Gene Information gene info

GENE:FLOT1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol FLOT1
FullNmae flotillin 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3757
EnsembleID ENSG00000137312
Uniprot O75955

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
FLOT1 pyroptosis 36697954 Mechanically, FLOT1 knockdown triggered apoptosis and pyroptosis. retulator signature
FLOT1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
FLOT1 GO:0001819,GO:0001931,GO:0001934,GO:0002020,GO:0002090,GO:0002090,GO:0005515,GO:0005765,GO:0005768,GO:0005769,GO:0005815,GO:0005886,GO:0005886,GO:0005886,GO:0005886,GO:0005901,GO:0005911,GO:0005912,GO:0005925,GO:0007409,GO:0009897,GO:0016020,GO:0016323,GO:0016600,GO:0016600,GO:0022617,GO:0030027,GO:0030864,GO:0031410,GO:0031410,GO:0032092,GO:0032226,GO:0032728,GO:0033227,GO:0034116,GO:0034141,GO:0034451,GO:0034976,GO:0035023,GO:0035255,GO:0042383,GO:0042470,GO:0044291,GO:0044854,GO:0044857,GO:0045121,GO:0045807,GO:0045807,GO:0048643,GO:0048786,GO:0050821,GO:0051092,GO:0051580,GO:0051580,GO:0070062,GO:0070528,GO:0070528,GO:0071360,GO:0072659,GO:0072659,GO:0098691,GO:0098691,GO:0098978,GO:0098982,GO:1901741,GO:1901890,GO:1901890,GO:2000049,GO:2000049

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
FLOT1 hsa:10211 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
FLOT2 FLOT1 19404397 23180781 physical association anti tag coimmunoprecipitation InnateDB
SELPLG FLOT1 19404397 23180781 physical association anti tag coimmunoprecipitation InnateDB
FLOT1 LCK 17634952 23180781 physical association anti tag coimmunoprecipitation InnateDB
FLOT1 LAT 17634952 23180781 physical association anti tag coimmunoprecipitation InnateDB
ITGAL FLOT1 17634952 23180781 physical association anti tag coimmunoprecipitation InnateDB
CXCR4 FLOT1 17634952 23180781 physical association anti tag coimmunoprecipitation InnateDB
FLOT1 CD48 17634952 23180781 physical association anti tag coimmunoprecipitation InnateDB
FLOT1 PTPRC 17634952 23180781 physical association anti tag coimmunoprecipitation InnateDB
FLOT1 ARG1 17113085 23180781 physical association pull down InnateDB
EED FLOT1 23180781 24457600 physical association anti tag coimmunoprecipitation InnateDB
SRPK1 FLOT1 23180781 23602568 phosphorylation reaction protein kinase assay InnateDB

Source Target Pmid Interactiontype Methods Database
AR FLOT1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
GATA2 FLOT1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TFAP2C FLOT1 20629094 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 FLOT1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 FLOT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA FLOT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF FLOT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 FLOT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 FLOT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETS1 FLOT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A FLOT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 FLOT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 FLOT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 FLOT1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS0000160683 FLOT1 19859982 25416803 mrna cleavage,inhibition array technology,experimental interaction detection TarBase
URS00005651EE FLOT1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003CF1AD FLOT1 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00001CC379 FLOT1 23622248 24886554 25416803 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,clash,miRNA interference luciferase reporter assay TarBase
URS00003AD2AA FLOT1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000170D8B FLOT1 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000006372A FLOT1 25416803 26807169 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004AE8D3 FLOT1 25416803 25793370 mrna cleavage,inhibition quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
SRC FLOT1 22135298 phosphorylation N/A PhosphoSite
FYN FLOT1 22135298 phosphorylation N/A PhosphoSite
CAV1 FLOT1 25361965 interaction type N/A PTMCode2
FLOT1 CAV1 25361965 interaction type N/A PTMCode2
SORBS2 FLOT1 25361965 interaction type N/A PTMCode2
FLOT1 SORBS2 25361965 interaction type N/A PTMCode2
APP FLOT1 25361965 interaction type N/A PTMCode2
FLOT1 APP 25361965 interaction type N/A PTMCode2
SORBS3 FLOT1 25361965 interaction type N/A PTMCode2
FLOT1 SORBS3 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
FAM90A1 FLOT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
YES1 FLOT1 25348397 N/A physical interaction ComPPI
COX5B FLOT1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SORBS3 FLOT1 25348397 N/A physical interaction ComPPI
VAMP2 FLOT1 25348397 N/A physical interaction ComPPI
SGTB FLOT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
VIM FLOT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
NGB FLOT1 14525934 15120622 25348397 27898060 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,two hybrid ComPPI,HPRD,OmniPath
RPS15 FLOT1 25348397 N/A physical interaction ComPPI
BBS2 FLOT1 18000879 24234451 25348397 colocalization,physical association two hybrid,confocal microscopy ComPPI,IntAct
CBL FLOT1 25348397 N/A physical interaction ComPPI
COPS5 FLOT1 18850735 24234451 25348397 association tandem affinity purification ComPPI,IntAct
SORBS1 FLOT1 11481476 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
FRS2 FLOT1 25348397 N/A physical interaction ComPPI
FLNA FLOT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
U2AF2 FLOT1 25348397 N/A physical interaction ComPPI
VAPA FLOT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
RAB7A FLOT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
UBC FLOT1 25348397 N/A physical interaction ComPPI
PDGFRA FLOT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
PICALM FLOT1 25348397 N/A physical interaction ComPPI
CANX FLOT1 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CDH1 FLOT1 25348397 N/A physical interaction ComPPI
YBX1 FLOT1 25348397 N/A physical interaction ComPPI
PTPN1 FLOT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CAV1 FLOT1 10212252 22936677 24234451 25204797 25348397 27898060 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct,OmniPath
GORASP2 FLOT1 25348397 N/A physical interaction ComPPI
SORBS2 FLOT1 14525934 15128873 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
PDHA1 FLOT1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
RAB2A FLOT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AQP1 FLOT1 23219802 24234451 25348397 association cross-linking study ComPPI,IntAct
ATP6AP2 FLOT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ARG1 FLOT1 14525934 17113085 24234451 25348397 N/A experimental interaction detection,pull down,in vitro ComPPI,HPRD,IntAct
ABCE1 FLOT1 25348397 N/A physical interaction ComPPI
SRPK1 FLOT1 23602568 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay ComPPI,IntAct
OCRL FLOT1 24234451 25107275 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
CA9 FLOT1 25348397 N/A physical interaction ComPPI
ATP6V1B1 FLOT1 25348397 N/A physical interaction ComPPI
VCAM1 FLOT1 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
EED FLOT1 25348397 N/A physical interaction ComPPI
CERS2 FLOT1 25348397 N/A physical interaction ComPPI
ATP2B4 FLOT1 23219802 24234451 25348397 association cross-linking study ComPPI,IntAct
FYN FLOT1 11598189 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CUL7 FLOT1 25348397 N/A physical interaction ComPPI
H3C1 FLOT1 25348397 N/A physical interaction ComPPI
PSMD4 FLOT1 18164080 25348397 27898060 N/A physical interaction ComPPI,OmniPath
SLC4A1 FLOT1 23219802 24234451 25348397 association cross-linking study ComPPI,IntAct
SVIL FLOT1 12202484 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
ABCA1 FLOT1 15469992 24234451 25348397 colocalization,physical association anti bait coimmunoprecipitation,cosedimentation through density gradient,physical interaction ComPPI,IntAct
PTRH2 FLOT1 25348397 N/A physical interaction ComPPI
BBS4 FLOT1 18000879 24234451 25348397 colocalization,physical association two hybrid,confocal microscopy ComPPI,IntAct
BACE1 FLOT1 24234451 24612608 25348397 physical association proximity ligation assay ComPPI,IntAct
S100A10 FLOT1 25348397 N/A physical interaction ComPPI
ATP6V1A FLOT1 21674799 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
SYNPO FLOT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
AURKB FLOT1 25348397 N/A physical interaction ComPPI
LAMTOR2 FLOT1 25348397 N/A physical interaction ComPPI
INCENP FLOT1 25348397 N/A physical interaction ComPPI
GNG12 FLOT1 25348397 N/A physical interaction ComPPI
LNX1 FLOT1 25348397 N/A physical interaction ComPPI
RAB5C FLOT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLOT1 GOLM1 14525934 16169070 24234451 25348397 physical association two hybrid,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
FLOT1 FLOT2 14525934 17113085 24167781 24234451 24809731 25348397 30021884 colocalization,physical association cross-linking study,experimental interaction detection,far western blotting,physical interaction,fluorescence microscopy,in vitro,confocal microscopy,proximity ligation assay ComPPI,HPRD,IntAct
FLOT1 UBXN6 25348397 N/A physical interaction ComPPI
FLOT1 ERLIN2 25348397 N/A physical interaction ComPPI
FLOT1 SLC12A4 25348397 N/A physical interaction ComPPI
FLOT1 SLC38A2 25348397 N/A physical interaction ComPPI
FLOT1 ACAT1 25348397 N/A physical interaction ComPPI
FLOT1 NDUFS6 25348397 N/A physical interaction ComPPI
FLOT1 SEL1L 25348397 N/A physical interaction ComPPI
FLOT1 NPLOC4 25348397 N/A physical interaction ComPPI
FLOT1 SLC25A11 25348397 N/A physical interaction ComPPI
FLOT1 HM13 25348397 N/A physical interaction ComPPI
FLOT1 MRPS5 25348397 N/A physical interaction ComPPI
FLOT1 MRPL58 25348397 N/A physical interaction ComPPI
FLOT1 MRPL55 25348397 N/A physical interaction ComPPI
FLOT1 SLC25A24 25348397 N/A physical interaction ComPPI
FLOT1 OCIAD1 25348397 N/A physical interaction ComPPI
FLOT1 ATP5F1A 25348397 N/A physical interaction ComPPI
FLOT1 ABCC1 25348397 N/A physical interaction ComPPI
FLOT1 MRPS31 25348397 N/A physical interaction ComPPI
FLOT1 TUBA1C 25348397 N/A physical interaction ComPPI
FLOT1 LMAN2 25348397 N/A physical interaction ComPPI
FLOT1 RAB31 25348397 N/A physical interaction ComPPI
FLOT1 MRPL50 25348397 N/A physical interaction ComPPI
FLOT1 MAEA 25348397 N/A physical interaction ComPPI
FLOT1 EMC1 25348397 N/A physical interaction ComPPI
FLOT1 MAN2A1 25348397 N/A physical interaction ComPPI
FLOT1 MRPL38 25348397 N/A physical interaction ComPPI
FLOT1 FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
FLOT1 CAPN10 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
FLOT1 PTOV1 15713644 25348397 27898060 N/A physical interaction ComPPI,OmniPath
FLOT1 OBSL1 25348397 N/A physical interaction ComPPI
FLOT1 CCDC8 25348397 N/A physical interaction ComPPI
FLOT1 OFD1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
FLOT1 FBF1 24234451 25348397 26638075 association physical interaction,proximity-dependent biotin identification ComPPI,IntAct
FLOT1 CAPZA2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLOT1 DBN1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLOT1 MYH9 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLOT1 MYEF2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLOT1 GOLT1B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLOT1 LIMA1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLOT1 TMEM63B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLOT1 MYO19 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLOT1 MMGT1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLOT1 CHMP4B 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
FLOT1 COX15 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
FLOT1 DLST 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
FLOT1 BBS1 18000879 24234451 25348397 colocalization,physical association two hybrid,confocal microscopy ComPPI,IntAct
FLOT1 BBS7 18000879 24234451 25348397 colocalization,physical association two hybrid,confocal microscopy ComPPI,IntAct
FLOT1 APP 14525934 16480949 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,two hybrid ComPPI,HPRD,IntAct,OmniPath
FLOT1 SLC25A5 24234451 24983503 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
FLOT1 CYC1 24234451 24983503 25348397 colocalization cosedimentation through density gradient ComPPI,IntAct
FLOT1 NME7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FLOT1 CCDC102B 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
FLOT1 PLEKHA7 24234451 25348397 28877994 association anti bait coimmunoprecipitation ComPPI,IntAct
FLOT1 ALDOA 23219802 24234451 25348397 association cross-linking study ComPPI,IntAct
SHBG FLOT1 14525934 15862967 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
ILVBL FLOT1 25348397 N/A physical interaction ComPPI
ECPAS FLOT1 25348397 N/A physical interaction ComPPI
FAM3C FLOT1 25348397 N/A physical interaction ComPPI
PCLO FLOT1 24234451 30021884 physical association cross-linking study IntAct
MYH15 FLOT1 24234451 30021884 physical association cross-linking study IntAct
L1TD1 FLOT1 24234451 25702638 association anti bait coimmunoprecipitation IntAct
SRC FLOT1 24983503 27898060 N/A N/A OmniPath
FYN FLOT1 11598189 19258392 27898060 N/A N/A OmniPath
FLOT1 CXCR4 17634952 27898060 N/A N/A OmniPath

Visualization