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GENE：CDH2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CDH2
FullNmae cadherin 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1759
EnsembleID ENSG00000170558
Uniprot P19022

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CDH2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CDH2 GO:0000902,GO:0003323,GO:0003723,GO:0005509,GO:0005509,GO:0005515,GO:0005737,GO:0005737,GO:0005788,GO:0005886,GO:0005886,GO:0005886,GO:0005911,GO:0005912,GO:0005912,GO:0005916,GO:0005925,GO:0007043,GO:0007043,GO:0007155,GO:0007156,GO:0007157,GO:0007275,GO:0007416,GO:0007420,GO:0008013,GO:0008013,GO:0009986,GO:0010001,GO:0014032,GO:0014069,GO:0014704,GO:0014704,GO:0016323,GO:0016324,GO:0016327,GO:0016339,GO:0016342,GO:0016342,GO:0019901,GO:0019903,GO:0021987,GO:0030027,GO:0030027,GO:0030054,GO:0030057,GO:0030864,GO:0034332,GO:0035995,GO:0042383,GO:0042802,GO:0043005,GO:0043410,GO:0044331,GO:0044331,GO:0044853,GO:0045177,GO:0045294,GO:0045295,GO:0045296,GO:0048514,GO:0048854,GO:0048872,GO:0050770,GO:0051146,GO:0051966,GO:0060019,GO:0060563,GO:0062023,GO:0070445,GO:0072659,GO:0090090,GO:0090497,GO:0097091,GO:0097118,GO:0097150,GO:0098609,GO:0098609,GO:0098793,GO:1902897,GO:2000809

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CDH2 hsa:1000 path:hsa04514 Cell adhesion molecules - Homo sapiens (human)
CDH2 hsa:1000 path:hsa05412 Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CDH1 CDH2 11884419 16424155 16461340 17307799 17617594 26192618 interaction type N/A ACSN
CDH2 CDH4 11884419 16424155 16461340 17307799 17617594 26192618 interaction type N/A ACSN
CDH2 KLRG1 11884419 16424155 16461340 17307799 17617594 26192618 interaction type N/A ACSN
CDH2 TNF 11884419 16424155 16461340 17307799 17617594 26192618 interaction type N/A ACSN
CDH2 IFNG 11884419 16424155 16461340 17307799 17617594 26192618 interaction type N/A ACSN
CDH2 PIP5K1C 17261850 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDH2 CTNND1 23180781 8660921 physical association anti tag coimmunoprecipitation InnateDB
DUSP26 CDH2 19043453 23180781 physical association anti tag coimmunoprecipitation InnateDB
FOXQ1 CDH2 23180781 25287361 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR CDH2 17297473 18535113 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
E2F4 CDH2 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXP3 CDH2 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 CDH2 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 CDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CDH2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
KLF8 CDH2 20728449 trascriptional regulation,stimulation inferred by curator TFlink
MSX2 CDH2 21730974 trascriptional regulation,stimulation inferred by curator TFlink
MZF1 CDH2 15541732 trascriptional regulation,stimulation inferred by curator TFlink
SNAI1 CDH2 21796367 trascriptional regulation,stimulation inferred by curator TFlink
SNAI2 CDH2 21796367 trascriptional regulation,stimulation inferred by curator TFlink
SP1 CDH2 15541732 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 CDH2 15541732 trascriptional regulation,stimulation inferred by curator TFlink
SP3 CDH2 15541732 trascriptional regulation,stimulation inferred by curator TFlink
TWIST1 CDH2 21796367 trascriptional regulation,stimulation inferred by curator TFlink
TWIST2 CDH2 19581928 21796367 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004F4657 CDH2 22370644 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS000029D9F1 CDH2 21282569 25416803 mrna cleavage,inhibition array technology TarBase
URS00004F4657 CDH2 22370644 22942087 25416803 mrna cleavage,inhibition array technology,western blot,miRNA interference luciferase reporter assay TarBase
URS0000338542 CDH2 19386588 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000065D58 CDH2 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000330617 CDH2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 CDH2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000321A1A CDH2 24374217 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5BAA CDH2 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000046CDA6 CDH2 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000076B539 CDH2 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00000254A6 CDH2 25416803 27331410 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS00004AE8D3 CDH2 25230372 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000034979B CDH2 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SRC CDH2 22135298 phosphorylation N/A PhosphoSite
CDH11 CDH2 25361965 interaction type N/A PTMCode2
CDH2 CDH11 25361965 interaction type N/A PTMCode2
LRRC7 CDH2 25361965 interaction type N/A PTMCode2
CDH2 LRRC7 25361965 interaction type N/A PTMCode2
ARVCF CDH2 25361965 interaction type N/A PTMCode2
CDH2 ARVCF 25361965 interaction type N/A PTMCode2
CDH2 PIK3R1 25361965 interaction type N/A PTMCode2
PIK3R1 CDH2 25361965 interaction type N/A PTMCode2
CDH2 CTNNA1 25361965 interaction type N/A PTMCode2
CTNNA1 CDH2 25361965 interaction type N/A PTMCode2
CDH2 CTNND2 25361965 interaction type N/A PTMCode2
CTNND2 CDH2 25361965 interaction type N/A PTMCode2
CDH2 JUP 25361965 interaction type N/A PTMCode2
JUP CDH2 25361965 interaction type N/A PTMCode2
CDH2 CTNNB1 25361965 interaction type N/A PTMCode2
CTNNB1 CDH2 25361965 interaction type N/A PTMCode2
CDH2 BOC 25361965 interaction type N/A PTMCode2
BOC CDH2 25361965 interaction type N/A PTMCode2
CDH2 CDH4 25361965 interaction type N/A PTMCode2
CDH4 CDH2 25361965 interaction type N/A PTMCode2
CDH2 PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 CDH2 25361965 interaction type N/A PTMCode2
CDH2 CTNND1 25361965 interaction type N/A PTMCode2
CTNND1 CDH2 25361965 interaction type N/A PTMCode2
CDON CDH2 25361965 interaction type N/A PTMCode2
CDH2 CDON 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
EXOC5 CDH2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PKP4 CDH2 25348397 N/A physical interaction ComPPI
RPS26 CDH2 25348397 N/A physical interaction ComPPI
SKP1 CDH2 25348397 N/A physical interaction ComPPI
FBXO17 CDH2 25348397 N/A physical interaction ComPPI
PTPN6 CDH2 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
CTNND1 CDH2 21357690 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
MRPL23 CDH2 25348397 N/A physical interaction ComPPI
CAVIN3 CDH2 25348397 N/A physical interaction ComPPI
ERBB2 CDH2 25348397 N/A physical interaction ComPPI
PIK3R1 CDH2 14525934 15192701 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PTPRO CDH2 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
CREBBP CDH2 13678586 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
SLC9A3R1 CDH2 25348397 N/A physical interaction ComPPI
PTPN22 CDH2 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
KTN1 CDH2 25348397 N/A physical interaction ComPPI
JUP CDH2 12604612 14525934 1639850 17098867 24234451 25348397 7650039 8074697 association,physical association anti bait coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
PRPH CDH2 25348397 N/A physical interaction ComPPI
PRKAR1A CDH2 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
UBC CDH2 25348397 N/A physical interaction ComPPI
NTRK1 CDH2 25348397 N/A physical interaction ComPPI
DDR1 CDH2 25348397 N/A physical interaction ComPPI
PTPN1 CDH2 11106648 12377785 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PDIA4 CDH2 25348397 N/A physical interaction ComPPI
PTPRB CDH2 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPRG CDH2 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPN7 CDH2 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
PTPRR CDH2 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
IQGAP1 CDH2 17098867 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN12 CDH2 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
GRIN2D CDH2 10862698 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
GNA13 CDH2 11136230 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
GRIN1 CDH2 10862698 14525934 17589506 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
RAB8B CDH2 25348397 N/A physical interaction ComPPI
SPTBN1 CDH2 25348397 N/A physical interaction ComPPI
EGFR CDH2 25348397 N/A physical interaction ComPPI
FGFR1 CDH2 25348397 N/A physical interaction ComPPI
PTPRC CDH2 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
LRRC7 CDH2 11729199 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CTNND2 CDH2 14525934 25348397 9971746 N/A experimental interaction detection,in vivo ComPPI,HPRD
DDR2 CDH2 25348397 N/A physical interaction ComPPI
CTNNB1 CDH2 12151522 12604612 14525934 17057644 17098867 17510365 17679699 18948590 21357690 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,tandem affinity purification ComPPI,HPRD,IntAct
ARVCF CDH2 11058098 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CTNNA1 CDH2 12604612 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
SSR4 CDH2 25348397 N/A physical interaction ComPPI
SUPT5H CDH2 25348397 N/A physical interaction ComPPI
SARS2 CDH2 25348397 N/A physical interaction ComPPI
CCNA2 CDH2 25348397 N/A physical interaction ComPPI
BOC CDH2 25348397 N/A physical interaction,in vivo ComPPI
CDON CDH2 12634428 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CDH2 FGFR4 14525934 25348397 9168198 N/A experimental interaction detection,in vitro ComPPI,HPRD
CDH2 CDH4 10662782 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CDH2 CDH11 14525934 14625392 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CDH2 GNA12 11136230 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
CDH2 ACTA1 25348397 N/A physical interaction ComPPI
CDH2 RYK 25348397 N/A physical interaction ComPPI
CDH2 RPL32 25348397 N/A physical interaction ComPPI
CDH2 MTHFD1 25348397 N/A physical interaction ComPPI
CDH2 PC 25348397 N/A physical interaction ComPPI
CDH2 RPL21 25348397 N/A physical interaction ComPPI
CDH2 RPL3 25348397 N/A physical interaction ComPPI
CDH2 RPL8 25348397 N/A physical interaction ComPPI
CDH2 MRPL58 25348397 N/A physical interaction ComPPI
CDH2 RPS16 25348397 N/A physical interaction ComPPI
CDH2 GAA 25348397 N/A physical interaction ComPPI
CDH2 TPM4 25348397 N/A physical interaction ComPPI
CDH2 MRPL49 25348397 N/A physical interaction ComPPI
CDH2 PTBP3 25348397 N/A physical interaction ComPPI
CDH2 TMEM256 25348397 N/A physical interaction ComPPI
CDH2 NENF 25348397 N/A physical interaction ComPPI
CDH2 PPT2 25348397 N/A physical interaction ComPPI
CDH2 IARS2 25348397 N/A physical interaction ComPPI
CDH2 DBN1 25348397 N/A physical interaction ComPPI
CDH2 FBXO45 25348397 N/A physical interaction ComPPI
CDH2 PSEN1 25348397 N/A physical interaction ComPPI
CDH2 CTNNA3 25348397 N/A physical interaction ComPPI
CDH2 NAA25 17098867 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDH2 PTPRK 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
CDH2 PTPRJ 19167335 24234451 25348397 dephosphorylation reaction phosphatase assay ComPPI,IntAct
CDH2 FAM20C 22582013 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
CDH2 KSR1 24234451 25348397 27086506 association anti tag coimmunoprecipitation ComPPI,IntAct
CDH2 LAMP1 24234451 25348397 29568061 association pull down,proximity-dependent biotin identification ComPPI,IntAct
RPL14 CDH2 25348397 N/A physical interaction ComPPI
GRIK2 CDH2 12151522 14525934 N/A experimental interaction detection HPRD
ARHGAP32 CDH2 12531901 14525934 N/A experimental interaction detection HPRD
CDH2 MTA3 24234451 26028330 association chromatin immunoprecipitation assay IntAct
CDH2 EHMT2 24234451 26028330 association chromatin immunoprecipitation assay IntAct
CDH2 GATA3 24234451 26028330 association chromatin immunoprecipitation assay IntAct
SRC CDH2 16371504 27898060 inhibition N/A OmniPath
CTNND1 CDH2 12604612 14610055 14625392 20371349 21357690 27898060 8660921 stimulant N/A OmniPath
PAX6 CDH2 19666824 27898060 stimulant N/A OmniPath
ARVCF CDH2 11058098 14610055 27898060 stimulant N/A OmniPath
CTNND2 CDH2 14610055 27898060 9971746 stimulant N/A OmniPath
CDH2 CDON 12634428 20160094 27898060 stimulant N/A OmniPath

Visualization










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