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GENE：RPS6KA6

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol RPS6KA6
FullNmae ribosomal protein S6 kinase A6
LocusType gene with protein product
Status Approved
HGNC_id HGNC:10435
EnsembleID ENSG00000072133
Uniprot Q9UK32

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
RPS6KA6 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
RPS6KA6 GO:0000287,GO:0001650,GO:0004672,GO:0004711,GO:0005515,GO:0005524,GO:0005654,GO:0005654,GO:0005730,GO:0005737,GO:0005739,GO:0005829,GO:0006978,GO:0006978,GO:0007165,GO:0007417,GO:0016310,GO:0018105,GO:0045992,GO:0070373,GO:0106310,GO:2000381

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
RPS6KA6 hsa:27330 path:hsa04010 MAPK signaling pathway - Homo sapiens (human)
RPS6KA6 hsa:27330 path:hsa04114 Oocyte meiosis - Homo sapiens (human)
RPS6KA6 hsa:27330 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
RPS6KA6 hsa:27330 path:hsa04714 Thermogenesis - Homo sapiens (human)
RPS6KA6 hsa:27330 path:hsa04720 Long-term potentiation - Homo sapiens (human)
RPS6KA6 hsa:27330 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
RPS6KA6 hsa:27330 path:hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)
RPS6KA6 hsa:27330 path:hsa04931 Insulin resistance - Homo sapiens (human)
RPS6KA6 hsa:27330 path:hsa05135 Yersinia infection - Homo sapiens (human)
RPS6KA6 hsa:27330 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR RPS6KA6 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
CTCF RPS6KA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 RPS6KA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A RPS6KA6 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000237AF9 RPS6KA6 18185580 25416803 mrna cleavage,inhibition array technology TarBase
URS000003ABC4 RPS6KA6 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000B59A2 RPS6KA6 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00000ECE9C RPS6KA6 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000040FA88 RPS6KA6 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000024B619 RPS6KA6 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000045B99E RPS6KA6 25416803 27418678 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
LMO4 RPS6KA6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBE2I RPS6KA6 25348397 N/A physical interaction ComPPI
HSP90AB1 RPS6KA6 22939624 24234451 25348397 physical association luminescence based mammalian interactome mapping ComPPI,IntAct
SPRED2 RPS6KA6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FZD5 RPS6KA6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MAPK3 RPS6KA6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NFYA RPS6KA6 25348397 N/A physical interaction ComPPI
SLC9A1 RPS6KA6 25348397 N/A physical interaction ComPPI
MED24 RPS6KA6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HSP90AA1 RPS6KA6 25348397 N/A physical interaction ComPPI
CLEC3B RPS6KA6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBAC1 RPS6KA6 25348397 N/A physical interaction ComPPI
RPLP1 RPS6KA6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
NR4A1 RPS6KA6 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
MBP RPS6KA6 25348397 N/A physical interaction ComPPI
CEBPZ RPS6KA6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MICAL1 RPS6KA6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PQBP1 RPS6KA6 25348397 N/A physical interaction ComPPI
CDC37 RPS6KA6 24189400 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
MASP1 RPS6KA6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
MPP1 RPS6KA6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RBPJ RPS6KA6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
ERG28 RPS6KA6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
DNMT1 RPS6KA6 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RPS6KA6 RXRA 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RPS6KA6 UFM1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RPS6KA6 ZNF746 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
RPS6KA6 APP 25348397 N/A physical interaction ComPPI
RPS6KA6 OSGIN1 25348397 N/A physical interaction ComPPI
MAPK14 RPS6KA6 15632195 27898060 N/A N/A OmniPath

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