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GENE：MYLK

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MYLK
FullNmae myosin light chain kinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7590
EnsembleID ENSG00000065534
Uniprot Q15746

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MYLK autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MYLK GO:0001725,GO:0001725,GO:0003779,GO:0004687,GO:0004687,GO:0005515,GO:0005516,GO:0005524,GO:0005737,GO:0005737,GO:0005829,GO:0005886,GO:0006468,GO:0006939,GO:0014820,GO:0014820,GO:0015629,GO:0030027,GO:0030027,GO:0030335,GO:0032060,GO:0032154,GO:0032154,GO:0046872,GO:0051928,GO:0060414,GO:0071476,GO:0090303

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MYLK hsa:4638 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
MYLK hsa:4638 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
MYLK hsa:4638 path:hsa04270 Vascular smooth muscle contraction - Homo sapiens (human)
MYLK hsa:4638 path:hsa04371 Apelin signaling pathway - Homo sapiens (human)
MYLK hsa:4638 path:hsa04510 Focal adhesion - Homo sapiens (human)
MYLK hsa:4638 path:hsa04611 Platelet activation - Homo sapiens (human)
MYLK hsa:4638 path:hsa04810 Regulation of actin cytoskeleton - Homo sapiens (human)
MYLK hsa:4638 path:hsa04921 Oxytocin signaling pathway - Homo sapiens (human)
MYLK hsa:4638 path:hsa04971 Gastric acid secretion - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MYLK PAK1 10092231 23180781 phosphorylation reaction protein kinase assay InnateDB
MYLK PAK2 10748018 23180781 phosphorylation reaction protein kinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR MYLK 18971253 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
GATA2 MYLK 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TP73 MYLK 19558638 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 MYLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA MYLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MYLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 MYLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 MYLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MYLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 MYLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS MYLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A MYLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF MYLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 MYLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 MYLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 MYLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 MYLK 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000AA464 MYLK 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS0000338542 MYLK 24486510 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS0000072E4C MYLK 20371350 22012620 23446348 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000E1E9E MYLK 20371350 22012620 23446348 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000284586 MYLK 20371350 22012620 23446348 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000204177 MYLK 20371350 22012620 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001496AE MYLK 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000FC8EB MYLK 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000075AAA0 MYLK 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000050CCE0 MYLK 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001EFBE3 MYLK 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00004214BB MYLK 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000DD591 MYLK 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001067D1 MYLK 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000035CC3E MYLK 25416803 26233958 mrna cleavage,inhibition experimental interaction detection,nucleotide sequence identification,quantitative reverse transcription pcr TarBase
URS0000171525 MYLK 25416803 26334100 mrna cleavage,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA MYLK 22135298 phosphorylation N/A PhosphoSite
MAPK3 MYLK 22135298 phosphorylation N/A PhosphoSite
SRC MYLK 22135298 phosphorylation N/A PhosphoSite
ABL1 MYLK 22135298 phosphorylation N/A PhosphoSite
GSK3B MYLK 22135298 phosphorylation N/A PhosphoSite
MAPK1 MYLK 22135298 phosphorylation N/A PhosphoSite
PAK1 MYLK 22135298 phosphorylation N/A PhosphoSite
MYLK MYL12B 22135298 phosphorylation N/A PhosphoSite
MYLK MYL2 22135298 phosphorylation N/A PhosphoSite
MYLK MYL9 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
PAK2 MYLK 10748018 14525934 2160950 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PPP1CB MYLK 25348397 N/A physical interaction ComPPI
CALM1 MYLK 25348397 N/A physical interaction ComPPI
PAK1 MYLK 25348397 N/A physical interaction,in vitro,in vivo ComPPI
PIK3R1 MYLK 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
PRKCA MYLK 14525934 25348397 3160694 N/A experimental interaction detection,in vitro ComPPI,HPRD
SRC MYLK 10362724 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
NCK1 MYLK 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
MAPK3 MYLK 10402467 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
GRB2 MYLK 17474147 24234451 25348397 physical association peptide array ComPPI,IntAct
JUN MYLK 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
MYLK CAMK2G 25348397 N/A in vitro,in vivo ComPPI
MYLK PRKG2 14525934 25348397 6547441 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MYLK ACTA1 11481347 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MYLK SVIL 14525934 17925381 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
MYLK CTTN 12408982 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
MYLK MLC1 25348397 N/A physical interaction ComPPI
MYLK ALK 25348397 N/A physical interaction ComPPI
MYLK TP53 25348397 N/A physical interaction ComPPI
MYLK GOPC 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
MYLK HSPB1 24234451 25277244 25348397 physical association reverse ras recruitment system,physical interaction ComPPI,IntAct
MYLK MYH9 25348397 N/A physical interaction ComPPI
MYLK ANLN 25348397 N/A physical interaction ComPPI
MYLK MYO19 25348397 N/A physical interaction ComPPI
MYLK MYL12A 21457715 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
MYLK CALM2 14525934 7947686 N/A experimental interaction detection HPRD
MYLK ACTC1 12110694 14525934 N/A experimental interaction detection HPRD
SDR42E2 MYLK 24234451 30021884 physical association cross-linking study IntAct
SRC MYLK 10362724 11113114 12408982 20861316 27898060 stimulant N/A OmniPath
PRKACA MYLK 11964068 15310280 27898060 N/A N/A OmniPath
ROCK1 MYLK 11283607 27898060 inhibition,stimulant N/A OmniPath
MYLK MYL9 11942626 17287340 18669648 19851336 21457715 27898060 stimulant N/A OmniPath
ABL1 MYLK 11113114 12408982 20861316 27898060 stimulant N/A OmniPath
CDK1 MYLK 10748018 11964068 27898060 N/A N/A OmniPath
PAK1 MYLK 10092231 27898060 inhibition N/A OmniPath
PAK2 MYLK 10748018 18088087 2160950 27898060 inhibition N/A OmniPath
MYLK MYL12A 17924679 19690332 21457715 27898060 stimulant N/A OmniPath
MYLK CALD1 20536391 27898060 inhibition N/A OmniPath
MYLK MYO18A 27898060 4522294 6893940 6934518 stimulant N/A OmniPath
CAMK2G MYLK 10748018 18088087 2160950 27898060 N/A N/A OmniPath
MYLK MYL12B 11942626 12429016 15946647 19562805 27898060 stimulant N/A OmniPath
MYLK MYL6B 10092231 27898060 stimulant N/A OmniPath
MYLK MYL2 22120626 25412762 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00008B7D70 MYLK 27087310 direct interaction,inhibition N/A NPInter

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