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GENE：UBE2B

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol UBE2B
FullNmae ubiquitin conjugating enzyme E2 B
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12473
EnsembleID ENSG00000119048
Uniprot P63146

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
UBE2B parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
UBE2B immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
UBE2B autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
UBE2B GO:0000209,GO:0000785,GO:0001701,GO:0001741,GO:0004842,GO:0004842,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005657,GO:0005737,GO:0005886,GO:0006281,GO:0006281,GO:0006301,GO:0006301,GO:0006325,GO:0006511,GO:0006511,GO:0006915,GO:0006974,GO:0007283,GO:0007288,GO:0009410,GO:0009411,GO:0010845,GO:0016567,GO:0016574,GO:0031625,GO:0033503,GO:0033503,GO:0035234,GO:0043066,GO:0043161,GO:0043161,GO:0043951,GO:0045141,GO:0050821,GO:0051026,GO:0051093,GO:0051865,GO:0061631,GO:0070193,GO:0070534,GO:0070936,GO:0070979,GO:0090263,GO:1901874,GO:2000242

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
UBE2B hsa:7320 path:hsa04120 Ubiquitin mediated proteolysis - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ETS1 UBE2B 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink

Source Target Pmid Interactiontype Methods Database
URS000027080C UBE2B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001919B0 UBE2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075C1E1 UBE2B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002A8BC6 UBE2B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000032AE90 UBE2B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003E5ECC UBE2B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 UBE2B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 UBE2B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000137EDE UBE2B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000019907A UBE2B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075B538 UBE2B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001C770D UBE2B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000160683 UBE2B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000000E601 UBE2B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000041FA2C UBE2B 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003BD367 UBE2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000008F0CF UBE2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000100748 UBE2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000007F792 UBE2B 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D UBE2B 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004E008F UBE2B 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000078918 UBE2B 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000475586 UBE2B 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00005ACA7C UBE2B 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000243FF1 UBE2B 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 UBE2B 23313552 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDC73 UBE2B 19410543 24234451 25348397 association pull down ComPPI,IntAct
RNF40 UBE2B 19410543 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
ZNRD2 UBE2B 25348397 N/A physical interaction ComPPI
PCNA UBE2B 25348397 N/A physical interaction ComPPI
CDKN1B UBE2B 25348397 N/A physical interaction ComPPI
SKP1 UBE2B 25348397 N/A physical interaction ComPPI
UBE2D1 UBE2B 25348397 N/A physical interaction ComPPI
PSMB2 UBE2B 25348397 N/A physical interaction ComPPI
ZYX UBE2B 25348397 N/A physical interaction ComPPI
DSTN UBE2B 25348397 N/A physical interaction ComPPI
UNC119 UBE2B 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
UBE2L3 UBE2B 25348397 N/A physical interaction ComPPI
SERPINH1 UBE2B 25348397 N/A physical interaction ComPPI
UBB UBE2B 25348397 N/A nuclear magnetic resonance,covalent binding,physical interaction,comigration in sds page ComPPI
UBC UBE2B 10388568 17550899 24234451 25348397 25582440 27898060 covalent binding nuclear magnetic resonance,covalent binding,physical interaction,comigration in sds page ComPPI,IntAct,OmniPath
RPS27A UBE2B 25348397 N/A nuclear magnetic resonance,covalent binding,physical interaction,comigration in sds page ComPPI
UBA52 UBE2B 25348397 N/A nuclear magnetic resonance,covalent binding,physical interaction,physical interaction,comigration in sds page ComPPI
SSBP1 UBE2B 25348397 N/A physical interaction ComPPI
POLH UBE2B 25348397 N/A physical interaction ComPPI
UBR5 UBE2B 25348397 N/A physical interaction ComPPI
CTR9 UBE2B 19410543 24234451 25348397 association pull down ComPPI,IntAct
RAD18 UBE2B 10884424 10908344 14525934 17720710 18316726 19549727 21422291 24234451 25348397 physical association two hybrid,experimental interaction detection,nuclear magnetic resonance,surface plasmon resonance,x-ray crystallography,physical interaction,two hybrid array,in vitro,in vivo,surface plasmon resonance array,two hybrid ComPPI,HPRD,IntAct
UBE2B UBR2 14525934 14585983 20080676 25348397 25582440 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
UBE2B CRMP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
UBE2B UBR1 14525934 16169070 21422291 24234451 25348397 physical association two hybrid,nuclear magnetic resonance,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
UBE2B BIRC2 25348397 N/A physical interaction ComPPI
UBE2B H2AC20 20080676 23339190 25348397 27898060 N/A physical interaction ComPPI,OmniPath
UBE2B NBN 25348397 N/A physical interaction ComPPI
UBE2B TP53 25348397 N/A physical interaction ComPPI
UBE2B MDM2 25348397 N/A physical interaction ComPPI
UBE2B CTNNB1 25348397 N/A physical interaction ComPPI
UBE2B UBA1 25348397 N/A physical interaction ComPPI
UBE2B ZMYM2 25348397 N/A physical interaction ComPPI
UBE2B UBE2C 25348397 N/A physical interaction ComPPI
UBE2B UBE2V2 25348397 N/A physical interaction ComPPI
UBE2B USP9X 25348397 N/A physical interaction ComPPI
UBE2B UBE2V1 25348397 N/A physical interaction ComPPI
UBE2B UBXN7 25348397 N/A physical interaction ComPPI
UBE2B AHCYL1 25348397 N/A physical interaction ComPPI
UBE2B SRXN1 25348397 N/A physical interaction ComPPI
UBE2B UBQLN1 25348397 N/A physical interaction ComPPI
UBE2B TYMS 25348397 N/A physical interaction ComPPI
UBE2B UBA2 25348397 N/A physical interaction ComPPI
UBE2B SEC24A 25348397 N/A physical interaction ComPPI
UBE2B SRSF2 25348397 N/A physical interaction ComPPI
UBE2B IGBP1 25348397 N/A physical interaction ComPPI
UBE2B ZRANB2 25348397 N/A physical interaction ComPPI
UBE2B PAICS 25348397 N/A physical interaction ComPPI
UBE2B PRDX5 25348397 N/A physical interaction ComPPI
UBE2B ERCC4 25348397 N/A physical interaction ComPPI
UBE2B TRIM45 25348397 N/A physical interaction ComPPI
UBE2B UBE2A 25348397 N/A physical interaction ComPPI
UBE2B KCMF1 25348397 N/A physical interaction ComPPI
UBE2B UBR4 19549727 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
UBE2B NIPSNAP1 25348397 N/A physical interaction ComPPI
UBE2B SARS2 25348397 N/A physical interaction ComPPI
UBE2B RNF4 25348397 N/A physical interaction ComPPI
UBE2B PRKN 25348397 N/A physical interaction ComPPI
UBE2B HLTF 18316726 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
UBE2B SHPRH 25348397 N/A pull down,physical interaction ComPPI
UBE2B IRF7 19549727 24234451 25348397 physical association two hybrid ComPPI,IntAct
UBE2B WDR61 19410543 24234451 25348397 association pull down ComPPI,IntAct
UBE2B RTF1 19410543 24234451 25348397 association pull down ComPPI,IntAct
CBX5 UBE2B 25348397 N/A physical interaction ComPPI
TTC1 UBE2B 25348397 N/A physical interaction ComPPI
NIPSNAP3A UBE2B 25348397 N/A physical interaction ComPPI
LEO1 UBE2B 19410543 24234451 25348397 association pull down ComPPI,IntAct
RNF20 UBE2B 19410543 24234451 25348397 ubiquitination reaction,association pull down,physical interaction,enzymatic study ComPPI,IntAct
CHEK1 UBE2B 19158510 20068082 27898060 stimulant N/A OmniPath
CLSPN UBE2B 18451105 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009B9EBE UBE2B 27087310 direct interaction,inhibition N/A NPInter

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