GENE:MTMR3
GeneInfo:
GeneAttribute | GeneDescription |
---|---|
GeneSymbol | MTMR3 |
FullNmae | myotubularin related protein 3 |
LocusType | gene with protein product |
Status | Approved |
HGNC_id | HGNC:7451 |
EnsembleID | ENSG00000100330 |
Uniprot | Q13615 |
Protein Structure:
Gene Description in Publicaton:
GeneSymbol | CellDeathType | PMID | Description | GeneType |
---|---|---|---|---|
MTMR3 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
MTMR3 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
MTMR3 | autophagy | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
GeneSymbol | Go id |
---|---|
MTMR3 | GO:0004438,GO:0004438,GO:0004438,GO:0004722,GO:0004722,GO:0004725,GO:0005515,GO:0005737,GO:0005737,GO:0005829,GO:0006470,GO:0006661,GO:0008138,GO:0010506,GO:0016020,GO:0016020,GO:0016236,GO:0019903,GO:0019903,GO:0042149,GO:0046856,GO:0046856,GO:0046872,GO:0052629,GO:0052629,GO:0052629,GO:0060304,GO:1904562,GO:2000785 |
KEGG Annotation:
GeneSymbol | GeneID | Pathway | Pathway Name |
---|---|---|---|
MTMR3 | hsa:8897 | path:hsa00562 | Inositol phosphate metabolism - Homo sapiens (human) |
MTMR3 | hsa:8897 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
MTMR3 | hsa:8897 | path:hsa04070 | Phosphatidylinositol signaling system - Homo sapiens (human) |
MTMR3 | hsa:8897 | path:hsa04140 | Autophagy - animal - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
AR | MTMR3 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
GATA1 | MTMR3 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
GATA2 | MTMR3 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
PRDM14 | MTMR3 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
SMARCA4 | MTMR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CEBPA | MTMR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
CTCF | MTMR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F1 | MTMR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
E2F4 | MTMR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
EGR1 | MTMR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
ETS1 | MTMR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXA1 | MTMR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOXP1 | MTMR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
FOS | MTMR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
HNF4A | MTMR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
MITF | MTMR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
RUNX1 | MTMR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TAL1 | MTMR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
VDR | MTMR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
TP53 | MTMR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
ZNF263 | MTMR3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
URS0000070B1D | MTMR3 | 23622248 25416803 26701625 | mrna cleavage,inhibition | clip,clash | TarBase |
URS00000BE495 | MTMR3 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
URS00000600E6 | MTMR3 | 22473208 23622248 25416803 | mrna cleavage,inhibition | clip,clash | TarBase |
URS0000330617 | MTMR3 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
URS000039E1E1 | MTMR3 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
URS00002075FA | MTMR3 | 22473208 23622248 25416803 | mrna cleavage,inhibition | clip,clash | TarBase |
URS0000157026 | MTMR3 | 23731011 25416803 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay | TarBase |
URS0000042E1F | MTMR3 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000DDD35 | MTMR3 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002B3783 | MTMR3 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000298BA3 | MTMR3 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000171CD1 | MTMR3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000008F0CF | MTMR3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000041CB9C | MTMR3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000040EE1D | MTMR3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000F0F49 | MTMR3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000007D64A | MTMR3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000475586 | MTMR3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00001496AE | MTMR3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000043D2C1 | MTMR3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000008AA34 | MTMR3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS0000118224 | MTMR3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002C02E4 | MTMR3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS000015188E | MTMR3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002CE0C6 | MTMR3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00000F6E49 | MTMR3 | 20371350 25416803 | mrna cleavage,inhibition | clip | TarBase |
URS00002AA55A | MTMR3 | 20371350 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS0000170CF4 | MTMR3 | 20371350 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
URS000049704B | MTMR3 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS00000E732F | MTMR3 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
URS0000585553 | MTMR3 | 25416803 26701625 | mrna cleavage,inhibition | clip | TarBase |
Source | Target | Pmid | Interactiontype | Methods | Database |
---|---|---|---|---|---|
EXOSC5 | MTMR3 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
GOLGA2 | MTMR3 | 24234451 25348397 26787466 | colocalization | fluorescence microscopy | ComPPI,IntAct |
EXOSC1 | MTMR3 | 12419256 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
EXOSC8 | MTMR3 | 12419256 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
EGLN3 | MTMR3 | 24234451 25348397 26972000 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
FGFR2 | MTMR3 | 25348397 | N/A | physical interaction | ComPPI |
ORC4 | MTMR3 | 25348397 | N/A | physical interaction | ComPPI |
CUL3 | MTMR3 | 25348397 | N/A | physical interaction | ComPPI |
SSBP1 | MTMR3 | 25348397 | N/A | physical interaction | ComPPI |
PLK1 | MTMR3 | 25348397 | N/A | physical interaction | ComPPI |
ATM | MTMR3 | 25348397 | N/A | physical interaction | ComPPI |
ALOX5 | MTMR3 | 25348397 | N/A | physical interaction | ComPPI |
AURKA | MTMR3 | 25348397 | N/A | physical interaction | ComPPI |
HIVEP1 | MTMR3 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
TRIM25 | MTMR3 | 25348397 | N/A | physical interaction | ComPPI |
EYA3 | MTMR3 | 25348397 | N/A | physical interaction | ComPPI |
MTOR | MTMR3 | 24234451 25348397 26787466 | association,physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
MLST8 | MTMR3 | 24234451 25348397 26787466 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
EXOSC7 | MTMR3 | 12419256 24234451 25348397 | physical association | two hybrid | ComPPI,IntAct |
RPTOR | MTMR3 | 24234451 25348397 26787466 | association,physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
MED18 | MTMR3 | 25348397 | N/A | physical interaction | ComPPI |
HEATR1 | MTMR3 | 25348397 | N/A | physical interaction | ComPPI |
NUP205 | MTMR3 | 25348397 | N/A | physical interaction | ComPPI |
PNO1 | MTMR3 | 25348397 | N/A | physical interaction | ComPPI |
KSR1 | MTMR3 | 24234451 25348397 27086506 | association | anti tag coimmunoprecipitation | ComPPI,IntAct |
MTMR4 | MTMR3 | 25348397 | N/A | physical interaction | ComPPI |
WRAP73 | MTMR3 | 25348397 | N/A | physical interaction | ComPPI |
ANKRD28 | MTMR3 | 24234451 24255178 25348397 | colocalization | physical interaction,proximity-dependent biotin identification | ComPPI,IntAct |
IPO5 | MTMR3 | 25348397 | N/A | physical interaction | ComPPI |
LONRF1 | MTMR3 | 24234451 25348397 | physical association | two hybrid,two hybrid array,two hybrid prey pooling approach | ComPPI,IntAct |
THOC2 | MTMR3 | 25348397 | N/A | physical interaction | ComPPI |
MTMR3 | TULP3 | 25348397 | N/A | physical interaction | ComPPI |
MTMR3 | MTOR | 26787466 27898060 | inhibition | N/A | OmniPath |