GENE：TNS3
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | TNS3 |
| FullNmae | tensin 3 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:21616 |
| EnsembleID | ENSG00000136205 |
| Uniprot | Q68CZ2 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| TNS3 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| TNS3 | GO:0002102,GO:0004721,GO:0005515,GO:0005829,GO:0005829,GO:0005925,GO:0005925,GO:0005925,GO:0016311,GO:0042995 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | TNS3 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | TNS3 | 18414489 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,chromatin immunoprecipitation assay | TFlink |
| GATA1 | TNS3 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | TNS3 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | TNS3 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| HIF1A | TNS3 | 18971253 19828020 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,inferred by curator | TFlink |
| FOXA1 | TNS3 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | TNS3 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| TFAP2C | TNS3 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | TNS3 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | TNS3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | TNS3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | TNS3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | TNS3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | TNS3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | TNS3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | TNS3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | TNS3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | TNS3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | TNS3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | TNS3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| VDR | TNS3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | TNS3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ZNF263 | TNS3 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F2 | TNS3 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS00000ED600 | TNS3 | 20215506 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS000009262D | TNS3 | 18591254 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000148B91 | TNS3 | 23622248 23824327 25416803 | mrna cleavage,inhibition | clip,clash | TarBase |
| URS0000237CBD | TNS3 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000076B539 | TNS3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000007F792 | TNS3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002F0130 | TNS3 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SRC | TNS3 | 22135298 | phosphorylation | N/A | PhosphoSite |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| IGHG1 | TNS3 | 15174051 24234451 25348397 | association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| ERBB2 | TNS3 | 16273093 24234451 25348397 | N/A | protein array,physical interaction | ComPPI,IntAct |
| KIT | TNS3 | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
| SRC | TNS3 | 19732724 24234451 25348397 | phosphorylation reaction,association,physical association | anti bait coimmunoprecipitation,protein kinase assay | ComPPI,IntAct |
| KHDRBS1 | TNS3 | 19732724 24234451 25348397 | physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| GAB1 | TNS3 | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
| APOA1 | TNS3 | 15174051 24234451 25348397 | association | anti bait coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| ENO1 | TNS3 | 25348397 | N/A | physical interaction | ComPPI |
| CDH1 | TNS3 | 19732724 24234451 25348397 | association,physical association | anti bait coimmunoprecipitation | ComPPI,IntAct |
| ILK | TNS3 | 19732724 24234451 25348397 | physical association | pull down | ComPPI,IntAct |
| PTPN12 | TNS3 | 25348397 | N/A | physical interaction | ComPPI |
| CFTR | TNS3 | 25348397 | N/A | physical interaction | ComPPI |
| UTRN | TNS3 | 25348397 | N/A | physical interaction | ComPPI |
| XPO1 | TNS3 | 25348397 | N/A | physical interaction | ComPPI |
| MET | TNS3 | 24234451 24728074 25348397 | N/A | fluorescence polarization spectroscopy | ComPPI,IntAct |
| EGFR | TNS3 | 24234451 24658140 25348397 | physical association | anti tag coimmunoprecipitation,ubiquitin reconstruction,physical interaction,luminescence based mammalian interactome mapping | ComPPI,IntAct |
| EPHA4 | TNS3 | 25348397 | N/A | physical interaction | ComPPI |
| SNTB1 | TNS3 | 25348397 | N/A | physical interaction | ComPPI |
| SNTB2 | TNS3 | 25348397 | N/A | physical interaction | ComPPI |
| DTNB | TNS3 | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | TNS3 | 25348397 | N/A | physical interaction | ComPPI |
| SRPK2 | TNS3 | 25348397 | N/A | physical interaction | ComPPI |
| MAT2B | TNS3 | 25348397 | N/A | physical interaction | ComPPI |
| GANAB | TNS3 | 25348397 | N/A | physical interaction | ComPPI |
| CTNNAL1 | TNS3 | 25348397 | N/A | physical interaction | ComPPI |
| DNPEP | TNS3 | 25348397 | N/A | physical interaction | ComPPI |
| DLC1 | TNS3 | 19732724 24234451 25348397 | physical association | pull down | ComPPI,IntAct |
| PYCR2 | TNS3 | 25348397 | N/A | physical interaction | ComPPI |
| PTK2 | TNS3 | 19732724 24234451 25348397 | colocalization,physical association | far western blotting,pull down,fluorescence microscopy | ComPPI,IntAct |
| DMD | TNS3 | 25348397 | N/A | physical interaction | ComPPI |
| BCAR1 | TNS3 | 19732724 24234451 25348397 | colocalization,physical association | anti bait coimmunoprecipitation,pull down,fluorescence microscopy | ComPPI,IntAct |
| NXF1 | TNS3 | 25348397 | N/A | physical interaction | ComPPI |
| ERBB3 | TNS3 | 16273093 24234451 25348397 | N/A | protein array,physical interaction | ComPPI,IntAct |
| MOV10 | TNS3 | 25348397 | N/A | physical interaction | ComPPI |
| TRIM47 | TNS3 | 25348397 | N/A | physical interaction | ComPPI |
| SRC | TNS3 | 19732724 27898060 | stimulant | N/A | OmniPath |