Gene Information gene info

  1. Home

GENE：DOK1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DOK1
FullNmae docking protein 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:2990
EnsembleID ENSG00000115325
Uniprot Q99704

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DOK1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
DOK1 GO:0005515,GO:0005634,GO:0005737,GO:0005829,GO:0005829,GO:0007165,GO:0007166,GO:0007169,GO:0007265,GO:0038145,GO:0043410,GO:0048471

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
IKBKB DOK1 15574499 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
ITGB2 DOK1 12606711 23180781 physical association pull down InnateDB
ITGB7 DOK1 12606711 23180781 physical association pull down InnateDB
RET DOK1 12087092 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
DOK1 MAP4K4 20005715 interaction type N/A PSP,SignaLink
DOK1 ABL1 20005715 interaction type N/A PSP
DOK1 ERBB2 20005715 interaction type N/A PSP,SignaLink
DOK1 ITGB3 12606711 18988627 20005715 interaction type N/A PSP,SignaLink
DOK1 ITGB2 12606711 18988627 20005715 interaction type N/A PSP,SignaLink
DOK1 ITGB1 20005715 interaction type N/A PSP,SignaLink
DOK1 INSR 20005715 interaction type N/A PSP,SignaLink
DOK1 LCK 20005715 interaction type N/A PSP
DOK1 FYN 20005715 interaction type N/A PSP
DOK1 LYN 20005715 interaction type N/A PSP
DOK1 RET 12087092 16153436 18988627 20005715 21071413 interaction type N/A PSP,SignaLink
DOK1 SRC 20005715 interaction type N/A PSP
DOK1 ITGB5 12606711 18988627 20005715 interaction type N/A PSP,SignaLink
DOK1 PLCG1 20005715 interaction type N/A PSP
DOK1 ITGB7 20005715 interaction type N/A PSP
DOK1 PTPN6 20005715 interaction type N/A PSP
DOK1 CSK 20005715 interaction type N/A PSP
DOK1 TEC 20005715 interaction type N/A PSP
DOK1 CRKL 20005715 interaction type N/A PSP
DOK1 INPP5D 10822173 18988627 20005715 21071413 interaction type N/A PSP,SignaLink
DOK1 ABL1 10567556 18988627 20005715 21071413 9008161 N/A N/A SignaLink
DOK1 CRKL 11071635 18988627 20005715 N/A N/A SignaLink
DOK1 SRC 20005715 N/A N/A SignaLink
DOK1 CSK 20005715 20005715 N/A N/A SignaLink
DOK1 FYN 20005715 20005715 N/A N/A SignaLink
DOK1 ITGB7 12606711 18988627 20005715 20005715 N/A N/A SignaLink
DOK1 LCK 20005715 20005715 N/A N/A SignaLink
DOK1 LYN 11071635 11825908 20005715 20005715 21071413 N/A N/A SignaLink
DOK1 PLCG1 20005715 20005715 N/A N/A SignaLink
DOK1 PTPN6 10585470 18988627 20005715 20005715 N/A N/A SignaLink
DOK1 TEC 11071635 11071635 11825908 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR DOK1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 DOK1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 DOK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 DOK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DOK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 DOK1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 DOK1 23028047 trascriptional regulation,stimulation inferred by curator TFlink
SMAD3 DOK1 N/A trascriptional regulation,stimulation inferred by curator TFlink
SMAD4 DOK1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
INSR DOK1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
IKBKB DOK1 22135298 phosphorylation N/A PhosphoSite
RET DOK1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
NCK2 DOK1 25361965 interaction type N/A PTMCode2
DOK1 NCK2 25361965 interaction type N/A PTMCode2
CSK DOK1 25361965 interaction type N/A PTMCode2
DOK1 CSK 25361965 interaction type N/A PTMCode2
DOK1 NCK1 25361965 interaction type N/A PTMCode2
NCK1 DOK1 25361965 interaction type N/A PTMCode2
DOK1 INSR 25361965 interaction type N/A PTMCode2
DOK1 GRB2 25361965 interaction type N/A PTMCode2
GRB2 DOK1 25361965 interaction type N/A PTMCode2
DOK1 CRKL 25361965 interaction type N/A PTMCode2
CRKL DOK1 25361965 interaction type N/A PTMCode2
DOK1 RET 25361965 interaction type N/A PTMCode2
DOK1 SRC 25361965 interaction type N/A PTMCode2
SRC DOK1 25361965 interaction type N/A PTMCode2
DOK1 FYN 25361965 interaction type N/A PTMCode2
FYN DOK1 25361965 interaction type N/A PTMCode2
DOK1 SH2D1A 25361965 interaction type N/A PTMCode2
SH2D1A DOK1 25361965 interaction type N/A PTMCode2
DOK1 ABL1 25361965 interaction type N/A PTMCode2
ABL1 DOK1 25361965 interaction type N/A PTMCode2
DOK1 PTPRH 25361965 interaction type N/A PTMCode2
PTPRH DOK1 25361965 interaction type N/A PTMCode2
DOK1 TEC 25361965 interaction type N/A PTMCode2
TEC DOK1 25361965 interaction type N/A PTMCode2
DOK1 GRB10 25361965 interaction type N/A PTMCode2
GRB10 DOK1 25361965 interaction type N/A PTMCode2
DOK1 PTPN6 25361965 interaction type N/A PTMCode2
PTPN6 DOK1 25361965 interaction type N/A PTMCode2
DOK1 SHC1 25361965 interaction type N/A PTMCode2
SHC1 DOK1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NCK2 DOK1 14525934 25348397 9737977 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
YES1 DOK1 11071635 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GABARAPL2 DOK1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
ITGB5 DOK1 12606711 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PTPRH DOK1 25348397 N/A in vivo ComPPI
PTPN6 DOK1 10585470 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MAP1LC3B DOK1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CRK DOK1 25348397 N/A physical interaction ComPPI
ERBB2 DOK1 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
VAV1 DOK1 25348397 N/A physical interaction ComPPI
TEC DOK1 10823839 11071635 11825908 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
KIT DOK1 11825908 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
LYN DOK1 11071635 11825908 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PIK3R1 DOK1 25348397 N/A physical interaction ComPPI
PTPN11 DOK1 15546884 24234451 25348397 27898060 association coimmunoprecipitation ComPPI,IntAct,OmniPath
SRC DOK1 11071635 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
GRB10 DOK1 11551902 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CRKL DOK1 11071635 14525934 24234451 25348397 25814554 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,validated two hybrid ComPPI,HPRD,IntAct
DOK1 ITGB3 12606711 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DOK1 SH2D1A 10852966 14525934 24234451 25348397 association coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
DOK1 NCK1 12087092 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
DOK1 MAP4K4 25348397 N/A in vivo ComPPI
DOK1 INPP5D 10822173 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
DOK1 FYN 14525934 15345598 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
DOK1 CSK 14525934 25348397 9221755 N/A experimental interaction detection,in vivo ComPPI,HPRD
DOK1 HCK 11071635 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DOK1 FES 11071635 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
DOK1 SHC1 11071635 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DOK1 ITGB1 25348397 N/A physical interaction,in vitro ComPPI
DOK1 RASA1 14525934 25348397 9008161 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DOK1 ITGB7 12606711 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
DOK1 INSR 11551902 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
DOK1 LCK 10799545 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
DOK1 RET 12087092 14525934 16153436 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
DOK1 DOK2 25348397 N/A physical interaction ComPPI
DOK1 FGR 11071635 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
DOK1 PLCG1 11071635 14525934 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
DOK1 ABL1 10567556 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
DOK1 CBLL1 25348397 N/A physical interaction ComPPI
DOK1 ABL2 25348397 N/A physical interaction ComPPI
DOK1 PTK6 25348397 N/A physical interaction ComPPI
DOK1 ITK 25348397 N/A physical interaction ComPPI
DOK1 BCR 25348397 N/A physical interaction ComPPI
DOK1 CD28 25348397 N/A physical interaction ComPPI
DOK1 GRB2 25348397 N/A physical interaction ComPPI
DOK1 EGFR 15476828 24234451 24658140 25348397 25402006 27898060 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct,OmniPath
DOK1 DOK3 25348397 N/A physical interaction ComPPI
DOK1 TLN1 25348397 N/A physical interaction ComPPI
DOK1 GABARAPL1 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
DOK1 SRMS 23822091 24234451 25348397 27898060 phosphorylation reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,protein kinase assay ComPPI,IntAct,OmniPath
ITGB2 DOK1 25348397 N/A in vitro ComPPI
COLGALT2 DOK1 25348397 N/A physical interaction ComPPI
LCK DOK1 10799545 27898060 stimulant N/A OmniPath
LYN DOK1 11071635 11825908 27898060 stimulant N/A OmniPath
PTPN1 DOK1 14766979 27898060 inhibition N/A OmniPath
FYN DOK1 11825908 15345598 27898060 stimulant N/A OmniPath
RET DOK1 11551902 12087092 16153436 16497976 19901323 27898060 stimulant N/A OmniPath
MAP3K5 DOK1 10688886 10852966 11042170 12087092 15574499 27898060 N/A N/A OmniPath
ABL1 DOK1 10567556 10688886 10823839 11071635 12777393 19823681 20697350 22974441 27898060 9008161 9822717 stimulant N/A OmniPath
INSR DOK1 10688886 11551902 12087092 15574499 15592455 16094384 16497976 19481264 19690332 19901323 27898060 9008160 stimulant N/A OmniPath
IKBKB DOK1 15574499 27898060 stimulant N/A OmniPath
DOK1 RASGRP3 27898060 9008161 9233798 stimulant N/A OmniPath
EFNB2 DOK1 27898060 9233798 stimulant N/A OmniPath
PTPRH DOK1 11278335 12101188 27898060 N/A N/A OmniPath

Visualization










  Return