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GENE：WWC1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol WWC1
FullNmae WW and C2 domain containing 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:29435
EnsembleID ENSG00000113645
Uniprot Q8IX03

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
WWC1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
WWC1 ferroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
WWC1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
WWC1 GO:0000122,GO:0003713,GO:0005515,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0005829,GO:0006355,GO:0016477,GO:0016477,GO:0019900,GO:0019900,GO:0030010,GO:0032386,GO:0032587,GO:0032991,GO:0035330,GO:0035330,GO:0035331,GO:0043410,GO:0045893,GO:0046621,GO:0046621,GO:0048471,GO:0060090,GO:0060090

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
WWC1 hsa:23286 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
WWC1 hsa:23286 path:hsa04392 Hippo signaling pathway - multiple species - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
WWC1 PRKCZ 15081397 23180781 phosphorylation reaction,physical association pull down,protein kinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR WWC1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 WWC1 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 WWC1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYCN WWC1 16093321 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 WWC1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
CEBPA WWC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF WWC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 WWC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 WWC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A WWC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF WWC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 WWC1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TCF7L2 WWC1 24072042 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000338542 WWC1 20584899 rna interference,inhibition experimental interaction detection miRSponge
URS00000ED600 WWC1 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS0000338542 WWC1 20584899 22473208 25416803 mrna cleavage,inhibition experimental interaction detection,clip TarBase
URS000018D2BE WWC1 22012620 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000096022 WWC1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001F373E WWC1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000008A99 WWC1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00003380CC WWC1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00005CC20C WWC1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 WWC1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000753AD WWC1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000013ABA3 WWC1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000075AB14 WWC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000035CC3E WWC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000005481D WWC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000016FD1A WWC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 WWC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000021D08 WWC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000508C13 WWC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000041E949 WWC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000027080C WWC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000346991 WWC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000070CD2 WWC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 WWC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 WWC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 WWC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F WWC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA WWC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00000600E6 WWC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 WWC1 23313552 25416803 mrna cleavage,inhibition clip TarBase
URS00004CCA62 WWC1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000486E0B WWC1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000047A67D WWC1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00001AFC71 WWC1 19536157 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
AURKA WWC1 22135298 phosphorylation N/A PhosphoSite
MAPK3 WWC1 22135298 phosphorylation N/A PhosphoSite
CDK1 WWC1 22135298 phosphorylation N/A PhosphoSite
MAPK1 WWC1 22135298 phosphorylation N/A PhosphoSite
RPS6KA1 WWC1 22135298 phosphorylation N/A PhosphoSite
ATM WWC1 22135298 phosphorylation N/A PhosphoSite
AURKB WWC1 22135298 phosphorylation N/A PhosphoSite
PRKCZ WWC1 22135298 phosphorylation N/A PhosphoSite
RPS6KA3 WWC1 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CDC73 WWC1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CDC5L WWC1 25348397 N/A physical interaction ComPPI
DYNLL1 WWC1 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PALS1 WWC1 25348397 N/A physical interaction ComPPI
DYNLL2 WWC1 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AMOT WWC1 24234451 24255178 24366813 25348397 colocalization,association anti tag coimmunoprecipitation,physical interaction,proximity-dependent biotin identification ComPPI,IntAct
YWHAG WWC1 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NF2 WWC1 25348397 N/A physical interaction ComPPI
PRKCA WWC1 25348397 N/A physical interaction ComPPI
MPDZ WWC1 25348397 N/A physical interaction ComPPI
CIT WWC1 25348397 N/A physical interaction ComPPI
RHPN1 WWC1 25348397 N/A physical interaction ComPPI
FEZ1 WWC1 14525934 16484223 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
YWHAB WWC1 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
YWHAZ WWC1 15161933 24234451 25348397 physical association pull down ComPPI,IntAct
BTRC WWC1 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CSNK1E WWC1 25348397 N/A physical interaction ComPPI
DCTN1 WWC1 25348397 N/A physical interaction ComPPI
PRKCZ WWC1 14525934 15081397 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD
MAPK6 WWC1 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PARD6B WWC1 25348397 N/A physical interaction ComPPI
FEZ2 WWC1 25348397 N/A physical interaction ComPPI
WWC1 DDN 12559952 14525934 18596123 25348397 27898060 N/A two hybrid,two hybrid ComPPI,HPRD,OmniPath
WWC1 AIFM1 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
WWC1 FAM219A 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
WWC1 LRIF1 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
WWC1 KIAA0513 14525934 17010949 25348397 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD
WWC1 DLC1 25348397 N/A physical interaction ComPPI
WWC1 LATS1 25348397 N/A physical interaction ComPPI
WWC1 LATS2 25348397 N/A physical interaction ComPPI
WWC1 TNIK 17043677 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
WWC1 PTPN14 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WWC1 MOV10 25348397 N/A physical interaction ComPPI
WWC1 NXF1 25348397 N/A physical interaction ComPPI
WWC1 ARRDC1 25348397 N/A physical interaction ComPPI
WWC1 YWHAE 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WWC1 YWHAH 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WWC1 ATAD3A 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WWC1 EPB41L2 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WWC1 EPB41L3 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WWC1 FBXW11 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
WWC1 WWC2 25348397 N/A physical interaction ComPPI
WWC1 WWC3 25348397 N/A physical interaction ComPPI
WWC1 XPO1 25348397 N/A physical interaction ComPPI
WWC1 TUBGCP4 25348397 N/A physical interaction ComPPI
WWC1 PTPN21 25348397 N/A physical interaction ComPPI
WWC1 TRIM25 25348397 N/A physical interaction ComPPI
WWC1 USP9X 25348397 N/A physical interaction ComPPI
WWC1 PATJ 25348397 N/A physical interaction ComPPI
WWC1 RAPGEF6 25348397 N/A physical interaction ComPPI
WWC1 AMOTL1 25348397 N/A physical interaction ComPPI
WWC1 DLG1 25348397 N/A physical interaction ComPPI
WWC1 MAEA 25348397 N/A physical interaction ComPPI
WWC1 MYO1C 25348397 N/A physical interaction ComPPI
WWC1 RMND5A 25348397 N/A physical interaction ComPPI
WWC1 ARMC8 25348397 N/A physical interaction ComPPI
WWC1 CPVL 25348397 N/A physical interaction ComPPI
WWC1 LIN7C 25348397 N/A physical interaction ComPPI
WWC1 DAG1 25348397 N/A physical interaction ComPPI
WWC1 EXOC1 25348397 N/A two hybrid,physical interaction ComPPI
WWC1 SNX4 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
WWC1 RIF1 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
YWHAQ WWC1 24234451 24366813 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKCI WWC1 25348397 N/A physical interaction ComPPI
H3C1 WWC1 25348397 N/A physical interaction ComPPI
DDR1 WWC1 18190796 27898060 N/A N/A OmniPath
RPS6KA1 WWC1 24269383 27898060 stimulant N/A OmniPath
PRKCZ WWC1 15081397 27898060 N/A N/A OmniPath
WWC1 PRKCZ 15081397 27898060 N/A N/A OmniPath
CDK1 WWC1 22784093 27898060 N/A N/A OmniPath
RPS6KA3 WWC1 24269383 27898060 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009BA05E WWC1 27087310 direct interaction,inhibition N/A NPInter

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