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GENE：TPR

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol TPR
FullNmae translocated promoter region, nuclear basket protein
LocusType gene with protein product
Status Approved
HGNC_id HGNC:12017
EnsembleID ENSG00000047410
Uniprot P12270

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
TPR pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TPR mitotic_cd 25789545 Here, we report that Tpr depletion induces mitotic catastrophe and enhances the rate of tetraploidy and polyploidy. retulator signature
TPR immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
TPR autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
TPR GO:0000122,GO:0000776,GO:0003682,GO:0003723,GO:0003729,GO:0005515,GO:0005634,GO:0005635,GO:0005643,GO:0005643,GO:0005643,GO:0005654,GO:0005737,GO:0005868,GO:0006404,GO:0006405,GO:0006406,GO:0006606,GO:0006913,GO:0006999,GO:0007094,GO:0010965,GO:0015631,GO:0017056,GO:0017056,GO:0031072,GO:0031453,GO:0031965,GO:0031990,GO:0032880,GO:0034399,GO:0034605,GO:0035457,GO:0042307,GO:0042405,GO:0042803,GO:0044615,GO:0045947,GO:0046827,GO:0046832,GO:0046832,GO:0051019,GO:0051301,GO:0070840,GO:0070849,GO:0072686,GO:0090267,GO:0090316,GO:1901673,GO:1901673

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
TPR hsa:7175 path:hsa03013 Nucleocytoplasmic transport - Homo sapiens (human)
TPR hsa:7175 path:hsa05014 Amyotrophic lateral sclerosis - Homo sapiens (human)
TPR hsa:7175 path:hsa05200 Pathways in cancer - Homo sapiens (human)
TPR hsa:7175 path:hsa05216 Thyroid cancer - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
CREB1 TPR 18160048 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 TPR 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA1 TPR 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
GATA2 TPR 19941826 trascriptional regulation,stimulation chromatin immunoprecipitation assay TFlink
HIF1A TPR 18971253 19828020 trascriptional regulation,stimulation chromatin immunoprecipitation array,inferred by curator TFlink
SMARCA4 TPR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF TPR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 TPR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 TPR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS TPR 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MYC TPR N/A trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00000ED600 TPR 20215506 25416803 mrna cleavage,inhibition array technology TarBase
URS0000079D48 TPR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00003D5391 TPR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000451A1 TPR 23622248 25416803 mrna cleavage,inhibition clash TarBase
URS00000CBE63 TPR 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00002C02E4 TPR 22100165 25416803 mrna cleavage,inhibition clip TarBase
URS00001DE669 TPR 22012620 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000005CF5F TPR 22012620 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000065D58 TPR 22012620 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000042B108 TPR 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00001B0D1E TPR 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000259AE4 TPR 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00004900F1 TPR 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000184017 TPR 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000075D15B TPR 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS000018E6CD TPR 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS00005CCD18 TPR 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000486E0B TPR 22012620 25416803 mrna cleavage,inhibition clip TarBase
URS0000016914 TPR 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00002A71AD TPR 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS0000285DCB TPR 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS00001EFEC1 TPR 25416803 27292025 mrna cleavage,inhibition clip TarBase
URS000004203C TPR 25416803 27292025 mrna cleavage,inhibition clip TarBase

Source Target Pmid Interactiontype Methods Database
PRKACA TPR 22135298 phosphorylation N/A PhosphoSite
CDK1 TPR 22135298 phosphorylation N/A PhosphoSite
CDK2 TPR 22135298 phosphorylation N/A PhosphoSite

Source Target Pmid Interactiontype Methods Database
CDC5L TPR 20467437 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
SAP18 TPR 25348397 N/A physical interaction ComPPI
NPM1 TPR 25348397 N/A physical interaction ComPPI
SNRPA1 TPR 25348397 N/A physical interaction ComPPI
RPL37A TPR 25348397 N/A physical interaction ComPPI
TRAF6 TPR 17353931 24234451 25348397 physical association anti bait coimmunoprecipitation ComPPI,IntAct
SNRPD1 TPR 25348397 N/A physical interaction ComPPI
LMNA TPR 24234451 25348397 29568061 association pull down,physical interaction ComPPI,IntAct
RAN TPR 25348397 N/A physical interaction ComPPI
RAD21 TPR 25348397 N/A physical interaction ComPPI
MCM2 TPR 25348397 N/A physical interaction ComPPI
RRS1 TPR 25348397 N/A physical interaction ComPPI
NF2 TPR 25348397 N/A physical interaction ComPPI
TXNIP TPR 25348397 N/A physical interaction ComPPI
MAPK1 TPR 25348397 N/A physical interaction,in vitro,in vivo ComPPI
HRAS TPR 25348397 N/A physical interaction ComPPI
SHC1 TPR 25348397 N/A in vitro ComPPI
PRKDC TPR 25348397 N/A physical interaction ComPPI
JUN TPR 24234451 25348397 25609649 association anti bait coimmunoprecipitation ComPPI,IntAct
SMAD2 TPR 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
NCOA3 TPR 25348397 N/A physical interaction ComPPI
RPL18A TPR 25348397 N/A physical interaction ComPPI
SFPQ TPR 25348397 N/A physical interaction ComPPI
U2AF2 TPR 25348397 N/A physical interaction ComPPI
RBM4 TPR 25348397 N/A physical interaction ComPPI
NTRK1 TPR 25348397 N/A physical interaction ComPPI
CANX TPR 24234451 25348397 29568061 association pull down ComPPI,IntAct
APC TPR 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
STIP1 TPR 25348397 N/A physical interaction ComPPI
MAP3K4 TPR 20936779 24234451 25348397 physical association physical interaction,two hybrid pooling approach,two hybrid fragment pooling approach ComPPI,IntAct
HNRNPU TPR 25348397 N/A physical interaction ComPPI
PTPN4 TPR 24234451 25348397 28330616 association pull down ComPPI,IntAct
GLRX TPR 25348397 N/A physical interaction ComPPI
TPR NUP98 25348397 N/A physical interaction,in vivo ComPPI
TPR NUP153 24234451 25348397 26496610 association anti tag coimmunoprecipitation,two hybrid,physical interaction,in vitro,in vivo ComPPI,IntAct
TPR HTT 15654337 25348397 27898060 N/A two hybrid,in vitro,in vivo ComPPI,OmniPath
TPR IFI16 25348397 N/A two hybrid,in vivo ComPPI
TPR NUP107 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TPR NUP205 25348397 N/A physical interaction ComPPI
TPR NUP93 25348397 N/A physical interaction ComPPI
TPR GTF2E2 25348397 N/A physical interaction ComPPI
TPR KAT8 25348397 N/A physical interaction ComPPI
TPR SIRT7 25348397 N/A physical interaction ComPPI
TPR NXF1 25348397 N/A physical interaction ComPPI
TPR SRSF5 25348397 N/A physical interaction ComPPI
TPR THOC6 25348397 N/A physical interaction ComPPI
TPR SART1 25348397 N/A physical interaction ComPPI
TPR SF3B6 25348397 N/A physical interaction ComPPI
TPR TAF15 25348397 N/A physical interaction ComPPI
TPR DDB1 25348397 N/A physical interaction ComPPI
TPR SNU13 25348397 N/A physical interaction ComPPI
TPR HNRNPA2B1 25348397 N/A physical interaction ComPPI
TPR DDX1 25348397 N/A physical interaction ComPPI
TPR CIRBP 25348397 N/A physical interaction ComPPI
TPR DDX3X 25348397 N/A physical interaction ComPPI
TPR BUD31 25348397 N/A physical interaction ComPPI
TPR EFTUD2 25348397 N/A physical interaction ComPPI
TPR RPL6 25348397 N/A physical interaction ComPPI
TPR SART3 25348397 N/A physical interaction ComPPI
TPR S100A9 25348397 N/A physical interaction ComPPI
TPR TOP1 24234451 25348397 30021884 physical association cross-linking study,physical interaction ComPPI,IntAct
TPR FN1 19738201 24234451 25348397 association cross-linking study,physical interaction ComPPI,IntAct
TPR ITGA4 25348397 N/A physical interaction ComPPI
TPR CBX7 21282530 24234451 25348397 association physical interaction,tandem affinity purification ComPPI,IntAct
TPR PCLAF 25348397 N/A physical interaction ComPPI
TPR HDAC9 23752268 24234451 25348397 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
TPR MAD1L1 24234451 24581499 25348397 physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
TPR LGR4 25348397 N/A physical interaction ComPPI
TPR STAU1 25348397 N/A physical interaction ComPPI
TPR CUL7 25348397 N/A physical interaction ComPPI
TPR OBSL1 25348397 N/A physical interaction ComPPI
TPR CCDC8 25348397 N/A physical interaction ComPPI
TPR EED 25348397 N/A physical interaction ComPPI
TPR SUMO2 25348397 N/A physical interaction ComPPI
TPR ATL3 25348397 N/A physical interaction ComPPI
TPR RRP12 25348397 N/A physical interaction ComPPI
TPR SRSF11 25348397 N/A physical interaction ComPPI
TPR MRE11 25348397 N/A physical interaction ComPPI
TPR MDM2 25348397 N/A physical interaction ComPPI
TPR FOXK2 24234451 25348397 25609649 association physical interaction,tandem affinity purification ComPPI,IntAct
TPR POU5F1 25348397 N/A physical interaction ComPPI
TPR ZC3HC1 25348397 N/A physical interaction ComPPI
TPR STYX 25348397 N/A physical interaction ComPPI
TPR PDHA1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TPR SDHA 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TPR SOD1 24234451 25348397 29128334 association cross-linking study,physical interaction ComPPI,IntAct
TPR UBE2A 25348397 N/A physical interaction ComPPI
TPR BRCA1 25348397 N/A physical interaction ComPPI
TPR CFTR 25348397 N/A physical interaction ComPPI
TPR RNF8 25348397 N/A anti bait coimmunoprecipitation,physical interaction ComPPI
TPR FOS 20195357 24234451 25348397 physical association display technology ComPPI,IntAct
TPR MAP1LC3A 20562859 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TPR VCAM1 22623428 24234451 25348397 association cross-linking study ComPPI,IntAct
TPR LRRK2 23075850 24234451 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TPR CDC20 24234451 24581499 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
TPR SF1 24234451 25348397 26420826 physical association two hybrid fragment pooling approach ComPPI,IntAct
TPR CHEK2 23178491 24234451 25348397 association tandem affinity purification ComPPI,IntAct
TPR NUP37 24234451 25348397 27194810 physical association two hybrid,two hybrid array ComPPI,IntAct
TPR DUSP19 24234451 25348397 28330616 association pull down ComPPI,IntAct
TPR OCRL 24234451 25107275 25348397 association anti tag coimmunoprecipitation ComPPI,IntAct
TPR CDK7 24234451 25348397 29568061 association pull down ComPPI,IntAct
TPR RAB5A 24234451 25348397 29568061 association pull down ComPPI,IntAct
TPR TGOLN2 24234451 25348397 29568061 association pull down ComPPI,IntAct
TPR STING1 24234451 25348397 29251827 association anti bait coimmunoprecipitation ComPPI,IntAct
YWHAQ TPR 25348397 N/A two hybrid ComPPI
SEPTIN2 TPR 25348397 N/A physical interaction ComPPI
H3C1 TPR 24234451 25348397 29568061 association proximity-dependent biotin identification ComPPI,IntAct
EEF1D TPR 25348397 N/A physical interaction ComPPI
EEF1B2 TPR 25348397 N/A physical interaction ComPPI
IK TPR 25348397 N/A physical interaction ComPPI
RRP7A TPR 25348397 N/A physical interaction ComPPI
TPR MAP9 24234451 30021884 physical association cross-linking study IntAct
MNT TPR 24234451 30021884 physical association cross-linking study IntAct
TPR NFXL1 24234451 30021884 physical association cross-linking study IntAct
TPR NDUFB7 24234451 30021884 physical association cross-linking study IntAct
TPR PHIP 24234451 30021884 physical association cross-linking study IntAct
TPR ADCY10 24234451 30021884 physical association cross-linking study IntAct
TPR ZNF721 24234451 30021884 physical association cross-linking study IntAct
TPR PCCB 24234451 30021884 physical association cross-linking study IntAct
TPR NPY2R 24234451 30021884 physical association cross-linking study IntAct
TPR ABCC12 24234451 30021884 physical association cross-linking study IntAct
TPR MAD1L1 18981471 24581499 27898060 stimulant N/A OmniPath
CDK1 TPR 24938596 27898060 N/A N/A OmniPath
MAPK1 TPR 12594221 18794356 27898060 stimulant N/A OmniPath
TPR MAD2L1 18981471 27898060 stimulant N/A OmniPath

Visualization










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