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GENE：MAP2K5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAP2K5
FullNmae mitogen-activated protein kinase kinase 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6845
EnsembleID ENSG00000137764
Uniprot Q13163

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAP2K5 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP2K5 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP2K5 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP2K5 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
MAP2K5 GO:0000122,GO:0000165,GO:0004672,GO:0004674,GO:0004708,GO:0004713,GO:0005515,GO:0005524,GO:0005819,GO:0007165,GO:0007507,GO:0016310,GO:0030307,GO:0032088,GO:0032717,GO:0034115,GO:0043154,GO:0043406,GO:0045944,GO:0046872,GO:0048009,GO:0050679,GO:0051247,GO:0060761,GO:0070375,GO:0071363,GO:0071499,GO:0090051,GO:0106310,GO:2000342,GO:2001240

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAP2K5 hsa:5607 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
MAP2K5 hsa:5607 path:hsa04540 Gap junction - Homo sapiens (human)
MAP2K5 hsa:5607 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
MAP2K5 hsa:5607 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
MAP2K5 hsa:5607 path:hsa05418 Fluid shear stress and atherosclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAP2K5 MAP3K3 17985933 23180781 physical association isothermal titration calorimetry,pull down InnateDB
MAP2K5 PRKCZ 11158308 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP2K5 PRKCI 11158308 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP2K5 EGR1 19032775 23180781 physical association anti tag coimmunoprecipitation InnateDB
MAP2K5 MAPK7 11242034 23331499 stimulation N/A SignaLink,SignaLink
MAP3K8 MAP2K5 10669751 23331499 stimulation N/A SignaLink
MAP3K20 MAP2K5 11042189 23331499 stimulation N/A SignaLink
MAP3K2 MAP2K5 11073940 11274363 19903815 23331499 stimulation N/A SignaLink
MAP3K3 MAP2K5 11073940 12912994 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GRB2 MAP2K5 20005715 interaction type N/A PSP,SignaLink
SQSTM1 MAP2K5 20005715 interaction type N/A PSP
SQSTM1 MAP2K5 19903815 20005715 20005715 21071413 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR MAP2K5 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 MAP2K5 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 MAP2K5 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MAP2K5 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
YBX1 MAP2K5 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 MAP2K5 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 MAP2K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MAP2K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 MAP2K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MAP2K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MAP2K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HIF1A MAP2K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MAP2K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MAP2K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 MAP2K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MAP2K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 MAP2K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR MAP2K5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC MAP2K5 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 MAP2K5 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS0000160683 MAP2K5 19859982 25416803 mrna cleavage,inhibition array technology,experimental interaction detection TarBase
URS000007A060 MAP2K5 24436253 25416803 mrna cleavage,inhibition experimental interaction detection TarBase

Source Target Pmid Interactiontype Methods Database
MAP2K5 MAPK7 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAPK7 MAP2K5 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAP2K5 PARD6A 25361965 interaction type N/A PTMCode2
PARD6A MAP2K5 25361965 interaction type N/A PTMCode2
MAP2K5 BAD 25361965 interaction type N/A PTMCode2
BAD MAP2K5 25361965 interaction type N/A PTMCode2
MAP2K5 MAP3K2 25361965 interaction type N/A PTMCode2
MAP3K2 MAP2K5 25361965 interaction type N/A PTMCode2
MAP2K5 MAP3K3 25361965 interaction type N/A PTMCode2
MAP3K3 MAP2K5 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
HSP90AB1 MAP2K5 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
BAD MAP2K5 25348397 N/A in vitro,in vivo ComPPI
DDIT4L MAP2K5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
ZNF426 MAP2K5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
GRB2 MAP2K5 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
GSK3B MAP2K5 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
YWHAZ MAP2K5 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
HSP90AA1 MAP2K5 25348397 N/A physical interaction ComPPI
ENO1 MAP2K5 25348397 N/A physical interaction ComPPI
RPL28 MAP2K5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
XRCC6 MAP2K5 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
PRKCZ MAP2K5 25348397 N/A physical interaction,in vivo ComPPI
PARD6A MAP2K5 25348397 N/A two hybrid,physical interaction,in vivo ComPPI
SQSTM1 MAP2K5 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAP2K5 MAPK7 24234451 25348397 7759517 physical association two hybrid,pull down,physical interaction,two hybrid array,in vitro,two hybrid prey pooling approach ComPPI,IntAct
MAP2K5 MAP3K2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
MAP2K5 MAP3K3 14743216 24234451 25241761 25348397 physical association two hybrid,physical interaction,in vivo,tandem affinity purification,proximity ligation assay ComPPI,IntAct
MAP2K5 STAMBP 16730941 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP2K5 CDC42BPB 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
MAP2K5 ASRGL1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP2K5 HSP90AA2P 25348397 N/A physical interaction ComPPI
MAP2K5 GCH1 25348397 N/A physical interaction ComPPI
MAP2K5 ESRRA 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAP2K5 NXF1 25348397 N/A physical interaction ComPPI
MAP2K5 TRAF7 25348397 N/A physical interaction ComPPI
MAP2K5 CDC37 25348397 N/A physical interaction ComPPI
MAP2K5 SIRT3 19343720 24234451 25348397 physical association pull down ComPPI,IntAct
MAP2K5 PFDN5 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAP2K5 C3ORF36 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAP2K5 ZNF620 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PRKCI MAP2K5 25348397 N/A physical interaction,in vivo ComPPI
LNX2 MAP2K5 21516116 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PAAT MAP2K5 25348397 N/A physical interaction ComPPI
VIM MAP2K5 24234451 30021884 physical association cross-linking study IntAct
MAP3K8 MAP2K5 10669751 27898060 stimulant N/A OmniPath
MAP3K2 MAP2K5 11073940 11274363 12912994 19903815 21988832 24975362 27898060 stimulant N/A OmniPath
MAP2K5 MAPK7 11242034 11739740 11782488 12628002 12912994 22267842 23612709 24975362 27898060 7646528 7759517 stimulant N/A OmniPath
MAPK7 MAP2K5 11739740 11782488 12628002 12912994 22267842 23612709 24975362 27898060 7646528 7759517 stimulant N/A OmniPath
PRKCZ MAP2K5 11158308 27898060 N/A N/A OmniPath
PRKCI MAP2K5 11158308 27898060 N/A N/A OmniPath
MAP3K3 MAP2K5 10593883 11073940 12813044 1291299 12912994 14743216 16861740 17985933 19903815 24975362 25241761 27898060 stimulant N/A OmniPath
MAP3K20 MAP2K5 11042189 27898060 stimulant N/A OmniPath

Visualization










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