Gene Information gene info

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GENE：TXNIP

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TXNIP
FullNmae thioredoxin interacting protein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:16952
EnsembleID ENSG00000265972
Uniprot Q9H3M7

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TXNIP immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TXNIP autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TXNIP GO:0000122,GO:0004857,GO:0005515,GO:0005737,GO:0005737,GO:0005829,GO:0006606,GO:0006954,GO:0007049,GO:0009410,GO:0009612,GO:0009749,GO:0015031,GO:0030216,GO:0031625,GO:0031625,GO:0032355,GO:0032570,GO:0042127,GO:0042542,GO:0043065,GO:0048008,GO:0051592,GO:0051782,GO:0071228,GO:0140052

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TXNIP hsa:10628 path:hsa04621 NOD-like receptor signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
TXNIP TXN 20023662 23180781 physical association anti tag coimmunoprecipitation InnateDB
NLRP3 TXNIP 20023662 23180781 24217221 physical association anti tag coimmunoprecipitation InnateDB
TXNIP FOXO1 23180781 24112473 physical association anti tag coimmunoprecipitation InnateDB
TXNIP NLRP3 23180781 24217221 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
AR TXNIP 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 TXNIP 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 TXNIP 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXO3 TXNIP 18226221 20656682 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 TXNIP 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA3 TXNIP 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 TXNIP 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC TXNIP 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
YBX1 TXNIP 19151767 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 TXNIP 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
FOXO1 TXNIP 23803610 trascriptional regulation,stimulation inferred by curator TFlink
HDAC1 TXNIP 19351825 trascriptional regulation,stimulation inferred by curator TFlink
HDAC10 TXNIP 20680488 trascriptional regulation,stimulation inferred by curator TFlink
KLF6 TXNIP 19808645 trascriptional regulation,stimulation inferred by curator TFlink
MED23 TXNIP 12543799 trascriptional regulation,stimulation inferred by curator TFlink
MLXIPL TXNIP 23803610 trascriptional regulation,stimulation inferred by curator TFlink
PPARA TXNIP 18848838 trascriptional regulation,stimulation inferred by curator TFlink
PPARG TXNIP 19808645 trascriptional regulation,stimulation inferred by curator TFlink
RBMX TXNIP 16707624 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000508C13 TXNIP 21271679 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000508C13 TXNIP 20371350 21271679 21572407 23446348 24398324 25416803 26196741 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,clip,miRNA interference luciferase reporter assay TarBase
URS0000521626 TXNIP 17612493 23446348 24398324 25416803 mrna cleavage,inhibition array technology,clip TarBase
URS0000345DEB TXNIP 20371350 25416803 mrna cleavage,inhibition nucleotide sequence identification TarBase
URS00000EED18 TXNIP 20371350 23446348 25416803 mrna cleavage,inhibition nucleotide sequence identification,clip TarBase
URS00000451A1 TXNIP 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001B341F TXNIP 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000013ABA3 TXNIP 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000184017 TXNIP 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000330617 TXNIP 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000237AF9 TXNIP 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000011DF TXNIP 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001B12A4 TXNIP 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000555DA6 TXNIP 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000008B558 TXNIP 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001067D1 TXNIP 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000224AEA TXNIP 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00004BCD9C TXNIP 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000000C73C TXNIP 20371350 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00004D84DB TXNIP 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075BDA4 TXNIP 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA TXNIP 20371350 22473208 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F TXNIP 20371350 22473208 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 TXNIP 20371350 22473208 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 TXNIP 20371350 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00003BBF48 TXNIP 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000029D9F1 TXNIP 22012620 25416803 27121770 mrna cleavage,inhibition clip,miRNA interference luciferase reporter assay TarBase
URS0000044FD7 TXNIP 22012620 25416803 27121770 mrna cleavage,inhibition clip,miRNA interference luciferase reporter assay TarBase
URS0000315338 TXNIP 20371350 23446348 24398324 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000021D7C8 TXNIP 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 TXNIP 20371350 22473208 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 TXNIP 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00002C7B2B TXNIP 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001C11BC TXNIP 20371350 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00002C0FCB TXNIP 20371350 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 TXNIP 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C TXNIP 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 TXNIP 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000001C659 TXNIP 20371350 21572407 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 TXNIP 20371350 22473208 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00001F5B39 TXNIP 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 TXNIP 20371350 22473208 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 TXNIP 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000C7662 TXNIP 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000040828B TXNIP 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000039A25B TXNIP 20371350 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00003758F0 TXNIP 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000031602A TXNIP 20371350 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000045B99E TXNIP 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000209F04 TXNIP 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000251D0B TXNIP 20371350 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000BA274 TXNIP 20371350 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C TXNIP 20371350 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000000EF0B TXNIP 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000023133F TXNIP 20371350 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A TXNIP 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000214763 TXNIP 20371350 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 TXNIP 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075D15B TXNIP 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003FBC84 TXNIP 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000122F23 TXNIP 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000246356 TXNIP 20371350 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000272A92 TXNIP 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000B989F TXNIP 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000BE495 TXNIP 20371350 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000AF45F TXNIP 21572407 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00004C6C6F TXNIP 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000334286 TXNIP 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000075B0F6 TXNIP 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000022AAA TXNIP 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000035CC3E TXNIP 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000338542 TXNIP 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000149319 TXNIP 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000079D48 TXNIP 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000018E72A TXNIP 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000A057E TXNIP 23592263 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000010F787 TXNIP 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000048D44E TXNIP 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000450F92 TXNIP 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000001EB3 TXNIP 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 TXNIP 20371350 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000585553 TXNIP 20371350 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS0000453664 TXNIP 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000E7139 TXNIP 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD002 TXNIP 20371350 23446348 24398324 25416803 mrna cleavage,inhibition clip TarBase
URS000058BB84 TXNIP 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000075D1FC TXNIP 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002F3336 TXNIP 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000D6C3F TXNIP 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001AFC71 TXNIP 23446348 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001123BD TXNIP 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000486E0B TXNIP 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D TXNIP 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000075A281 TXNIP 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000025EABA TXNIP 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000006F90B TXNIP 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000029D793 TXNIP 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000005A8ED TXNIP 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000002569A TXNIP 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 TXNIP 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000041CB9C TXNIP 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000040EE1D TXNIP 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001CC864 TXNIP 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000183BED TXNIP 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002DD349 TXNIP 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000519450 TXNIP 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002394F5 TXNIP 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00000F0F49 TXNIP 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000024CEE0 TXNIP 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000007D64A TXNIP 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
TXNIP TXN 25361965 interaction type N/A PTMCode2
TXN TXNIP 25361965 interaction type N/A PTMCode2
SCEL TXNIP 25361965 interaction type N/A PTMCode2
TXNIP SCEL 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
KPNA2 TXNIP 14525934 15234975 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
GATAD2B TXNIP 25348397 N/A physical interaction ComPPI
SAP30BP TXNIP 25348397 N/A physical interaction ComPPI
TXN2 TXNIP 25348397 N/A physical interaction ComPPI
HSPA8 TXNIP 25348397 N/A physical interaction ComPPI
HSPA13 TXNIP 25348397 N/A physical interaction ComPPI
CDKN1B TXNIP 25348397 N/A physical interaction ComPPI
HSP90AB1 TXNIP 25348397 N/A physical interaction ComPPI
KBTBD7 TXNIP 25348397 N/A physical interaction ComPPI
EIF5 TXNIP 25348397 N/A physical interaction ComPPI
SMURF2 TXNIP 14525934 15231748 24234451 25348397 physical association two hybrid,physical interaction,two hybrid ComPPI,HPRD,IntAct
TXNIP TXN 10419473 10814541 14525934 24234451 25348397 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
TXNIP TXNRD1 14525934 25348397 9207062 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
TXNIP SCEL 14525934 14632196 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,OmniPath
TXNIP ZBTB16 12821938 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
TXNIP ZBTB32 12821938 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
TXNIP HDAC1 12821938 14525934 20826751 25348397 27898060 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD,OmniPath
TXNIP FHL1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TXNIP ELAVL1 25348397 N/A physical interaction ComPPI
TXNIP ITCH 25348397 N/A physical interaction ComPPI
TXNIP ECD 23880345 24234451 25348397 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
TXNIP TP53 25348397 N/A physical interaction ComPPI
TXNIP DDIT4 21460850 25348397 27898060 N/A physical interaction ComPPI,OmniPath
TXNIP COPS5 25348397 N/A physical interaction ComPPI
TXNIP HDAC3 25348397 N/A physical interaction ComPPI
TXNIP RELA 25348397 N/A physical interaction ComPPI
TXNIP KDR 25348397 N/A physical interaction ComPPI
TXNIP RAB5A 25348397 N/A physical interaction ComPPI
TXNIP PRKAA1 25348397 N/A physical interaction ComPPI
TXNIP SLC2A1 25348397 N/A physical interaction ComPPI
TXNIP IL12RB1 25348397 N/A physical interaction ComPPI
TXNIP HSPB2 24234451 25348397 26465331 physical association two hybrid,physical interaction ComPPI,IntAct
TXNIP RGMA 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TXNIP PTPN11 25348397 N/A physical interaction ComPPI
TXNIP NLGN3 25348397 N/A physical interaction ComPPI
TXNIP DCAF16 25348397 N/A physical interaction ComPPI
TXNIP MYCBP2 25348397 N/A physical interaction ComPPI
TXNIP PER1 25348397 N/A physical interaction ComPPI
TXNIP MBD3 25348397 N/A physical interaction ComPPI
TXNIP MTA1 25348397 N/A physical interaction ComPPI
TXNIP FAM91A1 25348397 N/A physical interaction ComPPI
TXNIP CRY2 25348397 N/A physical interaction ComPPI
TXNIP KBTBD6 25348397 N/A physical interaction ComPPI
TXNIP WWP1 25348397 N/A physical interaction ComPPI
TXNIP CTTN 25348397 N/A physical interaction ComPPI
TXNIP FLNA 25348397 N/A physical interaction ComPPI
TXNIP SLC3A2 25348397 N/A physical interaction ComPPI
TXNIP DNAJC7 25348397 N/A physical interaction ComPPI
TXNIP STIP1 25348397 N/A physical interaction ComPPI
TXNIP JMJD1C 25348397 N/A physical interaction ComPPI
TXNIP TOX4 25348397 N/A physical interaction ComPPI
TXNIP YEATS2 25348397 N/A physical interaction ComPPI
TXNIP MRE11 25348397 N/A physical interaction ComPPI
TXNIP PARP1 25348397 N/A physical interaction ComPPI
TXNIP EPS15L1 25348397 N/A physical interaction ComPPI
TXNIP NUMA1 25348397 N/A physical interaction ComPPI
TXNIP TPR 25348397 N/A physical interaction ComPPI
TXNIP UBE2O 25348397 N/A physical interaction ComPPI
TXNIP TXNL1 25348397 N/A physical interaction ComPPI
TXNIP AHNAK 25348397 N/A physical interaction ComPPI
TXNIP NOP58 25348397 N/A physical interaction ComPPI
TXNIP SART1 25348397 N/A physical interaction ComPPI
TXNIP ADNP 25348397 N/A physical interaction ComPPI
TXNIP SCML2 25348397 N/A physical interaction ComPPI
TXNIP TRIM28 25348397 N/A physical interaction ComPPI
TXNIP ZBTB33 25348397 N/A physical interaction ComPPI
TXNIP STEEP1 25348397 N/A physical interaction ComPPI
TXNIP HSPA1A 25348397 N/A physical interaction ComPPI
TXNIP HSPA1B 25348397 N/A physical interaction ComPPI
TXNIP VAV2 24234451 25348397 26919541 N/A isothermal titration calorimetry,x-ray crystallography ComPPI,IntAct
TXNIP SRC 24234451 25348397 26919541 N/A isothermal titration calorimetry ComPPI,IntAct
RAD18 TXNIP 25348397 N/A physical interaction ComPPI

Source Target Pmid Interactiontype Methods Database
URS00009AD38B TXNIP 27087310 direct interaction,inhibition N/A NPInter

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