Gene Information gene info

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GENE：PRKD2

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol PRKD2
FullNmae protein kinase D2
LocusType gene with protein product
Status Approved
HGNC_id HGNC:17293
EnsembleID ENSG00000105287
Uniprot Q9BZL6

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
PRKD2 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRKD2 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
PRKD2 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
PRKD2 GO:0001525,GO:0001938,GO:0001938,GO:0002250,GO:0004672,GO:0004674,GO:0004674,GO:0004674,GO:0004697,GO:0004698,GO:0005080,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005737,GO:0005794,GO:0005829,GO:0005829,GO:0005886,GO:0006468,GO:0006468,GO:0007155,GO:0010595,GO:0018105,GO:0018105,GO:0018107,GO:0030148,GO:0030949,GO:0032743,GO:0032757,GO:0035556,GO:0035924,GO:0035924,GO:0038033,GO:0043536,GO:0043536,GO:0045743,GO:0045766,GO:0045766,GO:0045785,GO:0045944,GO:0045944,GO:0045944,GO:0046777,GO:0046777,GO:0046872,GO:0048010,GO:0048010,GO:0050852,GO:0050862,GO:0051091,GO:0051092,GO:0061154,GO:0070232,GO:0070374,GO:0089700,GO:0106310,GO:1902533,GO:2000573,GO:2001028,GO:2001028

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
PRKD2 hsa:25865 path:hsa04015 Rap1 signaling pathway - Homo sapiens (human)
PRKD2 hsa:25865 path:hsa04925 Aldosterone synthesis and secretion - Homo sapiens (human)
PRKD2 hsa:25865 path:hsa05208 Chemical carcinogenesis - reactive oxygen species - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
GRIP1 PRKD2 20005715 interaction type N/A PSP
YWHAH PRKD2 20005715 interaction type N/A PSP

Source Target Pmid Interactiontype Methods Database
ETS1 PRKD2 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 PRKD2 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
SMARCA4 PRKD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF PRKD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 PRKD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS PRKD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF PRKD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR PRKD2 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F4AC3 PRKD2 16822819 25416803 mrna cleavage,inhibition array technology TarBase
URS00000EC1BE PRKD2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001481F9 PRKD2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDAA PRKD2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000480E22 PRKD2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000043B1D PRKD2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000B1B47 PRKD2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000025307A PRKD2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000328C0D PRKD2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000451A1 PRKD2 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00005C1F22 PRKD2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000C5BAA PRKD2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00006DE17B PRKD2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD002 PRKD2 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 PRKD2 23824327 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CSNK1E PRKD2 22135298 phosphorylation N/A PhosphoSite
CSNK1D PRKD2 22135298 phosphorylation N/A PhosphoSite
PRKCH PRKD2 22135298 phosphorylation N/A PhosphoSite
PRKD2 VASP 22135298 phosphorylation N/A PhosphoSite
PRKD2 SSH1 22135298 phosphorylation N/A PhosphoSite
PRKD2 HDAC5 22135298 phosphorylation N/A PhosphoSite
PRKD2 PKD2 22135298 phosphorylation N/A PhosphoSite
PRKD2 MARK2 22135298 phosphorylation N/A PhosphoSite
PRKD2 PRKD2 22135298 phosphorylation N/A PhosphoSite
PRKD2 RIN1 22135298 phosphorylation N/A PhosphoSite
PRKD2 CIB1 22135298 phosphorylation N/A PhosphoSite
PRKCE PRKD2 22135298 phosphorylation N/A PhosphoSite
PRKCA PRKD2 22135298 phosphorylation N/A PhosphoSite
HDAC7 PRKD2 25361965 interaction type N/A PTMCode2
PRKD2 HDAC7 25361965 interaction type N/A PTMCode2
XPO1 PRKD2 25361965 interaction type N/A PTMCode2
PRKD2 XPO1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
GLRX3 PRKD2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RARB PRKD2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HSP90AB1 PRKD2 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
SNRNP70 PRKD2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
IFNAR1 PRKD2 25348397 N/A physical interaction ComPPI
HSP90AA1 PRKD2 25348397 N/A physical interaction ComPPI
ARFIP1 PRKD2 23695357 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
NTRK1 PRKD2 25348397 N/A physical interaction ComPPI
RRBP1 PRKD2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PSG3 PRKD2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HEY1 PRKD2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PDLIM7 PRKD2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CASK PRKD2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CHM PRKD2 19615732 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
XPO1 PRKD2 17962809 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAQ PRKD2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAH PRKD2 17962809 24234451 25348397 physical association pull down ComPPI,IntAct
SKP2 PRKD2 25348397 N/A physical interaction ComPPI
HDAC5 PRKD2 25348397 N/A physical interaction ComPPI
SYT2 PRKD2 22909819 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
HDAC7 PRKD2 14525934 15623513 17962809 24234451 25348397 phosphorylation reaction,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,pull down,physical interaction,protein kinase assay,in vitro,in vivo ComPPI,HPRD,IntAct
GORASP1 PRKD2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RAE1 PRKD2 25348397 N/A physical interaction ComPPI
PFDN1 PRKD2 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PHYHIP PRKD2 25348397 N/A physical interaction ComPPI
TGOLN2 PRKD2 25348397 N/A in vitro ComPPI
TSC22D4 PRKD2 25348397 N/A physical interaction ComPPI
PRKD2 HSP90AA2P 25348397 N/A physical interaction ComPPI
PRKD2 RXRA 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKD2 DST 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKD2 GRIP1 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKD2 MTF2 15231748 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKD2 RFFL 25348397 N/A physical interaction ComPPI
PRKD2 CDK10 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKD2 SEC23IP 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKD2 PRKD3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKD2 NGDN 25348397 N/A physical interaction ComPPI
PRKD2 NGRN 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKD2 PLA2G10 25348397 N/A physical interaction ComPPI
PRKD2 IL13RA2 25348397 N/A physical interaction ComPPI
PRKD2 ARPC5 25348397 N/A physical interaction ComPPI
PRKD2 GML 25348397 N/A physical interaction ComPPI
PRKD2 DOCK5 25348397 N/A physical interaction ComPPI
PRKD2 PTPN3 15231748 24234451 25348397 physical association two hybrid ComPPI,IntAct
PRKD2 CSNK1A1 17962809 24234451 25348397 phosphorylation reaction protein kinase assay ComPPI,IntAct
PRKD2 MYH9 22909819 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
PRKD2 STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
ST8SIA4 PRKD2 25348397 N/A physical interaction ComPPI
TPSB2 PRKD2 25348397 N/A physical interaction ComPPI
PRKD2 PRKD2 11062248 14525934 N/A experimental interaction detection HPRD
PRKCE PRKD2 11062248 12058027 16928771 18691976 19369195 27898060 stimulant N/A OmniPath
PRKD2 VASP 11090544 11809855 15546990 15694326 16490784 18445594 18485089 19798690 20371672 20483741 22942288 26440524 27898060 N/A N/A OmniPath
CSNK1E PRKD2 17962809 27898060 N/A N/A OmniPath
PRKD2 CIB1 23503467 27898060 N/A N/A OmniPath
ABL1 PRKD2 15604256 27898060 N/A N/A OmniPath
CDK1 PRKD2 12058027 27898060 N/A N/A OmniPath
CSNK1D PRKD2 17962809 27898060 N/A N/A OmniPath
PRKD2 SSH1 19567672 21525957 27898060 inhibition N/A OmniPath
PRKCH PRKD2 12058027 17962809 27898060 stimulant N/A OmniPath
PRKD2 PI4KB 16912074 27898060 stimulant N/A OmniPath

Visualization










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