Gene Information gene info

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GENE：ITGB5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ITGB5
FullNmae integrin subunit beta 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6160
EnsembleID ENSG00000082781
Uniprot P18084

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ITGB5 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ITGB5 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ITGB5 GO:0001618,GO:0005178,GO:0005515,GO:0005886,GO:0005925,GO:0005925,GO:0007160,GO:0007160,GO:0007179,GO:0007229,GO:0007229,GO:0008305,GO:0009986,GO:0009986,GO:0009986,GO:0016477,GO:0016477,GO:0033627,GO:0034684,GO:0035987,GO:0043149,GO:0043235,GO:0045335,GO:0046718,GO:0046872,GO:0070062,GO:0090136

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ITGB5 hsa:3693 path:hsa04145 Phagosome - Homo sapiens (human)
ITGB5 hsa:3693 path:hsa04148 Efferocytosis - Homo sapiens (human)
ITGB5 hsa:3693 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
ITGB5 hsa:3693 path:hsa04510 Focal adhesion - Homo sapiens (human)
ITGB5 hsa:3693 path:hsa04512 ECM-receptor interaction - Homo sapiens (human)
ITGB5 hsa:3693 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
ITGB5 hsa:3693 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
ITGB5 hsa:3693 path:hsa05205 Proteoglycans in cancer - Homo sapiens (human)
ITGB5 hsa:3693 path:hsa05410 Hypertrophic cardiomyopathy - Homo sapiens (human)
ITGB5 hsa:3693 path:hsa05412 Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human)
ITGB5 hsa:3693 path:hsa05414 Dilated cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ITGAV ITGB5 10837075 11146654 14697347 15031725 18353785 22035837 22470492 26192618 9295024 9763615 interaction type N/A ACSN
ITGB5 ITGA2 22470492 24309651 26192618 26519775 9295024 9763615 interaction type N/A ACSN
ITGB5 ITGA1 22470492 24309651 26192618 26519775 9295024 9763615 interaction type N/A ACSN
SP1 ITGB5 10964912 11007770 11013220 15001984 17705132 18353785 21252118 23338822 26192618 interaction type N/A ACSN
SMAD3 ITGB5 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
SMAD4 ITGB5 11013125 11074002 11279127 11376132 11792802 12702545 12809600 15265520 16179589 16713975 18768831 21042762 21098712 21614932 22331441 22652804 23784029 25374926 26192618 8515656 9389648 interaction type N/A ACSN
VTN ITGB5 26192618 26519775 interaction type N/A ACSN
JAK1 ITGB5 11306493 18633355 19833085 21840487 22470492 22595692 26192618 27216177 7512720 7521688 interaction type N/A ACSN
PLAU ITGB5 11306493 18633355 19833085 21840487 22470492 22595692 26192618 27216177 7512720 7521688 interaction type N/A ACSN
PLAUR ITGB5 11306493 18633355 19833085 21840487 22470492 22595692 26192618 27216177 7512720 7521688 interaction type N/A ACSN
ITGB5 CRK 10837075 11146654 14697347 15031725 18353785 22035837 22470492 26192618 9295024 9763615 interaction type N/A ACSN
ITGB5 DOCK1 10837075 11146654 14697347 15031725 18353785 22035837 22470492 26192618 9295024 9763615 interaction type N/A ACSN
ITGB5 BCAR1 10837075 11146654 14697347 15031725 18353785 22035837 22470492 26192618 9295024 9763615 interaction type N/A ACSN
ITGB5 SNTA1 15123239 23180781 physical association peptide array InnateDB
ITGB5 RACK1 23180781 9442085 physical association two hybrid InnateDB
ITGB5 TLN1 22025551 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ANXA5 ITGB5 12769841 20005715 21071413 interaction type N/A PSP,SignaLink
DAB1 ITGB5 20005715 interaction type N/A PSP
DOK1 ITGB5 12606711 18988627 20005715 interaction type N/A PSP,SignaLink
EPS8 ITGB5 20005715 interaction type N/A PSP
DAB1 ITGB5 12606711 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR ITGB5 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 ITGB5 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 ITGB5 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 ITGB5 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
PRDM14 ITGB5 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ITGB5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ITGB5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ITGB5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ITGB5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS ITGB5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ITGB5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ITGB5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 ITGB5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ITGB5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR ITGB5 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 ITGB5 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000338542 ITGB5 18668040 25416803 mrna cleavage,inhibition experimental interaction detection TarBase
URS0000324096 ITGB5 23622248 25416803 mrna cleavage,inhibition clash TarBase

Source Target Pmid Interactiontype Methods Database
PAK4 ITGB5 22135298 phosphorylation N/A PhosphoSite
ITGA5 ITGB5 25361965 interaction type N/A PTMCode2
ITGB5 ITGA5 25361965 interaction type N/A PTMCode2
ITGAV ITGB5 25361965 interaction type N/A PTMCode2
ITGB5 ITGAV 25361965 interaction type N/A PTMCode2
ITGA3 ITGB5 25361965 interaction type N/A PTMCode2
ITGB5 ITGA3 25361965 interaction type N/A PTMCode2
ITGB5 TLN1 25361965 interaction type N/A PTMCode2
TLN1 ITGB5 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GOLGA2 ITGB5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FHL3 ITGB5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRTAP10-8 ITGB5 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
EFEMP2 ITGB5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KRTAP3-2 ITGB5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGB5 KRT40 25348397 N/A two hybrid,physical interaction ComPPI
ITGB5 EHMT2 25348397 N/A two hybrid,physical interaction ComPPI
ITGB5 ANXA5 12769841 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
ITGB5 CCN1 11287419 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ITGB5 MYO10 14525934 15156152 21642953 24234451 25348397 27898060 physical association two hybrid,experimental interaction detection,pull down,competition binding,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
ITGB5 FHL2 14525934 16355270 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
ITGB5 FLNA 14525934 16355270 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
ITGB5 PALLD 14525934 16355270 25348397 N/A two hybrid,two hybrid ComPPI,HPRD
ITGB5 ITGA5 25348397 N/A physical interaction,in vitro,in vivo ComPPI
ITGB5 LTBP1 12358597 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
ITGB5 RACK1 14525934 25348397 9442085 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
ITGB5 TLN1 12606711 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ITGB5 ITGAV 14525934 1694173 24234451 25348397 7689573 association,physical association experimental interaction detection,chromatography technology,physical interaction,in vitro,solid phase assay ComPPI,HPRD,IntAct
ITGB5 P2RY2 25348397 N/A in vitro,in vivo ComPPI
ITGB5 EPS8 12606711 14525934 24234451 25348397 N/A experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct
ITGB5 DAB2 12606711 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ITGB5 DOK1 12606711 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ITGB5 DAB1 12606711 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ITGB5 NUMB 12606711 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
ITGB5 ZBTB17 12356872 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ITGB5 PAK4 12356872 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
ITGB5 ITGB3BP 10579726 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ITGB5 TNS2 12606711 14525934 24234451 25348397 N/A experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct
ITGB5 PTK2 25348397 N/A physical interaction ComPPI
ITGB5 ITGA3 25348397 N/A physical interaction ComPPI
ITGB5 PPARD 25348397 N/A physical interaction ComPPI
ITGB5 PDIA3 17170699 24234451 25348397 disulfide bond anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ITGB5 ALB 15174051 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ITGB5 SNTA1 25348397 N/A physical interaction ComPPI
ITGB5 EWSR1 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ITGB5 SRSF9 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ITGB5 EPHA2 25348397 N/A physical interaction ComPPI
ITGB5 MTUS2 25348397 N/A physical interaction ComPPI
ITGB5 KRTAP10-9 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGB5 NOTCH2NLA 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGB5 ATP1B3 25348397 N/A physical interaction ComPPI
ITGB5 KLK5 25348397 N/A physical interaction ComPPI
ITGB5 MFGE8 25348397 N/A physical interaction ComPPI
ITGB5 EDIL3 25348397 N/A physical interaction ComPPI
ITGB5 SPP1 25348397 N/A physical interaction ComPPI
ITGB5 PLP1 25348397 N/A physical interaction ComPPI
ITGB5 ADAM9 25348397 N/A physical interaction ComPPI
ITGB5 VTN 1694173 24234451 25348397 physical association physical interaction,solid phase assay ComPPI,IntAct
ITGB5 ST8SIA4 25348397 N/A physical interaction ComPPI
ITGB5 ADAM21 25348397 N/A physical interaction ComPPI
ITGB5 ADAM33 25348397 N/A physical interaction ComPPI
ITGB5 PRG3 25348397 N/A physical interaction ComPPI
ITGB5 ST8SIA3 25348397 N/A physical interaction ComPPI
ITGB5 INSL5 25348397 N/A physical interaction ComPPI
ITGB5 LRRC4 25348397 N/A physical interaction ComPPI
ITGB5 HNRNPL 25348397 N/A physical interaction ComPPI
ITGB5 ANGPTL4 21397862 24234451 25348397 association,physical association anti bait coimmunoprecipitation,surface plasmon resonance,proximity ligation assay ComPPI,IntAct
ITGB5 DCC 21642953 24234451 25348397 physical association competition binding ComPPI,IntAct
ITGB5 FDFT1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
ITGB5 GAPDH 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
ITGB5 GON4L 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
ITGB5 MYBPC2 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
ITGB5 TAF1 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
ITGB5 TTN 23414517 24234451 25348397 physical association two hybrid fragment pooling approach ComPPI,IntAct
ITGB5 FRMD5 24234451 25348397 25448675 physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
ITGB5 TLN2 24234451 25348397 25448675 physical association anti tag coimmunoprecipitation ComPPI,IntAct
ITGB5 FERMT2 24234451 25348397 25448675 physical association anti tag coimmunoprecipitation ComPPI,IntAct
ITGB5 APPBP2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGB5 KRT34 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGB5 CYSRT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGB5 KRT31 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGB5 KRTAP1-1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGB5 ZNF655 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGB5 KRTAP5-7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ITGB5 ITGB5 12606711 14525934 N/A experimental interaction detection HPRD
LTBP3 ITGB5 12358597 14525934 N/A experimental interaction detection HPRD
ITGB5 KRTAP10-7 24234451 physical association two hybrid array,two hybrid prey pooling approach IntAct
PAK4 ITGB5 12356872 20507994 27898060 stimulant N/A OmniPath
ADAM9 ITGB5 11162558 27898060 stimulant N/A OmniPath
ITGAV ITGB5 11162558 1694173 27898060 7689573 N/A N/A OmniPath
ITGB5 ITGAV 11162558 1694173 27898060 7689573 N/A N/A OmniPath

Visualization










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