GENE：RAC2
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | RAC2 |
| FullNmae | Rac family small GTPase 2 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:9802 |
| EnsembleID | ENSG00000128340 |
| Uniprot | P15153 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| RAC2 | lysosomal_cd | 36341760 | 220 lysosome-dependent cell death genes. | retulator signature |
| RAC2 | lysosomal_cd | 36341760 | The PCD-related genes contained the key regulatory genes of twelve PCD patterns which is mentioned above. Genes were collected from GSEA gene sets, KEGG, review articles, and manual collation [10]. The ultimate gene list was the concatenation regulatory genes of twelve PCD patterns. | regulator signature |
| RAC2 | immunogenic | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| RAC2 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
| RAC2 | apoptosis | 36779914 | Rac2 overexpression also aggravated the inflammatory response, induced activation of microglia and astrocytes, and enhanced apoptosis whereas knockdown of Rac2 had the opposite effects. | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| RAC2 | GO:0003924,GO:0005515,GO:0005525,GO:0005525,GO:0005635,GO:0005741,GO:0005789,GO:0005829,GO:0005829,GO:0005884,GO:0005886,GO:0005886,GO:0005886,GO:0005925,GO:0006935,GO:0007015,GO:0007015,GO:0007165,GO:0007186,GO:0007264,GO:0010310,GO:0010592,GO:0010592,GO:0010810,GO:0019887,GO:0030027,GO:0030031,GO:0030334,GO:0030670,GO:0042129,GO:0043020,GO:0043304,GO:0045453,GO:0045730,GO:0060263,GO:0060753,GO:0070062,GO:0070662,GO:0070668,GO:0071593,GO:0090023,GO:1902622,GO:1903955 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| RAC2 | hsa:5880 | path:hsa04010 | MAPK signaling pathway - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa04014 | Ras signaling pathway - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa04015 | Rap1 signaling pathway - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa04024 | cAMP signaling pathway - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa04062 | Chemokine signaling pathway - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa04071 | Sphingolipid signaling pathway - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa04310 | Wnt signaling pathway - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa04360 | Axon guidance - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa04370 | VEGF signaling pathway - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa04510 | Focal adhesion - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa04520 | Adherens junction - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa04613 | Neutrophil extracellular trap formation - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa04650 | Natural killer cell mediated cytotoxicity - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa04662 | B cell receptor signaling pathway - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa04664 | Fc epsilon RI signaling pathway - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa04666 | Fc gamma R-mediated phagocytosis - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa04670 | Leukocyte transendothelial migration - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa04810 | Regulation of actin cytoskeleton - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa05020 | Prion disease - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa05135 | Yersinia infection - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa05163 | Human cytomegalovirus infection - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa05170 | Human immunodeficiency virus 1 infection - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa05200 | Pathways in cancer - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa05210 | Colorectal cancer - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa05212 | Pancreatic cancer - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa05231 | Choline metabolism in cancer - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa05415 | Diabetic cardiomyopathy - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa05416 | Viral myocarditis - Homo sapiens (human) |
| RAC2 | hsa:5880 | path:hsa05418 | Fluid shear stress and atherosclerosis - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RAC2 | PAK1 | 10224076 23180781 23331499 9705280 | stimulation,physical association | pull down | InnateDB,SignaLink |
| RAC2 | ARHGDIA | 11368848 23180781 | physical association | two hybrid | InnateDB |
| RAC2 | S100A8 | 15642721 23180781 | physical association | pull down | InnateDB |
| RAC2 | S100A9 | 15642721 23180781 | physical association | pull down | InnateDB |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| ETS1 | RAC2 | 18971253 20019798 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| GATA1 | RAC2 | 19941826 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| GATA2 | RAC2 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| SMARCA4 | RAC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | RAC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | RAC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | RAC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| SPI1 | RAC2 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MYC | RAC2 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| RAC2 | ARFIP2 | 25361965 | interaction type | N/A | PTMCode2 |
| ARFIP2 | RAC2 | 25361965 | interaction type | N/A | PTMCode2 |
| RAC2 | ARHGDIA | 25361965 | interaction type | N/A | PTMCode2 |
| ARHGDIA | RAC2 | 25361965 | interaction type | N/A | PTMCode2 |
| RAC2 | RTKN | 25361965 | interaction type | N/A | PTMCode2 |
| RTKN | RAC2 | 25361965 | interaction type | N/A | PTMCode2 |
| RAC2 | CDC42 | 25361965 | interaction type | N/A | PTMCode2 |
| CDC42 | RAC2 | 25361965 | interaction type | N/A | PTMCode2 |
| RAC2 | DEF6 | 25361965 | interaction type | N/A | PTMCode2 |
| DEF6 | RAC2 | 25361965 | interaction type | N/A | PTMCode2 |
| RAC2 | NOXA1 | 25361965 | interaction type | N/A | PTMCode2 |
| NOXA1 | RAC2 | 25361965 | interaction type | N/A | PTMCode2 |
| RAC2 | PKN1 | 25361965 | interaction type | N/A | PTMCode2 |
| PKN1 | RAC2 | 25361965 | interaction type | N/A | PTMCode2 |
| RAC2 | PLCG2 | 25361965 | interaction type | N/A | PTMCode2 |
| PLCG2 | RAC2 | 25361965 | interaction type | N/A | PTMCode2 |
| RAC2 | NCF2 | 25361965 | interaction type | N/A | PTMCode2 |
| NCF2 | RAC2 | 25361965 | interaction type | N/A | PTMCode2 |
| RAC2 | GDI1 | 25361965 | interaction type | N/A | PTMCode2 |
| GDI1 | RAC2 | 25361965 | interaction type | N/A | PTMCode2 |
| ARHGDIB | RAC2 | 25361965 | interaction type | N/A | PTMCode2 |
| RAC2 | ARHGDIB | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| DEF6 | RAC2 | 14525934 15023524 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| CDC42 | RAC2 | 14525934 25348397 27898060 9748241 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| PAK2 | RAC2 | 25348397 | N/A | physical interaction | ComPPI |
| WAS | RAC2 | 14521508 24234451 25348397 | physical association | pull down | ComPPI,IntAct |
| ACTB | RAC2 | 11027608 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| XIAP | RAC2 | 22117219 24234451 25348397 | N/A | pull down | ComPPI,IntAct |
| SMAD4 | RAC2 | 14525934 15761153 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| PAK1 | RAC2 | 25348397 | N/A | pull down | ComPPI |
| SMAD1 | RAC2 | 14525934 15761153 25348397 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD |
| ARHGDIB | RAC2 | 10655614 14525934 24234451 25348397 27898060 | N/A | experimental interaction detection,x-ray crystallography,physical interaction,in vitro | ComPPI,HPRD,IntAct,OmniPath |
| CD81 | RAC2 | 25348397 | N/A | physical interaction | ComPPI |
| RTKN | RAC2 | 12516569 14525934 25348397 27898060 | N/A | experimental interaction detection,in vivo | ComPPI,HPRD,OmniPath |
| ARHGDIA | RAC2 | 11513578 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| ICMT | RAC2 | 14525934 25348397 9614111 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| RAP1GDS1 | RAC2 | 25348397 | N/A | physical interaction | ComPPI |
| U2AF2 | RAC2 | 25348397 | N/A | physical interaction | ComPPI |
| AGAP2 | RAC2 | 25348397 | N/A | physical interaction | ComPPI |
| PLD2 | RAC2 | 22106281 24234451 25348397 27898060 | physical association | anti tag coimmunoprecipitation,pull down,physical interaction,solid phase assay,gdp/gtp exchange assay | ComPPI,IntAct,OmniPath |
| CFTR | RAC2 | 25348397 | N/A | physical interaction | ComPPI |
| DOCK1 | RAC2 | 25348397 | N/A | physical interaction | ComPPI |
| ELMO2 | RAC2 | 25348397 | N/A | physical interaction | ComPPI |
| GDI1 | RAC2 | 14525934 25348397 9490022 | N/A | experimental interaction detection,in vitro,in vivo | ComPPI,HPRD |
| CUL1 | RAC2 | 11445862 14525934 25348397 27898060 | N/A | two hybrid,physical interaction,two hybrid | ComPPI,HPRD,OmniPath |
| NOS2 | RAC2 | 11457725 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| VCAM1 | RAC2 | 22623428 24234451 25348397 | association | cross-linking study,physical interaction | ComPPI,IntAct |
| ITGA4 | RAC2 | 25348397 | N/A | physical interaction | ComPPI |
| NCF2 | RAC2 | 11090627 14525934 24234451 25348397 9624165 9642115 | physical association | experimental interaction detection,isothermal titration calorimetry,physical interaction,in vivo | ComPPI,HPRD,IntAct |
| RAC2 | NOXA1 | 12716910 14525934 25348397 | N/A | two hybrid,two hybrid | ComPPI,HPRD |
| RAC2 | ARFIP2 | 11346801 14525934 24234451 25348397 | physical association | two hybrid,experimental interaction detection,two hybrid array,in vitro,two hybrid prey pooling approach | ComPPI,HPRD,IntAct |
| RAC2 | DOCK2 | 10559471 14525934 14737186 24234451 25348397 | association | experimental interaction detection,pull down,physical interaction | ComPPI,HPRD,IntAct |
| RAC2 | CHGB | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| RAC2 | AFG3L2 | 21900206 24234451 25348397 | physical association | two hybrid,physical interaction | ComPPI,IntAct |
| RAC2 | HDAC10 | 23752268 24234451 25348397 | association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RAC2 | ADAM22 | 21988832 24234451 25348397 | physical association | two hybrid,physical interaction,two hybrid array | ComPPI,IntAct |
| RAC2 | FBXO6 | 25348397 | N/A | physical interaction | ComPPI |
| RAC2 | RAC3 | 25348397 | N/A | physical interaction | ComPPI |
| RAC2 | TNFAIP8L2 | 22949657 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RAC2 | CYBB | 22366891 24234451 25348397 | colocalization | confocal microscopy | ComPPI,IntAct |
| RAC2 | WG | 25348397 | N/A | two hybrid | ComPPI |
| RAC2 | PAK | 10847683 14527437 24234451 25348397 | association,physical association | two hybrid,pull down,physical interaction | ComPPI,IntAct |
| RAC2 | RAC1 | 10847683 24234451 25348397 | physical association | pull down | ComPPI,IntAct |
| RAC2 | RAC2 | 24234451 9748241 | physical association | chromatography technology | IntAct |
| SH3RF1 | RAC2 | 27898060 9482736 | stimulant | N/A | OmniPath |
| RAC2 | PAK1 | 10224076 27898060 9705280 | stimulant | N/A | OmniPath |
| PAK1 | RAC2 | 10224076 27898060 9705280 | N/A | N/A | OmniPath |
| ARHGDIA | RAC2 | 11368848 11513578 27898060 9490022 | N/A | N/A | OmniPath |
| S100A9 | RAC2 | 15642721 27898060 | N/A | N/A | OmniPath |
| S100A8 | RAC2 | 15642721 27898060 | N/A | N/A | OmniPath |
| RAP1GDS1 | RAC2 | 21242305 27898060 | stimulant | N/A | OmniPath |