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GENE：DDIT4

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol DDIT4
FullNmae DNA damage inducible transcript 4
LocusType gene with protein product
Status Approved
HGNC_id HGNC:24944
EnsembleID ENSG00000168209
Uniprot Q9NX09

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
DDIT4 parthanatos 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DDIT4 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DDIT4 apoptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
DDIT4 apoptosis 36341760 The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. regulator signature

Go Annotation:

GeneSymbol Go id
DDIT4 GO:0001666,GO:0001666,GO:0001764,GO:0005515,GO:0005737,GO:0005739,GO:0005829,GO:0005829,GO:0006915,GO:0007420,GO:0030182,GO:0032007,GO:0032007,GO:0032984,GO:0035556,GO:0042771,GO:0045820,GO:0048011,GO:0051607,GO:0071549,GO:0071889,GO:0072593

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
DDIT4 hsa:54541 path:hsa04140 Autophagy - animal - Homo sapiens (human)
DDIT4 hsa:54541 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
DDIT4 hsa:54541 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
DDIT4 hsa:54541 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
HIF1A DDIT4 10102273 10428030 10428780 10435632 10804084 10823814 11557773 11559532 11744734 11756417 11884613 12402042 12676992 12743597 14672622 14684737 14699081 14762718 15024076 15059920 15199147 15240700 15312748 15369676 15379897 15545625 16110315 16126909 16127144 16517405 16517406 16585195 16782875 16888645 17143338 17418790 17533374 17785433 18054315 18056423 18158893 18718909 19211554 20028863 20427344 20535745 20855962 21051947 21765015 22006996 22841746 22850421 22988108 24006507 25043024 25103413 25732824 26192618 7493931 7500013 7508926 8089148 8702901 8955077 9486205 9525945 9707622 interaction type N/A ACSN
DDIT4 TSC1 18198340 19557001 26192618 interaction type N/A ACSN
DDIT4 TSC2 18198340 19557001 26192618 interaction type N/A ACSN
CUL4A DDIT4 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143 26192618 interaction type N/A ACSN
DDB1 DDIT4 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143 26192618 interaction type N/A ACSN
RBX1 DDIT4 11900249 12648680 12820959 15071497 15340381 15459660 15688063 1570337 15703371 16697054 17884153 18931676 19270156 19557001 19622404 19686080 19809470 19847258 20211143 26192618 interaction type N/A ACSN
DDIT4 CAB39 26192618 interaction type N/A ACSN
DDIT4 STK11 26192618 interaction type N/A ACSN
DDIT4 STRADA 26192618 interaction type N/A ACSN

Source Target Pmid Interactiontype Methods Database
ETS1 DDIT4 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 DDIT4 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 DDIT4 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
HIF1A DDIT4 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
FOXP3 DDIT4 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 DDIT4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA DDIT4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF DDIT4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 DDIT4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 DDIT4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 DDIT4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 DDIT4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS DDIT4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A DDIT4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF DDIT4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 DDIT4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 DDIT4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR DDIT4 18971253 21123297 trascriptional regulation,stimulation inferred by curator TFlink
TP53 DDIT4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 DDIT4 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ATF4 DDIT4 19059405 19439225 trascriptional regulation,stimulation inferred by curator TFlink
SP1 DDIT4 N/A trascriptional regulation,stimulation inferred by curator TFlink
TP63 DDIT4 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000170CF4 DDIT4 20018759 rna interference,inhibition array technology,experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS0000170CF4 DDIT4 20018759 20371350 25416803 mrna cleavage,inhibition array technology,experimental interaction detection,nucleotide sequence identification,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00003D5391 DDIT4 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000C5969 DDIT4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000018C928 DDIT4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000236310 DDIT4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS0000215483 DDIT4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00000C85B2 DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002FC5B0 DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000B989F DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001A7F58 DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000039A25B DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000008AA34 DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000AD02D DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003A8BB2 DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000080D0A DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000496C56 DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000319E1 DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000037B2E0 DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000118224 DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00004283FE DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075AEA5 DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000075B13F DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000029EBD DDIT4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00000F7766 DDIT4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000096022 DDIT4 21572407 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000153377 DDIT4 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS000012A1DD DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000171525 DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000055BBE5 DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00005E1A16 DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000140295 DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000237AF9 DDIT4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000040EC3B DDIT4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004CCA62 DDIT4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000003ABC4 DDIT4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004AF715 DDIT4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003E226A DDIT4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00003ACE11 DDIT4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000272039 DDIT4 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000005A8ED DDIT4 20371350 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00000FFC8B DDIT4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00002D0FC3 DDIT4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS00004F24A9 DDIT4 21572407 25416803 mrna cleavage,inhibition clip TarBase
URS000075D2F5 DDIT4 20371350 25416803 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
DDB1 DDIT4 25361965 interaction type N/A PTMCode2
DDIT4 DDB1 25361965 interaction type N/A PTMCode2
DDIT4 YWHAB 25361965 interaction type N/A PTMCode2
YWHAB DDIT4 25361965 interaction type N/A PTMCode2
DDIT4 CUL4A 25361965 interaction type N/A PTMCode2
CUL4A DDIT4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
TXNIP DDIT4 21460850 25348397 27898060 N/A physical interaction ComPPI,OmniPath
GSK3B DDIT4 25348397 N/A physical interaction ComPPI
YWHAB DDIT4 25348397 N/A physical interaction ComPPI
YWHAZ DDIT4 18198340 24234451 25348397 association pull down,physical interaction ComPPI,IntAct
UBC DDIT4 19557001 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
BTRC DDIT4 19557001 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PDPK1 DDIT4 21900206 24234451 25348397 physical association two hybrid,physical interaction ComPPI,IntAct
HUWE1 DDIT4 25348397 N/A physical interaction ComPPI
CUL4A DDIT4 19557001 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
HSPA4 DDIT4 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
PRKN DDIT4 25348397 N/A physical interaction ComPPI
NEDD4 DDIT4 25348397 N/A physical interaction ComPPI
LRIF1 DDIT4 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
DDIT4 DDB1 19557001 24234451 25348397 association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
DDIT4 HSPB2 24234451 25348397 26465331 physical association two hybrid,physical interaction ComPPI,IntAct
DDIT4 RIF1 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
DDIT4 PLCG1 19557001 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
DDIT4 LRRK2 24234451 25348397 29513927 N/A protein array ComPPI,IntAct
TP53 DDIT4 18431400 27898060 stimulant N/A OmniPath

Visualization










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