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GENE：FZD7

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FZD7
FullNmae frizzled class receptor 7
LocusType gene with protein product
Status Approved
HGNC_id HGNC:4045
EnsembleID ENSG00000155760
Uniprot O75084

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FZD7 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
FZD7 GO:0004930,GO:0005109,GO:0005515,GO:0005546,GO:0005886,GO:0005886,GO:0005886,GO:0006355,GO:0007186,GO:0010812,GO:0014834,GO:0016020,GO:0017147,GO:0017147,GO:0017147,GO:0019827,GO:0030165,GO:0030182,GO:0033077,GO:0034446,GO:0035567,GO:0038031,GO:0042327,GO:0042666,GO:0042813,GO:0042813,GO:0042813,GO:0043231,GO:0045893,GO:0045893,GO:0046330,GO:0048103,GO:0055038,GO:0060054,GO:0060070,GO:0060070,GO:0060070,GO:0060071,GO:0060231,GO:0060828,GO:0071300,GO:2000726

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FZD7 hsa:8324 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
FZD7 hsa:8324 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
FZD7 hsa:8324 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
FZD7 hsa:8324 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
FZD7 hsa:8324 path:hsa04916 Melanogenesis - Homo sapiens (human)
FZD7 hsa:8324 path:hsa04934 Cushing syndrome - Homo sapiens (human)
FZD7 hsa:8324 path:hsa05010 Alzheimer disease - Homo sapiens (human)
FZD7 hsa:8324 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
FZD7 hsa:8324 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
FZD7 hsa:8324 path:hsa05200 Pathways in cancer - Homo sapiens (human)
FZD7 hsa:8324 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
FZD7 hsa:8324 path:hsa05217 Basal cell carcinoma - Homo sapiens (human)
FZD7 hsa:8324 path:hsa05224 Breast cancer - Homo sapiens (human)
FZD7 hsa:8324 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
FZD7 hsa:8324 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FZD7 FZD7 22944199 26467481 bind,up-regulates activity N/A Signor
WNT8A FZD7 10097073 23331499 stimulation N/A SignaLink,SignaLink
PKN1 FZD7 24114839 phosphorylation reaction,stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
DLG4 FZD7 20005715 interaction type N/A PSP
DLG4 FZD7 12067714 12067714 18988627 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR FZD7 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 FZD7 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 FZD7 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 FZD7 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 FZD7 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYCN FZD7 16093321 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 FZD7 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 FZD7 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 FZD7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FZD7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FZD7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 FZD7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 FZD7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS FZD7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF FZD7 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 FZD7 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00004F4657 FZD7 20737575 rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00004F4657 FZD7 20737575 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS00000F31F4 FZD7 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 FZD7 19074876 25416803 mrna cleavage,inhibition array technology TarBase
URS000041FA2C FZD7 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00002ED720 FZD7 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001E0AEA FZD7 20371350 23592263 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000006372A FZD7 25416803 28364602 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000330617 FZD7 25416803 26780940 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004F859B FZD7 25416803 27815069 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001C770D FZD7 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002367FA FZD7 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000009A9A2 FZD7 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000383DF4 FZD7 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00006097A6 FZD7 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D15B FZD7 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000235862 FZD7 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
FZD7 CTNNB1 25361965 interaction type N/A PTMCode2
CTNNB1 FZD7 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SGTA FZD7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SGTB FZD7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
HPCAL1 FZD7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
NCALD FZD7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
AQP9 FZD7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
DLG4 FZD7 12067714 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
DLG2 FZD7 12067714 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
MAGI3 FZD7 14525934 15195140 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
SDCBP FZD7 18256285 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,far western blotting,surface plasmon resonance,fluorescence microscopy ComPPI,IntAct
UBQLN2 FZD7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EPN1 FZD7 25348397 N/A physical interaction ComPPI
DLG1 FZD7 12067714 14525934 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
UBQLN4 FZD7 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
ATP2B2 FZD7 25348397 N/A physical interaction ComPPI
NCS1 FZD7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
VNN2 FZD7 25348397 N/A physical interaction ComPPI
UBQLN1 FZD7 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
FFAR2 FZD7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FZD7 LAMP1 25348397 N/A physical interaction ComPPI
FZD7 UPK1A 25348397 N/A physical interaction ComPPI
FZD7 SLC39A4 25348397 N/A physical interaction ComPPI
FZD7 ZACN 25348397 N/A physical interaction ComPPI
FZD7 RSPO2 25348397 N/A physical interaction ComPPI
FZD7 ZNRF3 25348397 N/A physical interaction ComPPI
FZD7 WNT3 18313787 21314951 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
FZD7 BCL2L13 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FZD7 MGST1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FZD7 SLC30A4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FZD7 LEUTX 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FZD7 PRNP 24234451 28298427 physical association anti bait coimmunoprecipitation,bioluminescence resonance energy transfer,ubiquitin reconstruction IntAct
FZD7 CLPTM1 24234451 28298427 physical association ubiquitin reconstruction IntAct
FZD7 GNAS 24234451 28298427 physical association ubiquitin reconstruction IntAct
FZD7 PSME3IP1 24234451 28298427 physical association ubiquitin reconstruction IntAct
FZD7 PDAP1 24234451 28298427 physical association ubiquitin reconstruction IntAct
FZD7 SLC35B1 24234451 28298427 physical association ubiquitin reconstruction IntAct
FZD7 ADCY1 24234451 28298427 physical association ubiquitin reconstruction IntAct
FZD7 AIG1 24234451 28298427 physical association ubiquitin reconstruction IntAct
FZD7 CLN8 24234451 28298427 physical association ubiquitin reconstruction IntAct
TRAF2 FZD7 24234451 30561431 association virotrap IntAct
SHARPIN FZD7 24234451 30561431 association virotrap IntAct
TNFAIP3 FZD7 24234451 30561431 association virotrap IntAct
WNT2 FZD7 23815780 27898060 stimulant N/A OmniPath
WNT5A FZD7 10990458 27898060 stimulant N/A OmniPath
WNT8A FZD7 10097073 27898060 stimulant N/A OmniPath
WNT3A FZD7 18215320 27898060 stimulant N/A OmniPath
FZD7 GNAS 22944199 27898060 stimulant N/A OmniPath
WNT7A FZD7 22944199 27898060 stimulant N/A OmniPath
WNT11 FZD7 10862746 27898060 stimulant N/A OmniPath
WNT3 FZD7 18313787 21314951 24032637 27898060 stimulant N/A OmniPath
MYOC FZD7 19188438 27898060 N/A N/A OmniPath

Visualization










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