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GENE：ROR1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ROR1
FullNmae receptor tyrosine kinase like orphan receptor 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10256
EnsembleID ENSG00000185483
Uniprot Q01973

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ROR1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ROR1 GO:0001725,GO:0005515,GO:0005524,GO:0005737,GO:0005886,GO:0007275,GO:0007605,GO:0009986,GO:0010976,GO:0014002,GO:0016310,GO:0017147,GO:0017147,GO:0033674,GO:0042813,GO:0043123,GO:0043123,GO:0043235,GO:0043235,GO:0043679,GO:0048839,GO:0051092,GO:0051897

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ROR1 hsa:4919 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
STAT3 ROR1 23180781 25733697 physical association anti tag coimmunoprecipitation InnateDB
WNT5A ROR1 21481194 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR ROR1 18971253 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
E2F4 ROR1 17531812 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 ROR1 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 ROR1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 ROR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ROR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ROR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 ROR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 ROR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 ROR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 ROR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF ROR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 ROR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 ROR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 ROR1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 ROR1 20686606 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000122ED0 ROR1 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00004AAAFF ROR1 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS00005ACA7C ROR1 23824327 25416803 28735896 mrna cleavage,inhibition clip TarBase
URS0000330617 ROR1 25416803 26576539 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
TRIM21 ROR1 23153538 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PTPN6 ROR1 25348397 N/A physical interaction ComPPI
SRC ROR1 22439932 24234451 25348397 phosphorylation reaction,association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,protein kinase assay ComPPI,IntAct
WNT5A ROR1 25348397 N/A anti tag coimmunoprecipitation,physical interaction ComPPI
SERPINB13 ROR1 25348397 N/A physical interaction ComPPI
PTPRR ROR1 25348397 N/A physical interaction ComPPI
EGFR ROR1 22439932 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation ComPPI,IntAct
DUSP14 ROR1 25348397 N/A physical interaction ComPPI
PPM1B ROR1 25348397 N/A physical interaction ComPPI
ILKAP ROR1 25348397 N/A physical interaction ComPPI
DUSP19 ROR1 25348397 N/A physical interaction ComPPI
PPM1F ROR1 25348397 N/A physical interaction ComPPI
TBC1D4 ROR1 23153538 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
STYX ROR1 25348397 N/A physical interaction ComPPI
APP ROR1 25348397 N/A physical interaction ComPPI
ERBB3 ROR1 22439932 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
TBC1D1 ROR1 23153538 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
DUSP21 ROR1 25348397 N/A physical interaction ComPPI
MORC3 ROR1 23153538 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ROR1 TMEM17 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
ROR1 DUSP18 25348397 N/A physical interaction ComPPI
ROR1 DUSP29 25348397 N/A physical interaction ComPPI
ROR1 MFHAS1 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
TNIP1 ROR1 24234451 30561431 association virotrap IntAct
FADD ROR1 24234451 30561431 association virotrap IntAct
PLEC ROR1 24234451 30021884 physical association cross-linking study IntAct
ROR1 SRC 22439932 27898060 stimulant N/A OmniPath
WNT5A ROR1 18287027 21481194 22343533 23151663 26690702 27898060 stimulant N/A OmniPath

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