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GENE：NRG1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol NRG1
FullNmae neuregulin 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:7997
EnsembleID ENSG00000157168
Uniprot Q02297

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
NRG1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
NRG1 GO:0003222,GO:0003712,GO:0005125,GO:0005178,GO:0005576,GO:0005576,GO:0005615,GO:0005615,GO:0005654,GO:0005886,GO:0007154,GO:0007171,GO:0007399,GO:0007399,GO:0008083,GO:0008284,GO:0014032,GO:0016020,GO:0030154,GO:0030296,GO:0030296,GO:0030297,GO:0030879,GO:0030971,GO:0031334,GO:0031334,GO:0032148,GO:0035556,GO:0038127,GO:0038127,GO:0038129,GO:0038130,GO:0038133,GO:0038135,GO:0038138,GO:0042060,GO:0043125,GO:0045499,GO:0045892,GO:0048018,GO:0048513,GO:0050919,GO:0051048,GO:0051155,GO:0055007,GO:0060379,GO:0060956,GO:0070374

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
NRG1 hsa:3084 path:hsa01521 EGFR tyrosine kinase inhibitor resistance - Homo sapiens (human)
NRG1 hsa:3084 path:hsa04012 ErbB signaling pathway - Homo sapiens (human)
NRG1 hsa:3084 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NRG1 ERBB4 23331499 9275162 stimulation N/A SignaLink,SignaLink
NRG1 ERBB3 11555649 23331499 9275162 stimulation N/A SignaLink
NRG1 ERBB2 23331499 9275162 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR NRG1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
E2F4 NRG1 17531812 18971253 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
ETS1 NRG1 20019798 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXP3 NRG1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 NRG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA NRG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF NRG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 NRG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 NRG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 NRG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 NRG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A NRG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 NRG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 NRG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 NRG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TAL1 NRG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TP53 NRG1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ETV4 NRG1 N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001F0C23 NRG1 25416803 25560389 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
CDC5L NRG1 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
RHOBTB3 NRG1 25348397 N/A physical interaction ComPPI
HLA-DPB1 NRG1 25348397 N/A physical interaction ComPPI
HMOX1 NRG1 25348397 N/A physical interaction ComPPI
ERBB2 NRG1 25348397 N/A cosedimentation in solution,physical interaction ComPPI
ERBB4 NRG1 10537356 14525934 25348397 7721889 8062828 9565587 N/A experimental interaction detection,physical interaction ComPPI,HPRD
LEMD3 NRG1 25348397 N/A physical interaction ComPPI
SREBF2 NRG1 25348397 N/A physical interaction ComPPI
MGAT1 NRG1 25348397 N/A physical interaction ComPPI
ZDHHC17 NRG1 25348397 N/A physical interaction ComPPI
EGFR NRG1 24234451 24658140 25348397 physical association ubiquitin reconstruction,physical interaction ComPPI,IntAct
GLMN NRG1 25348397 N/A physical interaction ComPPI
ADGRL1 NRG1 25348397 N/A physical interaction ComPPI
LIMK1 NRG1 14525934 25348397 9685409 N/A experimental interaction detection,physical interaction,two hybrid ComPPI,HPRD
ATP7B NRG1 25348397 N/A physical interaction ComPPI
CNTNAP3 NRG1 25348397 N/A physical interaction ComPPI
LSR NRG1 25348397 N/A physical interaction ComPPI
SPTLC2 NRG1 25348397 N/A physical interaction ComPPI
POMT1 NRG1 25348397 N/A physical interaction ComPPI
B3GNT2 NRG1 25348397 N/A physical interaction ComPPI
C1GALT1C1 NRG1 25348397 N/A physical interaction ComPPI
GALNT11 NRG1 25348397 N/A physical interaction ComPPI
RNF130 NRG1 25348397 N/A physical interaction ComPPI
PIGU NRG1 25348397 N/A physical interaction ComPPI
TUBB3 NRG1 25348397 N/A physical interaction ComPPI
UQCRQ NRG1 25348397 N/A physical interaction ComPPI
TMEM39B NRG1 25348397 N/A physical interaction ComPPI
DNAAF5 NRG1 25348397 N/A physical interaction ComPPI
DEGS1 NRG1 25348397 N/A physical interaction ComPPI
MTCH1 NRG1 25348397 N/A physical interaction ComPPI
MC1R NRG1 25348397 N/A physical interaction ComPPI
NRG1 ERBB3 11555649 14525934 25348397 7592681 8702572 9565587 N/A experimental interaction detection,x-ray crystallography,physical interaction,comigration in non denaturing gel electrophoresis ComPPI,HPRD
NRG1 MBOAT7 25348397 N/A physical interaction ComPPI
NRG1 PGAP1 25348397 N/A physical interaction ComPPI
NRG1 KIAA2013 25348397 N/A physical interaction ComPPI
NRG1 TMTC3 25348397 N/A physical interaction ComPPI
NRG1 TMTC4 25348397 N/A physical interaction ComPPI
NRG1 SLC38A10 25348397 N/A physical interaction ComPPI
NRG1 SLC35B2 25348397 N/A physical interaction ComPPI
NRG1 NDUFA3 25348397 N/A physical interaction ComPPI
NRG1 CISD2 25348397 N/A physical interaction ComPPI
NRG1 SLC25A16 25348397 N/A physical interaction ComPPI
NRG1 RDH11 25348397 N/A physical interaction ComPPI
NRG1 FAM234B 25348397 N/A physical interaction ComPPI
NRG1 EXTL3 25348397 N/A physical interaction ComPPI
NRG1 SLC25A23 25348397 N/A physical interaction ComPPI
NRG1 NETO2 25348397 N/A physical interaction ComPPI
NRG1 TMEM63B 25348397 N/A physical interaction ComPPI
NRG1 ABCB10 25348397 N/A physical interaction ComPPI
NRG1 LARGE2 25348397 N/A physical interaction ComPPI
NRG1 B3GALNT2 25348397 N/A physical interaction ComPPI
NRG1 TMEM181 25348397 N/A physical interaction ComPPI
NRG1 INTS7 25348397 N/A physical interaction ComPPI
NRG1 MYO19 25348397 N/A physical interaction ComPPI
NRG1 SLC22A18 25348397 N/A physical interaction ComPPI
NRG1 NEK4 25348397 N/A physical interaction ComPPI
NRG1 ABCA3 25348397 N/A physical interaction ComPPI
NRG1 TMEM164 25348397 N/A physical interaction ComPPI
NRG1 OPA3 25348397 N/A physical interaction ComPPI
NRG1 HS6ST1 25348397 N/A physical interaction ComPPI
NRG1 SFXN3 25348397 N/A physical interaction ComPPI
NRG1 TM2D3 25348397 N/A physical interaction ComPPI
NRG1 DSE 25348397 N/A physical interaction ComPPI
NRG1 TMEM205 25348397 N/A physical interaction ComPPI
NRG1 LGR4 25348397 N/A physical interaction ComPPI
POMGNT2 NRG1 25348397 N/A physical interaction ComPPI
NRG1 IKZF4 14525934 15494726 27898060 N/A experimental interaction detection HPRD,OmniPath
NRG1 EGF 14525934 7730382 N/A experimental interaction detection HPRD
H2BC9 NRG1 24234451 30021884 physical association cross-linking study IntAct
NRG1 ADAM19 11116142 27898060 N/A N/A OmniPath
PRKCD NRG1 23720309 27898060 N/A N/A OmniPath
NRG1 ERBB2 1350381 14737100 27898060 7514177 stimulant N/A OmniPath
NRG1 ERBB4 10537356 14967450 27898060 7721889 8062828 9275162 9565587 stimulant N/A OmniPath
NRG1 ERBB3 11555649 17697999 27898060 7477375 7514177 7592681 8702572 9168115 9565587 stimulant N/A OmniPath

Visualization










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