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GENE：MMP13

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol MMP13
FullNmae matrix metallopeptidase 13
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7159
EnsembleID ENSG00000137745
Uniprot P45452

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
MMP13 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
MMP13 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
MMP13 GO:0001958,GO:0003417,GO:0004175,GO:0004222,GO:0004222,GO:0004222,GO:0004252,GO:0005509,GO:0005518,GO:0005576,GO:0005615,GO:0006508,GO:0008270,GO:0022617,GO:0022617,GO:0030198,GO:0030282,GO:0030574,GO:0030574,GO:0030574,GO:0031012,GO:0060349,GO:1904645

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
MMP13 hsa:4322 path:hsa04657 IL-17 signaling pathway - Homo sapiens (human)
MMP13 hsa:4322 path:hsa04926 Relaxin signaling pathway - Homo sapiens (human)
MMP13 hsa:4322 path:hsa04928 Parathyroid hormone synthesis, secretion and action - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ITGA11 MMP13 17420280 17600088 19913614 20129924 25076207 26148229 26192618 interaction type N/A ACSN
MMP13 LTBP1 21900405 26192618 interaction type N/A ACSN
MMP13 TGFB1 21900405 26192618 interaction type N/A ACSN
FOXO3 MMP13 10048576 16079281 16288288 16556862 17646672 19564415 22439866 26192618 8844971 interaction type N/A ACSN
MMP13 MMP13 26192618 interaction type N/A ACSN
MMP13 COL2A1 21900405 26192618 interaction type N/A ACSN
CREB1 MMP13 19815709 26192618 interaction type N/A ACSN
CXCL8 MMP13 17375198 23180781 protein cleavage protease assay InnateDB
MMP13 JUN 11689447 23180781 physical association anti tag coimmunoprecipitation InnateDB
FOS MMP13 11689447 23180781 physical association anti tag coimmunoprecipitation InnateDB
NR3C1 MMP13 11689447 23180781 physical association anti tag coimmunoprecipitation InnateDB
NCOA2 MMP13 11689447 23180781 physical association anti tag coimmunoprecipitation InnateDB
MMP13 CEBPB 19248099 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
CEBPB MMP13 19248099 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MAF MMP13 20067416 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
YBX1 MMP13 17822788 trascriptional regulation,stimulation affinity chromatography technology,inferred by curator,chromatin immunoprecipitation assay TFlink
RUNX1 MMP13 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 MMP13 18971253 22270366 trascriptional regulation,stimulation inferred by curator TFlink
JUN MMP13 18971253 20338993 trascriptional regulation,stimulation inferred by curator TFlink
TBP MMP13 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF MMP13 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 MMP13 18971253 trascriptional regulation,stimulation inferred by curator TFlink
PRDM14 MMP13 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CITED2 MMP13 12960175 trascriptional regulation,stimulation inferred by curator TFlink
ESR1 MMP13 19185056 trascriptional regulation,stimulation inferred by curator TFlink
HDAC4 MMP13 17656568 19423655 trascriptional regulation,stimulation inferred by curator TFlink
HDAC9 MMP13 18054336 trascriptional regulation,stimulation inferred by curator TFlink
ING2 MMP13 19437536 trascriptional regulation,stimulation inferred by curator TFlink
NFKB1 MMP13 12734180 19022820 trascriptional regulation,stimulation inferred by curator TFlink
RELA MMP13 12734180 19022820 trascriptional regulation,stimulation inferred by curator TFlink
RUNX2 MMP13 15564063 trascriptional regulation,stimulation inferred by curator TFlink
STAT1 MMP13 17179173 trascriptional regulation,stimulation inferred by curator TFlink
ETV4 MMP13 N/A trascriptional regulation,stimulation inferred by curator TFlink
FOS MMP13 N/A trascriptional regulation,stimulation inferred by curator TFlink
SMAD3 MMP13 N/A trascriptional regulation,stimulation inferred by curator TFlink
TP53 MMP13 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001A405B MMP13 19396866 rna interference,inhibition array technology,western blot,quantitative reverse transcription pcr miRSponge
URS0000008A99 MMP13 21427707 rna interference,inhibition array technology,western blot miRSponge
URS0000330617 MMP13 20131257 rna interference,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00001A405B MMP13 19396866 25416803 mrna cleavage,inhibition array technology,western blot,quantitative reverse transcription pcr TarBase
URS0000330617 MMP13 20131257 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00000821E0 MMP13 17875710 19948051 25416803 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr TarBase
URS00001B341F MMP13 19948051 25416803 mrna cleavage,inhibition quantitative reverse transcription pcr TarBase
URS0000008A99 MMP13 21427707 23732700 25416803 mrna cleavage,inhibition array technology,western blot,miRNA interference luciferase reporter assay TarBase
URS0000028BB8 MMP13 17612493 25416803 mrna cleavage,inhibition array technology TarBase
URS0000007340 MMP13 23762330 25416803 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
MMP13 TIMP3 25361965 interaction type N/A PTMCode2
TIMP3 MMP13 25361965 interaction type N/A PTMCode2
MMP13 ADAMTS5 25361965 interaction type N/A PTMCode2
ADAMTS5 MMP13 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
MMP14 MMP13 14525934 25348397 8663255 N/A experimental interaction detection,in vivo ComPPI,HPRD
LRP1 MMP13 10514495 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
MMP13 TIMP3 14525934 25348397 9065415 N/A experimental interaction detection,in vitro ComPPI,HPRD
MMP13 F12 10930399 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
MMP13 BCAN 10986281 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
MMP13 ADAMTS5 11032846 14525934 25348397 27898060 N/A experimental interaction detection,in vitro ComPPI,HPRD,OmniPath
MMP13 COL2A1 14525934 25348397 8609233 N/A experimental interaction detection,in vitro ComPPI,HPRD
CCL7 MMP13 25348397 N/A in vitro,in vivo ComPPI
MMP13 MMP13 10074939 14525934 N/A experimental interaction detection HPRD
MMP14 MMP13 27898060 8663255 N/A N/A OmniPath
MMP13 CXCL8 17375198 27898060 N/A N/A OmniPath
MMP13 CCL7 10947989 12149192 27898060 N/A N/A OmniPath

Visualization










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