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GENE：DCTN4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DCTN4
FullNmae dynactin subunit 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:15518
EnsembleID ENSG00000132912
Uniprot Q9UJW0

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DCTN4 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DCTN4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DCTN4 GO:0000776,GO:0000922,GO:0001725,GO:0005515,GO:0005634,GO:0005737,GO:0005813,GO:0005829,GO:0005868,GO:0005869,GO:0005925,GO:0005938,GO:0030017

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DCTN4 hsa:51164 path:hsa04814 Motor proteins - Homo sapiens (human)
DCTN4 hsa:51164 path:hsa04962 Vasopressin-regulated water reabsorption - Homo sapiens (human)
DCTN4 hsa:51164 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
DCTN4 hsa:51164 path:hsa05016 Huntington disease - Homo sapiens (human)
DCTN4 hsa:51164 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
DCTN4 hsa:51164 path:hsa05132 Salmonella infection - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
EGR1 DCTN4 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR DCTN4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 DCTN4 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F6 DCTN4 12909625 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
ETS1 DCTN4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 DCTN4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 DCTN4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 DCTN4 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 DCTN4 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 DCTN4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DCTN4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DCTN4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 DCTN4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DCTN4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DCTN4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF DCTN4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 DCTN4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR DCTN4 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001E0AEA DCTN4 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS00000DDD35 DCTN4 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00005651EE DCTN4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000451A1 DCTN4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001C770D DCTN4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002C02E4 DCTN4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003AFAD1 DCTN4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000209F04 DCTN4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000052E1A6 DCTN4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075A608 DCTN4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000043C1C3 DCTN4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000006BE7D DCTN4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000024B619 DCTN4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001F9A0F DCTN4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005ECFE5 DCTN4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000184017 DCTN4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000017DBB8 DCTN4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000C48FA DCTN4 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 DCTN4 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F DCTN4 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 DCTN4 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000003ABC4 DCTN4 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000065D58 DCTN4 22473208 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
ACTR1A DCTN4 25361965 interaction type N/A PTMCode2
DCTN4 ACTR1A 25361965 interaction type N/A PTMCode2
ANK2 DCTN4 25361965 interaction type N/A PTMCode2
DCTN4 ANK2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GOLGA2 DCTN4 21516116 24234451 25348397 25416956 26871637 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MIS18A DCTN4 25348397 N/A physical interaction ComPPI
PNMA1 DCTN4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
UQCRH DCTN4 25348397 N/A physical interaction ComPPI
EIF4G1 DCTN4 25348397 N/A physical interaction ComPPI
NTRK1 DCTN4 25348397 N/A physical interaction ComPPI
PDGFD DCTN4 25348397 N/A physical interaction ComPPI
MAPK8IP3 DCTN4 25348397 N/A physical interaction ComPPI
AKAP10 DCTN4 25348397 N/A physical interaction ComPPI
CAPZA1 DCTN4 25348397 N/A physical interaction ComPPI
DCTN1 DCTN4 24234451 25348397 26638075 27173435 association,physical association physical interaction,tandem affinity purification,proximity-dependent biotin identification,inference by socio-affinity scoring ComPPI,IntAct
ACTR1A DCTN4 10074429 10671518 14525934 22863883 25348397 26344197 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
RAB11A DCTN4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
GPS2 DCTN4 25348397 N/A physical interaction ComPPI
DYNC1H1 DCTN4 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TRIM25 DCTN4 25348397 N/A physical interaction ComPPI
RIC8A DCTN4 25348397 N/A physical interaction ComPPI
ATP7B DCTN4 14525934 16554302 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,OmniPath
DCTN2 DCTN4 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
CALCOCO2 DCTN4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
DCTN4 ACTR1B 25348397 N/A physical interaction ComPPI
DCTN4 SEH1L 25348397 N/A physical interaction ComPPI
DCTN4 MTUS2 21516116 24234451 25348397 25416956 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
DCTN4 CSPP1 25348397 N/A physical interaction ComPPI
DCTN4 C4BPB 25348397 N/A physical interaction ComPPI
DCTN4 CAPZA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DCTN4 CAPZB 25348397 N/A physical interaction ComPPI
DCTN4 DCTN5 25348397 N/A physical interaction ComPPI
DCTN4 DCTN6 25348397 N/A physical interaction ComPPI
DCTN4 DUSP13 25348397 N/A physical interaction ComPPI
DCTN4 DUSP13 25348397 N/A physical interaction ComPPI
DCTN4 KLHL2 25348397 N/A physical interaction ComPPI
DCTN4 BMERB1 25348397 N/A physical interaction ComPPI
DCTN4 ANK2 19109891 24234451 25348397 27898060 physical association pull down ComPPI,IntAct,OmniPath
ACTR10 DCTN4 25348397 N/A physical interaction ComPPI
RPS19BP1 DCTN4 25348397 N/A physical interaction ComPPI
DEFB127 DCTN4 25348397 N/A physical interaction ComPPI
DCTN4 DCTN4 10671518 14525934 N/A experimental interaction detection HPRD

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