GENE：RGS4
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | RGS4 |
| FullNmae | regulator of G protein signaling 4 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:10000 |
| EnsembleID | ENSG00000117152 |
| Uniprot | P49798 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| RGS4 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| RGS4 | GO:0001965,GO:0001975,GO:0003924,GO:0005096,GO:0005516,GO:0005634,GO:0005737,GO:0005886,GO:0007186,GO:0008277,GO:0010460,GO:0019901,GO:0032991,GO:0042220,GO:0045471,GO:0045744,GO:0051924,GO:0060160,GO:0061052,GO:0110053,GO:1900924,GO:1901380,GO:1990791,GO:2000463 |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | RGS4 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | RGS4 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| YBX1 | RGS4 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| CTCF | RGS4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| E2F1 | RGS4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| GATA2 | RGS4 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | RGS4 | 18260825 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| PROX1 | RGS4 | 22942256 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | RGS4 | 18260825 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GNAI1 | RGS4 | 25361965 | interaction type | N/A | PTMCode2 |
| RGS4 | GNAI1 | 25361965 | interaction type | N/A | PTMCode2 |
| PLCB1 | RGS4 | 25361965 | interaction type | N/A | PTMCode2 |
| RGS4 | PLCB1 | 25361965 | interaction type | N/A | PTMCode2 |
| GNA11 | RGS4 | 25361965 | interaction type | N/A | PTMCode2 |
| RGS4 | GNA11 | 25361965 | interaction type | N/A | PTMCode2 |
| ERBB3 | RGS4 | 25361965 | interaction type | N/A | PTMCode2 |
| RGS4 | ERBB3 | 25361965 | interaction type | N/A | PTMCode2 |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| GNAQ | RGS4 | 14525934 25348397 9405622 9660808 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| PTAFR | RGS4 | 11297424 14525934 25348397 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD |
| RGS4 | COPB1 | 10982407 14525934 25348397 | N/A | two hybrid,experimental interaction detection,in vivo,two hybrid | ComPPI,HPRD |
| RGS4 | COPB2 | 10982407 14525934 25348397 | N/A | two hybrid,experimental interaction detection,physical interaction,in vitro,in vivo,two hybrid | ComPPI,HPRD |
| RGS4 | PLCB1 | 11148035 14525934 25348397 27898060 | N/A | experimental interaction detection,in vitro | ComPPI,HPRD,OmniPath |
| RGS4 | GNAI1 | 11507164 14525934 22310500 25348397 27898060 9660808 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD,OmniPath |
| RGS4 | GNAO1 | 14525934 25348397 9660808 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| RGS4 | GNAI2 | 14525934 25348397 9660808 | N/A | experimental interaction detection,physical interaction,in vitro | ComPPI,HPRD |
| RGS4 | ERBB3 | 12840049 14525934 25348397 | N/A | experimental interaction detection,physical interaction,two hybrid | ComPPI,HPRD |
| RGS4 | KRIT1 | 10747990 25348397 27898060 | N/A | physical interaction | ComPPI,OmniPath |
| RGS4 | GABBR1 | 25348397 | N/A | physical interaction | ComPPI |
| RGS4 | EGFR | 24234451 24658140 25348397 | physical association | ubiquitin reconstruction,physical interaction | ComPPI,IntAct |
| RGS4 | PREPL | 25348397 | N/A | physical interaction | ComPPI |
| RGS4 | CHRM3 | 20385802 24234451 25348397 | physical association | anti tag coimmunoprecipitation,physical interaction | ComPPI,IntAct |
| RGS4 | CALM2 | 10747990 14525934 | N/A | experimental interaction detection | HPRD |
| RGS4 | GNAQ | 14634662 27898060 9012799 9405622 9660808 | inhibition | N/A | OmniPath |