GENE：IGFBP1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | IGFBP1 |
| FullNmae | insulin like growth factor binding protein 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:5469 |
| EnsembleID | ENSG00000146678 |
| Uniprot | P08833 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| IGFBP1 | pyroptosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| IGFBP1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| IGFBP1 | GO:0005102,GO:0005515,GO:0005520,GO:0005576,GO:0005615,GO:0005788,GO:0005794,GO:0007165,GO:0008286,GO:0014070,GO:0030307,GO:0031994,GO:0031994,GO:0031995,GO:0031995,GO:0042246,GO:0043567,GO:0090090 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| IGFBP1 | FOXO3 | 10102273 23180781 | physical association | electrophoretic mobility supershift assay | InnateDB |
| IGFBP1 | NR3C1 | 16239257 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| IGFBP1 | MED1 | 16239257 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| IGFBP1 | MED14 | 16239257 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| IGFBP1 | HMGA1 | 22745191 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| IGFBP1 | CEBPB | 22745191 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| IGFBP1 | HNF1A | 22745191 23180781 | physical association | anti tag coimmunoprecipitation | InnateDB |
| IGF1 | IGFBP1 | 14568572 23331499 | inhibition | N/A | SignaLink,SignaLink |
| IGF2 | IGFBP1 | 14568572 23331499 | inhibition | N/A | SignaLink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | IGFBP1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | IGFBP1 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| FOXO1 | IGFBP1 | 10385407 15200677 15987820 21401636 23603247 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay,DNase I footprinting | TFlink |
| NFYA | IGFBP1 | 10687862 | trascriptional regulation,stimulation | electrophoretic mobility shift assay | TFlink |
| NFYB | IGFBP1 | 10687862 | trascriptional regulation,stimulation | electrophoretic mobility shift assay | TFlink |
| SP1 | IGFBP1 | 2849945 8544848 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| HNF1A | IGFBP1 | 7684229 | trascriptional regulation,stimulation | inferred by curator,electrophoretic mobility shift assay | TFlink |
| CEBPA | IGFBP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | IGFBP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | IGFBP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | IGFBP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | IGFBP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | IGFBP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ATF4 | IGFBP1 | 16687408 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| ETS1 | IGFBP1 | 21401636 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EZH2 | IGFBP1 | 21903722 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HDAC9 | IGFBP1 | 12609987 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HOXA10 | IGFBP1 | 15200677 20478621 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PGR | IGFBP1 | 11117526 15987820 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PPARA | IGFBP1 | 20110263 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| DAND5 | IGFBP1 | 2849945 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SP3 | IGFBP1 | 8776721 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| WWTR1 | IGFBP1 | 20164440 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CREB1 | IGFBP1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HIF1A | IGFBP1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| URS0000272A3D | IGFBP1 | 21436257 | rna interference,inhibition | miRNA interference luciferase reporter assay | miRSponge |
| URS0000272A3D | IGFBP1 | 21436257 25416803 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| URS0000427B68 | IGFBP1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004719AB | IGFBP1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00002233F4 | IGFBP1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS0000001A7A | IGFBP1 | 21572407 25416803 | mrna cleavage,inhibition | clip | TarBase |
| URS00004F859B | IGFBP1 | 25416803 28051155 | mrna cleavage,inhibition | miRNA interference luciferase reporter assay | TarBase |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| CD59 | IGFBP1 | 25348397 | N/A | physical interaction | ComPPI |
| CTBP1 | IGFBP1 | 25348397 | N/A | physical interaction | ComPPI |
| CTBP2 | IGFBP1 | 25348397 | N/A | physical interaction | ComPPI |
| PLAT | IGFBP1 | 25348397 | N/A | physical interaction | ComPPI |
| TRIP6 | IGFBP1 | 25348397 | N/A | physical interaction | ComPPI |
| TIMP3 | IGFBP1 | 25348397 | N/A | physical interaction | ComPPI |
| TIMP1 | IGFBP1 | 25348397 | N/A | physical interaction | ComPPI |
| ADAMTS1 | IGFBP1 | 25348397 | N/A | physical interaction | ComPPI |
| GNB2 | IGFBP1 | 25348397 | N/A | physical interaction | ComPPI |
| MMP26 | IGFBP1 | 12119297 14525934 25348397 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| IGFBP4 | IGFBP1 | 16924115 24234451 25348397 | N/A | x-ray crystallography | ComPPI,IntAct |
| IGF2 | IGFBP1 | 10810289 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,bio-layer interferometry | ComPPI,HPRD |
| IGFBP1 | PTPN3 | 25348397 | N/A | physical interaction | ComPPI |
| IGFBP1 | SUSD5 | 25348397 | N/A | physical interaction | ComPPI |
| IGFBP1 | ZNF696 | 25348397 | N/A | physical interaction | ComPPI |
| IGFBP1 | PLXDC2 | 25348397 | N/A | physical interaction | ComPPI |
| IGFBP1 | ZNF664 | 25348397 | N/A | physical interaction | ComPPI |
| IGFBP1 | SMOC1 | 25348397 | N/A | physical interaction | ComPPI |
| IGFBP1 | GTPBP2 | 25348397 | N/A | physical interaction | ComPPI |
| IGFBP1 | LMF2 | 25348397 | N/A | physical interaction | ComPPI |
| IGFBP1 | NDST2 | 25348397 | N/A | physical interaction | ComPPI |
| IGFBP1 | USP46 | 25348397 | N/A | physical interaction | ComPPI |
| IGFBP1 | IGF1 | 16924115 22578544 24234451 25348397 | N/A | x-ray crystallography,physical interaction,bio-layer interferometry | ComPPI,IntAct |
| IGFBP1 | FAM20C | 24234451 25348397 26091039 | physical association | protein kinase assay | ComPPI,IntAct |
| TF | IGFBP1 | 11297622 14525934 | N/A | experimental interaction detection | HPRD |
| MAPKAPK2 | IGFBP1 | 27898060 7678248 | N/A | N/A | OmniPath |
| FOXO1 | IGFBP1 | 18391971 18985696 27898060 | stimulant | N/A | OmniPath |
| IGF2 | IGFBP1 | 10810289 14568572 22578544 27898060 | inhibition | N/A | OmniPath |
| CSNK2A1 | IGFBP1 | 18772238 19193607 19731965 19765076 20143870 23354097 24437487 25957086 27898060 7678248 7683525 | N/A | N/A | OmniPath |
| IGF1 | IGFBP1 | 10350456 14568572 22578544 27898060 | inhibition | N/A | OmniPath |
| MMP26 | IGFBP1 | 12119297 27898060 | N/A | N/A | OmniPath |