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GENE：FTH1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FTH1
FullNmae ferritin heavy chain 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3976
EnsembleID ENSG00000167996
Uniprot P02794

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FTH1 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FTH1 necroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
FTH1 mpt 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FTH1 lysosomal_cd 36341760 220 lysosome-dependent cell death genes. retulator signature
FTH1 lysosomal_cd 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
FTH1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FTH1 ferroptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature
FTH1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FTH1 autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
FTH1 autophagy 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
FTH1 GO:0004322,GO:0005506,GO:0005515,GO:0005576,GO:0005634,GO:0005737,GO:0005829,GO:0006826,GO:0006879,GO:0006880,GO:0006955,GO:0008043,GO:0008198,GO:0008199,GO:0008285,GO:0042802,GO:0044754,GO:0048147,GO:0070062,GO:0140315,GO:1904724,GO:1904813

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FTH1 hsa:2495 path:hsa04216 Ferroptosis - Homo sapiens (human)
FTH1 hsa:2495 path:hsa04217 Necroptosis - Homo sapiens (human)
FTH1 hsa:2495 path:hsa04978 Mineral absorption - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NFKB1 FTH1 15537542 21725609 23178297 23572150 26192618 interaction type N/A ACSN
FTH1 TSC1 17355907 23180781 physical association two hybrid InnateDB
FTH1 CXCR4 17056593 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR FTH1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 FTH1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 FTH1 18414489 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation array,chromatin immunoprecipitation assay TFlink
ETS1 FTH1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 FTH1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 FTH1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 FTH1 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
NFE2L2 FTH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SMARCA4 FTH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FTH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FTH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FTH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FTH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FTH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A FTH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FTH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF FTH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 FTH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 FTH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 FTH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 FTH1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF1 FTH1 17565989 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000003ABC4 FTH1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00002075FA FTH1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000075A281 FTH1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001A4ABF FTH1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003AFAD1 FTH1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000008C563 FTH1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002CF3F0 FTH1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000250A40 FTH1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000031D186 FTH1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000049FAE8 FTH1 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
FTH1 MAX 25361965 interaction type N/A PTMCode2
MAX FTH1 25361965 interaction type N/A PTMCode2
FTH1 FTL 25361965 interaction type N/A PTMCode2
FTL FTH1 25361965 interaction type N/A PTMCode2
FTH1 FTH1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KPNA2 FTH1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PPL FTH1 25348397 N/A physical interaction ComPPI
DAXX FTH1 21573799 21988832 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,pull down,physical interaction ComPPI,IntAct
MAPK9 FTH1 23602568 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
FTL FTH1 11591653 14525934 16169070 16189514 21516116 24234451 25348397 25416956 25910212 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,in vivo,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
FXR2 FTH1 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CST1 FTH1 25348397 N/A physical interaction ComPPI
TFRC FTH1 20133674 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
FTH1 CD99 14525934 15388255 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
FTH1 CRMP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FTH1 GOLM1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FTH1 UBR1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FTH1 BRD7 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
FTH1 CSF3R 14525934 15123426 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
FTH1 ELL3 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FTH1 PACSIN1 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
FTH1 PACSIN2 25348397 N/A physical interaction ComPPI
FTH1 TOLLIP 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
FTH1 UCHL5 25348397 N/A physical interaction ComPPI
FTH1 NR1I3 25348397 N/A physical interaction ComPPI
FTH1 NR3C1 25348397 N/A physical interaction ComPPI
FTH1 NR5A2 25348397 N/A physical interaction ComPPI
FTH1 TRAF4 25348397 N/A physical interaction ComPPI
FTH1 SPP1 25348397 N/A physical interaction ComPPI
FTH1 ATP6V1B1 25348397 N/A physical interaction ComPPI
FTH1 IGSF8 25348397 N/A physical interaction ComPPI
FTH1 CDC16 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FTH1 CSNK2B 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FTH1 GRB2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FTH1 LBP 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FTH1 MYL3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FTH1 SOX5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FTH1 YWHAE 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FTH1 PIAS4 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FTH1 TICAM2 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
FTH1 CDC25A 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FTH1 MAX 20195357 24234451 25348397 physical association display technology,physical interaction,tandem affinity purification ComPPI,IntAct
FTH1 SUPT16H 25348397 N/A physical interaction ComPPI
FTH1 ASB15 25348397 N/A physical interaction ComPPI
FTH1 ASB16 25348397 N/A physical interaction ComPPI
FTH1 AURKA 25348397 N/A physical interaction ComPPI
FTH1 AURKB 25348397 N/A physical interaction ComPPI
FTH1 CEP57 25348397 N/A physical interaction ComPPI
FTH1 TP53 25348397 N/A physical interaction ComPPI
FTH1 SDCBP 25348397 N/A physical interaction ComPPI
FTH1 NTAQ1 25348397 N/A physical interaction ComPPI
FTH1 PCBP1 25348397 N/A physical interaction ComPPI
FTH1 PCBP2 25348397 N/A physical interaction ComPPI
FTH1 PCBP3 25348397 N/A physical interaction ComPPI
FTH1 HSPB1 24234451 25277244 25348397 physical association anti bait coimmunoprecipitation,reverse ras recruitment system,physical interaction ComPPI,IntAct
FTH1 ARHGAP1 25348397 N/A physical interaction ComPPI
FTH1 HERC2 24234451 25348397 29426014 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FTH1 HERC2P3 25348397 N/A physical interaction ComPPI
FTH1 NCOA4 25348397 N/A physical interaction ComPPI
FTH1 TRUB2 25348397 N/A physical interaction ComPPI
FTH1 CDH1 25348397 N/A physical interaction ComPPI
FTH1 RBP4 25348397 N/A physical interaction ComPPI
FTH1 SDR16C5 25348397 N/A physical interaction ComPPI
FTH1 SEMG2 25348397 N/A physical interaction ComPPI
FTH1 SEMG1 25348397 N/A physical interaction ComPPI
FTH1 A2ML1 25348397 N/A physical interaction ComPPI
FTH1 HAL 25348397 N/A physical interaction ComPPI
FTH1 KLK5 25348397 N/A physical interaction ComPPI
FTH1 TREX2 25348397 N/A physical interaction ComPPI
FTH1 KLK10 25348397 N/A physical interaction ComPPI
FTH1 SERPINB7 25348397 N/A physical interaction ComPPI
FTH1 KLK7 25348397 N/A physical interaction ComPPI
FTH1 SERPINA12 25348397 N/A physical interaction ComPPI
FTH1 IL1RN 25348397 N/A physical interaction ComPPI
FTH1 ACP3 25348397 N/A physical interaction ComPPI
FTH1 PLBD1 25348397 N/A physical interaction ComPPI
FTH1 POF1B 25348397 N/A physical interaction ComPPI
FTH1 CRNN 25348397 N/A physical interaction ComPPI
FTH1 SERPINB4 25348397 N/A physical interaction ComPPI
FTH1 CPA4 25348397 N/A physical interaction ComPPI
FTH1 KLK11 25348397 N/A physical interaction ComPPI
FTH1 CASP14 25348397 N/A physical interaction ComPPI
FTH1 SERPINB3 25348397 N/A physical interaction ComPPI
FTH1 TGM5 25348397 N/A physical interaction ComPPI
FTH1 TGM1 25348397 N/A physical interaction ComPPI
FTH1 CTSV 25348397 N/A physical interaction ComPPI
FTH1 ALOX12B 25348397 N/A physical interaction ComPPI
FTH1 FLG 25348397 N/A physical interaction ComPPI
FTH1 ME1 25348397 N/A physical interaction ComPPI
FTH1 IVL 25348397 N/A physical interaction ComPPI
FTH1 IL37 25348397 N/A physical interaction ComPPI
FTH1 CST6 25348397 N/A physical interaction ComPPI
FTH1 ASAH1 25348397 N/A physical interaction ComPPI
FTH1 CALML3 25348397 N/A physical interaction ComPPI
FTH1 CAPNS2 25348397 N/A physical interaction ComPPI
FTH1 CPM 25348397 N/A physical interaction ComPPI
FTH1 LUC7L2 25348397 N/A physical interaction ComPPI
FTH1 TGM3 25348397 N/A physical interaction ComPPI
FTH1 CALML5 25348397 N/A physical interaction ComPPI
FTH1 NCCRP1 25348397 N/A physical interaction ComPPI
FTH1 CST4 25348397 N/A physical interaction ComPPI
FTH1 ECM1 25348397 N/A physical interaction ComPPI
FTH1 GM2A 25348397 N/A physical interaction ComPPI
FTH1 CFTR 25348397 N/A physical interaction ComPPI
FTH1 UBC 17082767 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
FTH1 TSC1 17355907 24234451 25348397 physical association two hybrid ComPPI,IntAct
FTH1 SCHIP1 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
FTH1 ATP6V1A 21674799 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
FTH1 OPTN 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
FTH1 BAG4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SET FTH1 25348397 N/A physical interaction ComPPI
FTH1 FTH1 11591653 14525934 1992356 24234451 25416956 physical association experimental interaction detection,two hybrid array HPRD,IntAct
GPR35 FTH1 24234451 28298427 physical association ubiquitin reconstruction IntAct
MAPT FTH1 24234451 26402096 association anti bait coimmunoprecipitation IntAct
CXCR4 FTH1 17056593 27898060 N/A N/A OmniPath
FTH1 TSC1 17355907 27898060 N/A N/A OmniPath
TSC1 FTH1 17355907 27898060 N/A N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008C01AB FTH1 27087310 direct interaction,inhibition N/A NPInter

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