Gene Information gene info

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GENE：IER3

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IER3
FullNmae immediate early response 3
LocusType gene with protein product
Status Approved
HGNC_id HGNC:5392
EnsembleID ENSG00000137331
Uniprot P46695

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IER3 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
IER3 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IER3 GO:0001562,GO:0003085,GO:0005515,GO:0005634,GO:0005634,GO:0005739,GO:0005829,GO:0006096,GO:0006282,GO:0006915,GO:0006974,GO:0007095,GO:0008630,GO:0009653,GO:0016020,GO:0043066,GO:0045732,GO:0045820,GO:0046822,GO:0050728,GO:1901029,GO:2000377

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
MAPK3 IER3 12356731 23180781 physical association anti tag coimmunoprecipitation,pull down InnateDB
MAPK1 IER3 12356731 23180781 physical association pull down InnateDB
APP IER3 21832049 23180781 physical association protein array InnateDB

Source Target Pmid Interactiontype Methods Database
AR IER3 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 IER3 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 IER3 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA1 IER3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 IER3 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
MYC IER3 12360408 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
NFKB1 IER3 12360408 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
REL IER3 12360408 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
RELA IER3 12360408 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
TP53 IER3 12360408 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 IER3 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 IER3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IER3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IER3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 IER3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF IER3 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HOXA1 IER3 17213808 trascriptional regulation,stimulation inferred by curator TFlink
SP1 IER3 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000F4AC3 IER3 16822819 25416803 mrna cleavage,inhibition array technology TarBase
URS0000122ED0 IER3 19088304 25416803 mrna cleavage,inhibition array technology TarBase
URS00000600E6 IER3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000042E1F IER3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000019D79B IER3 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000364FEF IER3 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001799A3 IER3 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS0000330617 IER3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00001B341F IER3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000298BA3 IER3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00000DDD35 IER3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002B3783 IER3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS00002075FA IER3 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000079D48 IER3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000041E780 IER3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000052E1A6 IER3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000A9FB9 IER3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000AD002 IER3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000482389 IER3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002E99CB IER3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000008C563 IER3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004214BB IER3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000235862 IER3 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001012BC IER3 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
MAPK1 IER3 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
IER3 MAPK1 25361965 interaction type N/A PTMCode2
MCL1 IER3 25361965 interaction type N/A PTMCode2
IER3 MCL1 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
SGTA IER3 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
MAPK1 IER3 16456541 24234451 25348397 phosphorylation reaction physical interaction,protein kinase assay,in vitro,in vivo ComPPI,IntAct
MAPK3 IER3 25348397 N/A physical interaction,in vitro,in vivo ComPPI
FHL2 IER3 25348397 N/A physical interaction ComPPI
PRNP IER3 18482256 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
BAG6 IER3 15451437 24234451 25348397 physical association two hybrid ComPPI,IntAct
MCL1 IER3 25348397 N/A two hybrid ComPPI
IER3 PPP2R5C 16456541 24234451 25348397 physical association anti tag coimmunoprecipitation,physical interaction,in vitro ComPPI,IntAct
IER3 PPP2R5B 16456541 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down,physical interaction,in vitro ComPPI,IntAct
IER3 PRNP 25348397 N/A physical interaction ComPPI
IER3 PML 25348397 N/A physical interaction ComPPI
IER3 APP 25348397 N/A physical interaction ComPPI
IER3 PTPA 25348397 N/A physical interaction ComPPI
IER3 MDM2 25348397 N/A physical interaction ComPPI
IER3 AQP2 25348397 N/A physical interaction ComPPI
IER3 PPP2CA 16456541 24234451 25348397 physical association anti tag coimmunoprecipitation,pull down ComPPI,IntAct
IER3 TNFSF10 15451437 24234451 25348397 physical association two hybrid ComPPI,IntAct
IER3 RELA 18191642 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down ComPPI,IntAct,OmniPath
IER3 CISD2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IER3 CD79A 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IER3 SLC13A4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IER3 TMBIM6 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IER3 FKBP7 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
IER3 TMX2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CAMLG IER3 15451437 24234451 25348397 physical association anti bait coimmunoprecipitation,two hybrid ComPPI,IntAct
BCL2 IER3 18191642 24234451 association chromatin immunoprecipitation assay IntAct
MAPK6 IER3 12356731 27898060 N/A N/A OmniPath
IER3 MAPK3 12356731 27898060 N/A N/A OmniPath
TP53 IER3 18431400 27898060 inhibition N/A OmniPath
SP1 IER3 11844788 27898060 stimulant N/A OmniPath
MAPK1 IER3 12356731 16456541 27898060 stimulant N/A OmniPath
IER3 MAPK1 12356731 16456541 27898060 stimulant N/A OmniPath
RUNX1 IER3 16368886 27898060 stimulant N/A OmniPath
IER3 PPP2R5C 16456541 27898060 inhibition N/A OmniPath

Visualization










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