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GENE：SLC7A5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol SLC7A5
FullNmae solute carrier family 7 member 5
LocusType gene with protein product
Status Approved
HGNC_id HGNC:11063
EnsembleID ENSG00000103257
Uniprot Q01650

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
SLC7A5 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
SLC7A5 cuproptosis 36010978 Derived from the genome-wide CRISPR-Cas9 loss-of-function test reported in previous literature, 347 potential cuproptosis-related genes (FDR < 0.05) were identified, and for a detailed list of genes, see聽Supplementary Table S1. Cuproptosis-related genes

Go Annotation:

GeneSymbol Go id
SLC7A5 GO:0002720,GO:0003333,GO:0005515,GO:0005765,GO:0005829,GO:0005886,GO:0005886,GO:0009925,GO:0010507,GO:0010629,GO:0014850,GO:0015171,GO:0015171,GO:0015171,GO:0015173,GO:0015175,GO:0015175,GO:0015175,GO:0015179,GO:0015190,GO:0015190,GO:0015196,GO:0015297,GO:0015349,GO:0015804,GO:0015804,GO:0015804,GO:0015818,GO:0015820,GO:0015821,GO:0015823,GO:0015823,GO:0015824,GO:0015827,GO:0015828,GO:0015829,GO:0016020,GO:0016020,GO:0016323,GO:0016324,GO:0016324,GO:0031528,GO:0032328,GO:0032729,GO:0032740,GO:0032753,GO:0042149,GO:0042605,GO:0042908,GO:0043231,GO:0055093,GO:0060252,GO:0070062,GO:0070327,GO:0071222,GO:0089718,GO:0089718,GO:0089718,GO:0097421,GO:0098591,GO:0098713,GO:0098713,GO:0150104,GO:1902024,GO:1903577,GO:1903801,GO:1903801,GO:1904556,GO:1905460,GO:1905534,GO:1990184

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
SLC7A5 hsa:8140 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
SLC7A5 hsa:8140 path:hsa05230 Central carbon metabolism in cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
AR SLC7A5 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ESR1 SLC7A5 18414489 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation array,chromatin immunoprecipitation assay TFlink
ETS1 SLC7A5 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 SLC7A5 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 SLC7A5 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA3 SLC7A5 21878914 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
FOXA1 SLC7A5 18971253 21878914 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
MYC SLC7A5 18414489 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 SLC7A5 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 SLC7A5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA SLC7A5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF SLC7A5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 SLC7A5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 SLC7A5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 SLC7A5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 SLC7A5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS SLC7A5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A SLC7A5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF SLC7A5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SPI1 SLC7A5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 SLC7A5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
ZNF263 SLC7A5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
SP1 SLC7A5 17023546 trascriptional regulation,stimulation inferred by curator TFlink
DAND5 SLC7A5 17023546 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001D69F6 SLC7A5 21439283 rna interference,inhibition western blot,quantitative reverse transcription pcr,immunohistochemistry,miRNA interference luciferase reporter assay miRSponge
URS00004929F1 SLC7A5 21378144 25416803 26701625 mrna cleavage,inhibition array technology,quantitative reverse transcription pcr,clip TarBase
URS00001D69F6 SLC7A5 20371350 21439283 25416803 26054677 26244545 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,immunohistochemistry,clip,miRNA interference luciferase reporter assay TarBase
URS00000AA464 SLC7A5 20304954 25416803 mrna cleavage,inhibition array technology TarBase
URS00001C3AC1 SLC7A5 19536157 23622248 25416803 26701625 mrna cleavage,inhibition clip,clash TarBase
URS00002B7450 SLC7A5 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS0000367985 SLC7A5 23527086 25416803 mrna cleavage,inhibition experimental interaction detection,western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00002971AB SLC7A5 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS0000016914 SLC7A5 22012620 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001B968D SLC7A5 22012620 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000B7E30 SLC7A5 22012620 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005CC20C SLC7A5 22012620 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005DEC41 SLC7A5 22012620 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000BF7F9 SLC7A5 22012620 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000032015F SLC7A5 22012620 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001CF056 SLC7A5 22012620 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000008C563 SLC7A5 22012620 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002C02E4 SLC7A5 22012620 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002AB575 SLC7A5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000239117 SLC7A5 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000D0874 SLC7A5 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000235862 SLC7A5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075C4B1 SLC7A5 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004E008F SLC7A5 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001ADE63 SLC7A5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00004B4B85 SLC7A5 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000435A77 SLC7A5 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000019D79B SLC7A5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000364FEF SLC7A5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001799A3 SLC7A5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00005CE113 SLC7A5 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005586D0 SLC7A5 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000411672 SLC7A5 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00006DE17B SLC7A5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001B12A4 SLC7A5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075B0F6 SLC7A5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 SLC7A5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000005CF5F SLC7A5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00002152A8 SLC7A5 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000065D58 SLC7A5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS0000214763 SLC7A5 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000047A8F SLC7A5 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000065FDF SLC7A5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS00000AF45F SLC7A5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000060AABB SLC7A5 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000308E4D SLC7A5 22012620 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000017CCCB SLC7A5 23592263 25416803 mrna cleavage,inhibition clip TarBase
URS000075A760 SLC7A5 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000036B845 SLC7A5 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001C770D SLC7A5 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001A7F58 SLC7A5 20371350 22012620 23592263 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005D35D9 SLC7A5 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000022AAA SLC7A5 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075AB14 SLC7A5 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000AB32B SLC7A5 20371350 23592263 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003380CC SLC7A5 22012620 24398324 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000077AED SLC7A5 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00001067D1 SLC7A5 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003758F0 SLC7A5 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000028FD1A SLC7A5 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS000021D7C8 SLC7A5 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00002CF3F0 SLC7A5 23446348 25416803 mrna cleavage,inhibition clip TarBase
URS00003CC709 SLC7A5 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00005F1B8C SLC7A5 20371350 25416803 mrna cleavage,inhibition clip TarBase
URS00001E96DA SLC7A5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00000821E0 SLC7A5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000284586 SLC7A5 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000040EE1D SLC7A5 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS000041CB9C SLC7A5 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000171CD1 SLC7A5 22473208 25416803 mrna cleavage,inhibition clip TarBase
URS0000028BB8 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000DD591 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002367FA SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002373FD SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000160683 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000527B00 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000096022 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002D0FC3 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000FFC8B SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000029D793 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000519450 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002D349B SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000486E0B SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000033B548 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000254A6 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000CBE63 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00001270D3 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00002CCA6E SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000043C1C3 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C5969 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003ACE11 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004C6C6F SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004D84DB SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003FBC84 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000419B5A SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000334286 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000C403E SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000020579D SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000004BACE SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000015A0D9 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005485E8 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000077DDE SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00003E226A SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00000913AC SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000025EABA SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005651EE SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000006372A SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00005CCD18 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS00004F859B SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000031D186 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000047A67D SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000250A40 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000001A7A SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075CC78 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075BDA4 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000355E82 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D814 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS000075D15B SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase
URS0000209F04 SLC7A5 25416803 26701625 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
CDC73 SLC7A5 25348397 N/A physical interaction ComPPI
TOMM22 SLC7A5 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
HNRNPU SLC7A5 25348397 N/A physical interaction ComPPI
IRAK1 SLC7A5 24234451 25348397 25852190 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
EGFR SLC7A5 24189400 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
NCSTN SLC7A5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
OCRL SLC7A5 24234451 25107275 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
NOS2 SLC7A5 25348397 N/A physical interaction ComPPI
TRIM25 SLC7A5 25348397 N/A physical interaction ComPPI
ELAVL1 SLC7A5 25348397 N/A physical interaction ComPPI
TGOLN2 SLC7A5 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
BET1 SLC7A5 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
CYLD SLC7A5 25348397 N/A physical interaction ComPPI
SLC3A2 SLC7A5 25348397 N/A physical interaction,in vitro ComPPI
TUBA1C SLC7A5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
CLN6 SLC7A5 24234451 30177828 association anti tag coimmunoprecipitation IntAct

Visualization










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