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GENE：IRS1

GeneInfo:

GeneAttribute GeneDescription
GeneSymbol IRS1
FullNmae insulin receptor substrate 1
LocusType gene with protein product
Status Approved
HGNC_id HGNC:6125
EnsembleID ENSG00000169047
Uniprot P35568

Protein Structure:

Gene Description in Publicaton:

GeneSymbol CellDeathType PMID Description GeneType
IRS1 autosis 38538696 The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) retulator signature

Go Annotation:

GeneSymbol Go id
IRS1 GO:0001784,GO:0005068,GO:0005080,GO:0005158,GO:0005158,GO:0005159,GO:0005515,GO:0005634,GO:0005654,GO:0005737,GO:0005829,GO:0005829,GO:0005829,GO:0005886,GO:0005886,GO:0005886,GO:0005899,GO:0005901,GO:0007165,GO:0008284,GO:0008286,GO:0008286,GO:0008286,GO:0008286,GO:0010907,GO:0030159,GO:0032000,GO:0032868,GO:0032869,GO:0042169,GO:0042593,GO:0043231,GO:0043434,GO:0043491,GO:0043548,GO:0043548,GO:0043548,GO:0043552,GO:0045725,GO:0045725,GO:0046326,GO:0046326,GO:0046627,GO:0046628,GO:0046628,GO:0046676,GO:0048009,GO:0071398

KEGG Annotation:

GeneSymbol GeneID Pathway Pathway Name
IRS1 hsa:3667 path:hsa04022 cGMP-PKG signaling pathway - Homo sapiens (human)
IRS1 hsa:3667 path:hsa04068 FoxO signaling pathway - Homo sapiens (human)
IRS1 hsa:3667 path:hsa04140 Autophagy - animal - Homo sapiens (human)
IRS1 hsa:3667 path:hsa04150 mTOR signaling pathway - Homo sapiens (human)
IRS1 hsa:3667 path:hsa04151 PI3K-Akt signaling pathway - Homo sapiens (human)
IRS1 hsa:3667 path:hsa04152 AMPK signaling pathway - Homo sapiens (human)
IRS1 hsa:3667 path:hsa04211 Longevity regulating pathway - Homo sapiens (human)
IRS1 hsa:3667 path:hsa04213 Longevity regulating pathway - multiple species - Homo sapiens (human)
IRS1 hsa:3667 path:hsa04722 Neurotrophin signaling pathway - Homo sapiens (human)
IRS1 hsa:3667 path:hsa04910 Insulin signaling pathway - Homo sapiens (human)
IRS1 hsa:3667 path:hsa04920 Adipocytokine signaling pathway - Homo sapiens (human)
IRS1 hsa:3667 path:hsa04923 Regulation of lipolysis in adipocytes - Homo sapiens (human)
IRS1 hsa:3667 path:hsa04930 Type II diabetes mellitus - Homo sapiens (human)
IRS1 hsa:3667 path:hsa04931 Insulin resistance - Homo sapiens (human)
IRS1 hsa:3667 path:hsa04932 Non-alcoholic fatty liver disease - Homo sapiens (human)
IRS1 hsa:3667 path:hsa04935 Growth hormone synthesis, secretion and action - Homo sapiens (human)
IRS1 hsa:3667 path:hsa04960 Aldosterone-regulated sodium reabsorption - Homo sapiens (human)
IRS1 hsa:3667 path:hsa05010 Alzheimer disease - Homo sapiens (human)
IRS1 hsa:3667 path:hsa05206 MicroRNAs in cancer - Homo sapiens (human)
IRS1 hsa:3667 path:hsa05415 Diabetic cardiomyopathy - Homo sapiens (human)

Protein-Protein Interaction(String):

Signalink 3.0 modificators

Source Target Pmid Interactiontype Methods Database
NGF IRS1 10086337 10826997 12175651 12444011 12767520 15099563 16931767 17604717 17764704 19030972 21540285 22421439 22465479 24036369 25071162 26192618 28645028 8621421 interaction type N/A ACSN
IRS1 GRB2 10086337 10826997 12175651 12444011 12767520 16931767 17604717 19030972 21540285 22465479 24036369 26192618 8621421 interaction type N/A ACSN
IGF1R IRS1 10086337 10826997 11274345 11557037 12175651 12220227 12444011 12556535 12655147 12767520 15629149 16931767 17145802 17673906 18988627 19030972 21071413 21540285 23331499 24103846 24782617 26192618 7559507 8530377 8662806 8776723 interaction type,stimulation N/A ACSN,SignaLink,SignaLink
IKBKB IRS1 12351658 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
PIK3R1 IRS1 11063744 11147812 16230374 23180781 24243840 29145629 physical association gst pull down,inferred by curator InnateDB,Reactome
IRS1 CHUK 12351658 23180781 phosphorylation reaction,physical association anti tag coimmunoprecipitation,in-gel kinase assay InnateDB
IRS1 JAK1 23180781 23331499 9233603 9492017 stimulation,physical association anti tag coimmunoprecipitation InnateDB,SignaLink
JAK3 IRS1 23180781 9233603 physical association anti tag coimmunoprecipitation InnateDB
IRS1 MTOR 15952059 23180781 physical association anti tag coimmunoprecipitation InnateDB
SMAD3 IRS1 18729074 23180781 physical association tandem affinity purification InnateDB
IRS1 SOCS7 16127460 23180781 physical association anti tag coimmunoprecipitation InnateDB
APP IRS1 21832049 23180781 physical association protein array InnateDB
IRS1 SOS1 29145629 7739560 8316835 8530377 8621421 8810325 8816480 9003010 9832424 9852124 physical association inferred by curator Reactome
JAK1 IRS1 11162588 23331499 29145629 7499365 9013940 9233603 interaction type,physical association inferred by curator Reactome,SignaLink
IL7 IRS1 29145629 9233603 9233603 physical association inferred by curator Reactome
IRS1 IRS2 10688912 11748924 15316008 17565041 18382766 18516053 29145629 9405487 physical association inferred by curator Reactome
IRS1 IRS1 10688912 11259577 11748924 15316008 17565041 18382766 18516053 20966354 26467481 29145629 9405487 bind,physical association,up-regulates activity inferred by curator Reactome,Signor
KRAS IRS1 24243840 29145629 enzymatic reaction inferred by curator Reactome
HRAS IRS1 24243840 29145629 enzymatic reaction inferred by curator Reactome
NRAS IRS1 24243840 29145629 enzymatic reaction inferred by curator Reactome
MAPK3 IRS1 29145629 7739560 8816480 enzymatic reaction inferred by curator Reactome
IRS1 JAK2 11208867 21071413 23331499 7782332 9492017 stimulation N/A SignaLink,SignaLink
PTPN1 IRS1 10660596 11579209 18988627 21071413 23331499 stimulation N/A SignaLink,SignaLink
IRS1 IRS4 11912194 23331499 stimulation N/A SignaLink,SignaLink
IRS1 PIK3CG 11943559 23331499 stimulation N/A SignaLink,SignaLink
INSR IRS1 11606564 12101187 15629149 16582879 18988627 23331499 7935368 8662806 stimulation N/A SignaLink,SignaLink
LTK IRS1 23331499 9223670 stimulation N/A SignaLink,SignaLink
PTPRF IRS1 10660596 15588985 18988627 23331499 8732688 stimulation N/A SignaLink,SignaLink
IRS1 SHC1 10807918 23331499 7499194 stimulation N/A SignaLink
IRS1 GRAP 11897402 23331499 stimulation N/A SignaLink

Source Target Pmid Interactiontype Methods Database
IRS1 PIK3R2 20005715 interaction type N/A PSP
IRS1 CHUK 20005715 interaction type N/A PSP
IRS1 PDPK1 20005715 interaction type N/A PSP
IRS1 JAK2 20005715 interaction type N/A PSP
IRS1 ERBB2 20005715 interaction type N/A PSP,SignaLink
IRS1 NTRK1 11147812 18988627 20005715 interaction type N/A PSP,SignaLink
IRS1 PRKCG 20005715 interaction type N/A PSP
IRS1 INSR 20005715 interaction type N/A PSP
IRS1 FYN 20005715 interaction type N/A PSP,SignaLink
IRS1 IGF1R 10082579 20005715 21071413 7559507 8776723 interaction type N/A PSP,SignaLink
IRS1 PTPRC 20005715 interaction type N/A PSP
IRS1 PTPRF 20005715 interaction type N/A PSP,SignaLink
IRS1 BCR 20005715 interaction type N/A PSP
IRS1 FER 20005715 interaction type N/A PSP
IRS1 ATP2A2 20005715 interaction type N/A PSP
IRS1 PTPN1 20005715 interaction type N/A PSP
IRS1 JAK1 20005715 interaction type N/A PSP,SignaLink
IRS1 MAPK1 20005715 interaction type N/A PSP
IRS1 TYK2 20005715 interaction type N/A PSP,SignaLink
IRS1 AKT1 20005715 interaction type N/A PSP
IRS1 PIK3CA 20005715 interaction type N/A PSP,SignaLink
IRS1 MTOR 20005715 interaction type N/A PSP
IRS1 MAPK8 20005715 interaction type N/A PSP
IRS1 MAPK9 20005715 interaction type N/A PSP
IRS1 JAK3 20005715 interaction type N/A PSP,SignaLink
IRS1 CSNK2B 20005715 interaction type N/A PSP
IRS1 CSNK2A1 20005715 interaction type N/A PSP
IRS1 PRKCQ 20005715 interaction type N/A PSP
IRS1 PTK2 20005715 21071413 9822703 interaction type N/A PSP,SignaLink
IRS1 PRKCZ 20005715 interaction type N/A PSP
IRS1 PRKCD 20005715 interaction type N/A PSP
IRS1 PTPN11 20005715 interaction type N/A PSP
IRS1 ROCK1 20005715 interaction type N/A PSP
IRS1 PIK3R3 20005715 21071413 9415396 interaction type N/A PSP,SignaLink
IRS1 ALK 20005715 interaction type N/A PSP
IRS1 NISCH 20005715 interaction type N/A PSP
IRS1 PRKCZ 20005715 N/A N/A SignaLink
IRS1 AKT1 20005715 20005715 N/A N/A SignaLink
IRS1 ALK 18988627 20005715 20005715 9174053 N/A N/A SignaLink
IRS1 ATP2A2 20005715 20005715 N/A N/A SignaLink
IRS1 BCR 12560071 18988627 20005715 20005715 N/A N/A SignaLink
IRS1 CHUK 12351658 12351658 18988627 20005715 20005715 21071413 N/A N/A SignaLink
IRS1 CSNK2A1 20005715 20005715 N/A N/A SignaLink
IRS1 CSNK2B 20005715 20005715 N/A N/A SignaLink
IRS1 FER 11006284 18988627 20005715 20005715 N/A N/A SignaLink
IRS1 INSR 11606564 20005715 20005715 21071413 8626379 N/A N/A SignaLink
IRS1 JAK2 20005715 20005715 N/A N/A SignaLink
IRS1 MAPK1 20005715 20005715 N/A N/A SignaLink
IRS1 MAPK8 10722755 10722755 11606564 20005715 20005715 21071413 N/A N/A SignaLink
IRS1 MAPK9 20005715 20005715 N/A N/A SignaLink
IRS1 MTOR 20005715 20005715 N/A N/A SignaLink
IRS1 NISCH 11912194 20005715 20005715 21071413 N/A N/A SignaLink
IRS1 PDPK1 15802620 18988627 20005715 20005715 N/A N/A SignaLink
IRS1 PIK3R2 20005715 20005715 N/A N/A SignaLink
IRS1 PRKCD 12031982 15516986 20005715 20005715 21071413 N/A N/A SignaLink
IRS1 PRKCG 20005715 20005715 N/A N/A SignaLink
IRS1 PRKCQ 20005715 20005715 N/A N/A SignaLink
IRS1 PTPN1 10660596 20005715 20005715 21071413 N/A N/A SignaLink
IRS1 PTPN11 20005715 20005715 21071413 8505282 9756938 N/A N/A SignaLink
IRS1 PTPRC 20005715 20005715 N/A N/A SignaLink
IRS1 ROCK1 11739394 18988627 20005715 20005715 N/A N/A SignaLink

Source Target Pmid Interactiontype Methods Database
AR IRS1 20610535 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
ETS1 IRS1 18971253 20019798 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
GATA2 IRS1 18971253 19941826 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
FOXP3 IRS1 20554955 trascriptional regulation,stimulation chromatin immunoprecipitation array TFlink
PRDM14 IRS1 18971253 20953172 trascriptional regulation,stimulation inferred by curator,chromatin immunoprecipitation assay TFlink
SMARCA4 IRS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CEBPA IRS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
CTCF IRS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F1 IRS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
E2F4 IRS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
EGR1 IRS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXA1 IRS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOXP1 IRS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
FOS IRS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
HNF4A IRS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
MITF IRS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
RUNX1 IRS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
TRIM28 IRS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink
VDR IRS1 18971253 trascriptional regulation,stimulation inferred by curator TFlink

Source Target Pmid Interactiontype Methods Database
URS00001D69F6 IRS1 18834857 21464990 rna interference,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00004F4657 IRS1 N/A 17827156 19391107 22431718 23201159 rna interference,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay miRSponge
URS00003BBF48 IRS1 22935141 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS000000C73C IRS1 22935141 rna interference,inhibition western blot,miRNA interference luciferase reporter assay miRSponge
URS00004F4657 IRS1 17827156 19391107 19439999 22431718 23201159 23714355 24690171 25416803 25477374 mrna cleavage,inhibition experimental interaction detection,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00001D69F6 IRS1 18834857 21464990 23603512 23893300 25416803 26617742 26893711 27119351 mrna cleavage,inhibition array technology,western blot,northern blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00003BBF48 IRS1 22935141 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS000000C73C IRS1 22935141 25416803 mrna cleavage,inhibition western blot,miRNA interference luciferase reporter assay TarBase
URS0000427B68 IRS1 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS00000B7E30 IRS1 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS000028DE3F IRS1 21572407 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000085F64 IRS1 21572407 23824327 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000076B539 IRS1 21572407 23824327 24906430 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00004719AB IRS1 21572407 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00002C28B2 IRS1 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS000016E46F IRS1 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS00001C04A2 IRS1 23824327 25416803 27418678 mrna cleavage,inhibition clip TarBase
URS0000136174 IRS1 23824327 25416803 mrna cleavage,inhibition clip TarBase
URS0000101787 IRS1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000055BBE5 IRS1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS0000171525 IRS1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS000012A1DD IRS1 19536157 25416803 mrna cleavage,inhibition clip TarBase
URS00002E92A8 IRS1 25416803 27069535 mrna cleavage,inhibition western blot,quantitative reverse transcription pcr,miRNA interference luciferase reporter assay TarBase
URS00004B83FE IRS1 25416803 27766036 mrna cleavage,inhibition miRNA interference luciferase reporter assay TarBase

Source Target Pmid Interactiontype Methods Database
PRKCD IRS1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PIM2 IRS1 22135298 phosphorylation N/A PhosphoSite
PRKCQ IRS1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
MAPK3 IRS1 22135298 phosphorylation N/A PhosphoSite
IGF1R IRS1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PIM3 IRS1 22135298 phosphorylation N/A PhosphoSite
MAPK1 IRS1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PLK1 IRS1 22135298 phosphorylation N/A PhosphoSite
ATR IRS1 22135298 phosphorylation N/A PhosphoSite
RPS6KB1 IRS1 22135298 phosphorylation N/A PhosphoSite
INSR IRS1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
IKBKB IRS1 22135298 phosphorylation N/A PhosphoSite
PIM1 IRS1 22135298 phosphorylation N/A PhosphoSite
MAPK8 IRS1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
PRKCB IRS1 22135298 phosphorylation N/A PhosphoSite
PRKCZ IRS1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
AKT1 IRS1 22135298 25361965 interaction type,phosphorylation N/A PhosphoSite,PTMCode2
NCK2 IRS1 25361965 interaction type N/A PTMCode2
IRS1 NCK2 25361965 interaction type N/A PTMCode2
GRB14 IRS1 25361965 interaction type N/A PTMCode2
IRS1 GRB14 25361965 interaction type N/A PTMCode2
PIK3CA IRS1 25361965 interaction type N/A PTMCode2
IRS1 PIK3CA 25361965 interaction type N/A PTMCode2
TYK2 IRS1 25361965 interaction type N/A PTMCode2
IRS1 TYK2 25361965 interaction type N/A PTMCode2
IRS1 MAPK1 25361965 interaction type N/A PTMCode2
IL4R IRS1 25361965 interaction type N/A PTMCode2
IRS1 IL4R 25361965 interaction type N/A PTMCode2
CSNK2A1 IRS1 25361965 interaction type N/A PTMCode2
IRS1 CSNK2A1 25361965 interaction type N/A PTMCode2
GHR IRS1 25361965 interaction type N/A PTMCode2
IRS1 GHR 25361965 interaction type N/A PTMCode2
IRS1 IGF1R 25361965 interaction type N/A PTMCode2
YWHAE IRS1 25361965 interaction type N/A PTMCode2
IRS1 YWHAE 25361965 interaction type N/A PTMCode2
IRS1 PRKCQ 25361965 interaction type N/A PTMCode2
PHIP IRS1 25361965 interaction type N/A PTMCode2
IRS1 PHIP 25361965 interaction type N/A PTMCode2
EGFR IRS1 25361965 interaction type N/A PTMCode2
IRS1 EGFR 25361965 interaction type N/A PTMCode2
IRS1 TUB 25361965 interaction type N/A PTMCode2
TUB IRS1 25361965 interaction type N/A PTMCode2
IRS1 SIK2 25361965 interaction type N/A PTMCode2
SIK2 IRS1 25361965 interaction type N/A PTMCode2
IRS1 RPTOR 25361965 interaction type N/A PTMCode2
RPTOR IRS1 25361965 interaction type N/A PTMCode2
IRS1 YWHAB 25361965 interaction type N/A PTMCode2
YWHAB IRS1 25361965 interaction type N/A PTMCode2
IRS1 KHDRBS1 25361965 interaction type N/A PTMCode2
KHDRBS1 IRS1 25361965 interaction type N/A PTMCode2
IRS1 NCL 25361965 interaction type N/A PTMCode2
NCL IRS1 25361965 interaction type N/A PTMCode2
IRS1 MAPK8 25361965 interaction type N/A PTMCode2
IRS1 AP3S1 25361965 interaction type N/A PTMCode2
AP3S1 IRS1 25361965 interaction type N/A PTMCode2
IRS1 SOCS3 25361965 interaction type N/A PTMCode2
SOCS3 IRS1 25361965 interaction type N/A PTMCode2
IRS1 PRKCD 25361965 interaction type N/A PTMCode2
IRS1 GRB2 25361965 interaction type N/A PTMCode2
GRB2 IRS1 25361965 interaction type N/A PTMCode2
IRS1 CAV1 25361965 interaction type N/A PTMCode2
CAV1 IRS1 25361965 interaction type N/A PTMCode2
IRS1 JAK1 25361965 interaction type N/A PTMCode2
JAK1 IRS1 25361965 interaction type N/A PTMCode2
IRS1 PDPK1 25361965 interaction type N/A PTMCode2
PDPK1 IRS1 25361965 interaction type N/A PTMCode2
IRS1 MAPK10 25361965 interaction type N/A PTMCode2
MAPK10 IRS1 25361965 interaction type N/A PTMCode2
IRS1 CHUK 25361965 interaction type N/A PTMCode2
CHUK IRS1 25361965 interaction type N/A PTMCode2
IRS1 PTPN1 25361965 interaction type N/A PTMCode2
PTPN1 IRS1 25361965 interaction type N/A PTMCode2
IRS1 IRS2 25361965 interaction type N/A PTMCode2
IRS2 IRS1 25361965 interaction type N/A PTMCode2
IRS1 PRKCZ 25361965 interaction type N/A PTMCode2
IRS1 JAK2 25361965 interaction type N/A PTMCode2
JAK2 IRS1 25361965 interaction type N/A PTMCode2
IRS1 ALK 25361965 interaction type N/A PTMCode2
ALK IRS1 25361965 interaction type N/A PTMCode2
IRS1 GRB10 25361965 interaction type N/A PTMCode2
GRB10 IRS1 25361965 interaction type N/A PTMCode2
IRS1 ROCK1 25361965 interaction type N/A PTMCode2
ROCK1 IRS1 25361965 interaction type N/A PTMCode2
IRS1 JAK3 25361965 interaction type N/A PTMCode2
JAK3 IRS1 25361965 interaction type N/A PTMCode2
IRS1 SHC1 25361965 interaction type N/A PTMCode2
SHC1 IRS1 25361965 interaction type N/A PTMCode2
IRS1 AKT1 25361965 interaction type N/A PTMCode2
CRK IRS1 25361965 interaction type N/A PTMCode2
IRS1 CRK 25361965 interaction type N/A PTMCode2
UBTF IRS1 25361965 interaction type N/A PTMCode2
IRS1 UBTF 25361965 interaction type N/A PTMCode2
PIK3R1 IRS1 25361965 interaction type N/A PTMCode2
IRS1 PIK3R1 25361965 interaction type N/A PTMCode2
IRS1 INSR 25361965 interaction type N/A PTMCode2
PIK3R2 IRS1 25361965 interaction type N/A PTMCode2
IRS1 PIK3R2 25361965 interaction type N/A PTMCode2
BCR IRS1 25361965 interaction type N/A PTMCode2
IRS1 BCR 25361965 interaction type N/A PTMCode2

Source Target Pmid Interactiontype Methods Database
NCK2 IRS1 25348397 N/A physical interaction ComPPI
PIK3R2 IRS1 11120660 12730242 14525934 25348397 7559478 N/A two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD
MAPK9 IRS1 12417588 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
SOCS3 IRS1 12228220 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
NPM1 IRS1 14525934 25348397 8633037 N/A experimental interaction detection,in vitro ComPPI,HPRD
TYK2 IRS1 14525934 25348397 8550573 N/A experimental interaction detection,in vivo ComPPI,HPRD
YWHAG IRS1 14525934 15324660 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
ROCK1 IRS1 11739394 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CRK IRS1 14525934 25348397 8621590 8810325 9837978 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
BCL2L1 IRS1 10679027 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
SIK2 IRS1 12624099 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
EGLN3 IRS1 24234451 25348397 26972000 association anti tag coimmunoprecipitation ComPPI,IntAct
ERBB2 IRS1 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
CBL IRS1 25348397 N/A physical interaction ComPPI
MAPK1 IRS1 14525934 16131083 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRKCQ IRS1 14525934 15364919 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
SOCS1 IRS1 11208867 12228220 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CBLB IRS1 25348397 N/A physical interaction ComPPI
MAPK8 IRS1 10722755 11606564 12351658 12417588 14525934 25348397 N/A two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid ComPPI,HPRD
PIK3R1 IRS1 11403293 11416002 12173038 12220227 1381348 14525934 14632132 16043515 16150444 16230374 23643389 24234451 25348397 7680095 7680644 8382612 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,biophysical,two hybrid,coimmunoprecipitation,cross-linking study,experimental interaction detection,nuclear magnetic resonance,pull down,surface plasmon resonance,physical interaction,enzymatic study,in vitro,in vivo ComPPI,HPRD,IntAct
PTPN11 IRS1 14525934 24234451 25348397 7513703 7935386 8505282 9756938 association experimental interaction detection,surface plasmon resonance,physical interaction,in vitro,in vivo,surface plasmon resonance array ComPPI,HPRD,IntAct
GRB10 IRS1 25348397 N/A physical interaction ComPPI
PLCG2 IRS1 25348397 N/A physical interaction ComPPI
SHC1 IRS1 14525934 25348397 7499194 N/A experimental interaction detection,in vitro ComPPI,HPRD
PRKCD IRS1 12031982 14525934 15364919 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
MAPK3 IRS1 25348397 N/A physical interaction ComPPI
KHDRBS1 IRS1 25348397 N/A physical interaction ComPPI
GRB2 IRS1 14525934 21706016 24234451 25348397 7488107 8388384 8810325 association anti tag coimmunoprecipitation,biophysical,experimental interaction detection,physical interaction,genetic,in vitro,in vivo ComPPI,HPRD,IntAct
SMAD3 IRS1 18729074 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
YWHAB IRS1 14525934 25348397 27898060 9422753 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
YWHAZ IRS1 14525934 25348397 9312143 N/A experimental interaction detection,in vivo ComPPI,HPRD
FES IRS1 10856136 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
UBTF IRS1 12554758 14525934 17332342 25348397 27898060 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD,OmniPath
IRS2 IRS1 25348397 N/A physical interaction ComPPI
GHR IRS1 14525934 25348397 7782332 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
PIK3CB IRS1 25348397 N/A physical interaction ComPPI
PIK3CA IRS1 16150444 23643389 24234451 25348397 association,physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,pull down,physical interaction ComPPI,IntAct
PIK3R3 IRS1 10417350 14525934 24234451 25348397 25814554 7542745 9415396 physical association two hybrid,experimental interaction detection,physical interaction,two hybrid array,in vitro,in vivo,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,HPRD,IntAct
UBC IRS1 25348397 N/A physical interaction ComPPI
NTRK1 IRS1 11147812 14525934 25348397 N/A two hybrid,experimental interaction detection,in vitro,two hybrid ComPPI,HPRD
DDR1 IRS1 25348397 N/A protein kinase assay ComPPI
TUB IRS1 10455176 14525934 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PTPRF IRS1 10660596 14525934 15588985 25348397 8732688 N/A experimental interaction detection,in vitro ComPPI,HPRD
CDH1 IRS1 11035789 25348397 27898060 N/A in vivo ComPPI,OmniPath
JAK1 IRS1 11162588 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
PTPN1 IRS1 10660596 11579209 14525934 24234451 25348397 dephosphorylation reaction experimental interaction detection,physical interaction,phosphatase assay,in vivo ComPPI,HPRD,IntAct
GRB14 IRS1 14525934 25348397 27898060 9748281 N/A two hybrid,experimental interaction detection,in vivo,two hybrid ComPPI,HPRD,OmniPath
NUMB IRS1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,validated two hybrid ComPPI,IntAct
PDPK1 IRS1 14525934 15802620 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
CAV1 IRS1 14525934 15003536 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
IKBKB IRS1 10722755 11606564 12351658 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro,in vivo ComPPI,HPRD
CSNK2A1 IRS1 14525934 25348397 8349691 N/A experimental interaction detection,in vitro ComPPI,HPRD
FER IRS1 11006284 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
PRKCZ IRS1 11063744 14525934 25348397 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
CYTH2 IRS1 17167487 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
PRKCG IRS1 14525934 15364919 25348397 N/A experimental interaction detection,in vitro ComPPI,HPRD
PABPC1 IRS1 23770097 24234451 25348397 27898060 association,physical association anti bait coimmunoprecipitation ComPPI,IntAct,OmniPath
RAD51 IRS1 14525934 14559999 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
RPS6KB1 IRS1 25348397 N/A physical interaction ComPPI
DVL2 IRS1 25348397 N/A physical interaction ComPPI
EGFR IRS1 16273093 24234451 25348397 N/A protein array,physical interaction ComPPI,IntAct
BCR IRS1 12560071 14525934 25348397 N/A experimental interaction detection,in vivo ComPPI,HPRD
YWHAH IRS1 25348397 N/A physical interaction ComPPI
SFN IRS1 15778465 24234451 25348397 physical association physical interaction,tandem affinity purification ComPPI,IntAct
YWHAE IRS1 14525934 24234451 25348397 9111084 9312143 association,physical association two hybrid,experimental interaction detection,pull down,physical interaction,competition binding,in vivo ComPPI,HPRD,IntAct
JAK3 IRS1 14525934 25348397 7499365 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IRS1 ATP2A1 14525934 25348397 9295312 N/A experimental interaction detection,in vivo ComPPI,HPRD
IRS1 CSNK2B 14525934 25348397 8349691 N/A experimental interaction detection,in vitro ComPPI,HPRD
IRS1 CHUK 12351658 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IRS1 JAK2 12960006 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IRS1 ATP2A2 14525934 25348397 9295312 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
IRS1 FYN 14525934 25348397 8631859 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD
IRS1 ATP2A3 12524443 14525934 25348397 27898060 N/A experimental interaction detection,in vitro,in vivo ComPPI,HPRD,OmniPath
IRS1 MTOR 11287630 14525934 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
IRS1 RPTOR 14525934 16354680 25348397 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD
IRS1 INSR 11606564 14525934 15629149 16582879 24234451 25348397 7935368 8662806 physical association anti bait coimmunoprecipitation,anti tag coimmunoprecipitation,two hybrid,experimental interaction detection,pull down,physical interaction,biochemical,in vitro,in vivo,two hybrid ComPPI,HPRD,IntAct
IRS1 IL4R 14525934 25348397 8599766 N/A experimental interaction detection,in vivo ComPPI,HPRD
IRS1 PTPRC 25348397 27898060 8557683 N/A in vivo ComPPI,OmniPath
IRS1 AKT1 10497255 14525934 25348397 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IRS1 AP3S1 14525934 25348397 27898060 9792713 N/A experimental interaction detection,physical interaction,in vitro ComPPI,HPRD,OmniPath
IRS1 PHIP 11018022 25348397 27898060 N/A two hybrid,in vitro,in vivo ComPPI,OmniPath
IRS1 ALK 14525934 25348397 9174053 N/A experimental interaction detection,physical interaction,in vivo ComPPI,HPRD
IRS1 PTK2 25348397 N/A physical interaction ComPPI
IRS1 BCL2 25348397 N/A physical interaction ComPPI
IRS1 NISCH 25348397 N/A physical interaction ComPPI
IRS1 ESR1 25348397 N/A physical interaction ComPPI
IRS1 NEDD4 25348397 N/A physical interaction ComPPI
IRS1 FBXW8 25348397 N/A physical interaction ComPPI
IRS1 APP 25348397 N/A physical interaction ComPPI
IRS1 SH2B1 25348397 N/A physical interaction ComPPI
IRS1 PTPRU 25348397 N/A physical interaction ComPPI
IRS1 FBXO25 25348397 N/A physical interaction ComPPI
IRS1 SIRT1 21241768 24234451 25348397 physical association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
IRS1 BCAR3 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array,luminescence based mammalian interactome mapping,validated two hybrid ComPPI,IntAct
IRS1 CUL7 25348397 N/A physical interaction ComPPI
IRS1 CYTH3 17167487 24234451 25348397 association anti bait coimmunoprecipitation,physical interaction ComPPI,IntAct
IRS1 EIF4E 23770097 24234451 25348397 association anti bait coimmunoprecipitation ComPPI,IntAct
IRS1 LRRK2 24234451 24947832 25348397 N/A protein array ComPPI,IntAct
IRS1 PTPRD 22305495 24234451 25348397 N/A protein array ComPPI,IntAct
HDAC2 IRS1 15522123 25348397 27898060 N/A physical interaction ComPPI,OmniPath
IGF1R IRS1 12220227 14525934 15629149 24234451 25348397 7541045 7559507 8530377 8662806 physical association two hybrid,experimental interaction detection,physical interaction,in vivo,two hybrid ComPPI,HPRD,IntAct
PELI1 IRS1 24234451 25348397 25814554 physical association two hybrid,physical interaction,two hybrid array ComPPI,IntAct
IRS1 IRS1 10411883 14525934 N/A experimental interaction detection HPRD
IRS1 PIN1 21454638 27898060 N/A N/A OmniPath
IRS1 SQSTM1 22761437 27898060 N/A N/A OmniPath
SRC IRS1 11259577 12351658 27898060 8349691 N/A N/A OmniPath
PTPN13 IRS1 17638892 27898060 inhibition N/A OmniPath
PRKAA2 IRS1 12624099 27898060 N/A N/A OmniPath
PRKACA IRS1 17360977 27898060 inhibition N/A OmniPath
PRKCA IRS1 15069075 16574739 27898060 inhibition,stimulant N/A OmniPath
NTRK2 IRS1 27898060 9374521 stimulant N/A OmniPath
PTPN1 IRS1 10660596 11579209 1157921 15632081 27898060 inhibition,stimulant N/A OmniPath
NTRK1 IRS1 11147812 27898060 stimulant N/A OmniPath
PLK1 IRS1 12351658 15849359 20135346 27898060 inhibition N/A OmniPath
PRKCD IRS1 11606564 12006582 12031982 12351658 14583092 15069075 15143153 15199052 15364919 15516986 16046301 16099428 16129690 16503154 16611834 16914728 17360977 18949383 18952604 25843719 27898060 inhibition,stimulant N/A OmniPath
SOCS3 IRS1 12228220 23115649 27898060 inhibition N/A OmniPath
PTPRF IRS1 10660596 15588985 27898060 8732688 inhibition,stimulant N/A OmniPath
CHUK IRS1 12351658 27898060 inhibition N/A OmniPath
IRS1 JAK3 27898060 7499365 9233603 N/A N/A OmniPath
INS IRS1 12409308 27898060 inhibition,stimulant N/A OmniPath
MAP2K1 IRS1 11160134 27898060 inhibition N/A OmniPath
MAPK9 IRS1 12417588 14579029 27898060 9335553 inhibition,stimulant N/A OmniPath
RPS6KA1 IRS1 12351658 14769130 15001544 16020478 17709744 21798082 27898060 inhibition N/A OmniPath
IGF1R IRS1 10082579 11416002 11557037 12220227 12525499 15629149 15829723 17827393 21798082 27898060 7537849 7541045 7559507 8530377 8662806 8776723 stimulant N/A OmniPath
APP IRS1 21832049 27898060 N/A N/A OmniPath
IRS1 APP 21832049 27898060 N/A N/A OmniPath
IRS1 NCK1 27898060 8265614 stimulant N/A OmniPath
PRKCQ IRS1 15364919 27898060 stimulant N/A OmniPath
IRS1 GRB2 11259577 12173038 21706016 22974441 27898060 7486683 7488107 8114695 8196603 8265614 8388384 8491186 8536716 8810325 stimulant N/A OmniPath
MAPK3 IRS1 14769130 15001544 15576463 16020478 16099428 16123357 27898060 9335553 inhibition N/A OmniPath
JAK1 IRS1 11162588 11591769 27898060 7499365 7544789 8756628 9233603 9492017 stimulant N/A OmniPath
IRS1 JAK1 11162588 27898060 7499365 9233603 9492017 stimulant N/A OmniPath
IRS1 PIK3CA 11160134 12933652 1380456 1381348 14511371 16150444 16354680 20966354 23604317 23643389 27898060 9374521 stimulant N/A OmniPath
PIK3CA IRS1 11160134 12933652 14511371 16150444 16354680 20966354 23604317 23643389 27898060 inhibition N/A OmniPath
PRKCZ IRS1 11063744 15069075 15516986 16020478 16129678 17360977 27898060 inhibition,stimulant N/A OmniPath
IRS1 SHC1 10807918 27898060 7499194 stimulant N/A OmniPath
PIK3R1 IRS1 11403293 11416002 12107746 12173038 12220227 12594288 12730242 12783867 12960006 1381348 14511371 14632132 14684612 15169905 15183122 15249583 15380067 15514089 16043515 16150444 16230374 16354680 16455755 19561084 21798082 22974441 23439647 25814554 27898060 7486683 7539611 7680095 7680644 8175658 8382612 9415395 9564850 N/A N/A OmniPath
IRS1 PIK3R1 11403293 11416002 12107746 12173038 12220227 12594288 12730242 12783867 12960006 1381348 14511371 14632132 14684612 15169905 15183122 15249583 15380067 15514089 16043515 16150444 16230374 16354680 16455755 19561084 21798082 22974441 23439647 25814554 27898060 7486683 7539611 7680095 7680644 8175658 8382612 9415395 9564850 stimulant N/A OmniPath
TNF IRS1 11287630 27898060 inhibition,stimulant N/A OmniPath
MAPK1 IRS1 15001544 16131083 17242212 19651622 27898060 inhibition N/A OmniPath
PTPN11 IRS1 10660596 11781100 22974441 27898060 7513703 7515062 7935386 8505282 9756938 inhibition N/A OmniPath
IRS1 MTOR 11287630 15952059 16354680 27898060 N/A N/A OmniPath
MTOR IRS1 11287630 15952059 16354680 27898060 9335553 inhibition N/A OmniPath
INSR IRS1 11606564 11781100 12220227 1385403 15629149 15870194 16582879 17167487 18083107 19534553 2159922 27898060 7499194 7537849 7651388 7935368 8626379 8626723 8662806 stimulant N/A OmniPath
MAP2K7 IRS1 17360977 27898060 inhibition N/A OmniPath
IL4R IRS1 12704343 27898060 7537849 8599766 9697832 stimulant N/A OmniPath
IRS1 JAK2 11208867 12960006 27898060 7782332 9492017 stimulant N/A OmniPath
MAPK8 IRS1 10722755 11606564 12351658 12417588 12510059 14579029 15314024 18728222 27898060 inhibition N/A OmniPath
RPS6KB1 IRS1 14769130 15306821 15364919 15604215 16020478 16914728 17081983 17277771 17640984 18220336 18952604 19369195 20594869 21850561 23045529 26297026 27898060 9312143 inhibition,stimulant N/A OmniPath
IKBKB IRS1 10722755 11606564 12351658 12555073 15613682 17229808 18077418 18160431 19651622 21040800 27898060 inhibition N/A OmniPath
SMAD3 IRS1 18729074 27898060 N/A N/A OmniPath
LTK IRS1 27898060 9223670 stimulant N/A OmniPath
IRS1 PIK3CB 11416002 27898060 stimulant N/A OmniPath
SIK2 IRS1 12624099 27898060 stimulant N/A OmniPath
YWHAH IRS1 27898060 9312143 inhibition N/A OmniPath
IRS1 IRS4 11912194 27898060 stimulant N/A OmniPath
IRS1 GRAP 11897402 27898060 stimulant N/A OmniPath
IRS1 PIK3CG 11943559 27898060 stimulant N/A OmniPath
SIK1 IRS1 12351658 12624099 15199052 16099428 16129690 27898060 N/A N/A OmniPath

Visualization










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