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GENE：CDKN2C

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol CDKN2C
FullNmae cyclin dependent kinase inhibitor 2C
LocusType gene with protein product
Status Approved
HGNC_id HGNC:1789
EnsembleID ENSG00000123080
Uniprot P42773

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
CDKN2C mitotic_cd 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
CDKN2C autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
CDKN2C GO:0000079,GO:0000079,GO:0004861,GO:0004861,GO:0005515,GO:0005634,GO:0005634,GO:0005737,GO:0005737,GO:0005829,GO:0007049,GO:0008285,GO:0008285,GO:0019901,GO:0019901,GO:0030308,GO:0042326,GO:0048709,GO:0072089,GO:2000045,GO:2000045,GO:2000647

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
CDKN2C hsa:1031 path:hsa01522 Endocrine resistance - Homo sapiens (human)
CDKN2C hsa:1031 path:hsa04110 Cell cycle - Homo sapiens (human)
CDKN2C hsa:1031 path:hsa04934 Cushing syndrome - Homo sapiens (human)
CDKN2C hsa:1031 path:hsa05166 Human T-cell leukemia virus 1 infection - Homo sapiens (human)
CDKN2C hsa:1031 path:hsa05202 Transcriptional misregulation in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR CDKN2C 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 CDKN2C 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 CDKN2C 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
PRDM14 CDKN2C 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 CDKN2C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA CDKN2C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF CDKN2C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 CDKN2C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 CDKN2C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A CDKN2C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF CDKN2C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR CDKN2C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 CDKN2C 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MEN1 CDKN2C 10523037 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 CDKN2C N/A trascriptional regulation,stimulation inferred by curator TFlink
E2F2 CDKN2C N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000EED18 CDKN2C 21128241 rna interference,inhibition experimental interaction detection,quantitative reverse transcription pcr miRSponge
URS00000EED18 CDKN2C 21128241 25416803 mrna cleavage,inhibition experimental interaction detection,quantitative reverse transcription pcr TarBase

Source Target Pmid Interactiontype Methods Database
CDKN2C MCM2 25361965 interaction type N/A PTMCode2
MCM2 CDKN2C 25361965 interaction type N/A PTMCode2
CDKN2C CDK6 25361965 interaction type N/A PTMCode2
CDK6 CDKN2C 25361965 interaction type N/A PTMCode2
CDKN2C MCM10 25361965 interaction type N/A PTMCode2
MCM10 CDKN2C 25361965 interaction type N/A PTMCode2
CDC6 CDKN2C 25361965 interaction type N/A PTMCode2
CDKN2C CDC6 25361965 interaction type N/A PTMCode2
CDK4 CDKN2C 25361965 interaction type N/A PTMCode2
CDKN2C CDK4 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
CRX CDKN2C 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
SORBS3 CDKN2C 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2C CDK6 14525934 17353931 18394558 23602568 24234451 25348397 25416956 25910212 27107012 8001816 8840966 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,two hybrid array,in vitro,in vivo,tandem affinity purification,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,split luciferase complementation,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
CDKN2C CDKN2A 25348397 N/A in vitro ComPPI
CDKN2C TLE1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CDKN2C SNU13 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CDKN2C DRAP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CDKN2C UNC119 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CDKN2C RBM48 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CDKN2C LRIF1 14525934 16169070 25348397 N/A two hybrid,physical interaction,two hybrid ComPPI,HPRD
CDKN2C CDK4 14525934 17353931 21988832 23455922 23602568 24234451 25348397 25416956 25910212 27107012 8001816 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,tandem affinity purification,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,split luciferase complementation,validated two hybrid,barcode fusion genetics two hybrid ComPPI,HPRD,IntAct
CDKN2C APLP1 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CDKN2C GDF9 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CDKN2C CCDC90B 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CDKN2C COPS6 14525934 16169070 24234451 25348397 physical association two hybrid,physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CDKN2C QPCTL 25348397 N/A physical interaction ComPPI
CDKN2C TP53 14525934 16169070 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach,two hybrid ComPPI,HPRD,IntAct
CDKN2C ATM 25348397 N/A physical interaction ComPPI
CDKN2C ATR 25348397 N/A physical interaction ComPPI
CDKN2C MAPK8 25348397 N/A physical interaction ComPPI
CDKN2C MAPK10 25348397 N/A physical interaction ComPPI
CDKN2C PPP2CA 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDKN2C LY96 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDKN2C GOPC 21988832 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDKN2C REL 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CDKN2C TCF4 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CDKN2C TCF12 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CDKN2C AHCYL1 24234451 25348397 25416956 25910212 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
CDKN2C NAGK 24234451 25348397 25416956 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,validated two hybrid ComPPI,IntAct
CDKN2C NIF3L1 24234451 25348397 25416956 25910212 physical association physical interaction,two hybrid array,two hybrid prey pooling approach,two hybrid bait and prey pooling approach,validated two hybrid ComPPI,IntAct
CDKN2C ANKRD44 25348397 N/A physical interaction ComPPI
CDKN2C GAS2L1 25348397 N/A physical interaction ComPPI
CDKN2C CCND3 25348397 N/A physical interaction ComPPI
CDKN2C ANGPTL4 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDKN2C GREB1 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDKN2C MTA3 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDKN2C NAT2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDKN2C SCGB2A2 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDKN2C ST14 24234451 25348397 25640309 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
CDKN2C EZH2 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CDKN2C CCND1 25348397 N/A physical interaction ComPPI
CDKN2C CDA 25348397 N/A physical interaction ComPPI
CDKN2C AVP 25348397 N/A physical interaction ComPPI
CDKN2C PROSER2 25348397 N/A physical interaction ComPPI
CDKN2C PYM1 25348397 N/A physical interaction ComPPI
CDKN2C SLX1A 25348397 N/A physical interaction ComPPI
CDKN2C COL20A1 25348397 N/A physical interaction ComPPI
CDKN2C RIF1 16169070 24234451 25348397 physical association two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
CDKN2C LNX2 24234451 25348397 27107012 physical association validated two hybrid,barcode fusion genetics two hybrid ComPPI,IntAct
CDKN2C CTDSP1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2C PBX4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2C KRT31 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2C PLEKHG4 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2C POU6F2 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2C DMBX1 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2C DDIT4L 24234451 25348397 physical association two hybrid,two hybrid array,two hybrid prey pooling approach ComPPI,IntAct
CDKN2C CDK6 11124804 16915296 17353931 18394558 23602568 25416956 26186194 27898060 8001816 8840966 8891723 inhibition,stimulant N/A OmniPath
CDKN2C CDK4 11900540 16915296 17353931 21988832 23455922 23602568 25416956 26186194 27898060 8001816 8891723 inhibition N/A OmniPath
KMT2A CDKN2C 16997566 27898060 stimulant N/A OmniPath

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