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GENE：MAP3K2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MAP3K2
FullNmae mitogen-activated protein kinase kinase kinase 2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6854
EnsembleID ENSG00000169967
Uniprot Q9Y2U5

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MAP3K2 necroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP3K2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MAP3K2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MAP3K2 GO:0000165,GO:0004672,GO:0004674,GO:0004709,GO:0005515,GO:0005524,GO:0005654,GO:0005737,GO:0005829,GO:0016310,GO:0019901,GO:0035556,GO:0046872,GO:0071260,GO:0106310

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MAP3K2 hsa:10746 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
MAP3K2 hsa:10746 path:hsa04540 Gap junction - Homo sapiens (human)
MAP3K2 hsa:10746 path:hsa04912 GnRH signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAP3K2 MAP3K2 11343802 23180781 phosphorylation reaction in-gel kinase assay InnateDB
MAP2K7 MAP3K2 10713157 23180781 physical association gst pull down InnateDB
MAP2K4 MAP3K2 10713157 23180781 physical association gst pull down InnateDB
MAP3K2 MAP2K7 10713157 23180781 physical association gst pull down InnateDB
MAP3K2 MAPK8 10713157 23180781 physical association gst pull down InnateDB
MAP3K2 MAPKAP1 15988011 23180781 physical association anti tag coimmunoprecipitation InnateDB
IKBKG MAP3K2 20098747 23180781 physical association protein array InnateDB
MAP3K2 MAP2K4 11343802 18988627 23331499 7997270 stimulation N/A SignaLink,SignaLink
MAP3K2 MAP2K1 11343802 23331499 stimulation N/A SignaLink,SignaLink
MAP3K2 MAP2K5 11073940 11274363 19903815 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
NFKBIA MAP3K2 20005715 interaction type N/A PSP
SH2D2A MAP3K2 20005715 interaction type N/A PSP
YWHAB MAP3K2 20005715 interaction type N/A PSP,SignaLink
YWHAE MAP3K2 20005715 interaction type N/A PSP
YWHAG MAP3K2 20005715 interaction type N/A PSP
YWHAZ MAP3K2 20005715 interaction type N/A PSP
NFKBIA MAP3K2 10085062 18988627 20005715 N/A N/A SignaLink
YWHAZ MAP3K2 20005715 20005715 N/A N/A SignaLink
SH2D2A MAP3K2 11073940 11073940 20005715 20005715 21071413 N/A N/A SignaLink
YWHAE MAP3K2 20005715 20005715 N/A N/A SignaLink
YWHAG MAP3K2 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
GATA1 MAP3K2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 MAP3K2 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 MAP3K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MAP3K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MAP3K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MAP3K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 MAP3K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MAP3K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MAP3K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MAP3K2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000009262D MAP3K2 18591254 25416803 mrna cleavage,inhibition array technology TarBase
URS00003D5391 MAP3K2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001A7F58 MAP3K2 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000170CF4 MAP3K2 22942087 25416803 mrna cleavage,inhibition array technology TarBase
URS00001B0D1E MAP3K2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000042B108 MAP3K2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 MAP3K2 22473208 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000042E1F MAP3K2 22473208 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004C689A MAP3K2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000007A060 MAP3K2 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000031E12 MAP3K2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003677B2 MAP3K2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003E6EFA MAP3K2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000037E170 MAP3K2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000052E1A6 MAP3K2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000037D7E5 MAP3K2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003883FE MAP3K2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000012930C MAP3K2 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 MAP3K2 22473208 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002075FA MAP3K2 22473208 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002B3783 MAP3K2 22473208 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000298BA3 MAP3K2 22473208 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000039E1E1 MAP3K2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000AD002 MAP3K2 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000101787 MAP3K2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075A281 MAP3K2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000039A25B MAP3K2 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000006B702 MAP3K2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001F373E MAP3K2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000006A1CB MAP3K2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00001A4ABF MAP3K2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003AFAD1 MAP3K2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000FFE5F MAP3K2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00004719AB MAP3K2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000D0BB4 MAP3K2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000057A7C MAP3K2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000075E2C3 MAP3K2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002F0130 MAP3K2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000170D8B MAP3K2 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 MAP3K2 25416803 27498924 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000008A99 MAP3K2 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001CF056 MAP3K2 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAP3K2 CTNNB1 22135298 phosphorylation N/A PhosphoSite
WNK1 MAP3K2 25361965 interaction type N/A PTMCode2
MAP3K2 WNK1 25361965 interaction type N/A PTMCode2
MAP3K2 XIAP 25361965 interaction type N/A PTMCode2
XIAP MAP3K2 25361965 interaction type N/A PTMCode2
MAP3K2 MAP3K5 25361965 interaction type N/A PTMCode2
MAP3K5 MAP3K2 25361965 interaction type N/A PTMCode2
MAP3K2 MAP2K7 25361965 interaction type N/A PTMCode2
MAP2K7 MAP3K2 25361965 interaction type N/A PTMCode2
MAP2K5 MAP3K2 25361965 interaction type N/A PTMCode2
MAP3K2 MAP2K5 25361965 interaction type N/A PTMCode2
MAP2K4 MAP3K2 25361965 interaction type N/A PTMCode2
MAP3K2 MAP2K4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
YWHAG MAP3K2 14525934 15324660 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
XIAP MAP3K2 18761086 24234451 24975362 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
HSP90AB1 MAP3K2 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
CBY1 MAP3K2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
MAPK8 MAP3K2 10713157 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PKN2 MAP3K2 10818102 12640115 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
GSK3B MAP3K2 25348397 N/A physical interaction ComPPI
YWHAB MAP3K2 15324660 17353931 24234451 24255178 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAZ MAP3K2 14525934 24234451 25348397 26496610 9452471 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,IntAct
UBC MAP3K2 20588253 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
HSP90AA1 MAP3K2 25348397 N/A physical interaction ComPPI
BTRC MAP3K2 25348397 N/A physical interaction ComPPI
AXIN1 MAP3K2 25348397 N/A physical interaction ComPPI
AXIN2 MAP3K2 25348397 N/A physical interaction ComPPI
MAP2K4 MAP3K2 14525934 25348397 7997270 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MAP3K5 MAP3K2 12912994 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
NFKBIA MAP3K2 10085062 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MAP2K5 MAP3K2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
STK38 MAP3K2 25348397 N/A physical interaction ComPPI
PKM MAP3K2 25348397 N/A protein kinase assay ComPPI
RAB3IP MAP3K2 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
YWHAQ MAP3K2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAPK7 MAP3K2 25348397 N/A physical interaction ComPPI
NEDD4L MAP3K2 25348397 N/A physical interaction ComPPI
YWHAH MAP3K2 17979178 24234451 25348397 association tandem affinity purification ComPPI,IntAct
SFN MAP3K2 15778465 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
YWHAE MAP3K2 14525934 24234451 25348397 26496610 9452471 colocalization,association,physical association anti tag coimmunoprecipitation,coimmunoprecipitation,experimental interaction detection,physical interaction,imaging technique,in vivo ComPPI,HPRD,IntAct
CTNNB1 MAP3K2 25348397 N/A physical interaction ComPPI
STX3 MAP3K2 25348397 N/A physical interaction ComPPI
NEDD4 MAP3K2 25348397 N/A physical interaction ComPPI
MAP2K7 MAP3K2 25348397 N/A physical interaction,in vitro,in vivo ComPPI
WNK1 MAP3K2 25348397 N/A in vitro,in vivo ComPPI
SMURF1 MAP3K2 14525934 15820682 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,OmniPath
MAP2K3 MAP3K2 25348397 N/A physical interaction ComPPI
TRIM25 MAP3K2 25348397 N/A physical interaction ComPPI
BIRC2 MAP3K2 25348397 N/A physical interaction ComPPI
MAP3K2 SH2D2A 12640115 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
MAP3K2 IKBKG 25348397 N/A physical interaction ComPPI
MAP3K2 PIBF1 25348397 N/A physical interaction ComPPI
MAP3K2 STUB1 20588253 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP3K2 HSP90AA2P 25348397 N/A physical interaction ComPPI
MAP3K2 STAMBP 25348397 N/A physical interaction ComPPI
MAP3K2 USP2 25348397 N/A physical interaction ComPPI
MAP3K2 MAP3K3 14743216 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
MAP3K2 TRAF7 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
MAP3K2 SMYD3 25348397 N/A x-ray crystallography,methylation reaction,physical interaction,methyltransferase radiometric assay ComPPI
FLNA MAP3K2 24234451 30021884 physical association cross-linking study IntAct
MAP3K2 MAP2K1 11343802 27898060 stimulant N/A OmniPath
STK38 MAP3K2 17906693 27898060 inhibition N/A OmniPath
MAP3K2 MAP2K4 10713157 11343802 17906693 27898060 7997270 9162092 stimulant N/A OmniPath
IKBKG MAP3K2 20098747 27898060 N/A N/A OmniPath
MAP3K2 NFKBIA 10085062 27898060 stimulant N/A OmniPath
MAP3K2 MAPK1 27898060 8226933 stimulant N/A OmniPath
MAP3K2 MAP2K5 11073940 11274363 12912994 19903815 21988832 24975362 27898060 stimulant N/A OmniPath
MAP2K7 MAP3K2 10713157 24975362 27898060 9372971 N/A N/A OmniPath
MAP3K2 MAP2K7 10713157 24975362 27898060 9372971 stimulant N/A OmniPath
MAP3K2 MAPK8 10713157 27898060 N/A N/A OmniPath
MAP3K2 MAPKAP1 15988011 27898060 N/A N/A OmniPath
MAP3K2 PROK2 10818102 27898060 stimulant N/A OmniPath

Visualization










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