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GENE：KLF4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol KLF4
FullNmae KLF transcription factor 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6348
EnsembleID ENSG00000136826
Uniprot O43474

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
KLF4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
KLF4 GO:0000122,GO:0000785,GO:0000785,GO:0000791,GO:0000976,GO:0000978,GO:0000978,GO:0000981,GO:0000981,GO:0001010,GO:0001228,GO:0002067,GO:0002357,GO:0003700,GO:0005515,GO:0005654,GO:0005654,GO:0005667,GO:0005829,GO:0006357,GO:0006366,GO:0007500,GO:0008013,GO:0008270,GO:0008285,GO:0009913,GO:0010628,GO:0010629,GO:0015630,GO:0016525,GO:0019827,GO:0031077,GO:0031490,GO:0032088,GO:0032526,GO:0032717,GO:0034115,GO:0035019,GO:0035166,GO:0043154,GO:0045429,GO:0045444,GO:0045595,GO:0045892,GO:0045893,GO:0045893,GO:0045893,GO:0045944,GO:0045944,GO:0045944,GO:0046985,GO:0048679,GO:0048730,GO:0050728,GO:0051247,GO:0051247,GO:0051973,GO:0060070,GO:0060761,GO:0061436,GO:0061629,GO:0061629,GO:0071363,GO:0071499,GO:0090051,GO:0120222,GO:1902895,GO:1903672,GO:1904998,GO:1990830,GO:1990837,GO:1990841,GO:2000134,GO:2000342

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
KLF4 hsa:9314 path:hsa04550 Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human)
KLF4 hsa:9314 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
STAT6 KLF4 10485906 12223527 12244147 14610620 15634881 23124025 24204259 26192618 interaction type N/A ACSN
KLF4 PTGS2 10432118 10925299 12193690 21093321 21670502 23390297 26192618 6357187 interaction type N/A ACSN
KLF4 PPARG 10432118 10925299 12193690 21093321 21670502 23390297 26192618 6357187 interaction type N/A ACSN
KLF8 KLF4 17671186 19216735 19506021 19751731 19901072 20964627 21416054 21681822 26192618 association N/A ACSN
KLF4 BCL9 19751731 19901072 26192618 association N/A ACSN
EGR1 KLF4 20690147 23180781 physical association anti tag coimmunoprecipitation InnateDB
OCLN KLF4 23180781 24318462 physical association anti tag coimmunoprecipitation InnateDB
KLF4 TJP1 23180781 24318462 physical association anti tag coimmunoprecipitation InnateDB
CDKN2B KLF4 21746878 23180781 physical association anti tag coimmunoprecipitation InnateDB
CDH1 KLF4 21746878 23180781 physical association anti tag coimmunoprecipitation InnateDB
KLF4 CLDN5 23180781 24318462 physical association anti tag coimmunoprecipitation InnateDB
KLF4 NOTCH1 23180781 25644173 physical association anti tag coimmunoprecipitation InnateDB
KLF4 CXCR4 23180781 25644173 physical association anti tag coimmunoprecipitation InnateDB
KLF4 BCL2 23180781 25644173 physical association anti tag coimmunoprecipitation InnateDB
KLF4 NDRG2 23180781 25889839 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR KLF4 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA1 KLF4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 KLF4 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TP63 KLF4 20972454 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CEBPA KLF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF KLF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 KLF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 KLF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS KLF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF KLF4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
APC KLF4 12387883 trascriptional regulation,stimulation inferred by curator TFlink
CDX2 KLF4 11521200 23202735 trascriptional regulation,stimulation inferred by curator TFlink
HDAC1 KLF4 15051827 trascriptional regulation,stimulation inferred by curator TFlink
HDAC2 KLF4 19486889 trascriptional regulation,stimulation inferred by curator TFlink
HDAC4 KLF4 21118993 trascriptional regulation,stimulation inferred by curator TFlink
PPARG KLF4 23275339 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 KLF4 19328795 trascriptional regulation,stimulation inferred by curator TFlink
SOX9 KLF4 18977346 trascriptional regulation,stimulation inferred by curator TFlink
TCF7L2 KLF4 18977346 trascriptional regulation,stimulation inferred by curator TFlink
TCF4 KLF4 18977346 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000008F0CF KLF4 22593189 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS00004AC389 KLF4 20075075 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS0000315338 KLF4 20981674 rna interference,inhibition array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS000001C659 KLF4 20981674 rna interference,inhibition array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000008A99 KLF4 \N rna interference,inhibition miRNA interference luciferase reporter assay miRSponge
URS00004F4657 KLF4 19409607 \N rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000C85B2 KLF4 19541842 rna interference,inhibition western blot miRSponge
URS00004F4657 KLF4 18927107 19409607 23312222 25273883 25416803 26181633 26197891 28380435 mrna cleavage,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miR2Disease,TarBase
URS00004AC389 KLF4 20075075 24216130 24573354 25416803 26191201 27669739 27764757 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000C85B2 KLF4 19541842 25416803 25923408 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS000001C659 KLF4 20981674 25416803 26877610 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000315338 KLF4 20981674 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004929F1 KLF4 21378144 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS000008F0CF KLF4 22593189 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000237AF9 KLF4 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00002152A8 KLF4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000076995 KLF4 22751119 24281002 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000171CD1 KLF4 23867820 25416803 mrna cleavage,inhibition western blot TarBase
URS000031BC7D KLF4 23807165 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EED18 KLF4 24415058 25362853 25416803 28250026 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001E3523 KLF4 24084696 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase
URS000000C73C KLF4 25218589 25416803 mrna cleavage,inhibition western blot,rna immunoprecipitation,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000034B6F5 KLF4 24855559 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr TarBase
URS00002FC5B0 KLF4 25416803 26471298 27871067 mrna cleavage,inhibition western blot,rna immunoprecipitation,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase
URS0000272A3D KLF4 25416803 26020233 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000ED600 KLF4 25416803 27279635 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
CTBP1 KLF4 25361965 interaction type N/A PTMCode2
KLF4 CTBP1 25361965 interaction type N/A PTMCode2
TP53 KLF4 25361965 interaction type N/A PTMCode2
KLF4 TP53 25361965 interaction type N/A PTMCode2
HDAC5 KLF4 25361965 interaction type N/A PTMCode2
KLF4 HDAC5 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SKP1 KLF4 25348397 N/A physical interaction ComPPI
SP1 KLF4 12034813 22282354 25348397 27898060 9651398 N/A physical interaction,in vitro ComPPI,OmniPath
PRKCD KLF4 25348397 N/A physical interaction ComPPI
CREBBP KLF4 10666450 17908689 21482710 21539536 25348397 27898060 N/A physical interaction,in vitro,in vivo ComPPI,OmniPath
EP300 KLF4 17908689 20711222 21252119 21482710 25348397 27898060 N/A physical interaction ComPPI,OmniPath
CTBP1 KLF4 19751731 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HGS KLF4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDH1 KLF4 25348397 N/A physical interaction ComPPI
SMARCA4 KLF4 25348397 N/A physical interaction ComPPI
ELK1 KLF4 25348397 N/A physical interaction,in vivo ComPPI
PPARG KLF4 25348397 N/A physical interaction ComPPI
RELA KLF4 25348397 N/A physical interaction ComPPI
KDM6A KLF4 22801502 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HUWE1 KLF4 25348397 N/A physical interaction ComPPI
CUL2 KLF4 25348397 N/A physical interaction ComPPI
CUL1 KLF4 25348397 N/A physical interaction ComPPI
VHL KLF4 22284679 25348397 27898060 N/A physical interaction ComPPI,OmniPath
HDAC2 KLF4 15561714 19486889 21252119 25348397 27898060 N/A physical interaction ComPPI,OmniPath
KLF6 KLF4 10802067 25348397 27898060 N/A physical interaction,in vivo ComPPI,OmniPath
KLF4 HDAC5 25348397 N/A physical interaction,in vivo ComPPI
KLF4 HDAC1 25348397 N/A physical interaction ComPPI
KLF4 KAT5 17827213 25348397 27898060 N/A physical interaction ComPPI,OmniPath
KLF4 HDAC7 25348397 N/A physical interaction ComPPI
KLF4 ELOB 25348397 N/A physical interaction ComPPI
KLF4 APP 25348397 N/A physical interaction ComPPI
KLF4 SETD7 25348397 N/A physical interaction ComPPI
KLF4 AURKA 25348397 N/A physical interaction ComPPI
KLF4 FBXO22 25348397 N/A physical interaction ComPPI
KLF4 FBXO32 25348397 N/A physical interaction ComPPI
KLF4 BAALC 25348397 N/A physical interaction ComPPI
KLF4 KDM6B 22801502 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KLF4 MBD3 24048479 24234451 25348397 association,physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
KLF4 YAP1 24234451 25348397 25531778 N/A anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
KLF4 GYS1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KLF4 HSF2BP 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KLF4 PAX9 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
KLF4 DVL3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SPI1 KLF4 17762869 24234451 association chromatin immunoprecipitation assay IntAct
KLF4 SMAD2 20375011 27898060 N/A N/A OmniPath
FOXO1 KLF4 18375530 27898060 stimulant N/A OmniPath
STAT3 KLF4 17129668 27898060 stimulant N/A OmniPath
KLF4 SRF 21673106 27898060 inhibition N/A OmniPath

Visualization










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