GENE：UPP1
GeneInfo:
| GeneAttribute | GeneDescription |
|---|---|
| GeneSymbol | UPP1 |
| FullNmae | uridine phosphorylase 1 |
| LocusType | gene with protein product |
| Status | Approved |
| HGNC_id | HGNC:12576 |
| EnsembleID | ENSG00000183696 |
| Uniprot | Q16831 |
Protein Structure:
Gene Description in Publicaton:
| GeneSymbol | CellDeathType | PMID | Description | GeneType |
|---|---|---|---|---|
| UPP1 | autosis | 38538696 | The 18 RCD signatures collected from previous studies. Supplementary Table of Figures.xlsx (https://github.com/zwxiangya/RCDscore) | retulator signature |
Go Annotation:
| GeneSymbol | Go id |
|---|---|
| UPP1 | GO:0004850,GO:0004850,GO:0005654,GO:0005829,GO:0005829,GO:0006139,GO:0006218,GO:0006218,GO:0006248,GO:0006249,GO:0009032,GO:0042149,GO:0042802,GO:0044206,GO:0046050,GO:0046074,GO:0046079,GO:0047847 |
KEGG Annotation:
| GeneSymbol | GeneID | Pathway | Pathway Name |
|---|---|---|---|
| UPP1 | hsa:7378 | path:hsa00240 | Pyrimidine metabolism - Homo sapiens (human) |
| UPP1 | hsa:7378 | path:hsa00983 | Drug metabolism - other enzymes - Homo sapiens (human) |
| UPP1 | hsa:7378 | path:hsa01100 | Metabolic pathways - Homo sapiens (human) |
| UPP1 | hsa:7378 | path:hsa01232 | Nucleotide metabolism - Homo sapiens (human) |
Protein-Protein Interaction(String):
Gene-Drug Network:
Signalink 3.0 modificators
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| AR | UPP1 | 20610535 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| E2F4 | UPP1 | 17531812 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| GATA2 | UPP1 | 18971253 19941826 | trascriptional regulation,stimulation | inferred by curator,chromatin immunoprecipitation assay | TFlink |
| YBX1 | UPP1 | 19151767 | trascriptional regulation,stimulation | chromatin immunoprecipitation assay | TFlink |
| FOXP3 | UPP1 | 20554955 | trascriptional regulation,stimulation | chromatin immunoprecipitation array | TFlink |
| SMARCA4 | UPP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CEBPA | UPP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| CTCF | UPP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| EGR1 | UPP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOXA1 | UPP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FOS | UPP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| HNF4A | UPP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| MITF | UPP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| TRIM28 | UPP1 | 18971253 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| NFKB1 | UPP1 | 20544543 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| RELA | UPP1 | 20544543 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| STAT1 | UPP1 | 20544543 | trascriptional regulation,stimulation | inferred by curator | TFlink |
| FLI1 | UPP1 | N/A | trascriptional regulation,stimulation | inferred by curator | TFlink |
| Source | Target | Pmid | Interactiontype | Methods | Database |
|---|---|---|---|---|---|
| VIM | UPP1 | 11278417 14525934 25348397 | N/A | experimental interaction detection,physical interaction,in vitro,in vivo | ComPPI,HPRD |
| WBP2 | UPP1 | 25348397 | N/A | physical interaction | ComPPI |
| TP53BP1 | UPP1 | 24234451 25348397 29656893 | association | proximity-dependent biotin identification | ComPPI,IntAct |
| UBE2D1 | UPP1 | 25348397 | N/A | physical interaction | ComPPI |
| MCM2 | UPP1 | 25348397 | N/A | physical interaction | ComPPI |
| CTDP1 | UPP1 | 25348397 | N/A | physical interaction | ComPPI |
| UPP1 | WDR45B | 25348397 | N/A | physical interaction | ComPPI |
| UPP1 | GPD1L | 25348397 | N/A | physical interaction | ComPPI |