GENE:DAG1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | DAG1 |
| FullNmae | dystroglycan 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:2666 |
| EnsembleID | ENSG00000173402 |
| Uniprot | Q14118 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| DAG1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| DAG1 | GO:0001618,GO:0001954,GO:0002009,GO:0002011,GO:0002162,GO:0003007,GO:0003779,GO:0005509,GO:0005515,GO:0005576,GO:0005576,GO:0005604,GO:0005604,GO:0005615,GO:0005615,GO:0005615,GO:0005654,GO:0005737,GO:0005788,GO:0005796,GO:0005829,GO:0005856,GO:0005886,GO:0005886,GO:0005912,GO:0005925,GO:0005925,GO:0006509,GO:0007411,GO:0008307,GO:0009897,GO:0010470,GO:0010717,GO:0014850,GO:0014894,GO:0015031,GO:0015631,GO:0016010,GO:0016011,GO:0016020,GO:0016203,GO:0016323,GO:0016340,GO:0016476,GO:0017166,GO:0021675,GO:0021682,GO:0022011,GO:0030027,GO:0030175,GO:0030336,GO:0031103,GO:0031643,GO:0033268,GO:0034399,GO:0034453,GO:0042169,GO:0042383,GO:0043034,GO:0043231,GO:0043236,GO:0043237,GO:0043403,GO:0043409,GO:0043434,GO:0044853,GO:0044877,GO:0045211,GO:0046718,GO:0048167,GO:0048714,GO:0050807,GO:0051393,GO:0051898,GO:0060055,GO:0060441,GO:0060445,GO:0062023,GO:0070062,GO:0070938,GO:0071260,GO:0071397,GO:0071679,GO:0071711,GO:0098684,GO:0098696,GO:0098942,GO:0098978,GO:0098982,GO:0099524,GO:1904261 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| DAG1 | hsa:1605 | path:hsa04512 | ECM-receptor interaction - Homo sapiens (human) |
| DAG1 | hsa:1605 | path:hsa05410 | Hypertrophic cardiomyopathy - Homo sapiens (human) |
| DAG1 | hsa:1605 | path:hsa05412 | Arrhythmogenic right ventricular cardiomyopathy - Homo sapiens (human) |
| DAG1 | hsa:1605 | path:hsa05414 | Dilated cardiomyopathy - Homo sapiens (human) |
| DAG1 | hsa:1605 | path:hsa05416 | Viral myocarditis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | DAG1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | DAG1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | DAG1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| TFAP2C | DAG1 | 20629094 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | DAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | DAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | DAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | DAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | DAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXP1 | DAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | DAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | DAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | DAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | DAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | DAG1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000076995 | DAG1 | 21169019 25416803 | mrna cleavage,inhibition | quantitative reverse transcription pcr | TarBase |
| URS0000338542 | DAG1 | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS0000065D58 | DAG1 | 18668040 25416803 | mrna cleavage,inhibition | experimental interaction detection | TarBase |
| URS00000BE495 | DAG1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS000035CC3E | DAG1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS0000153377 | DAG1 | 23622248 25416803 | mrna cleavage,inhibition | clash | TarBase |
| URS00001E0AEA | DAG1 | 22473208 25416803 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| NCK1 | DAG1 | 25361965 | interaction type | N/A | PTMCode2 |
| DAG1 | NCK1 | 25361965 | interaction type | N/A | PTMCode2 |
| LAMA5 | DAG1 | 25361965 | interaction type | N/A | PTMCode2 |
| DAG1 | LAMA5 | 25361965 | interaction type | N/A | PTMCode2 |
| DAG1 | BGN | 25361965 | interaction type | N/A | PTMCode2 |
| BGN | DAG1 | 25361965 | interaction type | N/A | PTMCode2 |
| DAG1 | SGCD | 25361965 | interaction type | N/A | PTMCode2 |
| SGCD | DAG1 | 25361965 | interaction type | N/A | PTMCode2 |
| DAG1 | GRB2 | 25361965 | interaction type | N/A | PTMCode2 |
| GRB2 | DAG1 | 25361965 | interaction type | N/A | PTMCode2 |
| DAG1 | CAV1 | 25361965 | interaction type | N/A | PTMCode2 |
| CAV1 | DAG1 | 25361965 | interaction type | N/A | PTMCode2 |
| DAG1 | SRC | 25361965 | interaction type | N/A | PTMCode2 |
| SRC | DAG1 | 25361965 | interaction type | N/A | PTMCode2 |
| DAG1 | DMD | 25361965 | interaction type | N/A | PTMCode2 |
| DMD | DAG1 | 25361965 | interaction type | N/A | PTMCode2 |
| DAG1 | FYN | 25361965 | interaction type | N/A | PTMCode2 |
| FYN | DAG1 | 25361965 | interaction type | N/A | PTMCode2 |
| DAG1 | AGRN | 25361965 | interaction type | N/A | PTMCode2 |
| AGRN | DAG1 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| SH3KBP1 | DAG1 | 25348397 | N/A | physical interaction | ComPPI |
| AGR3 | DAG1 | 25348397 | N/A | two hybrid,physical interaction | ComPPI |
| AGR2 | DAG1 | 25348397 | N/A | physical interaction | ComPPI |
| PPP1CB | DAG1 | 25348397 | N/A | physical interaction | ComPPI |
| LGALS9C | DAG1 | 25348397 | N/A | physical interaction | ComPPI |
| PIK3R1 | DAG1 | 17474147 24234451 25348397 | physical association | peptide array | ComPPI,IntAct |
| SRC | DAG1 | 17474147 24234451 25348397 | physical association | peptide array,physical interaction,in vitro,in vivo | ComPPI,IntAct |
| SHC1 | DAG1 | 25348397 | N/A | physical interaction,in vivo | ComPPI |
| NCK1 | DAG1 | 17474147 24234451 25348397 | physical association | peptide array,physical interaction | ComPPI,IntAct |
| GRB2 | DAG1 | 10903901 17474147 24234451 25348397 27898060 7744812 | physical association | peptide array,physical interaction,in vitro,in vivo | ComPPI,IntAct,OmniPath |
| ITGB1 | DAG1 | 25348397 | N/A | physical interaction | ComPPI |
| WWP1 | DAG1 | 25348397 | N/A | in vitro | ComPPI |
| ACTN1 | DAG1 | 25348397 | N/A | physical interaction | ComPPI |
| BGN | DAG1 | 25348397 | N/A | in vitro,in vivo | ComPPI |
| CDH1 | DAG1 | 25348397 | N/A | physical interaction | ComPPI |
| CDH5 | DAG1 | 25348397 | N/A | physical interaction | ComPPI |
| WWP2 | DAG1 | 25348397 | N/A | in vitro | ComPPI |
| TLN1 | DAG1 | 25348397 | N/A | physical interaction | ComPPI |
| MAGI1 | DAG1 | 25348397 | N/A | in vitro | ComPPI |
| CAV1 | DAG1 | 25348397 | N/A | physical interaction | ComPPI |
| MAP2 | DAG1 | 25348397 | N/A | physical interaction | ComPPI |
| VCL | DAG1 | 25348397 | N/A | physical interaction | ComPPI |
| WWC1 | DAG1 | 25348397 | N/A | physical interaction | ComPPI |
| TNF | DAG1 | 25348397 | N/A | physical interaction | ComPPI |
| UTRN | DAG1 | 10767429 10769203 24234451 25348397 27898060 | association | cross-linking study,phage display,pull down,physical interaction,in vitro | ComPPI,IntAct,OmniPath |
| CSK | DAG1 | 25348397 | N/A | physical interaction | ComPPI |
| CAV3 | DAG1 | 10988290 25348397 27898060 | N/A | physical interaction,in vitro,in vivo | ComPPI,OmniPath |
| DAG1 | LAMA1 | 25348397 | N/A | in vitro,in vivo | ComPPI |
| DAG1 | LAMA2 | 25348397 | N/A | physical interaction,in vitro,in vivo | ComPPI |
| DAG1 | DRP2 | 25348397 | N/A | two hybrid,physical interaction,in vivo | ComPPI |
| DAG1 | LAMA5 | 24234451 25348397 | association | cross-linking study,physical interaction,in vitro | ComPPI,IntAct |
| DAG1 | RAPSN | 11342559 25348397 27898060 7619516 | N/A | physical interaction,in vitro,in vivo | ComPPI,OmniPath |
| DAG1 | DMD | 10355629 10932245 22937058 24234451 25348397 27898060 7592992 | N/A | pull down,x-ray crystallography,physical interaction | ComPPI,IntAct,OmniPath |
| DAG1 | PRX | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | FYN | 17474147 24234451 25348397 | physical association | peptide array,physical interaction | ComPPI,IntAct |
| DAG1 | AGRN | 24234451 25348397 | association | cross-linking study,physical interaction | ComPPI,IntAct |
| DAG1 | TUBA1A | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | PTK2 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | ELAVL1 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | CORO7 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | HLA-DPA1 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | CEACAM21 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | LGALS8 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | LGALS9 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | GINM1 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | HTR3C | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | CLIC4 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | DNAJB1 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | VPS45 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | PCDHGA5 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | PCDHGB4 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | TCTN2 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | PCDHB11 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | PCDHAC2 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | FKBP9 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | TNFSF8 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | IL13RA2 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | TRIM25 | 25348397 | N/A | physical interaction | ComPPI |
| DAG1 | NCSTN | 18942891 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| DAG1 | PSEN1 | 18942891 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| DAG1 | LAMP1 | 24234451 25348397 29568061 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| DAG1 | DAG1 | 11423118 24234451 | N/A | x-ray crystallography,enzyme linked immunosorbent assay | IntAct |
| DAG1 | HSPA5 | 24234451 | association | cross-linking study | IntAct |
| DAG1 | CAT | 24234451 | association | cross-linking study | IntAct |
| DAG1 | LCP1 | 24234451 | association | cross-linking study | IntAct |
| DAG1 | SGCB | 24234451 | association | cross-linking study | IntAct |
| DAG1 | PSMB2 | 24234451 | association | cross-linking study | IntAct |
| DAG1 | RBBP4 | 24234451 | association | cross-linking study | IntAct |
| DAG1 | POF1B | 24234451 | association | cross-linking study | IntAct |
| DAG1 | TPI1 | 24234451 | association | cross-linking study | IntAct |
| DAG1 | GPC1 | 24234451 | association | cross-linking study | IntAct |
| DAG1 | SLC3A2 | 24234451 | association | cross-linking study | IntAct |
| DAG1 | SGCD | 24234451 | association | cross-linking study | IntAct |
| DAG1 | SGCE | 24234451 | association | cross-linking study | IntAct |
| DAG1 | MDH1 | 24234451 | association | cross-linking study | IntAct |
| DAG1 | H4C1 | 24234451 | association | cross-linking study | IntAct |
| DAG1 | RPIA | 24234451 | association | cross-linking study | IntAct |
| DAG1 | ABCC4 | 24234451 | association | cross-linking study | IntAct |
| DAG1 | GOT1 | 24234451 | association | cross-linking study | IntAct |
| DAG1 | GOT2 | 24234451 | association | cross-linking study | IntAct |
| DAG1 | PSMA2 | 24234451 | association | cross-linking study | IntAct |
| DAG1 | PSMB4 | 24234451 | association | cross-linking study | IntAct |
| DAG1 | LGALS7 | 24234451 | association | cross-linking study | IntAct |
| DAG1 | LAMB1 | 24234451 | association | cross-linking study | IntAct |
| DAG1 | AZGP1 | 24234451 | association | cross-linking study | IntAct |
| DAG1 | DTNB | 24234451 | association | cross-linking study | IntAct |
| DAG1 | HARS1 | 24234451 | association | cross-linking study | IntAct |
| DAG1 | UBR7 | 24234451 | association | cross-linking study | IntAct |
| DAG1 | KIDINS220 | 24234451 | association | cross-linking study | IntAct |
| DAG1 | PDIA4 | 24234451 | association | cross-linking study | IntAct |
| DAG1 | SNTB2 | 24234451 | association | cross-linking study | IntAct |
| SRC | DAG1 | 11724572 12795607 17474147 27898060 | inhibition,stimulant | N/A | OmniPath |
