Gene Information gene info

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GENE：PLCD1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PLCD1
FullNmae phospholipase C delta 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9060
EnsembleID ENSG00000187091
Uniprot P51178

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PLCD1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PLCD1 GO:0004435,GO:0004435,GO:0005509,GO:0005515,GO:0005546,GO:0005737,GO:0005886,GO:0006644,GO:0016042,GO:0032794,GO:0046488,GO:0048015,GO:0051209,GO:0070062

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PLCD1 hsa:5333 path:hsa00562 Inositol phosphate metabolism - Homo sapiens (human)
PLCD1 hsa:5333 path:hsa01100 Metabolic pathways - Homo sapiens (human)
PLCD1 hsa:5333 path:hsa04020 Calcium signaling pathway - Homo sapiens (human)
PLCD1 hsa:5333 path:hsa04070 Phosphatidylinositol signaling system - Homo sapiens (human)
PLCD1 hsa:5333 path:hsa04919 Thyroid hormone signaling pathway - Homo sapiens (human)
PLCD1 hsa:5333 path:hsa04933 AGE-RAGE signaling pathway in diabetic complications - Homo sapiens (human)
PLCD1 hsa:5333 path:hsa05131 Shigellosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GATA1 PLCD1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 PLCD1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 PLCD1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CEBPA PLCD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PLCD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PLCD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 PLCD1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 PLCD1 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS00002075FA PLCD1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002367FA PLCD1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B989F PLCD1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00006097A6 PLCD1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000000EF0B PLCD1 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075C4B1 PLCD1 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
SMARCD1 PLCD1 25348397 N/A physical interaction ComPPI
TGM2 PLCD1 10518533 14525934 24234451 25348397 9512491 N/A experimental interaction detection,physical interaction,enzyme linked immunosorbent assay,in vitro,in vivo ComPPI,HPRD,IntAct
PAXIP1 PLCD1 25348397 N/A physical interaction ComPPI
KPNB1 PLCD1 14525934 16115628 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,experimental interaction detection,pull down,in vitro,in vivo ComPPI,HPRD,IntAct,OmniPath
HGS PLCD1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
RALA PLCD1 14525934 15817490 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
IQGAP1 PLCD1 23982733 24234451 25348397 27898060 colocalization fluorescence microscopy ComPPI,IntAct,OmniPath
RALB PLCD1 14525934 15817490 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
PLCD1 GAP43 12805215 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
PLCD1 APP 25348397 N/A physical interaction ComPPI
PLCD1 IL31RA 25348397 N/A physical interaction ComPPI
PLCD1 GDF5 25348397 N/A physical interaction ComPPI
PLCD1 KIF3A 25348397 N/A physical interaction ComPPI
PLCD1 NTAQ1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
PLCD1 CALM2 14525934 15817490 N/A experimental interaction detection HPRD
PLEC PLCD1 24234451 30021884 physical association cross-linking study IntAct

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