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GENE：LRP6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol LRP6
FullNmae LDL receptor related protein 6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6698
EnsembleID ENSG00000070018
Uniprot O75581

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
LRP6 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
LRP6 GO:0001933,GO:0005041,GO:0005102,GO:0005109,GO:0005515,GO:0005576,GO:0005769,GO:0005783,GO:0005794,GO:0005886,GO:0005886,GO:0005901,GO:0006469,GO:0007204,GO:0007268,GO:0009986,GO:0014029,GO:0014033,GO:0015026,GO:0016055,GO:0017147,GO:0017147,GO:0017147,GO:0019210,GO:0019534,GO:0031410,GO:0031901,GO:0034392,GO:0042802,GO:0042803,GO:0042813,GO:0043025,GO:0043434,GO:0044340,GO:0045202,GO:0045787,GO:0045893,GO:0045944,GO:0051091,GO:0051091,GO:0060070,GO:0060070,GO:0060070,GO:0060070,GO:0060070,GO:0071397,GO:0071542,GO:0071901,GO:0072659,GO:0090118,GO:0090244,GO:0098609,GO:1901998,GO:1904948,GO:1904953,GO:1990851,GO:1990851,GO:1990851,GO:1990909,GO:1990909

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
LRP6 hsa:4040 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
LRP6 hsa:4040 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
LRP6 hsa:4040 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)
LRP6 hsa:4040 path:hsa05010 Alzheimer disease - Homo sapiens (human)
LRP6 hsa:4040 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
LRP6 hsa:4040 path:hsa05200 Pathways in cancer - Homo sapiens (human)
LRP6 hsa:4040 path:hsa05224 Breast cancer - Homo sapiens (human)
LRP6 hsa:4040 path:hsa05225 Hepatocellular carcinoma - Homo sapiens (human)
LRP6 hsa:4040 path:hsa05226 Gastric cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
LRP6 DVL2 16273260 23371553 26192618 interaction type N/A ACSN
LRP6 CAV1 16890161 23180781 physical association anti tag coimmunoprecipitation InnateDB
WNT1 LRP6 11029007 11448771 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
DKK1 LRP6 11357136 11448771 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
LRP6 AXIN1 12897152 16340998 18988627 23331499 stimulation N/A SignaLink,SignaLink
TDGF1 LRP6 23022962 interaction type,stimulation N/A SignaLink
KREMEN1 LRP6 12050670 23331499 stimulation N/A SignaLink
KREMEN2 LRP6 12050670 23331499 stimulation N/A SignaLink
GSK3B LRP6 16340998 16365045 23331499 stimulation N/A SignaLink
CSNK1G1 LRP6 16340998 23331499 stimulation N/A SignaLink
LRP6 MACF1 16815997 23331499 stimulation N/A SignaLink
CDK14 LRP6 20627573 23331499 stimulation N/A SignaLink
PRKACA LRP6 18981475 23331499 stimulation N/A SignaLink
CSNK1A1L LRP6 20229235 23331499 stimulation N/A SignaLink
GRK6 LRP6 20229235 23331499 stimulation N/A SignaLink
CSNK1A1 LRP6 20229235 23331499 stimulation N/A SignaLink
CSNK1D LRP6 20229235 23331499 stimulation N/A SignaLink
CSNK1E LRP6 20229235 23331499 stimulation N/A SignaLink
CAPRIN2 LRP6 19619488 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AXIN1 LRP6 20005715 interaction type N/A PSP
AXIN1 LRP6 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR LRP6 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 LRP6 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 LRP6 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 LRP6 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 LRP6 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 LRP6 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 LRP6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA LRP6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 LRP6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 LRP6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A LRP6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 LRP6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 LRP6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 LRP6 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000041FA2C LRP6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00004B83FE LRP6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000170CF4 LRP6 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000345DEB LRP6 24289859 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS000015F70F LRP6 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003D8730 LRP6 24704686 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001D69F6 LRP6 23811937 25416803 26239517 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000427B68 LRP6 20371350 21572407 22927820 23313552 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB LRP6 20371350 21572407 22927820 23313552 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002233F4 LRP6 20371350 21572407 22927820 23313552 23446348 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000002569A LRP6 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000018CD09 LRP6 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000023F8DA LRP6 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000005A8ED LRP6 21572407 22927820 25416803 mrna cleavage,inhibition clip TarBase
URS000076B539 LRP6 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AA845 LRP6 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB LRP6 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000009262D LRP6 25416803 28337300 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000272A3D LRP6 25416803 25605017 mrna cleavage,inhibition rna immunoprecipitation,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CSNK1E LRP6 22135298 phosphorylation N/A PhosphoSite
CSNK1G1 LRP6 22135298 phosphorylation N/A PhosphoSite
PRKACA LRP6 22135298 phosphorylation N/A PhosphoSite
MAPK3 LRP6 22135298 phosphorylation N/A PhosphoSite
GSK3B LRP6 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAPK1 LRP6 22135298 phosphorylation N/A PhosphoSite
CDK14 LRP6 22135298 phosphorylation N/A PhosphoSite
GSK3A LRP6 22135298 phosphorylation N/A PhosphoSite
CSNK1A1 LRP6 22135298 phosphorylation N/A PhosphoSite
DVL2 LRP6 25361965 interaction type N/A PTMCode2
LRP6 DVL2 25361965 interaction type N/A PTMCode2
LRP6 AXIN1 25361965 interaction type N/A PTMCode2
AXIN1 LRP6 25361965 interaction type N/A PTMCode2
LRP6 WNT3A 25361965 interaction type N/A PTMCode2
WNT3A LRP6 25361965 interaction type N/A PTMCode2
LRP6 DKK2 25361965 interaction type N/A PTMCode2
DKK2 LRP6 25361965 interaction type N/A PTMCode2
LRP6 WNT1 25361965 interaction type N/A PTMCode2
WNT1 LRP6 25361965 interaction type N/A PTMCode2
LRP6 ANTXR1 25361965 interaction type N/A PTMCode2
ANTXR1 LRP6 25361965 interaction type N/A PTMCode2
LRP6 ANTXR2 25361965 interaction type N/A PTMCode2
ANTXR2 LRP6 25361965 interaction type N/A PTMCode2
LRP6 GSK3B 25361965 interaction type N/A PTMCode2
LRP6 FZD5 25361965 interaction type N/A PTMCode2
FZD5 LRP6 25361965 interaction type N/A PTMCode2
LRP6 DKK1 25361965 interaction type N/A PTMCode2
DKK1 LRP6 25361965 interaction type N/A PTMCode2
LRP6 DVL1 25361965 interaction type N/A PTMCode2
DVL1 LRP6 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
DKK1 LRP6 11357136 11448771 14525934 21944579 21984209 24234451 25348397 physical association dynamic light scattering,experimental interaction detection,light scattering,molecular sieving,pull down,x-ray crystallography,physical interaction,enzyme linked immunosorbent assay,in vivo,amplified luminescent proximity homogeneous assay,bio-layer interferometry ComPPI,HPRD,IntAct
PTPRH LRP6 25348397 N/A physical interaction ComPPI
SERPINF1 LRP6 25348397 N/A physical interaction ComPPI
DAB2 LRP6 22491013 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
FZD5 LRP6 12857724 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
WNT5A LRP6 25348397 N/A physical interaction ComPPI
GSK3B LRP6 14525934 16365045 16890161 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vitro ComPPI,HPRD,IntAct
PDGFRB LRP6 21245321 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RASD2 LRP6 25348397 N/A physical interaction ComPPI
UBB LRP6 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBC LRP6 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
RPS27A LRP6 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
UBA52 LRP6 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
AXIN1 LRP6 12897152 14525934 22682247 24234451 24976009 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,in vivo ComPPI,HPRD,IntAct
CAV1 LRP6 16890161 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction,fluorescence microscopy ComPPI,IntAct
IQGAP1 LRP6 25348397 N/A physical interaction ComPPI
GSK3A LRP6 16365045 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
EEA1 LRP6 16890161 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
EPN1 LRP6 25348397 N/A physical interaction ComPPI
RAB11A LRP6 16890161 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
RASSF1 LRP6 25348397 N/A physical interaction ComPPI
CTNNB1 LRP6 16890161 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ETV6 LRP6 25348397 N/A physical interaction ComPPI
TAZ LRP6 25348397 N/A physical interaction ComPPI
ANTXR1 LRP6 14525934 16564009 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,in vitro,in vivo ComPPI,HPRD,IntAct
FCGRT LRP6 25348397 N/A physical interaction ComPPI
WNT3A LRP6 12897152 14525934 14739301 21944579 22726442 24234451 25348397 physical association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo,bio-layer interferometry ComPPI,HPRD,IntAct
LRP6 DKK2 11357136 11742004 14525934 21944579 24234451 25348397 N/A experimental interaction detection,physical interaction,in vivo,bio-layer interferometry ComPPI,HPRD,IntAct
LRP6 WNT1 11029007 11448771 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
LRP6 FZD8 11029007 11448771 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
LRP6 ANTXR2 14525934 16564009 24234451 25348397 colocalization,physical association anti tag coimmunoprecipitation,experimental interaction detection,fluorescence microscopy,in vitro,in vivo ComPPI,HPRD,IntAct
LRP6 TLNRD1 14525934 16989816 25348397 27898060 N/A experimental interaction detection,in vivo ComPPI,HPRD,OmniPath
LRP6 NPC1 25348397 N/A physical interaction ComPPI
LRP6 APOB 25348397 N/A physical interaction ComPPI
LRP6 ZNRF3 22575959 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
LRP6 LRRK2 22899650 24234451 25348397 27013965 colocalization,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction,confocal microscopy ComPPI,IntAct
LRP6 ATP13A2 22645275 24234451 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
LRP6 CAPRIN2 18762581 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
LRP6 SOST 15908424 21471202 21944579 24234451 25348397 association,physical association pull down,x-ray crystallography,physical interaction,tandem affinity purification,bio-layer interferometry ComPPI,IntAct
LRP6 LGR4 25348397 N/A physical interaction ComPPI
LRP6 PARP16 25348397 N/A physical interaction ComPPI
LRP6 POMK 25348397 N/A physical interaction ComPPI
LRP6 CHST9 25348397 N/A physical interaction ComPPI
LRP6 GAS8 25348397 N/A physical interaction ComPPI
LRP6 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
LRP6 CSNK1A1 25348397 N/A physical interaction ComPPI
LRP6 SCGB1D1 25348397 N/A physical interaction ComPPI
LRP6 TENT4A 25348397 N/A physical interaction ComPPI
LRP6 PRSS37 25348397 N/A physical interaction ComPPI
LRP6 MGAT4C 25348397 N/A physical interaction ComPPI
LRP6 ADAM33 25348397 N/A physical interaction ComPPI
LRP6 KLK5 25348397 N/A physical interaction ComPPI
LRP6 WNT10B 25348397 N/A physical interaction ComPPI
LRP6 DKKL1 25348397 N/A physical interaction ComPPI
LRP6 IGFBP4 18528331 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
LRP6 RIPK4 23371553 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
LRP6 AMMECR1 21304492 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
LRP6 BAMBI 18838381 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
LRP6 CKLF 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ST8SIA4 LRP6 25348397 N/A physical interaction ComPPI
TGIF2LY LRP6 25348397 N/A physical interaction ComPPI
LRP6 LRP6 12897152 14525934 21984209 24234451 physical association anti tag coimmunoprecipitation,dynamic light scattering,experimental interaction detection,molecular sieving HPRD,IntAct
LRP6 SOSTDC1 12900447 21944579 27898060 N/A N/A OmniPath
LRP6 MESD 16126904 16263759 18505367 27898060 N/A N/A OmniPath
PRKACA LRP6 18981475 27898060 stimulant N/A OmniPath
CDH1 LRP6 20940130 27898060 stimulant N/A OmniPath
CSNK1A1 LRP6 16341017 20229235 27898060 stimulant N/A OmniPath
CAV1 LRP6 16890161 27898060 stimulant N/A OmniPath
WNT2 LRP6 15578921 27898060 stimulant N/A OmniPath
WNT1 LRP6 11029007 11448771 15578921 16126904 18505367 21078818 27898060 stimulant N/A OmniPath
CSNK1E LRP6 16513652 20229235 27898060 stimulant N/A OmniPath
GSK3A LRP6 14731402 16365045 20229235 27898060 stimulant N/A OmniPath
MAPK3 LRP6 14731402 16341017 16890161 18772438 20974802 21304492 21887268 24794231 25301071 25500543 25735981 26140605 27898060 stimulant N/A OmniPath
CSNK1D LRP6 20229235 27898060 stimulant N/A OmniPath
MAPK1 LRP6 20974802 27898060 stimulant N/A OmniPath
IGFBP4 LRP6 18528331 27898060 N/A N/A OmniPath
WNT5A LRP6 15578921 27898060 stimulant N/A OmniPath
DKK1 LRP6 11357136 1144877 11448771 11516963 15035989 16126904 18505367 21944579 21984209 26186194 27898060 inhibition,stimulant N/A OmniPath
LRP6 AXIN1 12897152 16341 16890161 18632848 19107203 20128690 22682247 23959799 27898060 inhibition,stimulant N/A OmniPath
DVL1 LRP6 17569865 27898060 stimulant N/A OmniPath
LRP6 GSK3B 16365045 16890161 19107203 27898060 inhibition N/A OmniPath
GSK3B LRP6 16341 16341017 16365045 16890161 19107203 27898060 stimulant N/A OmniPath
WNT4 LRP6 15578921 27898060 stimulant N/A OmniPath
DAB2 LRP6 22491013 27898060 inhibition N/A OmniPath
MAPK8 LRP6 20974802 27898060 stimulant N/A OmniPath
DVL2 LRP6 10196136 27898060 stimulant N/A OmniPath
KREMEN2 LRP6 12050670 27898060 inhibition,stimulant N/A OmniPath
WNT16 LRP6 15578921 27898060 stimulant N/A OmniPath
WNT3A LRP6 12897152 14739301 15578921 16890161 21078818 21944579 22726442 27898060 stimulant N/A OmniPath
FZD8 LRP6 11029007 11448771 15908424 21078818 27898060 stimulant N/A OmniPath
WNT10B LRP6 15578921 27898060 stimulant N/A OmniPath
WNT7A LRP6 15578921 27898060 stimulant N/A OmniPath
WNT11 LRP6 15578921 27898060 stimulant N/A OmniPath
GRK5 LRP6 2787365 27898060 stimulant N/A OmniPath
PTH1R LRP6 23151663 27898060 stimulant N/A OmniPath
RSPO3 LRP6 16543246 27898060 N/A N/A OmniPath
CSNK1G1 LRP6 16341016 17569865 27898060 inhibition,stimulant N/A OmniPath
ZNRF3 LRP6 22575959 23151663 27898060 inhibition N/A OmniPath
AMER1 LRP6 21304492 27898060 stimulant N/A OmniPath
WNT3 LRP6 15578921 27898060 stimulant N/A OmniPath
WNT10A LRP6 15578921 27898060 stimulant N/A OmniPath
WNT5B LRP6 15578921 27898060 stimulant N/A OmniPath
CSNK1A1L LRP6 19293931 21606194 27898060 stimulant N/A OmniPath
CAPRIN2 LRP6 18762581 19619488 27898060 stimulant N/A OmniPath
CDK14 LRP6 16341017 17698587 19801552 20059949 27898060 stimulant N/A OmniPath
WNT8B LRP6 15578921 27898060 stimulant N/A OmniPath
WNT9B LRP6 20093360 27898060 stimulant N/A OmniPath
WNT9A LRP6 15578921 27898060 stimulant N/A OmniPath
CCN2 LRP6 18528331 27898060 stimulant N/A OmniPath

Visualization










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