Gene Information gene info

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GENE：ERCC5

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol ERCC5
FullNmae ERCC excision repair 5, endonuclease
LocusType gene with protein product
Status Approved
HGNC_id HGNC:3437
EnsembleID ENSG00000134899
Uniprot P28715

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
ERCC5 pyroptosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ERCC5 immunogenic 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature
ERCC5 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
ERCC5 GO:0000109,GO:0000405,GO:0000724,GO:0000993,GO:0003684,GO:0003690,GO:0003697,GO:0003697,GO:0004519,GO:0004520,GO:0004520,GO:0004520,GO:0005515,GO:0005634,GO:0005634,GO:0005654,GO:0006283,GO:0006283,GO:0006285,GO:0006289,GO:0006289,GO:0006289,GO:0008047,GO:0009411,GO:0009411,GO:0010225,GO:0032991,GO:0042803,GO:0043066,GO:0044877,GO:0046872,GO:0050790

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
ERCC5 hsa:2073 path:hsa03420 Nucleotide excision repair - Homo sapiens (human)

Protein-Protein Interaction(String):

Gene-Drug Network:

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
ERCC5 SQSTM1 23180781 8652557 physical association anti tag coimmunoprecipitation InnateDB
ERCC5 ERCC3 23180781 8652557 physical association anti tag coimmunoprecipitation InnateDB
ERCC5 EP300 22954786 23180781 physical association anti tag coimmunoprecipitation InnateDB
CREBBP ERCC5 22954786 23180781 physical association anti tag coimmunoprecipitation InnateDB

Source Target Pmid Interactiontype Methods Database
ETS1 ERCC5 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 ERCC5 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
SMARCA4 ERCC5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA ERCC5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF ERCC5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 ERCC5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
GATA2 ERCC5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A ERCC5 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 ERCC5 17893230 trascriptional regulation,stimulation inferred by curator TFlink
YY1 ERCC5 17893230 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
CCNH ERCC5 25348397 N/A physical interaction ComPPI
PCNA ERCC5 10408173 14525934 25348397 9305916 N/A affinity chromatography technology,experimental interaction detection,physical interaction,biochemical,in vitro,in vivo ComPPI,HPRD
ERCC3 ERCC5 25348397 N/A coimmunoprecipitation,physical interaction,physical interaction ComPPI
GTF2H1 ERCC5 11259578 14525934 25348397 8652557 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
EWSR1 ERCC5 14525934 16713569 24234451 25348397 physical association two hybrid,physical interaction,two hybrid array,two hybrid ComPPI,HPRD,IntAct
RAD51 ERCC5 25348397 N/A physical interaction ComPPI
BRCA2 ERCC5 25348397 N/A physical interaction ComPPI
SPTA1 ERCC5 25348397 N/A physical interaction ComPPI
GTF2H4 ERCC5 14525934 16246722 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CDK7 ERCC5 23602568 24234451 25348397 29568061 association pull down,physical interaction,tandem affinity purification,proximity-dependent biotin identification ComPPI,IntAct
GTF2H2 ERCC5 25348397 N/A coimmunoprecipitation,physical interaction ComPPI
POLR2A ERCC5 14525934 16246722 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
HSPB1 ERCC5 24234451 25277244 25348397 physical association reverse ras recruitment system,physical interaction ComPPI,IntAct
ERCC5 ERCC2 14525934 25348397 8652557 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ERCC5 ERCC6 14525934 25348397 8652557 N/A coimmunoprecipitation,experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ERCC5 NTHL1 14525934 25348397 9927729 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
ERCC5 TAF10 25348397 N/A physical interaction ComPPI
ERCC5 BCL6 16147992 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
ERCC5 PIDD1 25348397 N/A physical interaction ComPPI
ERCC5 ERCC6 25348397 N/A physical interaction ComPPI
ERCC5 DTL 25348397 N/A physical interaction ComPPI
ERCC5 LRPPRC 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ERCC5 TGS1 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ERCC5 GTF2H5 24234451 25348397 26496610 association anti tag coimmunoprecipitation,physical interaction ComPPI,IntAct
ERCC5 PALB2 25348397 N/A physical interaction ComPPI
ERCC5 BRCA1 25348397 N/A physical interaction ComPPI
ERCC5 GADD45A 17268471 24234451 25348397 27898060 physical association anti bait coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct,OmniPath
ERCC5 PCNA 10408173 16713569 18079701 19279666 20713449 27898060 9305916 stimulant N/A OmniPath
ERCC5 EP300 22954786 27898060 N/A N/A OmniPath
ERCC5 ERCC2 20840796 27898060 8652557 stimulant N/A OmniPath

Source Target Pmid Interactiontype Methods Database
URS00009AD521 ERCC5 27087310 direct interaction,inhibition N/A NPInter

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