20068082 27898060 stimulant N/A OmniPath
CDK2 CDC7 10846177 17927916 27898060 N/A N/A OmniPath
CDC7 MCM7 10846177 12614612 21070963 27898060 stimulant N/A OmniPath
CDC7 ESCO1 23314252 27898060 inhibition N/A OmniPath
CDC7 MCM2 10373538 10508166 10523313 10846177 10964916 11568184 12614612 16446360 16826239 16864800 16899510 17062569 17081983 17927916 18286467 18669648 19270162 19647517 19692334 21596784 23066029 24234446 26549452 27898060 9407029 stimulant N/A OmniPath
CDC7 RAD18 21098111 27898060 N/A N/A OmniPath
CDK1 CDC7 10846177 27898060 stimulant N/A OmniPath
CDC7 PSIP1 27898060 7231784 stimulant N/A OmniPath
CDC7 MCM4 10508166 10846177 12614612 17018296 19270162 21070963 24234446 27898060 9407029 stimulant N/A OmniPath
CDC7 CLSPN 18084324 23598722 27898060 N/A N/A OmniPath

Visualization