GENE：RCAN1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | RCAN1 |
| FullNmae | regulator of calcineurin 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:3040 |
| EnsembleID | ENSG00000159200 |
| Uniprot | P53805 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| RCAN1 | mitotic_cd | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| RCAN1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| RCAN1 | GO:0002931,GO:0003676,GO:0005515,GO:0005634,GO:0005737,GO:0006979,GO:0007614,GO:0008597,GO:0019722,GO:0031987,GO:0033173,GO:0048741,GO:0070885 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| RCAN1 | hsa:1827 | path:hsa04919 | Thyroid hormone signaling pathway - Homo sapiens (human) |
| RCAN1 | hsa:1827 | path:hsa04921 | Oxytocin signaling pathway - Homo sapiens (human) |
| RCAN1 | hsa:1827 | path:hsa05167 | Kaposi sarcoma-associated herpesvirus infection - Homo sapiens (human) |
Protein-Protein Interaction(String):
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RCAN1 | TOLLIP | 19716405 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| RCAN1 | IRAK1 | 19716405 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| RCAN1 | TRAF6 | 19716405 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | RCAN1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ESR1 | RCAN1 | 18414489 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| ETS1 | RCAN1 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA2 | RCAN1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | RCAN1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | RCAN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | RCAN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | RCAN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | RCAN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | RCAN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | RCAN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | RCAN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | RCAN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | RCAN1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT2 | RCAN1 | 22426484 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000324096 | RCAN1 | 17699775 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS0000237AF9 | RCAN1 | 18185580 25416803 | mrna cleavage,inhibition | array technology | TarBase |
| URS00001067D1 | RCAN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000298BA3 | RCAN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000031602A | RCAN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000075ABF4 | RCAN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000065FDF | RCAN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000000EF0B | RCAN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003E226A | RCAN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000032BDF4 | RCAN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00003AA845 | RCAN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000096022 | RCAN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000BA274 | RCAN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003ABC4 | RCAN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002C0FCB | RCAN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00005FDCD1 | RCAN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003FD55 | RCAN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000272A92 | RCAN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000045147B | RCAN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000070B1D | RCAN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS000003575B | RCAN1 | 23824327 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00000EED18 | RCAN1 | 25416803 28292468 | mrna cleavage,inhibition | western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay | TarBase |
| URS00002CF3F0 | RCAN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| URS000039A25B | RCAN1 | 25416803 27292025 | mrna cleavage,inhibition | clip | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| TRAF6 | RCAN1 | 25348397 | N/A | physical interaction | ComPPI |
| UXT | RCAN1 | 14525934 15264020 25348397 27898060 | N/A | two hybrid,experimental interaction detection,in vitro,in vivo,two hybrid | ComPPI,HPRD,OmniPath |
| PRKACB | RCAN1 | 19755121 24234451 25348397 27898060 | phosphorylation reaction | protein kinase assay | ComPPI,IntAct,OmniPath |
| MAPK3 | RCAN1 | 12063245 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| GSK3B | RCAN1 | 12063245 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| HSP90AA1 | RCAN1 | 25348397 | N/A | physical interaction | ComPPI |
| STAT2 | RCAN1 | 25348397 | N/A | physical interaction | ComPPI |
| BTRC | RCAN1 | 18575781 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| GSK3A | RCAN1 | 25348397 | N/A | physical interaction | ComPPI |
| IRAK1 | RCAN1 | 25348397 | N/A | physical interaction | ComPPI |
| RAF1 | RCAN1 | 25348397 | N/A | pull down | ComPPI |
| TOLLIP | RCAN1 | 25348397 | N/A | physical interaction | ComPPI |
| TRIM25 | RCAN1 | 25348397 | N/A | physical interaction | ComPPI |
| PPP3R1 | RCAN1 | 25348397 | N/A | physical interaction | ComPPI |
| MAP3K3 | RCAN1 | 14525934 16126726 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| RCAN1 | PPP3CA | 10861295 12063245 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| RCAN1 | HSP90AA2P | 25348397 | N/A | physical interaction | ComPPI |
| RCAN1 | FBXW4 | 25348397 | N/A | physical interaction | ComPPI |
| RCAN1 | FBXW11 | 25348397 | N/A | physical interaction | ComPPI |
| RCAN1 | APP | 25348397 | N/A | physical interaction | ComPPI |
| RCAN1 | PABIR1 | 25348397 | N/A | physical interaction | ComPPI |
| RCAN1 | PPP3CC | 25348397 | N/A | physical interaction | ComPPI |
| RCAN1 | USP22 | 25348397 25546086 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| RCAN1 | PPP3CB | 25348397 | N/A | physical interaction | ComPPI |
| RCAN1 | ARMT1 | 25348397 | N/A | physical interaction | ComPPI |
| RCAN1 | SRBD1 | 25348397 | N/A | physical interaction | ComPPI |
| RCAN1 | CST5 | 25348397 | N/A | physical interaction | ComPPI |
| RCAN1 | AMY1C | 25348397 | N/A | physical interaction | ComPPI |
| RCAN1 | ZG16B | 25348397 | N/A | physical interaction | ComPPI |
| RCAN1 | CLEC3A | 25348397 | N/A | physical interaction | ComPPI |
| RCAN1 | CAPN1 | 25348397 | N/A | enzymatic study | ComPPI |
| CST2 | RCAN1 | 25348397 | N/A | physical interaction | ComPPI |
| RCAN1 | PPP3CA | 10861295 12063245 12554096 23118980 26186194 27898060 | inhibition | N/A | OmniPath |
| PPP3CA | RCAN1 | 10861295 12063245 23118980 26186194 27898060 | N/A | N/A | OmniPath |
| PRKACA | RCAN1 | 25753203 27898060 | N/A | N/A | OmniPath |
| MAP3K14 | RCAN1 | 18056702 27898060 | stimulant | N/A | OmniPath |
| TRAF6 | RCAN1 | 19716405 27898060 | N/A | N/A | OmniPath |
| MAPK3 | RCAN1 | 12063245 19413330 19651622 20068231 27898060 | stimulant | N/A | OmniPath |
| MAP2K6 | RCAN1 | 12063245 27898060 | N/A | N/A | OmniPath |
| GSK3B | RCAN1 | 12063245 19651622 20068231 27898060 | N/A | N/A | OmniPath |
| MAP3K3 | RCAN1 | 12809556 16126726 19081932 21965663 27898060 | stimulant | N/A | OmniPath |
| RCAN1 | IRAK1 | 19716405 27898060 | N/A | N/A | OmniPath |
| PPP3CB | RCAN1 | 12063245 27898060 | N/A | N/A | OmniPath |
| RCAN1 | TOLLIP | 19716405 27898060 | N/A | N/A | OmniPath |
| DYRK1A | RCAN1 | 12809556 16126726 27898060 | stimulant | N/A | OmniPath |
| PPP3CC | RCAN1 | 12063245 27898060 | N/A | N/A | OmniPath |