Gene Information gene info

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GENE：CCND3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CCND3
FullNmae cyclin D3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1585
EnsembleID ENSG00000112576
Uniprot P30281

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CCND3 mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CCND3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CCND3 GO:0000079,GO:0000082,GO:0000082,GO:0000082,GO:0000122,GO:0000307,GO:0000307,GO:0001934,GO:0004693,GO:0005515,GO:0005634,GO:0005654,GO:0005654,GO:0005737,GO:0005829,GO:0007165,GO:0016538,GO:0019901,GO:0042098,GO:0042127,GO:0044772,GO:0045737,GO:0051301,GO:0061575,GO:0061575,GO:0097130

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CCND3 hsa:896 path:hsa04110 Cell cycle - Homo sapiens (human)
CCND3 hsa:896 path:hsa04115 p53 signaling pathway - Homo sapiens (human)
CCND3 hsa:896 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
CCND3 hsa:896 path:hsa04218 Cellular senescence - Homo sapiens (human)
CCND3 hsa:896 path:hsa04310 Wnt signaling pathway - Homo sapiens (human)
CCND3 hsa:896 path:hsa04390 Hippo signaling pathway - Homo sapiens (human)
CCND3 hsa:896 path:hsa04510 Focal adhesion - Homo sapiens (human)
CCND3 hsa:896 path:hsa04630 JAK-STAT signaling pathway - Homo sapiens (human)
CCND3 hsa:896 path:hsa05162 Measles - Homo sapiens (human)
CCND3 hsa:896 path:hsa05164 Influenza A - Homo sapiens (human)
CCND3 hsa:896 path:hsa05165 Human papillomavirus infection - Homo sapiens (human)
CCND3 hsa:896 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
CCND3 hsa:896 path:hsa05169 Epstein-Barr virus infection - Homo sapiens (human)
CCND3 hsa:896 path:hsa05200 Pathways in cancer - Homo sapiens (human)
CCND3 hsa:896 path:hsa05203 Viral carcinogenesis - Homo sapiens (human)
CCND3 hsa:896 path:hsa05207 Chemical carcinogenesis - receptor activation - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CREB1 CCND3 18160048 23180781 physical association anti tag coimmunoprecipitation InnateDB
LYL1 CCND3 18160048 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 CCND3 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 CCND3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 CCND3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP53 CCND3 19861536 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP73 CCND3 19861536 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
TP63 CCND3 19861536 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 CCND3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 CCND3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CCND3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CCND3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CCND3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CCND3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CCND3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS CCND3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 CCND3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CCND3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 CCND3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 CCND3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 CCND3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR CCND3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 CCND3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF5 CCND3 16300731 trascriptional regulation,stimulation inferred by curator TFlink
ETV4 CCND3 17467662 trascriptional regulation,stimulation inferred by curator TFlink
NR3C1 CCND3 9154817 trascriptional regulation,stimulation inferred by curator TFlink
STAT3 CCND3 15184887 trascriptional regulation,stimulation inferred by curator TFlink
FLI1 CCND3 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT5A CCND3 N/A trascriptional regulation,stimulation inferred by curator TFlink
STAT5B CCND3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS000040EE1D CCND3 22217655 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS00000EED18 CCND3 18406353 rna interference,inhibition western blot miRSponge
URS00000F0F49 CCND3 18701644 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00000F0F49 CCND3 18701644 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000EED18 CCND3 18406353 25416803 mrna cleavage,inhibition western blot TarBase
URS000040EE1D CCND3 22217655 23544130 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS00003D5391 CCND3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS000005481D CCND3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000330617 CCND3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000324096 CCND3 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000F6E49 CCND3 23967867 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr TarBase
URS00001799A3 CCND3 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000019D79B CCND3 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS0000364FEF CCND3 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000007D64A CCND3 23544130 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000235862 CCND3 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000009A9A2 CCND3 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00002578DA CCND3 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C CCND3 25416803 26144250 26191187 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
MAPK11 CCND3 22135298 phosphorylation N/A PhosphoSite
GSK3B CCND3 22135298 phosphorylation N/A PhosphoSite
MAPK12 CCND3 22135298 phosphorylation N/A PhosphoSite
MAPK13 CCND3 22135298 phosphorylation N/A PhosphoSite
ATF5 CCND3 25361965 interaction type N/A PTMCode2
CCND3 ATF5 25361965 interaction type N/A PTMCode2
AREG CCND3 25361965 interaction type N/A PTMCode2
CCND3 AREG 25361965 interaction type N/A PTMCode2
DMTF1 CCND3 25361965 interaction type N/A PTMCode2
CCND3 DMTF1 25361965 interaction type N/A PTMCode2
CDK4 CCND3 25361965 interaction type N/A PTMCode2
CCND3 CDK4 25361965 interaction type N/A PTMCode2
CDKN1A CCND3 25361965 interaction type N/A PTMCode2
CCND3 CDKN1A 25361965 interaction type N/A PTMCode2
CDK6 CCND3 25361965 interaction type N/A PTMCode2
CCND3 CDK6 25361965 interaction type N/A PTMCode2
RUNX1 CCND3 25361965 interaction type N/A PTMCode2
CCND3 RUNX1 25361965 interaction type N/A PTMCode2
MCM10 CCND3 25361965 interaction type N/A PTMCode2
CCND3 MCM10 25361965 interaction type N/A PTMCode2
CCND3 PCNA 25361965 interaction type N/A PTMCode2
PCNA CCND3 25361965 interaction type N/A PTMCode2
CCND3 SUMO1 25361965 interaction type N/A PTMCode2
SUMO1 CCND3 25361965 interaction type N/A PTMCode2
CDKN1B CCND3 25361965 interaction type N/A PTMCode2
CCND3 CDKN1B 25361965 interaction type N/A PTMCode2
AKAP8 CCND3 25361965 interaction type N/A PTMCode2
CCND3 AKAP8 25361965 interaction type N/A PTMCode2
CRABP2 CCND3 25361965 interaction type N/A PTMCode2
CCND3 CRABP2 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
PPP1CC CCND3 25348397 N/A physical interaction,antibody array ComPPI
EFEMP2 CCND3 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
RARA CCND3 12482873 14525934 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
PCNA CCND3 14525934 25348397 7908906 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CDKN1A CCND3 14525934 15232106 16189514 21988832 24234451 25241761 25348397 25416956 26496610 27107012 association,physical association anti tag coimmunoprecipitation,experimental interaction detection,protein array,physical interaction,mammalian protein protein interaction trap,two hybrid array,two hybrid pooling approach,in vitro,proximity ligation assay,two hybrid prey pooling approach,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
NPDC1 CCND3 11042687 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
CDKN2C CCND3 25348397 N/A physical interaction ComPPI
CDK6 CCND3 11360184 14525934 15232106 17517622 21516116 23602568 24234451 25348397 25416956 27107012 29997244 8114739 association,physical association anti bait coimmunoprecipitation,bioluminescence resonance energy transfer,two hybrid,experimental interaction detection,protein array,physical interaction,mammalian protein protein interaction trap,two hybrid array,in vitro,in vivo,tandem affinity purification,luminescence based mammalian interactome mapping,two hybrid prey pooling approach,split luciferase complementation,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
CDKN1B CCND3 10342870 14525934 16189514 24234451 25348397 physical association experimental interaction detection,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,in vitro,in vivo ComPPI,HPRD,IntAct
PPP1CB CCND3 17274640 24234451 25348397 physical association physical interaction,antibody array ComPPI,IntAct
CRABP2 CCND3 12482873 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
STAP1 CCND3 25348397 N/A physical interaction ComPPI
ETV1 CCND3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
RB1 CCND3 25348397 N/A physical interaction ComPPI
CREBBP CCND3 25348397 N/A physical interaction ComPPI
VDR CCND3 14525934 16105657 21988832 24234451 25348397 27898060 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
RBX1 CCND3 25348397 N/A physical interaction ComPPI
DMTF1 CCND3 14525934 25348397 8887674 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MCM10 CCND3 14525934 15232106 24234451 25348397 N/A experimental interaction detection,protein array,physical interaction,in vitro ComPPI,HPRD,IntAct
CLU CCND3 25348397 N/A physical interaction ComPPI
RBL2 CCND3 14525934 16600870 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CDKN1C CCND3 25348397 N/A physical interaction ComPPI
PPP1CA CCND3 25348397 N/A physical interaction ComPPI
SIL1 CCND3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
PRKAR2A CCND3 16721056 24234451 25348397 physical association anti tag coimmunoprecipitation ComPPI,IntAct
NME1 CCND3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HNRNPL CCND3 25348397 N/A physical interaction ComPPI
MAPK6 CCND3 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
TSC2 CCND3 25348397 N/A physical interaction ComPPI
NCOA2 CCND3 12130539 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
CDK2 CCND3 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
POLD1 CCND3 25348397 N/A physical interaction ComPPI
CDK5 CCND3 23455922 23602568 24234451 25348397 association,physical association physical interaction,two hybrid array,tandem affinity purification,two hybrid prey pooling approach ComPPI,IntAct
PRKN CCND3 25348397 N/A physical interaction ComPPI
CASP2 CCND3 12011445 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
TFIP11 CCND3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CDK4 CCND3 10342870 11896535 14525934 14641107 15232106 16189514 19237555 21516116 21988832 24234451 25348397 25416956 25910212 26496610 27107012 9106657 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,light scattering,molecular sieving,protein array,x-ray crystallography,physical interaction,two hybrid array,two hybrid pooling approach,in vitro,in vivo,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,split luciferase complementation,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
DTNBP1 CCND3 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FAS CCND3 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDK11B CCND3 21988832 24234451 25348397 physical association two hybrid,physical interaction,in vitro,in vivo ComPPI,IntAct
ATF5 CCND3 14525934 15358120 21988832 24234451 25348397 27898060 physical association two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
EIF3K CCND3 14525934 15327989 21988832 24234451 25348397 27898060 physical association anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct,OmniPath
CDK14 CCND3 14525934 17517622 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
CDK3 CCND3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CCND3 RUNX1 14525934 16287839 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
CCND3 MAF1 14525934 16189514 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CCND3 ATP5F1C 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CCND3 AREG 11469683 14525934 24234451 25241761 25348397 physical association experimental interaction detection,physical interaction,in vivo,proximity ligation assay ComPPI,HPRD,IntAct
CCND3 AKAP8 14525934 14641107 25348397 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
CCND3 CDK11A 25348397 N/A physical interaction ComPPI
CCND3 APP 25348397 N/A physical interaction ComPPI
CCND3 MYB 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CCND3 GC 21988832 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
CCND3 CDK1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CCND3 ZNF2 25348397 N/A physical interaction ComPPI
CCND3 KLK5 25348397 N/A physical interaction ComPPI
MAPK4 CCND3 14525934 16360641 25348397 N/A two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid ComPPI,HPRD
POLR3GL CCND3 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CDKN1A CCND3 15232106 16189514 16328436 21988832 23443559 23880157 25241761 25416956 26186194 26496610 27898060 8756624 9716181 inhibition N/A OmniPath
CCND3 CCNE1 16609025 27898060 stimulant N/A OmniPath
CCND3 CDK6 11360184 15232106 16782892 17517622 21516116 23602568 25416956 26186194 27898060 8114739 9716181 stimulant N/A OmniPath
CDKN1B CCND3 10342870 10597239 11360184 16189514 16328436 16782892 23718855 26186194 27898060 8978686 9716181 inhibition N/A OmniPath
CCND3 CDK4 10342870 11360184 11896535 14641107 15232106 16189514 16782892 16985050 17517622 19237555 21516116 21988832 23880157 25416956 26186194 26496610 27898060 9106657 9716181 stimulant N/A OmniPath
PPP1CA CCND3 16331257 27898060 stimulant N/A OmniPath
MAPK11 CCND3 15252116 15326477 16331257 22885699 27898060 N/A N/A OmniPath
GSK3B CCND3 15252116 15326477 16331257 27898060 inhibition N/A OmniPath

Visualization










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