GENE：BMP4
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | BMP4 |
| FullNmae | bone morphogenetic protein 4 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:1071 |
| EnsembleID | ENSG00000125378 |
| Uniprot | P12644 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| BMP4 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| BMP4 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| BMP4 | autophagy | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| BMP4 | apoptosis | 30522702 | Bone morphogenetic protein 4 (BMP4) has an important role in regulating cellular proliferation, differentiation and apoptosis. | retulator signature |
| BMP4 | apoptosis | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| BMP4 | GO:0000122,GO:0000122,GO:0001649,GO:0001656,GO:0001657,GO:0001658,GO:0001822,GO:0001823,GO:0001843,GO:0001934,GO:0001938,GO:0001958,GO:0002043,GO:0002062,GO:0002244,GO:0002320,GO:0003007,GO:0003014,GO:0003129,GO:0003139,GO:0003148,GO:0003149,GO:0003163,GO:0003180,GO:0003184,GO:0003197,GO:0003279,GO:0003323,GO:0005125,GO:0005125,GO:0005515,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005615,GO:0005788,GO:0006366,GO:0007281,GO:0007492,GO:0007500,GO:0008083,GO:0008201,GO:0008284,GO:0008284,GO:0008285,GO:0008285,GO:0009791,GO:0009948,GO:0010159,GO:0010453,GO:0010628,GO:0010629,GO:0010718,GO:0021537,GO:0021904,GO:0021978,GO:0021983,GO:0030218,GO:0030224,GO:0030225,GO:0030501,GO:0030509,GO:0030509,GO:0030509,GO:0030509,GO:0030513,GO:0032092,GO:0032331,GO:0032967,GO:0033085,GO:0033088,GO:0035116,GO:0035990,GO:0035993,GO:0036305,GO:0039706,GO:0042056,GO:0042306,GO:0042475,GO:0042476,GO:0042487,GO:0042491,GO:0042733,GO:0043065,GO:0043068,GO:0045603,GO:0045606,GO:0045662,GO:0045666,GO:0045669,GO:0045778,GO:0045786,GO:0045839,GO:0045843,GO:0045892,GO:0045893,GO:0045944,GO:0045944,GO:0045944,GO:0048286,GO:0048392,GO:0048661,GO:0048663,GO:0048701,GO:0048745,GO:0048745,GO:0050679,GO:0050680,GO:0050918,GO:0051145,GO:0051150,GO:0055007,GO:0055020,GO:0060235,GO:0060272,GO:0060363,GO:0060391,GO:0060391,GO:0060395,GO:0060425,GO:0060426,GO:0060433,GO:0060438,GO:0060440,GO:0060441,GO:0060442,GO:0060449,GO:0060502,GO:0060503,GO:0060513,GO:0060592,GO:0060684,GO:0060686,GO:0060687,GO:0060976,GO:0061036,GO:0061047,GO:0061626,GO:0070244,GO:0070374,GO:0070700,GO:0071773,GO:0072104,GO:0072125,GO:0072179,GO:0072197,GO:0072200,GO:0090191,GO:0090194,GO:1900182,GO:1900745,GO:1902894,GO:1904238,GO:1904706,GO:1904753,GO:1905312,GO:1905770,GO:2000005,GO:2000007,GO:2000636,GO:2001237 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| BMP4 | hsa:652 | path:hsa04060 | Cytokine-cytokine receptor interaction - Homo sapiens (human) |
| BMP4 | hsa:652 | path:hsa04350 | TGF-beta signaling pathway - Homo sapiens (human) |
| BMP4 | hsa:652 | path:hsa04390 | Hippo signaling pathway - Homo sapiens (human) |
| BMP4 | hsa:652 | path:hsa04550 | Signaling pathways regulating pluripotency of stem cells - Homo sapiens (human) |
| BMP4 | hsa:652 | path:hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| BMP4 | hsa:652 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| BMP4 | hsa:652 | path:hsa05217 | Basal cell carcinoma - Homo sapiens (human) |
| BMP4 | hsa:652 | path:hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| E2F1 | BMP4 | 12629508 18971253 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| ESR1 | BMP4 | 18414489 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation array,chromatin immunoprecipitation assay | TFlink |
| ETS1 | BMP4 | 15695386 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA3 | BMP4 | 21878914 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXA1 | BMP4 | 18971253 21878914 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| MYC | BMP4 | 12695333 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | BMP4 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| PRDM14 | BMP4 | 18971253 20953172 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| CEBPA | BMP4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | BMP4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F4 | BMP4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | BMP4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | BMP4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | BMP4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | BMP4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TAL1 | BMP4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TP53 | BMP4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXL1 | BMP4 | 17873379 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| POU5F1 | BMP4 | 17068183 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SOX2 | BMP4 | 24477565 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| BMP4 | BMPR1B | 25361965 | interaction type | N/A | PTMCode2 |
| BMPR1B | BMP4 | 25361965 | interaction type | N/A | PTMCode2 |
| BMP4 | FSTL1 | 25361965 | interaction type | N/A | PTMCode2 |
| FSTL1 | BMP4 | 25361965 | interaction type | N/A | PTMCode2 |
| BMP4 | BMPER | 25361965 | interaction type | N/A | PTMCode2 |
| BMPER | BMP4 | 25361965 | interaction type | N/A | PTMCode2 |
| BMP4 | SOSTDC1 | 25361965 | interaction type | N/A | PTMCode2 |
| SOSTDC1 | BMP4 | 25361965 | interaction type | N/A | PTMCode2 |
| BMP4 | GREM2 | 25361965 | interaction type | N/A | PTMCode2 |
| GREM2 | BMP4 | 25361965 | interaction type | N/A | PTMCode2 |
| BMP4 | BGN | 25361965 | interaction type | N/A | PTMCode2 |
| BGN | BMP4 | 25361965 | interaction type | N/A | PTMCode2 |
| BMP4 | NOG | 25361965 | interaction type | N/A | PTMCode2 |
| NOG | BMP4 | 25361965 | interaction type | N/A | PTMCode2 |
| BMP4 | SMAD4 | 25361965 | interaction type | N/A | PTMCode2 |
| SMAD4 | BMP4 | 25361965 | interaction type | N/A | PTMCode2 |
| BMP4 | CTNNB1 | 25361965 | interaction type | N/A | PTMCode2 |
| CTNNB1 | BMP4 | 25361965 | interaction type | N/A | PTMCode2 |
| BMP4 | HTRA1 | 25361965 | interaction type | N/A | PTMCode2 |
| HTRA1 | BMP4 | 25361965 | interaction type | N/A | PTMCode2 |
| BMP4 | BMPR2 | 25361965 | interaction type | N/A | PTMCode2 |
| BMPR2 | BMP4 | 25361965 | interaction type | N/A | PTMCode2 |
| BMPR1A | BMP4 | 25361965 | interaction type | N/A | PTMCode2 |
| BMP4 | BMPR1A | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ZFYVE9 | BMP4 | 14525934 15231748 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,IntAct |
| SUFU | BMP4 | 25348397 | N/A | physical interaction | ComPPI |
| BMP4 | BMPR2 | 14525934 25348397 7644468 8702914 | N/A | coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| BMP4 | BMPR1A | 11241215 14525934 20860622 21054789 24234451 25348397 7644468 8702914 | physical association | experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,surface plasmon resonance array | ComPPI,HPRD,IntAct |
| BMP4 | HTRA1 | 14525934 14973287 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| BMP4 | BMP8B | 10894154 11427739 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| BMP4 | NOG | 10657699 11706034 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| BMP4 | BMPR1B | 11282024 14525934 25348397 7811286 8702914 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| BMP4 | STAP2 | 14525934 25348397 7644468 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| BMP4 | SOSTDC1 | 14525934 15020244 25348397 | N/A | experimental interaction detection,physical interaction,in vivo | ComPPI,HPRD |
| BMP4 | BMPER | 12897139 14525934 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| BMP4 | GREM2 | 14525934 15039429 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| BMP4 | BGN | 14525934 15173106 15775969 25348397 27898060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| BMP4 | CHRDL1 | 11441185 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD,OmniPath |
| BMP4 | BMP1 | 25348397 | N/A | coimmunoprecipitation | ComPPI |
| BMP4 | TWSG1 | 25348397 | N/A | physical interaction | ComPPI |
| BMP4 | DCAF16 | 25348397 | N/A | physical interaction | ComPPI |
| BMP4 | SLC22A23 | 25348397 | N/A | physical interaction | ComPPI |
| BMP4 | UBE2O | 25348397 | N/A | physical interaction | ComPPI |
| BMP4 | PDP1 | 25348397 | N/A | physical interaction | ComPPI |
| BMP4 | PROS1 | 25348397 | N/A | physical interaction | ComPPI |
| BMP4 | CALR | 25348397 | N/A | physical interaction | ComPPI |
| BMP4 | RGMB | 25348397 | N/A | physical interaction | ComPPI |
| BMP4 | FSTL1 | 20860622 24234451 25348397 | N/A | surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| BMP4 | WFIKKN1 | 21054789 24234451 25348397 | N/A | surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| BMP4 | WFIKKN2 | 21054789 24234451 25348397 | N/A | surface plasmon resonance,surface plasmon resonance array | ComPPI,IntAct |
| BMP4 | C12ORF60 | 24234451 25348397 25416956 | physical association | mammalian protein protein interaction trap | ComPPI,IntAct |
| BMP4 | BMP4 | 14525934 7644468 7673243 | N/A | experimental interaction detection | HPRD |
| CHRDL2 | BMP4 | 14525934 14660436 | N/A | experimental interaction detection | HPRD |
| SIX1 | BMP4 | 12874121 27898060 | stimulant | N/A | OmniPath |
| NOTCH1 | BMP4 | 17537801 27898060 | stimulant | N/A | OmniPath |
| BMP4 | BMPR2 | 12045205 27898060 7644468 7673243 8006002 8702914 | stimulant | N/A | OmniPath |
| NOG | BMP4 | 10657699 11706034 12700180 27898060 | inhibition | N/A | OmniPath |