Gene Information gene info

  1. Home

GENE：RAB5A

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RAB5A
FullNmae RAB5A, member RAS oncogene family
LocusType gene with protein product
Status Approved
HGNC_id HGNC:9783
EnsembleID ENSG00000144566
Uniprot P20339

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RAB5A autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
RAB5A autophagy 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RAB5A GO:0001726,GO:0003924,GO:0003924,GO:0003925,GO:0005515,GO:0005525,GO:0005654,GO:0005737,GO:0005768,GO:0005769,GO:0005829,GO:0005829,GO:0005886,GO:0006886,GO:0006897,GO:0006897,GO:0006909,GO:0008021,GO:0010008,GO:0010008,GO:0012505,GO:0015629,GO:0019003,GO:0030424,GO:0030424,GO:0030425,GO:0030425,GO:0030669,GO:0030670,GO:0031901,GO:0032009,GO:0036465,GO:0036477,GO:0042470,GO:0043025,GO:0043195,GO:0043231,GO:0043679,GO:0044788,GO:0045022,GO:0045121,GO:0045335,GO:0045921,GO:0048169,GO:0051036,GO:0051489,GO:0051489,GO:0070062,GO:0098559,GO:0098842,GO:0150093,GO:2000286,GO:2000300,GO:2000785

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RAB5A hsa:5868 path:hsa04014 Ras signaling pathway - Homo sapiens (human)
RAB5A hsa:5868 path:hsa04137 Mitophagy - animal - Homo sapiens (human)
RAB5A hsa:5868 path:hsa04144 Endocytosis - Homo sapiens (human)
RAB5A hsa:5868 path:hsa04145 Phagosome - Homo sapiens (human)
RAB5A hsa:5868 path:hsa04148 Efferocytosis - Homo sapiens (human)
RAB5A hsa:5868 path:hsa04962 Vasopressin-regulated water reabsorption - Homo sapiens (human)
RAB5A hsa:5868 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
RAB5A hsa:5868 path:hsa05022 Pathways of neurodegeneration - multiple diseases - Homo sapiens (human)
RAB5A hsa:5868 path:hsa05132 Salmonella infection - Homo sapiens (human)
RAB5A hsa:5868 path:hsa05146 Amoebiasis - Homo sapiens (human)
RAB5A hsa:5868 path:hsa05152 Tuberculosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 RAB5A 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 RAB5A 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 RAB5A 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 RAB5A 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000315338 RAB5A 23418453 25416803 25755726 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002C0FCB RAB5A 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000CBE63 RAB5A 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS000035CC3E RAB5A 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00002E857A RAB5A 24574214 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
MAPK3 RAB5A 22135298 phosphorylation N/A PhosphoSite
PRKCE RAB5A 22135298 phosphorylation N/A PhosphoSite
RAB5A APPL1 25361965 interaction type N/A PTMCode2
APPL1 RAB5A 25361965 interaction type N/A PTMCode2
RAB5A RIN1 25361965 interaction type N/A PTMCode2
RIN1 RAB5A 25361965 interaction type N/A PTMCode2
RAB5A STX4 25361965 interaction type N/A PTMCode2
STX4 RAB5A 25361965 interaction type N/A PTMCode2
RAB5A EEA1 25361965 interaction type N/A PTMCode2
EEA1 RAB5A 25361965 interaction type N/A PTMCode2
RAB5A GGA1 25361965 interaction type N/A PTMCode2
GGA1 RAB5A 25361965 interaction type N/A PTMCode2
RAB5A OCRL 25361965 interaction type N/A PTMCode2
OCRL RAB5A 25361965 interaction type N/A PTMCode2
PIK3C3 RAB5A 25361965 interaction type N/A PTMCode2
RAB5A PIK3C3 25361965 interaction type N/A PTMCode2
APPL2 RAB5A 25361965 interaction type N/A PTMCode2
RAB5A APPL2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CDC73 RAB5A 25348397 N/A physical interaction ComPPI
RAB4A RAB5A 25348397 N/A physical interaction ComPPI
SH3GLB1 RAB5A 25348397 N/A physical interaction ComPPI
SH3KBP1 RAB5A 25348397 N/A physical interaction ComPPI
RPN1 RAB5A 25348397 N/A physical interaction ComPPI
COL1A2 RAB5A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BAG3 RAB5A 25348397 N/A physical interaction ComPPI
LDHB RAB5A 25348397 N/A physical interaction ComPPI
LDHA RAB5A 25348397 N/A physical interaction ComPPI
AGTR1 RAB5A 11682489 25348397 27898060 N/A two hybrid,physical interaction,in vivo ComPPI,OmniPath
TAF12 RAB5A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EMD RAB5A 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RABGGTB RAB5A 14525934 24234451 25348397 29568061 7991565 association experimental interaction detection,pull down,physical interaction,in vitro,proximity-dependent biotin identification ComPPI,HPRD,IntAct
RIN1 RAB5A 11703925 14525934 17403676 24234451 25348397 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
RABAC1 RAB5A 10329441 14525934 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
APPL1 RAB5A 14525934 15016378 17581628 24234451 25348397 29568061 colocalization,association,physical association experimental interaction detection,pull down,surface plasmon resonance,physical interaction,two hybrid array,fluorescence microscopy,in vitro,in vivo,two hybrid prey pooling approach,proximity-dependent biotin identification ComPPI,HPRD,IntAct
TXNIP RAB5A 25348397 N/A physical interaction ComPPI
PIK3R1 RAB5A 25348397 N/A physical interaction ComPPI
SLAMF1 RAB5A 25348397 N/A physical interaction ComPPI
NOTCH1 RAB5A 25348397 N/A physical interaction ComPPI
GDI2 RAB5A 10512627 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
RAB8A RAB5A 25348397 N/A physical interaction ComPPI
KDR RAB5A 25348397 N/A physical interaction ComPPI
RHOT2 RAB5A 25348397 N/A physical interaction ComPPI
ITGB1 RAB5A 16754960 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
ABCD3 RAB5A 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
NCOR1 RAB5A 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB7A RAB5A 25348397 N/A physical interaction ComPPI
CTSD RAB5A 25348397 N/A physical interaction ComPPI
PIK3CB RAB5A 25348397 N/A physical interaction ComPPI
BTRC RAB5A 25348397 N/A physical interaction ComPPI
LEMD3 RAB5A 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HAX1 RAB5A 25348397 N/A physical interaction ComPPI
KCNA5 RAB5A 25348397 N/A physical interaction ComPPI
TPR RAB5A 24234451 25348397 29568061 association pull down ComPPI,IntAct
CFTR RAB5A 21455491 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PTGIR RAB5A 18498773 20395296 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TNF RAB5A 25348397 N/A physical interaction ComPPI
RAB1A RAB5A 25348397 N/A physical interaction ComPPI
CHM RAB5A 24234451 25348397 29568061 association pull down,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RABGGTA RAB5A 24234451 25348397 29568061 association pull down,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RAB2A RAB5A 25348397 N/A physical interaction ComPPI
STX4 RAB5A 11884531 14525934 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,OmniPath
RABEP1 RAB5A 14525934 15378032 24234451 25348397 8521472 9045618 N/A two hybrid,experimental interaction detection,x-ray crystallography,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
KIF3B RAB5A 25348397 N/A physical interaction ComPPI
RABGEF1 RAB5A 25348397 N/A physical interaction ComPPI
RUFY1 RAB5A 25348397 N/A physical interaction ComPPI
RBSN RAB5A 11062261 14525934 16034420 24234451 25348397 29568061 association experimental interaction detection,physical interaction,in vitro,proximity-dependent biotin identification ComPPI,HPRD,IntAct
RAB5A TSC2 14525934 25348397 9045618 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RAB5A SDCBP 14525934 15014045 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
RAB5A EEA1 10491193 11870209 14525934 14600265 16902405 24234451 25348397 9697774 physical association two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
RAB5A RAB37 10722846 25348397 27898060 N/A two hybrid,physical interaction ComPPI,OmniPath
RAB5A USP6NL 11099046 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
RAB5A TBC1D3 25348397 N/A in vivo ComPPI
RAB5A ALS2CL 14525934 15388334 25348397 27898060 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
RAB5A RIN2 12972505 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
RAB5A TBC1D3C 12359748 25348397 27898060 N/A in vivo ComPPI,OmniPath
RAB5A CHML 14525934 24234451 25348397 29568061 8294464 9730828 association experimental interaction detection,pull down,physical interaction,in vitro,proximity-dependent biotin identification ComPPI,HPRD,IntAct
RAB5A APPL2 14525934 15016378 24234451 25348397 29568061 association experimental interaction detection,physical interaction,in vitro,proximity-dependent biotin identification ComPPI,HPRD,IntAct
RAB5A OCRL 14525934 16902405 21378754 24234451 25107275 25348397 colocalization,association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,fluorescence polarization spectroscopy,molecular sieving,pull down,physical interaction,enzyme linked immunosorbent assay,imaging technique,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
RAB5A RASA1 11536198 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
RAB5A RIN3 25348397 N/A physical interaction ComPPI
RAB5A RIT2 25348397 N/A physical interaction ComPPI
RAB5A VPS45 24234451 25348397 29568061 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
RAB5A PIK3C3 25348397 N/A physical interaction ComPPI
RAB5A ZFYVE28 25348397 N/A physical interaction ComPPI
RAB5A ITSN1 25348397 N/A physical interaction ComPPI
RAB5A ELAVL1 25348397 N/A physical interaction ComPPI
RAB5A KCTD7 25348397 N/A physical interaction ComPPI
RAB5A RABEP2 25348397 N/A physical interaction ComPPI
RAB5A SGSM3 25348397 N/A physical interaction ComPPI
RAB5A TBC1D15 25348397 N/A physical interaction ComPPI
RAB5A TBC1D17 25348397 N/A physical interaction ComPPI
RAB5A ANKFY1 15328530 24234451 25348397 physical association pull down,physical interaction ComPPI,IntAct
RAB5A RAB11A 25348397 N/A physical interaction ComPPI
RAB5A TF 25348397 N/A physical interaction ComPPI
RAB5A TYRP1 25348397 N/A physical interaction ComPPI
RAB5A SNCA 25348397 N/A physical interaction ComPPI
RAB5A ATP13A2 25348397 N/A physical interaction ComPPI
RAB5A IGF2BP2 25348397 N/A physical interaction ComPPI
RAB5A MOV10 25348397 N/A physical interaction ComPPI
RAB5A MOGS 25348397 N/A physical interaction ComPPI
RAB5A KCNN3 25348397 N/A physical interaction ComPPI
RAB5A SUN2 21988832 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,two hybrid,physical interaction ComPPI,IntAct
RAB5A NME2 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RAB5A DNAAF2 25348397 N/A physical interaction ComPPI
RAB5A RAB31 25348397 N/A physical interaction ComPPI
RAB5A UNK 25348397 N/A physical interaction ComPPI
RAB5A RAB11B 25348397 N/A physical interaction ComPPI
RAB5A RAB1C 25348397 N/A physical interaction ComPPI
RAB5A RAB1B 25348397 N/A physical interaction ComPPI
RAB5A ARF1 25348397 N/A physical interaction ComPPI
RAB5A RAP1A 25348397 N/A physical interaction ComPPI
RAB5A RAP1B 25348397 N/A physical interaction ComPPI
RAB5A RAB8B 25348397 N/A physical interaction ComPPI
RAB5A UQCRC2 25348397 N/A physical interaction ComPPI
RAB5A MED4 25348397 N/A physical interaction ComPPI
RAB5A ENTPD6 25348397 N/A physical interaction ComPPI
RAB5A HIVEP1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB5A RAB5C 17353931 24234451 25348397 26496610 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB5A MKNK1 25348397 N/A physical interaction ComPPI
RAB5A MAP3K20 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB5A RABL6 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB5A PRMT9 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB5A SPECC1 25348397 N/A physical interaction ComPPI
RAB5A MICOS13 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB5A C1ORF52 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB5A CAVIN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB5A LRRK2 25348397 N/A physical interaction ComPPI
RAB5A NEURL4 25348397 N/A physical interaction ComPPI
RAB5A HERC2 25348397 N/A physical interaction ComPPI
RAB5A HERC2P3 25348397 N/A physical interaction ComPPI
RAB5A HTATIP2 25348397 N/A physical interaction ComPPI
RAB5A ACSL4 25348397 N/A physical interaction ComPPI
RAB5A TSG101 25348397 N/A physical interaction ComPPI
RAB5A CHMP5 25348397 N/A physical interaction ComPPI
RAB5A DUSP22 25348397 N/A physical interaction ComPPI
RAB5A DUSP9 25348397 N/A physical interaction ComPPI
RAB5A RAB2B 25348397 N/A physical interaction ComPPI
RAB5A ATE1 25348397 N/A physical interaction ComPPI
RAB5A FZD4 25348397 N/A physical interaction ComPPI
RAB5A DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RAB5A MTSS1 25348397 N/A physical interaction ComPPI
RAB5A IKBKE 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
RAB5A TM9SF4 19893578 24234451 25348397 27898060 colocalization cosedimentation through density gradient,fluorescence microscopy ComPPI,IntAct,OmniPath
RAB5A ALS2 21300063 24234451 25348397 physical association pull down ComPPI,IntAct
RAB5A TGFBRAP1 24234451 25266290 25348397 colocalization confocal microscopy ComPPI,IntAct
RAB5A CDKN2A 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RAB5A VPS8 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RAB5A DDX52 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RAB5A LNPEP 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RAB5A FAM135A 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RAB5A GRPEL1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RAB5A SLC6A15 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RAB5A DDX24 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RAB5A GTPBP4 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RAB5A OSBPL9 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RAB5A VPS33A 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RAB5A NUP205 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RAB5A DDX54 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RAB5A HAGH 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RAB5A TCEAL1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RAB5A IGF2R 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RAB5A VPS18 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RAB5A USP11 24234451 25348397 29568061 association pull down,proximity-dependent biotin identification ComPPI,IntAct
RAB5A UHRF1BP1L 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
RAB5A GNL3 24234451 25348397 29568061 association pull down ComPPI,IntAct
RAB5A RBM33 24234451 25348397 29568061 association pull down ComPPI,IntAct
RAB5A YTHDF3 24234451 25348397 29568061 association pull down ComPPI,IntAct
RAB5A KARS1 24234451 25348397 29568061 association pull down ComPPI,IntAct
RAB5A PCMT1 24234451 25348397 29568061 association pull down ComPPI,IntAct
RAB5A LANCL1 24234451 25348397 29568061 association pull down ComPPI,IntAct
RAB5A SEC16A 24234451 25348397 29568061 association pull down ComPPI,IntAct
RAB5A DLAT 24234451 25348397 29568061 association pull down ComPPI,IntAct
GDI1 RAB5A 25348397 N/A physical interaction ComPPI
VAMP3 RAB5A 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
DDX19B RAB5A 25348397 N/A physical interaction ComPPI
RAB22A RAB5A 25348397 N/A physical interaction ComPPI
RAB5A RAB5A 14525934 15782196 N/A experimental interaction detection HPRD
PRKCE RAB5A 24872409 27898060 N/A N/A OmniPath
RABGEF1 RAB5A 10720461 11452015 19759177 23048039 27898060 stimulant N/A OmniPath
RABEP1 RAB5A 10720461 11452015 11718716 15328530 15378032 27898060 8521472 9045618 9524117 inhibition,stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009AE7D5 RAB5A 27087310 direct interaction,inhibition N/A NPInter

Visualization










  Return