Gene Information gene info

  1. Home

GENE：BUB1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol BUB1
FullNmae BUB1 mitotic checkpoint serine/threonine kinase
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1148
EnsembleID ENSG00000169679
Uniprot O43683

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
BUB1 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
BUB1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
BUB1 GO:0000776,GO:0000776,GO:0000940,GO:0004672,GO:0004672,GO:0004672,GO:0004674,GO:0005515,GO:0005524,GO:0005634,GO:0005654,GO:0005829,GO:0005829,GO:0006338,GO:0006915,GO:0007059,GO:0007063,GO:0007094,GO:0007094,GO:0016020,GO:0016310,GO:0043231,GO:0051301,GO:0051754,GO:0051983,GO:0106310,GO:0140995,GO:2000720

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
BUB1 hsa:699 path:hsa04110 Cell cycle - Homo sapiens (human)
BUB1 hsa:699 path:hsa04114 Oocyte meiosis - Homo sapiens (human)
BUB1 hsa:699 path:hsa04914 Progesterone-mediated oocyte maturation - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
APC2 BUB1 10477750 11402067 11535616 12640463 15024386 15279786 15592459 17303408 17376779 17498870 17660363 18022367 18590585 19154723 19182530 19503101 21270334 23197039 26192618 7575488 8824189 9790499 interaction type N/A ACSN
BUB1 BUB3 10477750 11402067 11535616 12640463 15024386 15279786 15592459 17303408 17376779 17498870 17660363 18022367 18590585 19154723 19182530 19503101 21270334 23180781 23197039 25416956 26192618 7575488 8824189 9790499 interaction type,physical association two hybrid ACSN,InnateDB
CDC20 BUB1 10477750 11402067 11535616 12640463 15024386 15279786 15592459 17303408 17376779 17498870 17660363 18022367 18590585 19154723 19182530 19503101 21270334 23197039 26192618 7575488 8824189 9790499 interaction type N/A ACSN
AURKB BUB1 12925766 14767480 15249581 16571674 17956729 26192618 interaction type N/A ACSN
BIRC5 BUB1 12925766 14767480 15249581 16571674 17956729 26192618 interaction type N/A ACSN
INCENP BUB1 12925766 14767480 15249581 16571674 17956729 26192618 interaction type N/A ACSN
BRCA1 BUB1 10367887 10779360 10962562 11877377 12024039 12170778 12496474 12771027 15242590 15459660 15485915 16818604 19004803 19357644 19686080 19788416 19793801 20029420 21060331 21337561 26192618 9346961 9892649 interaction type N/A ACSN
BUB1 SMC3 10477750 11402067 11535616 12640463 15024386 15279786 15592459 17303408 17376779 17498870 17660363 18022367 18590585 19154723 19182530 19503101 21270334 23197039 26192618 7575488 8824189 9790499 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
E2F4 BUB1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ESR1 BUB1 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 BUB1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 BUB1 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 BUB1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 BUB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA BUB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS BUB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A BUB1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00003E5ECC BUB1 23110129 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr TarBase
URS000052E1A6 BUB1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000021D7C8 BUB1 22012620 23622248 25416803 mrna cleavage,inhibition clip,clash TarBase
URS00004AC389 BUB1 23125021 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS000075A9CF BUB1 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004F4657 BUB1 22012620 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004E008F BUB1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002FF522 BUB1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00005E6F45 BUB1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000137EDE BUB1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000019907A BUB1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000039E1E1 BUB1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000007FBA BUB1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00000F6E49 BUB1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000246356 BUB1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00002FB065 BUB1 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000008C563 BUB1 21572407 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000486E0B BUB1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000061E50F BUB1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000039607D BUB1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00005ACA7C BUB1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A BUB1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000058276F BUB1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000AA464 BUB1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000367985 BUB1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A BUB1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000012930C BUB1 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000209F04 BUB1 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001CF056 BUB1 21572407 23824327 24906430 25416803 mrna cleavage,inhibition clip TarBase
URS00002F5FEE BUB1 21572407 23824327 24906430 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDK1 BUB1 22135298 phosphorylation N/A PhosphoSite
BUB1 BUB3 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
BUB1 CDC20 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
BUB1 BUB1 22135298 phosphorylation N/A PhosphoSite
BUB1 H2AC11 22135298 phosphorylation N/A PhosphoSite
ATM BUB1 22135298 phosphorylation N/A PhosphoSite
PLK1 BUB1 25361965 interaction type N/A PTMCode2
BUB1 PLK1 25361965 interaction type N/A PTMCode2
APC BUB1 25361965 interaction type N/A PTMCode2
BUB1 APC 25361965 interaction type N/A PTMCode2
SPC25 BUB1 25361965 interaction type N/A PTMCode2
BUB1 SPC25 25361965 interaction type N/A PTMCode2
NUF2 BUB1 25361965 interaction type N/A PTMCode2
BUB1 NUF2 25361965 interaction type N/A PTMCode2
CDC20 BUB1 25361965 interaction type N/A PTMCode2
BUB1 AP1B1 25361965 interaction type N/A PTMCode2
AP1B1 BUB1 25361965 interaction type N/A PTMCode2
BUB1 NDEL1 25361965 interaction type N/A PTMCode2
NDEL1 BUB1 25361965 interaction type N/A PTMCode2
BUB3 BUB1 25361965 interaction type N/A PTMCode2
BUB1 ZWINT 25361965 interaction type N/A PTMCode2
ZWINT BUB1 25361965 interaction type N/A PTMCode2
ZW10 BUB1 25361965 interaction type N/A PTMCode2
BUB1 ZW10 25361965 interaction type N/A PTMCode2
BUB1B BUB1 25361965 interaction type N/A PTMCode2
BUB1 BUB1B 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
RBPMS BUB1 25348397 N/A physical interaction ComPPI
SNW1 BUB1 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
CDC5L BUB1 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
FBP2 BUB1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
FBP1 BUB1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
NDC80 BUB1 20360068 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
ANP32B BUB1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
TGFB1 BUB1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
TP53BP1 BUB1 25348397 N/A physical interaction ComPPI
CRK BUB1 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
RDH12 BUB1 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
SMAD1 BUB1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
HRAS BUB1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
SHC1 BUB1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
CDC16 BUB1 25348397 N/A physical interaction ComPPI
SFRP2 BUB1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
APC BUB1 11283619 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
BUB3 BUB1 11283619 14525934 21988832 24234451 25348397 25416956 26496610 9660858 association,physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vivo,two hybrid prey pooling approach,validated two hybrid ComPPI,HPRD,IntAct
BUB1 RAE1 11352911 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
BUB1 CDC20 14525934 15525512 24234451 25348397 26496610 association anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD,IntAct
BUB1 AP2B1 25348397 N/A two hybrid ComPPI
BUB1 AP3B1 12419313 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
BUB1 AP1B1 12419313 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
BUB1 AP4B1 12419313 14525934 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
BUB1 PLK1 14525934 16760428 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
BUB1 SVIL 14525934 20309963 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
BUB1 HDAC1 14525934 15388328 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BUB1 KNL1 20360068 22660415 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid,physical interaction,tandem affinity purification ComPPI,IntAct
BUB1 UBR5 20360068 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
BUB1 DSN1 20360068 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
BUB1 ZWINT 20360068 24234451 25348397 26496610 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
BUB1 SPC25 20360068 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
BUB1 BUB1B 20360068 24234451 25348397 25852190 association,physical association anti tag coimmunoprecipitation,physical interaction,tandem affinity purification ComPPI,IntAct
BUB1 SPC24 20360068 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
BUB1 NSL1 20360068 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
BUB1 NUF2 20360068 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
BUB1 CDK1 14525934 16760428 25348397 N/A experimental interaction detection,physical interaction ComPPI,HPRD
BUB1 CENPE 25348397 N/A physical interaction ComPPI
BUB1 NXF1 25348397 N/A physical interaction ComPPI
BUB1 MLF1 25348397 N/A physical interaction ComPPI
BUB1 RABL6 25348397 N/A physical interaction ComPPI
BUB1 BPTF 25348397 N/A physical interaction ComPPI
BUB1 MAD2L1 25348397 N/A physical interaction ComPPI
BUB1 CDK2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BUB1 CDKN2AIP 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BUB1 SEH1L 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BUB1 PLEC 25348397 N/A physical interaction ComPPI
BUB1 HPS5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BUB1 KIF26B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
BUB1 NCAPH2 25348397 N/A physical interaction ComPPI
BUB1 BRINP3 25348397 N/A physical interaction ComPPI
BUB1 DNA2 25348397 N/A physical interaction ComPPI
BUB1 HNRNPCL1 25348397 N/A physical interaction ComPPI
BUB1 HSF1 24234451 25348397 27173435 association,physical association physical interaction,tandem affinity purification,inference by socio-affinity scoring ComPPI,IntAct
BUB1 CFAP161 24234451 25348397 physical association physical interaction,inference by socio-affinity scoring ComPPI,IntAct
BUB1 ZW10 15824131 24234451 25348397 colocalization fluorescence microscopy ComPPI,IntAct
BUB1 NDEL1 17600710 24234451 25348397 colocalization fluorescence technology ComPPI,IntAct
BUB1 PMF1 20360068 24234451 25348397 physical association tandem affinity purification ComPPI,IntAct
BUB1 MYC 21150319 24234451 25348397 association tandem affinity purification ComPPI,IntAct
BUB1 AKT1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 ALDOB 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 TRMO 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 AOPEP 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 MSANTD3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 TSTD2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 CDC14B 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 CDK8 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 CORO2A 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 CTSV 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 CYLC2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 DVL1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 FANCC 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 FRAT2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 GALNT12 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 HEMGN 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 HSD17B3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 IGFBP3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 LEF1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 CCDC180 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 MAPKAPK3 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 MAP2K1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 NANS 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 PPP2CB 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 RASA1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 SEC61B 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 SFRP4 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 STX17 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 TBC1D2 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 TDRD7 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 TMOD1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 TMEFF1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 ZNF189 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 ZNF510 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 RRP1B 20926688 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
EIF4EBP1 BUB1 10198256 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vitro,proximity ligation assay ComPPI,HPRD,IntAct
XPA BUB1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
MIS12 BUB1 20360068 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
BAAT BUB1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
ARIH2 BUB1 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid prey pooling approach,two hybrid ComPPI,HPRD,IntAct
PPP3R2 BUB1 24234451 24412244 25348397 physical association two hybrid,two hybrid array ComPPI,IntAct
BUB1 BUB1 20360068 24234451 physical association tandem affinity purification IntAct
TEX264 BUB1 24234451 30021884 physical association cross-linking study IntAct
BUB1 SKP1 12769845 27898060 N/A N/A OmniPath
BUB1 FZR1 17158872 27898060 N/A N/A OmniPath
BUB1 PLK1 16760428 19228686 27898060 stimulant N/A OmniPath
ATM BUB1 22099307 27898060 stimulant N/A OmniPath
CDK1 BUB1 16760428 27898060 stimulant N/A OmniPath
BUB1 SMC1A 15604152 27898060 stimulant N/A OmniPath
BUB1 CDC20 10704439 15525512 18669648 18767875 18995837 19413330 23443559 25306918 25669885 26186194 26496610 26811472 27898060 inhibition,stimulant N/A OmniPath
KNL1 BUB1 17981135 19141287 20220147 20360068 21199919 22660415 26186194 26496610 27898060 stimulant N/A OmniPath
BUB1 H2AC11 24055156 26190260 27898060 N/A N/A OmniPath

Visualization










  Return